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All Outputs (73)

OP0152-PC Knowledge and Confidence of Practice Nurses in the Management of Osteoarthritis (OA): Pre- and Post-Evaluation of an OA Self-Management Training Programme (2014)
Journal Article
Healey, E. L., Ryan, S., McHugh, G. A., Main, C. J., Porcheret, M., Ong, B. N., …Dziedzic, K. S. (2014). OP0152-PC Knowledge and Confidence of Practice Nurses in the Management of Osteoarthritis (OA): Pre- and Post-Evaluation of an OA Self-Management Training Programme. Annals of the Rheumatic Diseases, 72(Suppl 3), A103.3-A104. https://doi.org/10.1136/annrheumdis-2013-eular.357

Background In the United Kingdom (UK), practice nurses do not routinely consult with individuals with OA as most OA care is provided by general practitioners. However, evidence suggests that practice nurses are most likely to provide self-management... Read More about OP0152-PC Knowledge and Confidence of Practice Nurses in the Management of Osteoarthritis (OA): Pre- and Post-Evaluation of an OA Self-Management Training Programme.

Should there be a Quality and Outcomes Framework domain for osteoarthritis? A cross-sectional survey in general practice (2013)
Journal Article
Clarson, L. E., Nicholl, B. I., Bishop, A., Edwards, J., Daniel, R., & Mallen, C. (2013). Should there be a Quality and Outcomes Framework domain for osteoarthritis? A cross-sectional survey in general practice. Quality in Primary Care, 21(2), 97-103

BackgroundDespite being a chronic condition with a high prevalence and significant associated morbidity that is managed predominantly in primary care, osteoarthritis (OA) does not feature in the Quality and Outcomes Framework (QOF) component of theUK... Read More about Should there be a Quality and Outcomes Framework domain for osteoarthritis? A cross-sectional survey in general practice.

MAGNETIC NANOPARTICLE MEDIATED GENE DELIVERY IN OLIGODENDROGLIAL CELLS: A COMPARISON OF DIFFERENTIATED CELLS VERSUS PRECURSOR FORMS (2012)
Journal Article
JENKINS, S. I., PICKARD, M. R., & CHARI, D. M. (2013). MAGNETIC NANOPARTICLE MEDIATED GENE DELIVERY IN OLIGODENDROGLIAL CELLS: A COMPARISON OF DIFFERENTIATED CELLS VERSUS PRECURSOR FORMS. Nano LIFE, 03(02), Article 1243001. https://doi.org/10.1142/s1793984412430015

Magnetic nanoparticles (MNPs) have emerged as a major platform for the formulation of magnetic vectors for nonviral gene delivery. Notably the application of "magnetofection" strategies (use of magnetic fields to increase MNP–cell interactions) can s... Read More about MAGNETIC NANOPARTICLE MEDIATED GENE DELIVERY IN OLIGODENDROGLIAL CELLS: A COMPARISON OF DIFFERENTIATED CELLS VERSUS PRECURSOR FORMS.

Fe3O4-PEI-RITC Magnetic Nanoparticles with Imaging and Gene Transfer Capability: Development of a Tool for Neural Cell Transplantation Therapies (2011)
Journal Article
Yiu, H. H. P., Pickard, M. R., Olariu, C. I., Williams, S. R., Chari, D. M., & Rosseinsky, M. J. (2012). Fe3O4-PEI-RITC Magnetic Nanoparticles with Imaging and Gene Transfer Capability: Development of a Tool for Neural Cell Transplantation Therapies. Pharmaceutical Research, 29(5), 1328-1343. https://doi.org/10.1007/s11095-011-0632-1

Purpose To develop Fe3O4-PEI-RITC magnetic nanoparticles with multimodal MRI-fluorescence imaging and transfection capability, for use in neural cell replacement therapies. Methods The Fe3O4-PEI-RITC MNPs were synthesised through a multi-step ch... Read More about Fe3O4-PEI-RITC Magnetic Nanoparticles with Imaging and Gene Transfer Capability: Development of a Tool for Neural Cell Transplantation Therapies.

Magnetic Nanoparticle-Mediated Gene Transfer to Oligodendrocyte Precursor Cell Transplant Populations Is Enhanced by Magnetofection Strategies (2011)
Journal Article
Jenkins, S. I., Pickard, M. R., Granger, N., & Chari, D. M. (2011). Magnetic Nanoparticle-Mediated Gene Transfer to Oligodendrocyte Precursor Cell Transplant Populations Is Enhanced by Magnetofection Strategies. ACS Nano, 5(8), 6527-6538. https://doi.org/10.1021/nn2018717

This study has tested the feasibility of using physical delivery methods, employing static and oscillating field “magnetofection” techniques, to enhance magnetic nanoparticle-mediated gene transfer to rat oligodendrocyte precursor cells derived for t... Read More about Magnetic Nanoparticle-Mediated Gene Transfer to Oligodendrocyte Precursor Cell Transplant Populations Is Enhanced by Magnetofection Strategies.

ApoE isoform-specific regulation of regeneration in the peripheral nervous system (2011)
Journal Article
Comley, L. H., Fuller, H. R., Wishart, T. M., Mutsaers, C. A., Thomson, D., Wright, A. K., …Gillingwater, T. H. (2011). ApoE isoform-specific regulation of regeneration in the peripheral nervous system. Human molecular genetics, 20(12), 2406-2421. https://doi.org/10.1093/hmg/ddr147

Apolipoprotein E (apoE) is a 34 kDa glycoprotein with three distinct isoforms in the human population (apoE2, apoE3 and apoE4) known to play a major role in differentially influencing risk to, as well as outcome from, disease and injury in the centra... Read More about ApoE isoform-specific regulation of regeneration in the peripheral nervous system.

The transfection of multipotent neural precursor/stem cell transplant populations with magnetic nanoparticles (2010)
Journal Article
Pickard, M. R., Barraud, P., & Chari, D. M. (2011). The transfection of multipotent neural precursor/stem cell transplant populations with magnetic nanoparticles. Biomaterials, 32(9), 2274-2284. https://doi.org/10.1016/j.biomaterials.2010.12.007

Multipotent neural precursor/stem cells (NPCs) are a major transplant population with key properties to promote repair in several neuropathological conditions. Magnetic nanoparticle (MNP)-based vector systems, in turn, offer a combination of key bene... Read More about The transfection of multipotent neural precursor/stem cell transplant populations with magnetic nanoparticles.

Magnetic Nanoparticle Labeling of Astrocytes Derived for Neural Transplantation (2010)
Journal Article
Pickard, M. R., Jenkins, S. I., Koller, C. J., Furness, D. N., & Chari, D. M. (2011). Magnetic Nanoparticle Labeling of Astrocytes Derived for Neural Transplantation. Tissue Engineering Part C: Methods, 17(1), 89-99. https://doi.org/10.1089/ten.tec.2010.0170

Astrocytes are a major transplant cell population to promote neural repair in a range of pathological conditions. In this context, the development of robust methods to label neural transplant populations (for subsequent detection and cell tracking in... Read More about Magnetic Nanoparticle Labeling of Astrocytes Derived for Neural Transplantation.

Valproate and Bone Loss: iTRAQ Proteomics Show that Valproate Reduces Collagens and Osteonectin in SMA Cells (2010)
Journal Article
Fuller, H. R., Man, N. T., Lam, L. T., Shamanin, V. A., Androphy, E. J., & Morris, G. E. (2010). Valproate and Bone Loss: iTRAQ Proteomics Show that Valproate Reduces Collagens and Osteonectin in SMA Cells. Journal of Proteome Research, 9(8), 4228-4233. https://doi.org/10.1021/pr1005263

Valproate is commonly used as an anticonvulsant and mood stabilizer, but its long-term side-effects can include bone loss. As a histone deacetylase (HDAC) inhibitor, valproate has also been considered for treatment of spinal muscular atrophy (SMA). U... Read More about Valproate and Bone Loss: iTRAQ Proteomics Show that Valproate Reduces Collagens and Osteonectin in SMA Cells.

Mesenchymal stem cell-conditioned medium accelerates skin wound healing: An in vitro study of fibroblast and keratinocyte scratch assays (2010)
Journal Article
Walter, M., Wright, K., Fuller, H., MacNeil, S., & Johnson, W. (2010). Mesenchymal stem cell-conditioned medium accelerates skin wound healing: An in vitro study of fibroblast and keratinocyte scratch assays. Experimental Cell Research, 316(7), 1271-1281. https://doi.org/10.1016/j.yexcr.2010.02.026

We have used in vitro scratch assays to examine the relative contribution of dermal fibroblasts and keratinocytes in the wound repair process and to test the influence of mesenchymal stem cell (MSC) secreted factors on both skin cell types. Scratch a... Read More about Mesenchymal stem cell-conditioned medium accelerates skin wound healing: An in vitro study of fibroblast and keratinocyte scratch assays.

Enhancement of Magnetic Nanoparticle-Mediated Gene Transfer to Astrocytes by ‘Magnetofection‘: Effects of Static and Oscillating Fields (2010)
Journal Article
Pickard, M., & Chari, D. (2010). Enhancement of Magnetic Nanoparticle-Mediated Gene Transfer to Astrocytes by ‘Magnetofection‘: Effects of Static and Oscillating Fields. Nanomedicine, 5(2), 217-232. https://doi.org/10.2217/nnm.09.109

Aims: To assess the feasibility of using magnetic nanoparticles (MNPs) to transfect astrocytes derived for transplantation and determine if transfection efficacy can be enhanced by static and oscillating magnetic fields. Methods: Astrocytes were tran... Read More about Enhancement of Magnetic Nanoparticle-Mediated Gene Transfer to Astrocytes by ‘Magnetofection‘: Effects of Static and Oscillating Fields.

The SMN Interactome Includes Myb-Binding Protein 1a (2009)
Journal Article
Fuller, H. R., Man, N. T., Lam, L. T., Thanh, L. T., Keough, R. A., Asperger, A., …Morris, G. E. (2010). The SMN Interactome Includes Myb-Binding Protein 1a. Journal of Proteome Research, 9(1), 556-563. https://doi.org/10.1021/pr900884g

Understanding networks of interacting proteins is a major goal in cell biology. The survival of motor neurons protein (SMN) interacts, directly or indirectly, with a large number of other proteins and reduced levels of SMN cause the inherited disorde... Read More about The SMN Interactome Includes Myb-Binding Protein 1a.

Uptake of systemically administered magnetic nanoparticles (MNPs) in areas of experimental spinal cord injury (SCI) (2008)
Journal Article
Jeffery, N. D., McBain, S. C., Dobson, J., & Chari, D. M. (2009). Uptake of systemically administered magnetic nanoparticles (MNPs) in areas of experimental spinal cord injury (SCI). Journal of Tissue Engineering and Regenerative Medicine, 3(2), 153-157. https://doi.org/10.1002/term.139

The regenerative potential of the adult central nervous system (CNS) is limited, contributing to poor recovery from neurological insult. Many genes have been identified that promote neural regeneration, but the current viral methods used to mediate n... Read More about Uptake of systemically administered magnetic nanoparticles (MNPs) in areas of experimental spinal cord injury (SCI).

A two-site ELISA can quantify upregulation of SMN protein by drugs for spinal muscular atrophy (2008)
Journal Article
thi Man, N., Humphrey, E., Lam, L. T., Fuller, H. R., Lynch, T. A., Sewry, C. A., …Morris, G. E. (2008). A two-site ELISA can quantify upregulation of SMN protein by drugs for spinal muscular atrophy. Neurology, 71(22), 1757-1763. https://doi.org/10.1212/01.wnl.0000313038.34337.b1

Objectives: Spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by loss of lower motor neurons during early or postnatal development. Severity is variable and is inversely related to the levels of survival of motor neurons... Read More about A two-site ELISA can quantify upregulation of SMN protein by drugs for spinal muscular atrophy.