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All Outputs (63)

Inhibition of influenza H5N1 invasion by modified heparin derivatives (2015)
Journal Article
Skidmore, M. A., Kajaste-Rudnitski, A., Wells, N. M., Guimond, S. E., Rudd, T. R., Yates, E. A., & Vicenzi, E. Inhibition of influenza H5N1 invasion by modified heparin derivatives. MedChemComm, 6(4), 640-646. https://doi.org/10.1039/c4md00516c

Influenza remains a serious health threat, with resistance to frontline drugs becoming more common, and new treatments urgently sought. One strategy for the inhibition of the attachment of influenza to host cells is to employ chemically modified hepa... Read More about Inhibition of influenza H5N1 invasion by modified heparin derivatives.

Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism. (2015)
Journal Article
(2015). Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism. Current Biology, 161 - 172. https://doi.org/10.1016/j.cub.2015.11.055

The evolution of parasitism is a recurrent event in the history of life and a core problem in evolutionary biology. Trypanosomatids are important parasites and include the human pathogens Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp., wh... Read More about Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism..

Quantifying interspecific variation in dispersal ability of noctuid moths using an advanced tethered flight technique (2015)
Journal Article
Jones, H. B., Lim, K. S., Bell, J. R., Hill, J. K., & Chapman, J. W. (2016). Quantifying interspecific variation in dispersal ability of noctuid moths using an advanced tethered flight technique. Ecology and Evolution, 6(1), 181-190. https://doi.org/10.1002/ece3.1861

Dispersal plays a crucial role in many aspects of species' life histories, yet is often difficult to measure directly. This is particularly true for many insects, especially nocturnal species (e.g. moths) that cannot be easily observed under natural... Read More about Quantifying interspecific variation in dispersal ability of noctuid moths using an advanced tethered flight technique.

Heterosis Increases Fertility, Fecundity and Survival of Laboratory-Produced F1 Hybrid Males of the Malaria Mosquito Anopheles coluzzii (2015)
Journal Article
(2015). Heterosis Increases Fertility, Fecundity and Survival of Laboratory-Produced F1 Hybrid Males of the Malaria Mosquito Anopheles coluzzii. G3: Genes | Genomes | Genetics, 2693-2709. https://doi.org/10.1534/g3.115.021436

The success of vector control strategies aiming to decrease disease transmission via the release of sterile or genetically-modified male mosquitoes critically depends on mating between laboratory-reared males and wild females. Unfortunately, mosquito... Read More about Heterosis Increases Fertility, Fecundity and Survival of Laboratory-Produced F1 Hybrid Males of the Malaria Mosquito Anopheles coluzzii.

Changes in large-scale climate alter spatial synchrony of aphid pests (2015)
Journal Article
Sheppard, L. W., Bell, J. R., Harrington, R., & Reuman, D. C. (2016). Changes in large-scale climate alter spatial synchrony of aphid pests. Nature Climate Change, 6, Article 610-613. https://doi.org/10.1038/NCLIMATE2881

Spatial synchrony, the tendency of distant populations to fluctuate similarly, is a major concern in ecology1,2,3,4,5,6,7,8. Except in special circumstances3,9, researchers historically had difficulty identifying drivers of synchrony in field systems... Read More about Changes in large-scale climate alter spatial synchrony of aphid pests.

Transfection with thymidine kinase permits bromodeoxyuridine labelling of DNA replication in the human malaria parasite Plasmodium falciparum (2015)
Journal Article
(2015). Transfection with thymidine kinase permits bromodeoxyuridine labelling of DNA replication in the human malaria parasite Plasmodium falciparum. Malaria Journal, 490-?. https://doi.org/10.1186/s12936-015-1014-7

Background Plasmodium falciparum, the causative agent of severe human malaria, is an early-diverging protozoan whose lifecycle has many unusual features, including its modes of replication. Research on the Plasmodium cell cycle, which occurs primari... Read More about Transfection with thymidine kinase permits bromodeoxyuridine labelling of DNA replication in the human malaria parasite Plasmodium falciparum.

The proteome of the infectious bronchitis virus Beau-R virion. (2015)
Journal Article
(2015). The proteome of the infectious bronchitis virus Beau-R virion. Journal of General Virology, 3499 - 3506. https://doi.org/10.1099/jgv.0.000304

Infectious bronchitis is a highly contagious respiratory disease of poultry caused by the coronavirus infectious bronchitis virus (IBV). It was thought that coronavirus virions were composed of three major viral structural proteins until investigatio... Read More about The proteome of the infectious bronchitis virus Beau-R virion..

P2X 7 receptor activity regulation: the role of CD44 proteoglycan GAG chains (2015)
Journal Article
Moura, G., Lucena, S., Andrade De Lima, M., Nascimento, F., Gesteira, T., Nader, H., …Tersariol, I. (2015). P2X 7 receptor activity regulation: the role of CD44 proteoglycan GAG chains. Cell death and disease, https://doi.org/10.1038/cddis.2015.340

P2X7 receptors have received special attention in the literature for their involvement in several diseases characterized by inflammatory processes such as cancer, arthritis, neurodegenerative pathologies and chronic pains.

Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region (2015)
Journal Article
Russo. (2015). Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region. PloS one, e0142509 - e0142509. https://doi.org/10.1371/journal.pone.0142509

Malaria is an infectious disease caused by Plasmodium parasites. It results in an annual death-toll of ~ 600,000. Resistance to all medications currently in use exists, and novel antimalarial drugs are urgently needed. Plasmepsin V (PmV) is an essent... Read More about Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region.

Disclosing the results of the invasive cervical cancer review to patients: a survey of lead colposcopists across England (2015)
Journal Article
Sherman, S., Nailer, E., Pearmain, P., Todd, R., & Redman, C. (2015). Disclosing the results of the invasive cervical cancer review to patients: a survey of lead colposcopists across England. Cytopathology, 237-241. https://doi.org/10.1111/cyt.12283

Objective: To survey lead colposcopists to explore the extent to which patients are currently being invited to discuss the results of their invasive cervical cancer review, the reasons why this might not be happening and the clinician experience. Met... Read More about Disclosing the results of the invasive cervical cancer review to patients: a survey of lead colposcopists across England.

Does extreme asymmetric dominance promote hybridization between Anopheles coluzzii and Anopheles gambiae s.s. in seasonal malaria mosquito communities of West Africa? (2015)
Journal Article
(2015). Does extreme asymmetric dominance promote hybridization between Anopheles coluzzii and Anopheles gambiae s.s. in seasonal malaria mosquito communities of West Africa?. Parasites and Vectors, https://doi.org/10.1186/s13071-015-1190-x

Background Anopheles gambiae s.s. and An. coluzzii are two of the most important malaria vector species in sub-Saharan Africa. These recently-diverged sibling species do not exhibit intrinsic post-zygotic barriers to reproduction and are thought to... Read More about Does extreme asymmetric dominance promote hybridization between Anopheles coluzzii and Anopheles gambiae s.s. in seasonal malaria mosquito communities of West Africa?.

Odorant receptor-based discovery of natural repellents of human lice (2015)
Journal Article
(2015). Odorant receptor-based discovery of natural repellents of human lice. Journal of Chemical Ecology, 103 - 109. https://doi.org/10.1016/j.ibmb.2015.10.009

The body louse, Pediculus humanus humanus, is an obligate blood-feeding ectoparasite and an important insect vector that mediates the transmission of diseases to humans. The analysis of the body louse genome revealed a drastic reduction of the chemos... Read More about Odorant receptor-based discovery of natural repellents of human lice.

The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products (2015)
Journal Article
Rafiq, Q. A., Ortega, I., Jenkins, S. I., Wilson, S. L., Patel, A. K., Barnes, A. L., …Smith, D. (2015). The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products. Regenerative Medicine, 989 -1003. https://doi.org/10.2217/rme.15.56

Although the importance of translation for the development of tissue engineering, regenerative medicine and cell-based therapies is widely recognized, the process of translation is less well understood. This is particularly the case among some early... Read More about The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products.

The molecular characterisation of Escherichia coli K1 isolated from neonatal nasogastric feeding tubes (2015)
Journal Article
Masood. (2015). The molecular characterisation of Escherichia coli K1 isolated from neonatal nasogastric feeding tubes. BMC Infectious Diseases, https://doi.org/10.1186/s12879-015-1210-7

Background The most common cause of Gram-negative bacterial neonatal meningitis is E. coli K1. It has a mortality rate of 10–15 %, and neurological sequelae in 30–50 % of cases. Infections can be attributable to nosocomial sources, however the pre-c... Read More about The molecular characterisation of Escherichia coli K1 isolated from neonatal nasogastric feeding tubes.

Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage. (2015)
Journal Article
Forrester-Soto. (2015). Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage. Frontiers in Microbiology, 1037 - 1037. https://doi.org/10.3389/fmicb.2015.01037

Previous imported cases of Lassa fever (LF) into the United Kingdom from the Ivory Coast and Mali, as well as the detection of Lassa virus (LASV) among the Mastomys natalensis population within Mali has led to the suggestion that the endemic area for... Read More about Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage..

Genomic dissection of the 1994 Cronobacter sakazakii outbreak in a French neonatal intensive care unit (2015)
Journal Article
Masood. (2015). Genomic dissection of the 1994 Cronobacter sakazakii outbreak in a French neonatal intensive care unit. BMC Genomics, https://doi.org/10.1186/s12864-015-1961-y

Background: Cronobacter sakazakii is a member of the genus Cronobacter that has frequently been isolated from powdered infant formula (PIF) and linked with rare but fatal neonatal infections such as meningitis and necrotising enterocolitis. The Cron... Read More about Genomic dissection of the 1994 Cronobacter sakazakii outbreak in a French neonatal intensive care unit.

Post-translational allosteric activation of the P2X 7 receptor through glycosaminoglycan chains of CD44 proteoglycans (2015)
Journal Article
Moura, G., Lucena, S., Andrade De Lima, M., Nascimento, F., Gesteira, T., Nader, H., …Tersariol, I. (2015). Post-translational allosteric activation of the P2X 7 receptor through glycosaminoglycan chains of CD44 proteoglycans. Cell Death Discovery, 1, 15005--15005. https://doi.org/10.1038/cddiscovery.2015.5

Here, we present evidence for the positive allosteric modulation of the P2X7 receptor through glycosaminoglycans (GAGs) in CHO (cell line derived from the ovary of the Chinese hamster) cells. The marked potentiation of P2X7 activity through GAGs in t... Read More about Post-translational allosteric activation of the P2X 7 receptor through glycosaminoglycan chains of CD44 proteoglycans.

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke (2015)
Journal Article
Wong, R., Pradillo, J. M., Denes, A., Dhungana, H., Malm, T., Koistinaho, J., …Maysami, S. (2015). A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke. Journal of Cerebral Blood Flow and Metabolism, 36(3), 596-605. https://doi.org/10.1177/0271678X15606714

Stroke represents a global challenge and is a leading cause of permanent disability worldwide. Despite much effort, translation of research findings to clinical benefit has not yet been successful. Failure of neuroprotection trials is considered, in... Read More about A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke.

Non-random patterns in viral diversity (2015)
Journal Article
Anthony, S., Islam, A., Johnson, C., Navarrete-Macias, I., Liang, E., Jain, K., …Lipkin, W. (2015). Non-random patterns in viral diversity. Nature communications, https://doi.org/10.1038/ncomms9147

It is currently unclear whether changes in viral communities will ever be predictable. Here we investigate whether viral communities in wildlife are inherently structured (inferring predictability) by looking at whether communities are assembled thro... Read More about Non-random patterns in viral diversity.