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Experimental swap of anopheles gambiae's assortative mating preferences demonstrates key role of X-chromosome divergence island in incipient sympatric speciation (2015)
Journal Article
(2015). Experimental swap of anopheles gambiae's assortative mating preferences demonstrates key role of X-chromosome divergence island in incipient sympatric speciation. PLOS genetics, https://doi.org/10.1371/journal.pgen.1005141

Although many theoretical models of sympatric speciation propose that genes responsible for assortative mating amongst incipient species should be associated with genomic regions protected from recombination, there are few data to support this theory... Read More about Experimental swap of anopheles gambiae's assortative mating preferences demonstrates key role of X-chromosome divergence island in incipient sympatric speciation.

Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells. (2015)
Journal Article
(2015). Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells. Frontiers in Cellular Neuroscience, 130 - ?. https://doi.org/10.3389/fncel.2015.00130

Loud sound exposure exacerbates aminoglycoside ototoxicity, increasing the risk of permanent hearing loss and degrading the quality of life in affected individuals. We previously reported that loud sound exposure induces temporary threshold shifts (T... Read More about Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells..

Comprehensive evaluation of Toxoplasma gondii VEG and Neospora caninum LIV genomes with tachyzoite stage transcriptome and proteome defines novel transcript features. (2015)
Journal Article
(2015). Comprehensive evaluation of Toxoplasma gondii VEG and Neospora caninum LIV genomes with tachyzoite stage transcriptome and proteome defines novel transcript features. PloS one, e0124473 - ?. https://doi.org/10.1371/journal.pone.0124473

Toxoplasma gondii is an important protozoan parasite that infects all warm-blooded animals and causes opportunistic infections in immuno-compromised humans. Its closest relative, Neospora caninum, is an important veterinary pathogen that causes spont... Read More about Comprehensive evaluation of Toxoplasma gondii VEG and Neospora caninum LIV genomes with tachyzoite stage transcriptome and proteome defines novel transcript features..

Astrocyte and Neuronal Plasticity in the Somatosensory System (2015)
Journal Article
Sims, R. E., Butcher, J. B., Rheinallt Parri, H., & Glazewski, S. (2015). Astrocyte and Neuronal Plasticity in the Somatosensory System. Neural Plasticity, 2015, Article 732014. https://doi.org/10.1155/2015/732014

Changing the whisker complement on a rodent’s snout can lead to two forms of experience-dependent plasticity (EDP) in the neurons of the barrel cortex, where whiskers are somatotopically represented. One form, termed coding plasticity, concerns chang... Read More about Astrocyte and Neuronal Plasticity in the Somatosensory System.

Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells (2015)
Journal Article
(2015). Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells. Prostate, 693 -705. https://doi.org/10.1002/pros.22952

BACKGROUND: New therapies are required for castrate-resistant prostate cancer (CRPC), and growth-arrest specific 5 (GAS5) lncRNA, which riborepresses androgen receptor action, may offer novel opportunities in this regard. This lncRNA promotes the apo... Read More about Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells.

Description of Siccibacter colletis sp. nov., a novel species isolated from plant material, and emended description of Siccibacter turicensis (2015)
Journal Article
Masood. (2015). Description of Siccibacter colletis sp. nov., a novel species isolated from plant material, and emended description of Siccibacter turicensis. International Journal of Systematic and Evolutionary Microbiology, 1335 - 1341. https://doi.org/10.1099/ijs.0.000108

A re-evaluation of the taxonomic position of two strains, 1383T and 2249, isolated from poppy seeds and tea leaves, which had been identified as Siccibacter turicensis (formerly Cronobacter zurichensis ), was carried out. The analysis included phenot... Read More about Description of Siccibacter colletis sp. nov., a novel species isolated from plant material, and emended description of Siccibacter turicensis.

Functional analysis of sirtuin genes in multiple Plasmodium falciparum strains. (2015)
Journal Article
(2015). Functional analysis of sirtuin genes in multiple Plasmodium falciparum strains. PloS one, e0118865 - ?. https://doi.org/10.1371/journal.pone.0118865

Plasmodium falciparum, the causative agent of severe human malaria, employs antigenic variation to avoid host immunity. Antigenic variation is achieved by transcriptional switching amongst polymorphic var genes, enforced by epigenetic modification of... Read More about Functional analysis of sirtuin genes in multiple Plasmodium falciparum strains..

SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells (2015)
Journal Article
Vicente, C., Andrade De Lima, M., Nader, H., & Toma, L. (2015). SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells. Journal of Experimental & Clinical Cancer Research, 34, 25--25. https://doi.org/10.1186/s13046-015-0141-x

Background SULF2 is a 6-O-endosulfatase which removes 6-O sulfate residues from N-glucosamine present on heparan sulfate (HS). The sulfation pattern of HS influences signaling events mediated by heparan sulfate proteoglycans (HSPGs) located on cell... Read More about SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells.

A role for the long non-coding RNA growth arrest specific transcript 5 (GAS5) in cytokine-induced beta cell death (2015)
Journal Article
(2015). A role for the long non-coding RNA growth arrest specific transcript 5 (GAS5) in cytokine-induced beta cell death. Diabetic Medicine, 39 - 39. https://doi.org/10.1111/dme.12668

Pro-inflammatory cytokines are known inducers of beta cell death in the pathogenesis of Type 1 diabetes and mediate their effects through the perturbation of multiple regulatory gene networks. GAS5, a long non-coding RNA whose expression negatively c... Read More about A role for the long non-coding RNA growth arrest specific transcript 5 (GAS5) in cytokine-induced beta cell death.

Heparin derivatives for the targeting of multiple activities in the inflammatory response. (2015)
Journal Article
Veraldi, N., Hughes, A., Rudd, T., Thomas, H., Edwards, S., Hadfield, L., …Yates, E. (2015). Heparin derivatives for the targeting of multiple activities in the inflammatory response. Carbohydrate Polymers, 400 - 407. https://doi.org/10.1016/j.carbpol.2014.09.079

An attractive strategy for ameliorating symptoms arising from the multi-faceted processes of excessive and/or continual inflammation would be to identify compounds able to interfere with multiple effectors of inflammation. The well-tolerated pharmace... Read More about Heparin derivatives for the targeting of multiple activities in the inflammatory response..

Synchrotron radiation macromolecular crystallography: science and spin-offs. (2015)
Journal Article
(2015). Synchrotron radiation macromolecular crystallography: science and spin-offs. IUCrJ, 283 - 291. https://doi.org/10.1107/S205225251402795X

A current overview of synchrotron radiation (SR) in macromolecular crystallography (MX) instrumentation, methods and applications is presented. Automation has been and remains a central development in the last decade, as have the rise of remote acces... Read More about Synchrotron radiation macromolecular crystallography: science and spin-offs..

Distribution of Lutzomyia longipalpis chemotype populations in São Paulo state, Brazil. (2015)
Journal Article
(2015). Distribution of Lutzomyia longipalpis chemotype populations in São Paulo state, Brazil. PLoS Neglected Tropical Diseases, e0003620 - ?. https://doi.org/10.1371/journal.pntd.0003620

BACKGROUND: American visceral leishmaniasis (AVL) is an emerging disease in the state of São Paulo, Brazil. Its geographical expansion and the increase in the number of human cases has been linked to dispersion of Lutzomyia longipalpis into urban are... Read More about Distribution of Lutzomyia longipalpis chemotype populations in São Paulo state, Brazil..

New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences. (2015)
Journal Article
Forrester-Soto. (2015). New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences. PloS one, e0117849 - e0117849. https://doi.org/10.1371/journal.pone.0117849

To generate the most diverse phylogenetic dataset for the flaviviruses to date, we determined the genomic sequences and phylogenetic relationships of 14 flaviviruses, of which 10 are primarily associated with Culex spp. mosquitoes. We analyze these d... Read More about New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences..

The germline of the malaria mosquito produces abundant miRNAs, endo-siRNAs, piRNAs and 29-nt small RNAs. (2015)
Journal Article
Castellano, L., Rizzi, E., Krell, J., Di Cristina, M., Galizi, R., Mori, A., …Nolan, T. (2015). The germline of the malaria mosquito produces abundant miRNAs, endo-siRNAs, piRNAs and 29-nt small RNAs. BMC Genomics, 100 - ?. https://doi.org/10.1186/s12864-015-1257-2

BACKGROUND: Small RNAs include different classes essential for endogenous gene regulation and cellular defence against genomic parasites. However, a comprehensive analysis of the small RNA pathways in the germline of the mosquito Anopheles gambiae ha... Read More about The germline of the malaria mosquito produces abundant miRNAs, endo-siRNAs, piRNAs and 29-nt small RNAs..

Monoclonal antibodies directed to fucoidan preparations from brown algae. (2015)
Journal Article
Torode, T., Marcus, S., Jam, M., Tonon, T., Blackburn, R., Hervé, C., & Knox, J. (2015). Monoclonal antibodies directed to fucoidan preparations from brown algae. PloS one, e0118366 - ?. https://doi.org/10.1371/journal.pone.0118366

Cell walls of the brown algae contain a diverse range of polysaccharides with useful bioactivities. The precise structures of the sulfated fucan/fucoidan group of polysaccharides and their roles in generating cell wall architectures and cell properti... Read More about Monoclonal antibodies directed to fucoidan preparations from brown algae..

Triaging informative cis -regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development (2015)
Journal Article
Horrocks. (2015). Triaging informative cis -regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development. Parasites and Vectors, 81 -?. https://doi.org/10.1186/s13071-015-0701-0

BackgroundOver 2700 genes are subject to stage-specific regulation during the intraerythrocytic development of the human malaria parasite Plasmodium falciparum. Bioinformatic analyses have identified a large number of over-represented motifs in the 5... Read More about Triaging informative cis -regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development.

Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin (2015)
Journal Article
(2015). Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin. PLoS Biology, e1002049 - e1002049. https://doi.org/10.1371/journal.pbio.1002049

Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble monomers assemble into large transmembrane pores via conformational transiti... Read More about Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin.

G-Quadruplexes in Pathogens: A Common Route to Virulence Control? (2015)
Journal Article
(2015). G-Quadruplexes in Pathogens: A Common Route to Virulence Control?. PLOS pathogens a peer-reviewed open-access journal published by the Public Library of Science, e1004562 -?. https://doi.org/10.1371/journal.ppat.1004562

DNA can form several secondary structures besides the classic double helix: one that has received much attention in recent years is the G-quadruplex (G4). This is a stable four-stranded structure formed by the stacking of quartets of guanine bases. R... Read More about G-Quadruplexes in Pathogens: A Common Route to Virulence Control?.

Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates. (2015)
Journal Article
Glazewski, S., & Barth, A. L. (2015). Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates. European Journal of Neuroscience, 41(4), 410 - 419. https://doi.org/10.1111/ejn.12805

Although subthreshold inputs of neocortical sensory neurons are broadly tuned, the spiking output is more restricted. These subthreshold inputs provide a substrate for stimulus intensity-dependent changes their spiking output, as well as for experien... Read More about Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates..