Skip to main content

Research Repository

Advanced Search

All Outputs (857)

The interaction of aluminium-based adjuvants with THP-1 macrophages in vitro: Implications for cellular survival and systemic translocation. (2020)
Journal Article
(2020). The interaction of aluminium-based adjuvants with THP-1 macrophages in vitro: Implications for cellular survival and systemic translocation. Journal of Inorganic Biochemistry, 110915 - ?. https://doi.org/10.1016/j.jinorgbio.2019.110915

Within clinical vaccinations, recombinant antigens are routinely entrapped inside or adsorbed onto the surface of aluminium salts in order to increase their immunological potency in vivo. The efficacy of these immunisations is highly dependent upon t... Read More about The interaction of aluminium-based adjuvants with THP-1 macrophages in vitro: Implications for cellular survival and systemic translocation..

Different Plant Viruses Induce Changes in Feeding Behavior of Specialist and Generalist Aphids on Common Bean That Are Likely to Enhance Virus Transmission (2020)
Journal Article
Gilligan, C., Pickett, J., Tungadi, T., Murphy, A., Pate, A., Woodcock, C., …Donnelly, R. (2020). Different Plant Viruses Induce Changes in Feeding Behavior of Specialist and Generalist Aphids on Common Bean That Are Likely to Enhance Virus Transmission. Frontiers in Plant Science, 10, 1811. https://doi.org/10.3389/fpls.2019.01811

Bean common mosaic virus (BCMV), bean common mosaic necrosis virus (BCMNV), and cucumber mosaic virus (CMV) cause serious epidemics in common bean (Phaseolus vulgaris), a vital food security crop in many low-to-medium income countries, particularly i... Read More about Different Plant Viruses Induce Changes in Feeding Behavior of Specialist and Generalist Aphids on Common Bean That Are Likely to Enhance Virus Transmission.

Inhibition of BACE1, the ß-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus. (2020)
Journal Article
Mycroft-West, C. J., Devlin, A. J., Cooper, L. C., Procter, P., Miller, G. J., Fernig, D. G., …Skidmore, M. A. (2020). Inhibition of BACE1, the ß-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus. Neural Regeneration Research, 15(8), 1546 - 1553. https://doi.org/10.4103/1673-5374.274341

The pharmaceutical and anticoagulant agent heparin, a member of the glycosaminoglycan family of carbohydrates, has previously been identified as a potent inhibitor of a key Alzheimer's disease drug target, the primary neuronal ß-secretase, ß-site amy... Read More about Inhibition of BACE1, the ß-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus..

Molecular Characterization of Circulating Microbiome Signatures in Rheumatoid Arthritis (2020)
Journal Article
Hammad, D., Hider, S., Liyanapathirana, V., & Tonge, D. (2020). Molecular Characterization of Circulating Microbiome Signatures in Rheumatoid Arthritis. Frontiers in Cellular and Infection Microbiology, 9, Article 440. https://doi.org/10.3389/fcimb.2019.00440

Rheumatoid Arthritis (RA) has been increasingly associated with perturbations to the microbial communities that reside in and on the body (the microbiome), in both human and animal studies. To date, such studies have mainly focused on the microbial c... Read More about Molecular Characterization of Circulating Microbiome Signatures in Rheumatoid Arthritis.

Population genetic structure and predominance of cyclical parthenogenesis in the bird cherry–oat aphid Rhopalosiphum padi in England (2020)
Journal Article
Morales-Hojas, R., Gonzalez-Uriarte, A., Alvira Iraizoz, F., Jenkins, T., Alderson, L., Kruger, T., …Bell, J. R. (2020). Population genetic structure and predominance of cyclical parthenogenesis in the bird cherry–oat aphid Rhopalosiphum padi in England. Evolutionary Applications, 13(5), 1009-1025. https://doi.org/10.1111/eva.12917

Genetic diversity is the determinant for pest species’ success and vector competence. Understanding the ecological and evolutionary processes that determine the genetic diversity is fundamental to help identify the spatial scale at which pest populat... Read More about Population genetic structure and predominance of cyclical parthenogenesis in the bird cherry–oat aphid Rhopalosiphum padi in England.

Aluminum and Amyloid-ß in Familial Alzheimer's Disease. (2020)
Journal Article
(2020). Aluminum and Amyloid-ß in Familial Alzheimer's Disease. Journal of Alzheimer's Disease, 1627-1635. https://doi.org/10.3233/JAD-191140

Genetic predispositions associated with metabolism of the amyloid-ß protein precursor underlie familial Alzheimer's disease; a form of dementia characterized by early disease onset and elevated levels of cortical amyloid-ß. Human exposure to aluminum... Read More about Aluminum and Amyloid-ß in Familial Alzheimer's Disease..

Electrophysiological properties of neurons grown on soft polymer scaffolds reveal the potential to develop neuromimetic culture environments (2020)
Journal Article
Evans, M. G., Al-Shakli, A., & Chari, D. M. (2020). Electrophysiological properties of neurons grown on soft polymer scaffolds reveal the potential to develop neuromimetic culture environments. Integrative Biology, 395-403. https://doi.org/10.1093/intbio/zyz033

Tissue engineering methodologies for various physiological systems are seeing a significant trend towards 3-D cell culture in or on ‘soft’ polymeric hydrogel materials, widely considered to provide a more biomimetic environment for cell growth versus... Read More about Electrophysiological properties of neurons grown on soft polymer scaffolds reveal the potential to develop neuromimetic culture environments.

Sensing the Danger Signals: cis-Jasmone Reduces Aphid Performance on Potato and Modulates the Magnitude of Released Volatiles (2020)
Journal Article
(2020). Sensing the Danger Signals: cis-Jasmone Reduces Aphid Performance on Potato and Modulates the Magnitude of Released Volatiles. Frontiers in Ecology and Evolution, https://doi.org/10.3389/fevo.2019.00499

In response to herbivory, plants synthesize and release variable mixtures of herbivore-induced plant volatiles (HIPVs) as indirect defense traits. Such induction of indirect plant defense can also be “switched on” by certain chemicals known as primin... Read More about Sensing the Danger Signals: cis-Jasmone Reduces Aphid Performance on Potato and Modulates the Magnitude of Released Volatiles.

Invasion biology, ecology, and management of western flower thrips (2020)
Journal Article
Kirk. (2020). Invasion biology, ecology, and management of western flower thrips. Annual Review of Entomology, 17-37. https://doi.org/10.1146/annurev-ento-011019-024947

The western flower thrips, Frankliniella occidentalis, first arose as an important invasive pest of many crops during the 1970s-1980s. The tremendous growth in international agricultural trade that developed then fostered the invasiveness of western... Read More about Invasion biology, ecology, and management of western flower thrips.

From theory to experiments for testing the proximate mechanisms of mast seeding: an agenda for an experimental ecology. (2019)
Journal Article
(2019). From theory to experiments for testing the proximate mechanisms of mast seeding: an agenda for an experimental ecology. Ecology Letters, 210-220. https://doi.org/10.1111/ele.13442

Highly variable and synchronised production of seeds by plant populations, known as masting, is implicated in many important ecological processes, but how it arises remains poorly understood. The lack of experimental studies prevents underlying mecha... Read More about From theory to experiments for testing the proximate mechanisms of mast seeding: an agenda for an experimental ecology..

Prevalence of multidrug-, extensive drug-, and pandrug-resistant commensal Escherichia coli isolated from healthy humans in community settings in low- and middle-income countries: a systematic review and meta-analysis. (2019)
Journal Article
(2019). Prevalence of multidrug-, extensive drug-, and pandrug-resistant commensal Escherichia coli isolated from healthy humans in community settings in low- and middle-income countries: a systematic review and meta-analysis. Global Health Action, 1815272 - ?. https://doi.org/10.1080/16549716.2020.1815272

BACKGROUND: The majority of existing studies aimed at investigating the incidence and prevalence of multidrug-resistance by bacteria have been performed in healthcare settings. Relatively few studies have been conducted in community settings, but the... Read More about Prevalence of multidrug-, extensive drug-, and pandrug-resistant commensal Escherichia coli isolated from healthy humans in community settings in low- and middle-income countries: a systematic review and meta-analysis..

Spatial genetic structure and diversity of natural populations of Aesculus hippocastanum L. in Greece (2019)
Journal Article
(2019). Spatial genetic structure and diversity of natural populations of Aesculus hippocastanum L. in Greece. PloS one, 1-27. https://doi.org/10.1371/journal.pone.0226225

Horse-chestnut (Aesculus hippocastanum L.) is an endemic and relict species from the Mediterranean biodiversity hotspot and a popular ornamental tree. Knowledge about the evolutionary history of this species remains scarce. Here, we ask what historic... Read More about Spatial genetic structure and diversity of natural populations of Aesculus hippocastanum L. in Greece.

Forgotten Fibrocytes: A Neglected, Supporting Cell Type of the Cochlea With the Potential to be an Alternative Therapeutic Target in Hearing Loss. (2019)
Journal Article
(2019). Forgotten Fibrocytes: A Neglected, Supporting Cell Type of the Cochlea With the Potential to be an Alternative Therapeutic Target in Hearing Loss. Frontiers in Cellular Neuroscience, https://doi.org/10.3389/fncel.2019.00532

Cochlear fibrocytes are a homeostatic supporting cell type embedded in the vascularized extracellular matrix of the spiral ligament, within the lateral wall. Here, they participate in the connective tissue syncytium that enables potassium recirculati... Read More about Forgotten Fibrocytes: A Neglected, Supporting Cell Type of the Cochlea With the Potential to be an Alternative Therapeutic Target in Hearing Loss..

Volatiles of bacteria associated with parasitoid habitats elicit distinct olfactory responses in an aphid parasitoid and its hyperparasitoid (2019)
Journal Article
(2019). Volatiles of bacteria associated with parasitoid habitats elicit distinct olfactory responses in an aphid parasitoid and its hyperparasitoid. Functional Ecology, https://doi.org/10.1111/1365-2435.13503

To locate mating partners and essential resources such as food, oviposition sites and shelter, insects rely to a large extent on chemical cues. While most research has focused on cues derived from plants and insects, there is mounting evidence that i... Read More about Volatiles of bacteria associated with parasitoid habitats elicit distinct olfactory responses in an aphid parasitoid and its hyperparasitoid.

CRISPR/Cas9-mediated gene deletion of the ompA gene in symbiotic Cedecea neteri impairs biofilm formation and reduces gut colonization of Aedes aegypti mosquitoes (2019)
Journal Article
Hegde, S., Nilyanimit, P., Kozlova, E., Anderson, E. R., Narra, H. P., Sahni, S. K., …Hughes, G. L. (2019). CRISPR/Cas9-mediated gene deletion of the ompA gene in symbiotic Cedecea neteri impairs biofilm formation and reduces gut colonization of Aedes aegypti mosquitoes. PLoS Neglected Tropical Diseases, 13(12), e0007883. https://doi.org/10.1371/journal.pntd.0007883

Aluminium in human brain tissue: how much is too much? (2019)
Journal Article
(2019). Aluminium in human brain tissue: how much is too much?. Journal of Biological Inorganic Chemistry, 1279-1282. https://doi.org/10.1007/s00775-019-01710-0

A burgeoning body of research confirms and affirms the presence of aluminium in human brain tissue. Recently, the first data on aluminium content of brain tissue from donors with diagnoses of familial Alzheimer's disease, autism spectrum disorder, mu... Read More about Aluminium in human brain tissue: how much is too much?.

The potential for a released autosomal X-shredder becoming a driving-Y chromosome and invasively suppressing wild populations of malaria mosquitoes (2019)
Journal Article
Alcalay, Y., Fuchs, S., Galizi, R., Bernardini, F., Elaine Haghighat-Khah, R., B. Rusch, D., …Aris Papathanos, P. (2019). The potential for a released autosomal X-shredder becoming a driving-Y chromosome and invasively suppressing wild populations of malaria mosquitoes. https://doi.org/10.1101/860551

Abstract Synthetic sex-ratio distorters based on X-chromosome shredding are predicted to be more efficient than sterile males for population suppression of malaria mosquitoes using genetic control. X-chromosome shredding operates through the targeted... Read More about The potential for a released autosomal X-shredder becoming a driving-Y chromosome and invasively suppressing wild populations of malaria mosquitoes.

Effect of ß-1/3,1/6-glucan upon immune responses and bacteria in the gut of healthy common carp (Cyprinus carpio) (2019)
Journal Article
(2019). Effect of ß-1/3,1/6-glucan upon immune responses and bacteria in the gut of healthy common carp (Cyprinus carpio). Journal of Fish Biology, https://doi.org/10.1111/jfb.14222

ß-glucans are frequently included in the diet of healthy common carp Cyprinus carpio as a pre-emptive measure for combatting disease. In order to study the effect this has on the relationship between the gut bacteria and host immune response, carp we... Read More about Effect of ß-1/3,1/6-glucan upon immune responses and bacteria in the gut of healthy common carp (Cyprinus carpio).

Unexpected encounter of the parasitic kind. (2019)
Journal Article
(2019). Unexpected encounter of the parasitic kind. World Journal of Stem Cells, 904 - 919. https://doi.org/10.4252/wjsc.v11.i11.904

Both parasitology and stem cell research are important disciplines in their own right. Parasites are a real threat to human health causing a broad spectrum of diseases and significant annual rates morbidity and mortality globally. Stem cell research,... Read More about Unexpected encounter of the parasitic kind..