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Pleiotropic effects of extended blockade of CSF1R signaling in adult mice (2014)
Journal Article
Beard, P. (2014). Pleiotropic effects of extended blockade of CSF1R signaling in adult mice. Journal of Leukocyte Biology, 265 - 274. https://doi.org/10.1189/jlb.2A0114-006R

We investigated the role of CSF1R signaling in adult mice using prolonged treatment with anti-CSF1R antibody. Mutation of the CSF1 gene in the op/op mouse produces numerous developmental abnormalities. Mutation of the CSF1R has an even more penetrant... Read More about Pleiotropic effects of extended blockade of CSF1R signaling in adult mice.

Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder (2014)
Journal Article
Trent, S., Fry, J. P., Ojarikre, O. A., & Davies, W. (2014). Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder. Molecular Autism, 5, Article 21. https://doi.org/10.1186/2040-2392-5-21

Background
The 39,XY*O mouse, which lacks the orthologues of the ADHD and autism candidate genes STS (steroid sulphatase) and ASMT (acetylserotonin O-methyltransferase), exhibits behavioural phenotypes relevant to developmental disorders. The neurob... Read More about Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder.

TRAF2 Facilitates Vaccinia Virus Replication by Promoting Rapid Virus Entry (2014)
Journal Article
Beard, P. (2014). TRAF2 Facilitates Vaccinia Virus Replication by Promoting Rapid Virus Entry. Journal of Virology, 3664 - 3677. https://doi.org/10.1128/JVI.03013-13

<jats:title>ABSTRACT</jats:title> <jats:p> Tumor necrosis factor receptor (TNFR)-associated factor 2 (TRAF2) is a pivotal intracellular mediator of signaling pathways downstream of TNFR1 and -2 with known pro- and antiviral effects. We investigated i... Read More about TRAF2 Facilitates Vaccinia Virus Replication by Promoting Rapid Virus Entry.

Transgenic Anopheles gambiae expressing an antimalarial peptide suffer no significant fitness cost (2014)
Journal Article
(2014). Transgenic Anopheles gambiae expressing an antimalarial peptide suffer no significant fitness cost. PloS one, e88625 - ?. https://doi.org/10.1371/journal.pone.0088625

Mosquito-borne diseases present some of the greatest health challenges faced by the world today. In many cases, existing control measures are compromised by insecticide resistance, pathogen tolerance to drugs and the lack of effective vaccines. In li... Read More about Transgenic Anopheles gambiae expressing an antimalarial peptide suffer no significant fitness cost.

The evolution of massive stars and their spectra I. A non-rotating 60 Msun star from the zero-age main sequence to the pre-supernova stage (2014)
Journal Article
(2014). The evolution of massive stars and their spectra I. A non-rotating 60 Msun star from the zero-age main sequence to the pre-supernova stage. Astronomy & Astrophysics,

For the first time, the interior and spectroscopic evolution of a massive star is analyzed from the zero-age main sequence (ZAMS) to the pre-supernova (SN) stage. For this purpose, we combined stellar evolution models using the Geneva code and atmosp... Read More about The evolution of massive stars and their spectra I. A non-rotating 60 Msun star from the zero-age main sequence to the pre-supernova stage.

A Year In The Life Of: An Online Diary Of Keele Biochemistry Students’ Lives (2014)
Journal Article
(2014). A Year In The Life Of: An Online Diary Of Keele Biochemistry Students’ Lives. The Journal of Academic Development and Education, 15 -28

Students often find the transition from School to University and between levels
difficult. During Year 1 in particular, retention levels can be impacted significantly if
students have problems integrating socially, as well as academically. Universi... Read More about A Year In The Life Of: An Online Diary Of Keele Biochemistry Students’ Lives.

Differential effects of inbreeding and selection on male reproductive phenotype associated with the colonization and laboratory maintenance of Anopheles gambiae. (2014)
Journal Article
(2014). Differential effects of inbreeding and selection on male reproductive phenotype associated with the colonization and laboratory maintenance of Anopheles gambiae. Malaria Journal, 19 -?. https://doi.org/10.1186/1475-2875-13-19

BACKGROUND: Effective mating between laboratory-reared males and wild females is paramount to the success of vector control strategies aiming to decrease disease transmission via the release of sterile or genetically modified male mosquitoes. However... Read More about Differential effects of inbreeding and selection on male reproductive phenotype associated with the colonization and laboratory maintenance of Anopheles gambiae..

Genetic and environmental factors associated with laboratory rearing affect survival and assortative mating but not overall mating success in Anopheles gambiae sensu stricto. (2013)
Journal Article
(2013). Genetic and environmental factors associated with laboratory rearing affect survival and assortative mating but not overall mating success in Anopheles gambiae sensu stricto. PloS one, e82631 - ?. https://doi.org/10.1371/journal.pone.0082631

Anopheles gambiae sensu stricto, the main vector of malaria in Africa, is characterized by its vast geographical range and complex population structure. Assortative mating amongst the reproductively isolated cryptic forms that co-occur in many areas... Read More about Genetic and environmental factors associated with laboratory rearing affect survival and assortative mating but not overall mating success in Anopheles gambiae sensu stricto..

Identification of differentially expressed proteins in sulfadiazine resistant and sensitive strains of Toxoplasma gondii using difference-gel electrophoresis (DIGE). (2013)
Journal Article
(2013). Identification of differentially expressed proteins in sulfadiazine resistant and sensitive strains of Toxoplasma gondii using difference-gel electrophoresis (DIGE). International Journal for Parasitology: Drugs and Drug Resistance, 35 - 44. https://doi.org/10.1016/j.ijpddr.2012.12.002

Treatment options for toxoplasmosis in humans are generally limited to the use of sulfonamide and/or pyrimethamine-based compounds. However, there is increasing evidence for clinical therapy failures in patients suggesting the existence of drug resis... Read More about Identification of differentially expressed proteins in sulfadiazine resistant and sensitive strains of Toxoplasma gondii using difference-gel electrophoresis (DIGE)..

Risk practices for animal and human anthrax in Bangladesh: an exploratory study (2013)
Journal Article
Islam, M., Hossain, M., Mikolon, A., Parveen, S., Khan, M., Haider, N., …Luby, S. (2013). Risk practices for animal and human anthrax in Bangladesh: an exploratory study. https://doi.org/10.3402/iee.v3i0.21356

From August 2009 to October 2010, International Centre for Diarrheal Disease Research, Bangladesh and the Institute of Epidemiology, Disease Control and Research together investigated 14 outbreaks of anthrax which included 140 animal and 273 human ca... Read More about Risk practices for animal and human anthrax in Bangladesh: an exploratory study.

Can mass trapping reduce thrips damage and is it economically viable?: management of the western flower thrips in strawberry (2013)
Journal Article
(2013). Can mass trapping reduce thrips damage and is it economically viable?: management of the western flower thrips in strawberry. PloS one, e80787. https://doi.org/10.1371/journal.pone.0080787

The western flower thrips Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae) is a cosmopolitan, polyphagous insect pest that causes bronzing to fruit of strawberry (Fragaria x ananassa). The main aim of this study was to test whether mas... Read More about Can mass trapping reduce thrips damage and is it economically viable?: management of the western flower thrips in strawberry.

Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5 (2013)
Journal Article
Mourtada-Maarabouni, M., & Williams, G. T. (2013). Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5. BioMed Research International, 2013, Article 358015. https://doi.org/10.1155/2013/358015

Nonsense-mediated decay is a key RNA surveillance mechanism responsible for the rapid degradation of mRNAs containing premature termination codons and hence prevents the synthesis of truncated proteins. More recently, it has been shown that nonsense-... Read More about Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5.

On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca2+ (2013)
Journal Article
Córdula, C. R., Lima, M. A., Shinjo, S. K., Gesteira, T. F., Pol-Fachin, L., Coulson-Thomas, V. J., …Tersariol, I. L. S. (2013). On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca2+. Molecular BioSystems, 10(1), 54-64. https://doi.org/10.1039/C3MB70370C

The structurally diverse polysaccharide lyase enzymes are distributed from plants to animals but share common catalytic mechanisms. One, heparinase I (F. heparinum), is employed in the production of the major anticoagulant drug, low molecular weight... Read More about On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca2+.

Integrated transcriptomic and proteomic analysis of the global response of Wolbachia to doxycycline-induced stress. (2013)
Journal Article
(2013). Integrated transcriptomic and proteomic analysis of the global response of Wolbachia to doxycycline-induced stress. ISME Journal, 925 - 937. https://doi.org/10.1038/ismej.2013.192

The bacterium Wolbachia (order Rickettsiales), representing perhaps the most abundant vertically transmitted microbe worldwide, infects arthropods and filarial nematodes. In arthropods, Wolbachia can induce reproductive alterations and interfere with... Read More about Integrated transcriptomic and proteomic analysis of the global response of Wolbachia to doxycycline-induced stress..

"Wrong, but useful": negotiating uncertainty in infectious disease modelling. (2013)
Journal Article
(2013). "Wrong, but useful": negotiating uncertainty in infectious disease modelling. PloS one, e76277 - ?. https://doi.org/10.1371/journal.pone.0076277

For infectious disease dynamical models to inform policy for containment of infectious diseases the models must be able to predict; however, it is well recognised that such prediction will never be perfect. Nevertheless, the consensus is that althoug... Read More about "Wrong, but useful": negotiating uncertainty in infectious disease modelling..

The role of transmembrane channel-like proteins in the operation of hair cell mechanotransducer channels (2013)
Journal Article
(2013). The role of transmembrane channel-like proteins in the operation of hair cell mechanotransducer channels. Journal of General Physiology, 493 -505. https://doi.org/10.1085/jgp.201311068

Sound stimuli elicit movement of the stereocilia that make up the hair bundle of cochlear hair cells, putting tension on the tip links connecting the stereocilia and thereby opening mechanotransducer (MT) channels. Tmc1 and Tmc2, two members of the t... Read More about The role of transmembrane channel-like proteins in the operation of hair cell mechanotransducer channels.

Draft Genome Sequence of a Meningitic Isolate of Cronobacter sakazakii Clonal Complex 4, Strain 8399 (2013)
Journal Article
(2013). Draft Genome Sequence of a Meningitic Isolate of Cronobacter sakazakii Clonal Complex 4, Strain 8399. Genome Announcements, https://doi.org/10.1128/genomeA.00833-13

The Cronobacter sakazakii clonal lineage defined as clonal complex 4 (CC4), composed of nine sequence types, is associated with
severe cases of neonatal meningitis. To date, only closely related C. sakazakii sequence type 4 (ST4) strains have been s... Read More about Draft Genome Sequence of a Meningitic Isolate of Cronobacter sakazakii Clonal Complex 4, Strain 8399.

Phanta: a non-fluorescent photochromic acceptor for pcFRET. (2013)
Journal Article
(2013). Phanta: a non-fluorescent photochromic acceptor for pcFRET. PloS one, e75835 - ?. https://doi.org/10.1371/journal.pone.0075835

We have developed an orange non-fluorescent photochromic protein (quantum yield, 0.003) we call Phanta that is useful as an acceptor in pcFRET applications. Phanta can be repeatedly inter-converted between the two absorbing states by alternate exposu... Read More about Phanta: a non-fluorescent photochromic acceptor for pcFRET..

Marshalin, a microtubule minus-end binding protein, regulates cytoskeletal structure in the organ of Corti (2013)
Journal Article
(2013). Marshalin, a microtubule minus-end binding protein, regulates cytoskeletal structure in the organ of Corti. Biology open BiO / Company of Biologists, 1192 -1202. https://doi.org/10.1242/bio.20135603

Dramatic structural changes in microtubules (MT) and the assembly of complicated intercellular connections are seen during the development of the cellular matrix of the sense organ for hearing, the organ of Corti. This report examines the expression... Read More about Marshalin, a microtubule minus-end binding protein, regulates cytoskeletal structure in the organ of Corti.