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Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis. (2001)
Journal Article
Zaitsev, S. V., Appelskog, I. B., Kapelioukh, I. L., Yang, S. N., Köhler, M., Efendic, S., …Maarabouni, M. (2001). Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis. Diabetes, 50(suppl_1), Article S70. https://doi.org/10.2337/diabetes.50.2007.s70

Imidazoline compounds have been considered for the treatment of type 2 diabetes. We have now investigated the effects of imidazolines on interleukin (IL)-1beta-induced beta-cell apoptosis and the signal transduction pathways involved. Inhibition of C... Read More about Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis..

Characterization of a K<inf>ATP</inf> channel-independent pathway involved in potentiation of insulin secretion by efaroxan (2001)
Journal Article
Chan, S. L., Mourtada, M., & Morgan, N. G. (2001). Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan. Diabetes, 50(2), 340–347. https://doi.org/10.2337/diabetes.50.2.340

Efaroxan, like several other imidazoline reagents, elicits a glucose-dependent increase in insulin secretion from pancreatic β-cells. This response has been attributed to efaroxan-mediated blockade of KATP channels, with the subsequent gating of volt... Read More about Characterization of a K<inf>ATP</inf> channel-independent pathway involved in potentiation of insulin secretion by efaroxan.

Juvenile dispersal in Reed Warblers Acrocephalus scirpaceus at night (2000)
Journal Article
Bulyuk, V. N., Mukhin, A., Fedorov, V. A., Tsvey, A., & Kishkinev, D. (2000). Juvenile dispersal in Reed Warblers Acrocephalus scirpaceus at night. Avian Ecology and Behaviour, 5, 45-61

The aim of this study was to test whether juvenile dispersal in Reed Warblers Acrocephalus scirpaceus takes place at night. If this does occur then the questions arise: “in which part of the night, at what age and physiological condition do they disp... Read More about Juvenile dispersal in Reed Warblers Acrocephalus scirpaceus at night.

Spider communities as tools in monitoring reclaimed limestone quarry landforms (2000)
Journal Article
Wheater, C. P., Cullen, W. R., & Bell, J. R. (2000). Spider communities as tools in monitoring reclaimed limestone quarry landforms. Landscape Ecology, 15, 401–406. https://doi.org/10.1023/a%3A1008171023039

Spider communities are sensitive to a wide range of environmental factors and are potential ecological indicators which may be effective in the assessment and monitoring of restored ecosystems. One restoration technique of disused limestone quarry fa... Read More about Spider communities as tools in monitoring reclaimed limestone quarry landforms.

Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic β-cells (2000)
Journal Article
Mourtada, M., Elliott, J., Smith, S., & Morgan, N. (2000). Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic β-cells. Naunyn-Schmiedeberg's Archives of Pharmacology, 361, 146–154. https://doi.org/10.1007/s002109900158

Pancreatic β-cells express imidazoline binding sites which play a role in the regulation of insulin secretion, but it is not known whether ligands for these sites also affect other aspects of β-cell physiology. In the present study, we have investiga... Read More about Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic β-cells.

Imidazolines and pancreatic hormone secretion (1999)
Journal Article
MORGAN, N. G., CHAN, S. L., MOURTADA, M., MONKS, L. K., & RAMSDEN, C. A. (1999). Imidazolines and pancreatic hormone secretion. Annals of the New York Academy of Sciences, 881(1), 217-228. https://doi.org/10.1111/j.1749-6632.1999.tb09364.x

A range of imidazoline derivatives are known to be effective stimulators of insulin secretion, and this response correlates with closure of ATP-sensitive potassium channels in the pancreatic β-cell. However, mounting evidence indicates that potassium... Read More about Imidazolines and pancreatic hormone secretion.

Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans (1998)
Journal Article
Mourtada, M., Smith, S. A., & Morgan, N. G. (1998). Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans. European Journal of Pharmacology, 350(2-3), 251-258. https://doi.org/10.1016/S0014-2999%2898%2900245-3

One component of the mechanism by which imidazoline compounds promote insulin secretion involves closure of ATP-sensitive K+ channels in the β-cell plasma membrane. Recently, however, it has also been proposed that these compounds may exert important... Read More about Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans.

Insulin secretagogues with an imidazoline structure inhibit arginine-induced glucagon secretion from isolated rat islets of langerhans (1997)
Journal Article
Mourtada, M., Smith, S. A., & Morgan, N. G. (1997). Insulin secretagogues with an imidazoline structure inhibit arginine-induced glucagon secretion from isolated rat islets of langerhans. Biochemical and Biophysical Research Communications, 236(1), 162-166. https://doi.org/10.1006/bbrc.1997.6922

It is well documented that imidazoline compounds such as efaroxan and phentolamine act as potent insulin secretagogues bothin vivoandin vitro,an effect which is mediated principally by blockade of ATP-sensitive potassium channels in the pancreatic B-... Read More about Insulin secretagogues with an imidazoline structure inhibit arginine-induced glucagon secretion from isolated rat islets of langerhans.

Further insight into the role of metals in amyloid formation by IAPP1-37 and ProIAPP1-48
Journal Article
(2015). Further insight into the role of metals in amyloid formation by IAPP1-37 and ProIAPP1-48. https://doi.org/10.7243/2050-0866-4-4

Background: IAPP1-37 and ProIAPP1-48 are amyloidogenic peptides implicated in ß-cell death in diabetes. Interactions with metals may be involved in both the cytotoxicity of these peptides and their deposition as amyloids associated with diabetes-rela... Read More about Further insight into the role of metals in amyloid formation by IAPP1-37 and ProIAPP1-48.

Aedes aegyptigut transcriptomes respond differently to microbiome transplants from field-caught or laboratory-reared mosquitoes
Journal Article
Hegde, S., Brettell, L. E., Quek, S., Etebari, K., Saldaña, M. A., Asgari, S., …Hughes, G. L. Aedes aegyptigut transcriptomes respond differently to microbiome transplants from field-caught or laboratory-reared mosquitoes. arXiv, https://doi.org/10.1101/2023.03.16.532926

The mosquito microbiome is critical for host development and plays a major role in many aspects of mosquito biology. While the microbiome is commonly dominated by a small number of genera, there is considerable variation in composition among mosquito... Read More about Aedes aegyptigut transcriptomes respond differently to microbiome transplants from field-caught or laboratory-reared mosquitoes.

Inter-species microbiota transplantation recapitulates microbial acquisition and persistence in mosquitoes
Journal Article
Coon, K. L., Hegde, S., & Hughes, G. L. Inter-species microbiota transplantation recapitulates microbial acquisition and persistence in mosquitoes. arXiv, https://doi.org/10.1101/2021.10.06.463328

Background Mosquitoes harbor microbial communities that play important roles in their growth, survival, reproduction, and ability to transmit human pathogens. Microbiome transplantation approaches are often used to study host-microbe interactions and... Read More about Inter-species microbiota transplantation recapitulates microbial acquisition and persistence in mosquitoes.

Microbial interactions in the mosquito gut determine Serratia colonization and blood feeding propensity.
Journal Article
Kozlova, E. V., Hegde, S., Roundy, C. M., Golovko, G., A Saldana, M., Hart, C. E., …Hughes, G. L. Microbial interactions in the mosquito gut determine Serratia colonization and blood feeding propensity. arXiv, https://doi.org/10.1101/2020.04.14.039701

How microbe-microbe interactions dictate microbial complexity in the mosquito gut is unclear. Previously we found that Serratia, a gut symbiont that alters vector competence and is being considered for vector control, poorly colonized Aedes aegypti y... Read More about Microbial interactions in the mosquito gut determine Serratia colonization and blood feeding propensity..

Gut-associated bacteria invade the midgut epithelium of Aedes aegypti and stimulate innate immunity and suppress Zika virus infection in cells
Journal Article
Hegde, S., Voronin, D., Casas-Sanchez, A., Saldaña, M. A., Heinz, E., Acosta-Serrano, A., …Hughes, G. L. Gut-associated bacteria invade the midgut epithelium of Aedes aegypti and stimulate innate immunity and suppress Zika virus infection in cells. arXiv, https://doi.org/10.1101/866897

Microbiota within mosquitoes influence nutrition, immunity, fecundity, and the capacity to transmit pathogens. Despite their importance, we have a limited understanding of host-microbiota interactions, especially at the cellular level. It is evident... Read More about Gut-associated bacteria invade the midgut epithelium of Aedes aegypti and stimulate innate immunity and suppress Zika virus infection in cells.