All Outputs (73)

Awareness of rabies and response to dog bites in a Bangladesh community (2016)
Journal Article
Ghosh, S., Chowdhury, S., Haider, N., Bhowmik, R., Rana, M., Prue Marma, A., …Ahmed, B. (2016). Awareness of rabies and response to dog bites in a Bangladesh community. Veterinary Medicine and Science, 161 - 169. https://doi.org/10.1002/vms3.30

Community awareness regarding rabies and treatment seeking behaviours are critical both for the prevention and control of the disease in human and animals. We conducted a study to explore people's awareness about rabies, their attitudes towards dogs... Read More about Awareness of rabies and response to dog bites in a Bangladesh community.

Unique Insights in the Cervicovaginal Lactobacillus iners and L. crispatus Proteomes and Their Associations with Microbiota Dysbiosis. (2016)
Journal Article
Wastling. (2016). Unique Insights in the Cervicovaginal Lactobacillus iners and L. crispatus Proteomes and Their Associations with Microbiota Dysbiosis. PloS one, e0150767 -?. https://doi.org/10.1371/journal.pone.0150767

BACKGROUND: A Lactobacillus-dominated cervicovaginal microbiota (VMB) protects women from adverse reproductive health outcomes, but the role of L. iners in the VMB is poorly understood. Our aim was to explore the association between the cervicovagina... Read More about Unique Insights in the Cervicovaginal Lactobacillus iners and L. crispatus Proteomes and Their Associations with Microbiota Dysbiosis..

Crystal structure of a complex of Surfactant Protein D and Haemophilus influenzae lipopolysaccharide reveals shielding of core structures in SP-D resistant strains (2016)
Journal Article
Shrive, A., & Greenhough, T. (2016). Crystal structure of a complex of Surfactant Protein D and Haemophilus influenzae lipopolysaccharide reveals shielding of core structures in SP-D resistant strains. Infection and Immunity, 1585-1592. https://doi.org/10.1128/IAI.01239-15

The carbohydrate recognition domains (CRDs) of lung collectin surfactant protein D (SP-D) recognize sugar patterns on the surface of lung pathogens and promote phagocytosis. Using Haemophilus influenzae Eagan strains expressing well-characterized lip... Read More about Crystal structure of a complex of Surfactant Protein D and Haemophilus influenzae lipopolysaccharide reveals shielding of core structures in SP-D resistant strains.

Identification of Novel O-Linked Glycosylated Toxoplasma Proteins by Vicia villosa Lectin Chromatography. (2016)
Journal Article
(2016). Identification of Novel O-Linked Glycosylated Toxoplasma Proteins by Vicia villosa Lectin Chromatography. PloS one, e0150561 -?. https://doi.org/10.1371/journal.pone.0150561

Toxoplasma gondii maintains its intracellular life cycle using an extraordinary arsenal of parasite-specific organelles including the inner membrane complex (IMC), rhoptries, micronemes, and dense granules. While these unique compartments play critic... Read More about Identification of Novel O-Linked Glycosylated Toxoplasma Proteins by Vicia villosa Lectin Chromatography..

The CROPROTECT project and wider opportunities to improve farm productivity through web-based knowledge exchange. (2016)
Journal Article
Bruce. (2016). The CROPROTECT project and wider opportunities to improve farm productivity through web-based knowledge exchange. Food and Energy Security, 89 - 96. https://doi.org/10.1002/fes3.80

A key global 21st century challenge is to maximize agricultural production while minimizing use of resources such as land, water, and energy to meet rising demand for produce. To meet this challenge, while also adapting to climate change, agriculture... Read More about The CROPROTECT project and wider opportunities to improve farm productivity through web-based knowledge exchange..

Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia/reperfusion (2016)
Journal Article
Vasques, E., Cunha, J., Coelho, A., Sampietre, S., Patzina, R., Abdo, E., …D’Albuquerque, L. A. (2016). Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia/reperfusion. PloS one, 11, e0149630--e0149630. https://doi.org/10.1371/journal.pone.0149630

Background Ischemia and reperfusion (I/R) causes tissue damage and intracellular calcium levels are a factor of cell death. Sodium calcium exchanger (NCX) regulates calcium extrusion and Trisulfated Disaccharide (TD) acts on NCX decreasing intracell... Read More about Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia/reperfusion.

Development and characterisation of neurocompatible transfection grade magnetic nanoparticles for genetic modification of neural stem cells (2016)
Journal Article
Chari, & Adams. (2016). Development and characterisation of neurocompatible transfection grade magnetic nanoparticles for genetic modification of neural stem cells. Advanced healthcare materials, 841-849. https://doi.org/10.1002/adhm.201500885

Genetic modification of cell transplant populations and cell tracking ability are key underpinnings for effective cell therapies. Current strategies to achieve these goals utilize methods which are unsuitable for clinical translation because of relat... Read More about Development and characterisation of neurocompatible transfection grade magnetic nanoparticles for genetic modification of neural stem cells.

What is normal? Next generation sequencing-driven analysis of the human circulating miRNAOme (2016)
Journal Article
Tonge, D., & Gant, T. (2016). What is normal? Next generation sequencing-driven analysis of the human circulating miRNAOme. BMC Molecular Biology, https://doi.org/10.1186/s12867-016-0057-9

Background MicroRNAs (miRNAs) are short non-protein-coding RNA species that have a regulatory function in modulating protein translation and degradation of specific mRNAs. MicroRNAs are estimated to target approximately 60 % of all human mRNAs and a... Read More about What is normal? Next generation sequencing-driven analysis of the human circulating miRNAOme.

The hormone response element mimic sequence of GAS5 lncRNA is sufficient to induce apoptosis in breast cancer cells (2016)
Journal Article
(2016). The hormone response element mimic sequence of GAS5 lncRNA is sufficient to induce apoptosis in breast cancer cells. Oncotarget, https://doi.org/10.18632/oncotarget.7173

Growth arrest-specific 5 (GAS5) lncRNA promotes apoptosis, and its expression is down-regulated in breast cancer. GAS5 lncRNA is a decoy of glucocorticoid/related receptors; a stem-loop sequence constitutes the GAS5 hormone response element mimic (HR... Read More about The hormone response element mimic sequence of GAS5 lncRNA is sufficient to induce apoptosis in breast cancer cells.

The genomic basis of parasitism in the Strongyloides clade of nematodes. (2016)
Journal Article
(2016). The genomic basis of parasitism in the Strongyloides clade of nematodes. Nature genetics, 299 - 307. https://doi.org/10.1038/ng.3495

Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their c... Read More about The genomic basis of parasitism in the Strongyloides clade of nematodes..

From Stock Bottle to Vaccine: Elucidating the Particle Size Distributions of Aluminum Adjuvants Using Dynamic Light Scattering. (2016)
Journal Article
(2016). From Stock Bottle to Vaccine: Elucidating the Particle Size Distributions of Aluminum Adjuvants Using Dynamic Light Scattering. Frontiers in Chemistry, 48 - ?. https://doi.org/10.3389/fchem.2016.00048

The physicochemical properties of aluminum salts are key determinants of their resultant adjuvanticity in vivo when administered as part of a vaccine. While there are links between particle size and the efficacy of the immune response, the limited li... Read More about From Stock Bottle to Vaccine: Elucidating the Particle Size Distributions of Aluminum Adjuvants Using Dynamic Light Scattering..

Predicted optimum ambient temperatures for broiler chickens to dissipate metabolic heat do not affect performance or improve breast muscle quality (2016)
Journal Article
Beard. (2016). Predicted optimum ambient temperatures for broiler chickens to dissipate metabolic heat do not affect performance or improve breast muscle quality. British Poultry Science, 134 - 141. https://doi.org/10.1080/00071668.2015.1124067

An experiment was conducted to test the hypothesis that muscle damage in fast-growing broiler chickens is associated with an ambient temperature that does not permit the birds to lose metabolic heat resulting in physiological heat stress and a reduct... Read More about Predicted optimum ambient temperatures for broiler chickens to dissipate metabolic heat do not affect performance or improve breast muscle quality.

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae (2016)
Journal Article
Hammond, A., Galizi, R., Kyrou, K., Simoni, A., Siniscalchi, C., Katsanos, D., …Nolan, T. (2016). A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae. Nature Biotechnology, 78 - 83. https://doi.org/10.1038/nbt.3439

Gene drive systems that enable super-Mendelian inheritance of a transgene have the potential to modify insect populations over a timeframe of a few years. We describe CRISPR-Cas9 endonuclease constructs that function as gene drive systems in Anophele... Read More about A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae.