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All Outputs (96)

Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma (2022)
Journal Article
Napolitano, V., Mróz, P., Marciniak, M., Kalel, V. C., Softley, C. A., Janna Olmos, J. D., Tippler, B. G., Schorpp, K., Rioton, S., Fröhlich, T., Plettenburg, O., Hadian, K., Erdmann, R., Sattler, M., Popowicz, G. M., Dawidowski, M., & Dubin, G. (2022). Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma. European Journal of Medicinal Chemistry, 243, Article 114778. https://doi.org/10.1016/j.ejmech.2022.114778

Trypanosomiases are neglected tropical diseases caused by Trypanosoma (sub)species. Available treatments are limited and have considerable adverse effects and questionable efficacy in the chronic stage of the disease, urgently calling for the identif... Read More about Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.

Investigating the interaction between dengue viral envelope proteins and host receptor molecules (2022)
Thesis
Hyatt, J. G. Investigating the interaction between dengue viral envelope proteins and host receptor molecules. (Thesis). Keele University. https://keele-repository.worktribe.com/output/425037

Infection of dengue remains to this date a major socio-economic and public health challenge for large parts of the world, especially low- and middle- income countries in the tropics and sub-tropics. Despite the prevalence of the associated neglected... Read More about Investigating the interaction between dengue viral envelope proteins and host receptor molecules.

An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells (2022)
Thesis
Kavousi, N. An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells. (Thesis). Keele University. https://keele-repository.worktribe.com/output/425034

The serine/threonine protein phosphatase 4 holoenzyme consists of PP4 catalytic subunit (PP4c), which interacts with four different regulatory subunits (PP4R1, PP4R2, PP4R3, PP4R4). Previous studies have shown that PP4c acts as a tumour suppressor an... Read More about An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells.

Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds (2022)
Journal Article
Mogas Barcons, A., Chowdhury, F., Chari, D. M., & Adams, C. (2022). Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds. Materials, 16(1), Article 124. https://doi.org/10.3390/ma16010124

Spinal cord injury is debilitating with functional loss often permanent due to a lack of neuro-regenerative or neuro-therapeutic strategies. A promising approach to enhance biological function is through implantation of tissue engineered constructs,... Read More about Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds.

Sensitivity threshold of avian magnetic compass to oscillating magnetic field is species-specific (2022)
Journal Article
Bojarinova, J., Kavokin, K., Cherbunin, R., Sannikov, D., Fedorishcheva, A., Pakhomov, A., & Chernetsov, N. (2023). Sensitivity threshold of avian magnetic compass to oscillating magnetic field is species-specific. Behavioral Ecology and Sociobiology, 77(1), https://doi.org/10.1007/s00265-022-03282-7

One of the most unusual features of the avian magnetic compass is its sensitivity to weak oscillating magnetic fields (OMF) in the radiofrequency range. This effect, observed earlier in numerous experiments in European robins Erithacus rubecula and g... Read More about Sensitivity threshold of avian magnetic compass to oscillating magnetic field is species-specific.

Biological control interventions reduce pest abundance and crop damage while maintaining natural enemies in sub-Saharan Africa: a meta-analysis (2022)
Journal Article
Ratto, F., Bruce, T., Chipabika, G., Mwamakamba, S., Mkandawire, R., Khan, Z., Mkindi, A., Pittchar, J., Sallu, S., Whitfield, S., Wilson, K., & Sait, S. (2022). Biological control interventions reduce pest abundance and crop damage while maintaining natural enemies in sub-Saharan Africa: a meta-analysis. Proceedings of the Royal Society B: Biological Sciences, https://doi.org/10.1098/rspb.2022.1695

Insect pests are a major challenge to smallholder crop production in sub-Saharan Africa (SSA), where access to synthetic pesticides, which are linked to environmental and health risks, is often limited. Biological control interventions could offer a... Read More about Biological control interventions reduce pest abundance and crop damage while maintaining natural enemies in sub-Saharan Africa: a meta-analysis.

Interspecies microbiome transplantation recapitulates microbial acquisition in mosquitoes (2022)
Journal Article
Coon, K., Hegde, S., & Hughes, G. (2022). Interspecies microbiome transplantation recapitulates microbial acquisition in mosquitoes. Microbiome, 10, Article 58. https://doi.org/10.1186/s40168-022-01256-5

Background Mosquitoes harbor microbial communities that play important roles in their growth, survival, reproduction, and ability to transmit human pathogens. Microbiome transplantation approaches are often used to study host-microbe interactions and... Read More about Interspecies microbiome transplantation recapitulates microbial acquisition in mosquitoes.

Quantifying inherent predictability and spatial synchrony in the aphid vector Myzus persicae - field-scale patterns of abundance and regional forecasting error in the UK (2022)
Journal Article
Bell, J., Clark, S. J., Stevens, M., & Mead, A. (2023). Quantifying inherent predictability and spatial synchrony in the aphid vector Myzus persicae - field-scale patterns of abundance and regional forecasting error in the UK. Pest Management Science, 79(4), https://doi.org/10.1002/ps.7292

Background
Sugar beet is threatened by virus yellows, a disease complex vectored by aphids that reduces sugar content. We present an analysis of Myzus persicae population dynamics with and without neonicotinoid seed treatment. We use 6 years' yellow... Read More about Quantifying inherent predictability and spatial synchrony in the aphid vector Myzus persicae - field-scale patterns of abundance and regional forecasting error in the UK.

Biological Flora of Britain and Ireland: Viscum album (2022)
Journal Article
Thomas, P. A., Dering, M., Giertych, M. J., Iszkuło, G., Tomaszewski, D., & Briggs, J. (2022). Biological Flora of Britain and Ireland: Viscum album. Journal of Ecology, 111(3), 701-739. https://doi.org/10.1111/1365-2745.14036

This account presents information on all aspects of the biology of Viscum album L. (Mistletoe) that are relevant to understanding its ecological characteristics and behaviour. The main topics are presented within the standard framework of the Biologi... Read More about Biological Flora of Britain and Ireland: Viscum album.

Silencing RNAs expressed from W-linked PxyMasc “retrocopies” target that gene during female sex determination in Plutella xylostella (2022)
Journal Article
Harvey-Samuel, T., Xu, X., Anderson, M. A. E., Carabajal Paladino, L. Z., Purusothaman, D., Norman, V. C., Reitmayer, C. M., You, M., & Alphey, L. (2022). Silencing RNAs expressed from W-linked PxyMasc “retrocopies” target that gene during female sex determination in Plutella xylostella. Proceedings of the National Academy of Sciences of the United States of America, 119(46), https://doi.org/10.1073/pnas.2206025119

The Lepidoptera are an insect order of cultural, economic, and environmental importance, representing ∼10% of all described living species. Yet, for all but one of these species (silkmoth, Bombyx mori), the molecular genetics of how sexual fate is de... Read More about Silencing RNAs expressed from W-linked PxyMasc “retrocopies” target that gene during female sex determination in Plutella xylostella.

Demography of Common Swifts (Apus apus) breeding in the UK associated with local weather but not aphid biomass (2022)
Journal Article
Finch, T., Bell, J. R., Robinson, R. A., & Peach, W. J. (2023). Demography of Common Swifts (Apus apus) breeding in the UK associated with local weather but not aphid biomass. Ibis, 165(2), 420-435. https://doi.org/10.1111/ibi.13156

In common with many other insectivorous birds, the Common Swift Apus apus is undergoing population declines, with an estimated 57% reduction in abundance between 1995 and 2017 in the UK. The ultimate drivers of this decline are poorly understood but... Read More about Demography of Common Swifts (Apus apus) breeding in the UK associated with local weather but not aphid biomass.

Heparin: an established anticoagulant drug with therapeutic potential for COVID-19 (2022)
Thesis
McIntosh, O. G. Heparin: an established anticoagulant drug with therapeutic potential for COVID-19. (Thesis). Keele University. https://keele-repository.worktribe.com/output/424531

The biologically and medically important heparan sulphate and heparin polysaccharides have been previously shown to mediate viral cell entry for enveloped viruses. Furthermore, heparin and its analogues have been shown to have anti-inflammatory and a... Read More about Heparin: an established anticoagulant drug with therapeutic potential for COVID-19.

The chemical ecology of a model aphid pest, Myzus persicae, and its natural enemies (2022)
Thesis
Ali, J. The chemical ecology of a model aphid pest, Myzus persicae, and its natural enemies. (Thesis). Keele University. https://keele-repository.worktribe.com/output/424546

The peach potato aphid, Myzus persicae, is a serious crop pest with a worldwide distribution. It has short generation time, high reproductive rate and the ability to adapt to new hosts and develop resistance against major class of insecticides. There... Read More about The chemical ecology of a model aphid pest, Myzus persicae, and its natural enemies.

Community-Based Interventions for the Prevention and Control of Cutaneous Leishmaniasis: A Systematic Review (2022)
Journal Article
Polidano, K., Wenning, B., Ruiz-Cadavid, A., Dawaishan, B., Panchal, J., Gunasekara, S., Abebe, H., Morais, M., Price, H., & Dikomitis, L. (2022). Community-Based Interventions for the Prevention and Control of Cutaneous Leishmaniasis: A Systematic Review. Social Sciences, 11(10), Article 490. https://doi.org/10.3390/socsci11100490

<jats:p>We reviewed the evidence on community-based interventions for the prevention and control of cutaneous leishmaniasis (CL). Community initiatives tailored towards awareness and mobilisation are regarded as a priority area in the Neglected Tropi... Read More about Community-Based Interventions for the Prevention and Control of Cutaneous Leishmaniasis: A Systematic Review.

Building a brighter future for Africa with the African Light Source. (2022)
Journal Article
(2022). Building a brighter future for Africa with the African Light Source. Nature Reviews Physics, 1 - 2. https://doi.org/10.1038/s42254-022-00534-3

Africa is the only habitable continent that is not yet host to a light source - an important tool across disciplines. Scientists from the Executive Committee of the African Light Source Foundation discuss work towards building an advanced light sourc... Read More about Building a brighter future for Africa with the African Light Source..