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Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome. (2023)
Journal Article
Page, N., Taxiarchi, C., Tonge, D., Kuburic, J., Chesters, E., Kriezis, A., …Galizi, R. (in press). Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome. Communications Biology, 6, Article 850. https://doi.org/10.1038/s42003-023-05224-z

Understanding development and genetic regulation in the Anopheles gambiae germline is essential to engineer effective genetic control strategies targeting this malaria mosquito vector. These include targeting the germline to induce sterility or using... Read More about Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome..

Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome (2023)
Journal Article
Page, N., Taxiarchi, C., Tonge, D., Kuburic, J., Chesters, E., Kriezis, A., …Galizi, R. (2023). Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome. Communications Biology, 6(1), Article 850. https://doi.org/10.1038/s42003-023-05224-z

Understanding development and genetic regulation in the Anopheles gambiae germline is essential to engineer effective genetic control strategies targeting this malaria mosquito vector. These include targeting the germline to induce sterility or using... Read More about Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome.

Identification and characterization of two CRISPR-Cas systems associated with the mosquito microbiome (2023)
Journal Article
Hegde, S., Rauch, H. E., Hughes, G. L., & Shariat, N. (in press). Identification and characterization of two CRISPR-Cas systems associated with the mosquito microbiome. Access Microbiology, 5(8), https://doi.org/10.1099/acmi.0.000599.v3

The microbiome profoundly influences many traits in medically relevant vectors such as mosquitoes, and a greater functional understanding of host-microbe interactions may be exploited for novel microbial-based approaches to control mosquito-borne dis... Read More about Identification and characterization of two CRISPR-Cas systems associated with the mosquito microbiome.

Identification and characterization of two CRISPR/Cas systems associated with the mosquito microbiome (2023)
Journal Article
Hegde, S., Rauch, H. E., Hughes, G. L., & Shariat, N. (2023). Identification and characterization of two CRISPR/Cas systems associated with the mosquito microbiome. Access Microbiology, 5(8), https://doi.org/10.1099/acmi.0.000599.v4

The microbiome profoundly influences many traits in medically relevant vectors such as mosquitoes, and a greater functional understanding of host–microbe interactions may be exploited for novel microbial-based approaches to control mosquito-borne dis... Read More about Identification and characterization of two CRISPR/Cas systems associated with the mosquito microbiome.

In-solution and interface study on biological model membranes and their interaction with Prohibitin (2023)
Thesis
Piccinini, A. (2023). In-solution and interface study on biological model membranes and their interaction with Prohibitin. (Thesis). Keele University

Prohibitins (PHB) play a crucial role in premature cellular ageing, tumour suppression, cell cycle regulation, and apoptosis, and their deregulation is involved in viral infections, neurological and cardiovascular diseases and cancer. Despite the ess... Read More about In-solution and interface study on biological model membranes and their interaction with Prohibitin.

Factors influencing oviposition behaviour of the invasive pest, Drosophila suzukii, derived from interactions with other Drosophila species: potential applications for control (2023)
Journal Article
Tungadi, T. D., Powell, G., Shaw, B., & Fountain, M. T. (2023). Factors influencing oviposition behaviour of the invasive pest, Drosophila suzukii, derived from interactions with other Drosophila species: potential applications for control. Pest Management Science, 79(11), 4132-4139. https://doi.org/10.1002/ps.7693

Drosophila suzukii (Matsumura) or spotted wing Drosophila is a worldwide invasive pest of soft‐ and stone‐fruit production. Female D. suzukii lay their eggs in ripening fruit and the hatched larvae damage fruit from the inside, rendering it unmarketa... Read More about Factors influencing oviposition behaviour of the invasive pest, Drosophila suzukii, derived from interactions with other Drosophila species: potential applications for control.

Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming (2023)
Journal Article
Hyland, M., Mennan, C., Davies, R., Wilson, E., Tonge, D. P., Clayton, A., & Kehoe, O. (2023). Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming. Stem Cell Reviews and Reports, 19, 2391–2406. https://doi.org/10.1007/s12015-023-10586-2

Autoimmune conditions, such as rheumatoid arthritis, are characterised by a loss of immune tolerance, whereby the immune cells attack self-antigens causing pain and inflammation. These conditions can be brought into remission using pharmaceutical tre... Read More about Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming.

Decoding attraction: improving vine weevil monitoring by exploiting key sensory cues. (2023)
Journal Article
Fezza, E., Roberts, J. M., Bruce, T. J. A., Walsh, L. E., Gaffney, M. T., Pope, T. W., …Gaffney, M. T. (in press). Decoding attraction: improving vine weevil monitoring by exploiting key sensory cues. Pest Management Science, 10.1002/ps.7665. https://doi.org/10.1002/ps.7665

Monitoring is an integral component of integrated pest management (IPM) programmes used to inform crop management decisions. Vine weevil, Otiorhynchus sulcatus F. (Coleoptera: Curculionidae), continues to cause economically significant losses in hort... Read More about Decoding attraction: improving vine weevil monitoring by exploiting key sensory cues..

Within- and between-host dynamics of producer and non-producer pathogens (2023)
Journal Article
Pike, V. L., Stevens, E. J., Griffin, A. S., & King, K. C. (2023). Within- and between-host dynamics of producer and non-producer pathogens. Parasitology, https://doi.org/10.1017/S0031182023000586

For infections to be maintained in a population, pathogens must compete to colonize hosts and transmit between them. We use an experimental approach to investigate within-and-between host dynamics using the pathogen Pseudomonas aeruginosa and the ani... Read More about Within- and between-host dynamics of producer and non-producer pathogens.

Study to determine the rate of kill of anti-leishmanial drugs using a novel bioluminescence-based assay (2023)
Thesis
Freakley, A. L. (2023). Study to determine the rate of kill of anti-leishmanial drugs using a novel bioluminescence-based assay. (Thesis). Keele University

Leishmaniasis is a neglected tropical disease associated with poverty, deprived socio-economic settings and population displacement, primarily due to conflict. The causative agent are species of Leishmania parasites that are transmitted by sand flies... Read More about Study to determine the rate of kill of anti-leishmanial drugs using a novel bioluminescence-based assay.

Food safety news events classification via a hierarchical transformer model (2023)
Journal Article
Xiong, S., Tian, W., Batra, V., Fan, X., Xi, L., Liu, H., & Liu, L. (2023). Food safety news events classification via a hierarchical transformer model. Heliyon, 9(7), Article e17806. https://doi.org/10.1016/j.heliyon.2023.e17806

In light of the significance of regulatory authorities and the rising demand for information disclosure, a vast amount of information on food safety news reports is readily accessible on the Internet. The extraction of such information for precise cl... Read More about Food safety news events classification via a hierarchical transformer model.

ATR-FTIR spectroscopy of heparin: using multivariate analyses for next-generation quality control (2023)
Thesis
Devlin, A. J. (2023). ATR-FTIR spectroscopy of heparin: using multivariate analyses for next-generation quality control. (Thesis). Keele University

Heparin is a member of the glycosaminoglycan (GAG) family of naturally occurring, polydisperse, linear polysaccharides. Heparin is a ubiquitous anticoagulant drug, a member of the WHO’s list of vital medicines and the second used drug by weight after... Read More about ATR-FTIR spectroscopy of heparin: using multivariate analyses for next-generation quality control.

Occurrence of tuberculosis among people exposed to cattle in Bangladesh (2023)
Journal Article
Sarkar, S., Haider, N., Islam, A., Hossain, M. B., Hossain, K., Mafij Uddin, M. K., …Zeidner, N. (2023). Occurrence of tuberculosis among people exposed to cattle in Bangladesh. Veterinary Medicine and Science, 9(4), 1923-1933. https://doi.org/10.1002/vms3.1178

Background Tuberculosis (TB) has been an important public health concern in Bangladesh. The most common cause of human TB is Mycobacterium tuberculosis, while bovine TB is caused by Mycobacterium bovis. Objective The objective of this study was... Read More about Occurrence of tuberculosis among people exposed to cattle in Bangladesh.

Temporal variation in spider trophic interactions is explained by the influence of weather on prey communities, web building and prey choice (2023)
Journal Article
Cuff, J. P., Windsor, F. M., Tercel, M. P., Bell, J. R., Symondson, W. O., & Vaughan, I. P. (2023). Temporal variation in spider trophic interactions is explained by the influence of weather on prey communities, web building and prey choice. Ecography, 2023(7), https://doi.org/10.1111/ecog.06737

Generalist invertebrate predators are sensitive to weather conditions, but the relationship between their trophic interactions and weather is poorly understood. This study investigates how weather affects the identity and frequency of spider trophic... Read More about Temporal variation in spider trophic interactions is explained by the influence of weather on prey communities, web building and prey choice.

Optimized protocol for in vivo affinity purification proteomics and biochemistry using C. elegans (2023)
Journal Article
Desbois, M., Pak, J. S., Opperman, K. J., Giles, A. C., & Grill, B. (2023). Optimized protocol for in vivo affinity purification proteomics and biochemistry using C. elegans. STAR Protocols, 4(2), https://doi.org/10.1016/j.xpro.2023.102262

We present an optimized protocol for in vivo affinity purification proteomics and biochemistry using the model organism C. elegans. We describe steps for target tagging, large-scale culture, affinity purification using a cryomill, mass spectrometry a... Read More about Optimized protocol for in vivo affinity purification proteomics and biochemistry using C. elegans.

Multiple Lineages of Hantaviruses Harbored by the Iberian Mole ( Talpa occidentalis ) in Spain (2023)
Journal Article
Gu, S. H., Miñarro, M., Feliu, C., Hugot, J., Forrester, N. L., Weaver, S. C., …Forrester, N. L. (2023). Multiple Lineages of Hantaviruses Harbored by the Iberian Mole ( Talpa occidentalis ) in Spain. Viruses, 15(6), Article 1313. https://doi.org/10.3390/v15061313

The recent detection of both Nova virus (NVAV) and Bruges virus (BRGV) in European moles (Talpa europaea) in Belgium and Germany prompted a search for related hantaviruses in the Iberian mole (Talpa occidentalis). RNAlater®-preserved lung tissue from... Read More about Multiple Lineages of Hantaviruses Harbored by the Iberian Mole ( Talpa occidentalis ) in Spain.

Efficacy of selected botanical oils against the cassava whitefly (<i>Bemisia tabaci</i>) and their effects on its feeding behaviour (2023)
Journal Article
Amour, M., Wosula, E. N., Mrisho, L., Hoskins, C., Buss, D., Bruce, T., …Legg, J. P. (2023). Efficacy of selected botanical oils against the cassava whitefly (Bemisia tabaci) and their effects on its feeding behaviour. Journal of Applied Entomology, 147(7), 473-485. https://doi.org/10.1111/jen.13128

The control of the whitefly Bemisia tabaci relies heavily on the use of synthetic insecticides. There is a need to develop alternative control strategies due to concerns about impact of these insecticides on the environmental and human health, and th... Read More about Efficacy of selected botanical oils against the cassava whitefly (<i>Bemisia tabaci</i>) and their effects on its feeding behaviour.