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The 2022 dengue outbreak in Bangladesh: hypotheses for the late resurgence of cases and fatalities (2023)
Journal Article
Haider, N., N, H., Hasan, M. N., MN, H., Khalil, I., I, K., …MJ, U. (2023). The 2022 dengue outbreak in Bangladesh: hypotheses for the late resurgence of cases and fatalities. Journal of Medical Entomology, 60(4), 847-852. https://doi.org/10.1093/jme/tjad057

Bangladesh reported the highest number of annual deaths (n = 281) related to dengue virus infection in 2022 since the virus reappeared in the country in 2000. Earlier studies showed that >92% of the annual cases occurred between the months of... Read More about The 2022 dengue outbreak in Bangladesh: hypotheses for the late resurgence of cases and fatalities.

The stigma associated with cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL): A protocol for a systematic review (2023)
Journal Article
Nuwangi, H., Agampodi, T. C., Price, H. P., Shepherd, T., Weerakoon, K. G., & Agampodi, S. B. (2023). The stigma associated with cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL): A protocol for a systematic review. PloS one, 18(5), Article ARTN e0285663. https://doi.org/10.1371/journal.pone.0285663

Leishmaniasis is a neglected tropical disease with three main clinical types; cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), and visceral leishmaniasis (VL). CL and MCL are considered to be highly stigmatizing due to potentially dis... Read More about The stigma associated with cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL): A protocol for a systematic review.

Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome. (2023)
Other
Page, N., Taxiarchi, C., Tonge, D., Kuburic, J., Chesters, E., Kriezis, A., …Galizi, R. (2023). Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome. [PREPRINT]

Understanding development and genetic regulation in the Anopheles gambiae germline is essential to engineer effective genetic control strategies targeting this malaria mosquito vector. These include targeting the germline to induce sterility or using... Read More about Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome..

Human Exposure to Bats, Rodents and Monkeys in Bangladesh (2023)
Journal Article
Shanta, I. S., Luby, S. P., Hossain, K., Heffelfinger, J. D., Kilpatrick, A. M., Haider, N., …Gurley, E. S. (2023). Human Exposure to Bats, Rodents and Monkeys in Bangladesh. EcoHealth, https://doi.org/10.1007/s10393-023-01628-9

Bats, rodents and monkeys are reservoirs for emerging zoonotic infections. We sought to describe the frequency of human exposure to these animals and the seasonal and geographic variation of these exposures in Bangladesh. During 2013–2016, we conduct... Read More about Human Exposure to Bats, Rodents and Monkeys in Bangladesh.

The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence (2023)
Journal Article
Jangir, P., Ogunlana, L., Szili, P., Czikkely, M., P Shaw, L., Stevens, E. J., …R MacLean, C. (2023). The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence. eLife, 12, 1-22. https://doi.org/10.7554/elife.84395

Antimicrobial peptides (AMPs) offer a promising solution to the antibiotic resistance crisis. However, an unresolved serious concern is that the evolution of resistance to therapeutic AMPs may generate cross-resistance to host AMPs, compromising a co... Read More about The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence.

Explainable neural networks for trait-based multispecies distribution modelling—A case study with butterflies and moths (2023)
Journal Article
Bourhis, Y., Bell, J., Shortall, C., W., K., & Milne, A. (2023). Explainable neural networks for trait-based multispecies distribution modelling—A case study with butterflies and moths. Methods in Ecology and Evolution, 14(6), https://doi.org/10.1111/2041-210X.14097

Species response traits mediate environmental effects on species distribution. Traits are used in joint and multispecies distribution models (JSDMs and MSDMs) to enable community-wide shared parameters that characterise niche filtering along environm... Read More about Explainable neural networks for trait-based multispecies distribution modelling—A case study with butterflies and moths.

Long‐term trends in migrating Brassicogethes aeneus in the UK (2023)
Journal Article
Shortall, C., Cook, S. M., Mauchline, A. L., & Bell, J. (2023). Long‐term trends in migrating Brassicogethes aeneus in the UK. Pest Management Science, https://doi.org/10.1002/ps.7501

BACKGROUND The pollen beetle (Brassicogethes aeneus) causes significant yield loss in oilseed rape (Brassica napus). Predicting population changes remains a scientific challenge, especially since its phenology and abundance varies dramatically over... Read More about Long‐term trends in migrating Brassicogethes aeneus in the UK.

Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells (2023)
Journal Article
Llewellyn, J., Mallikarjun, V., Gilbert, H., Richardson, S., Hubbard, S., Swift, J., …Osipova, M. (2023). Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells. Proceedings of the National Academy of Sciences of the United States of America, https://doi.org/10.1073/pnas.2210745120

Cells respond to stress by synthesizing chaperone proteins that seek to correct protein misfolding and maintain function. However, abrogation of protein homeostasis is a hallmark of aging, leading to loss of function and the formation of proteotoxic... Read More about Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells.

Whole genome sequencing revealed a high level of antimicrobial resistance genes and virulence factors in a multidrug-resistant Citrobacter freundii BAU_TM8 strain isolated from a domesticated duck in Bangladesh (2023)
Other
Ahmed, T., Islam, S., Haider, N., Tonge, D., Hasan, B., Nuruzzaman, M., …Rahman Khan, S. (2023). Whole genome sequencing revealed a high level of antimicrobial resistance genes and virulence factors in a multidrug-resistant Citrobacter freundii BAU_TM8 strain isolated from a domesticated duck in Bangladesh. [PREPRINT]

Floral enhancement of arable field margins increases moth abundance and diversity (2023)
Journal Article
Blumgart, D., Botham, M. S., Menéndez, R., & Bell, J. R. (2023). Floral enhancement of arable field margins increases moth abundance and diversity. Journal of Insect Conservation, 27, 455–465. https://doi.org/10.1007/s10841-023-00469-9

Moth populations have declined across large parts of north-western Europe since the mid-20th century due, in part, to agricultural intensification. Agri-environment schemes (AES) are widely implemented across Europe to protect biodiversity in agricul... Read More about Floral enhancement of arable field margins increases moth abundance and diversity.

The potential future role of antiviral fabrics within healthcare systems (2023)
Journal Article
Morris, H., Forrester-Soto, N., & Ogrodnik, P. (in press). The potential future role of antiviral fabrics within healthcare systems. Journal of the Textile Institute, 115(3), 453-459. https://doi.org/10.1080/00405000.2023.2193278

Health care-associated infection is acquired by patients while receiving care and represents the most frequent adverse event with a prevalence internationally ranging from 5.7% to 19.1%. Whilst the role of textiles as a fomite in infection has been q... Read More about The potential future role of antiviral fabrics within healthcare systems.

Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination. (2023)
Journal Article
Turnbull. (2023). Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination. Glia, 71(7), 1683-1698. https://doi.org/10.1002/glia.24363

There is an urgent need for therapies that target the multicellular pathology of central nervous system (CNS) disease. Modified, nonanticoagulant heparins mimic the heparan sulfate glycan family and are known regulators of multiple cellular processes... Read More about Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination..

Validation of Recombinant Heparan Sulphate Reagents for CNS Repair. (2023)
Journal Article
Turnbull. (2023). Validation of Recombinant Heparan Sulphate Reagents for CNS Repair. Biology, 12(3), Article 407. https://doi.org/10.3390/biology12030407

Therapies that target the multicellular pathology of central nervous system (CNS) disease/injury are urgently required. Modified non-anticoagulant heparins mimic the heparan sulphate (HS) glycan family and have been proposed as therapeutics for CNS r... Read More about Validation of Recombinant Heparan Sulphate Reagents for CNS Repair..

Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State. (2023)
Journal Article
Devlin, A. J., Mycroft-West, C. J., Turnbull, J. E., Andrade De Lima, M., Guerrini, M., Yates, E. A., & Skidmore, M. A. (2023). Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State. ACS Central Science, 9, 381-392. https://doi.org/10.1021/acscentsci.2c01176

Heparin is a polydisperse, heterogeneous polysaccharide of the glycosaminoglycan (GAG) class that has found widespread clinical use as a potent anticoagulant and is classified as an essential medicine by the World Health Organization. The importance... Read More about Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State..

Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties. (2023)
Journal Article
Reynisson, J. (2023). Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms24043834

Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a promising target for antitumor therapy; the use of TDP1 inhibitors with a topoisomerase 1 poison such as topotecan is a potential combination therapy. In this work, a novel series of 3,5-disubstituted thiaz... Read More about Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties..

Induction of aphid resistance in tobacco by the cucumber mosaic virus CMV?2b mutant is jasmonate-dependent. (2023)
Journal Article
Arinaitwe, W., Tungadi, T. D., Pate, A. E., Joyce, J., Baek, E., Murphy, A. M., & Carr, J. P. (2023). Induction of aphid resistance in tobacco by the cucumber mosaic virus CMV?2b mutant is jasmonate-dependent. Molecular Plant Pathology, 24(4), 391 - 395. https://doi.org/10.1111/mpp.13305

Cucumber mosaic virus (CMV) is vectored by aphids, including Myzus persicae. Tobacco (Nicotiana tabacum 'Xanthi') plants infected with a mutant of the Fny strain of CMV (Fny-CMV?2b, which cannot express the CMV 2b protein) exhibit strong resistance a... Read More about Induction of aphid resistance in tobacco by the cucumber mosaic virus CMV?2b mutant is jasmonate-dependent..

qSanger: Quantification of Genetic Variants in Bacterial Cultures by Sanger Sequencing (2023)
Journal Article
Prakash, S., Racovita, A., Petrucci, T., Galizi, R., & Jaramillo, A. (in press). qSanger: Quantification of Genetic Variants in Bacterial Cultures by Sanger Sequencing. BioDesign Research, 5, Article 0007. https://doi.org/10.34133/bdr.0007

Genetic variations such as mutations and recombinations arise spontaneously in all cultured organisms. Although it is possible to identify nonneutral mutations by selection or counterselection, the identification of neutral mutations in a heterogeneo... Read More about qSanger: Quantification of Genetic Variants in Bacterial Cultures by Sanger Sequencing.