Skip to main content

Research Repository

Advanced Search

All Outputs (576)

Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. (2021)
Journal Article
Holden, M., Callaghan, M., Felson, D., Birrell, F., Nicholls, E., Jowett, S., …Peat, G. (2021). Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. BMJ Open, 11(3), Article e048196. https://doi.org/10.1136/bmjopen-2020-048196

BACKGROUND: Brace effectiveness for knee osteoarthritis (OA) remains unclear and international guidelines offer conflicting recommendations. Our trial will determine the clinical and cost-effectiveness of adding knee bracing (matched to patients' cli... Read More about Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial..

Individual participant data meta-analysis for external validation, recalibration, and updating of a flexible parametric prognostic model. (2021)
Journal Article
Ensor, J., Snell, K. I. E., Debray, T. P. A., Lambert, P. C., Look, M. P., Mamas, M. A., …Riley, R. D. (2021). Individual participant data meta-analysis for external validation, recalibration, and updating of a flexible parametric prognostic model. Statistics in Medicine, 40(13), 3066-3084. https://doi.org/10.1002/sim.8959

Individual participant data (IPD) from multiple sources allows external validation of a prognostic model across multiple populations. Often this reveals poor calibration, potentially causing poor predictive performance in some populations. However, r... Read More about Individual participant data meta-analysis for external validation, recalibration, and updating of a flexible parametric prognostic model..

Dominant and Modifiable Risk Factors for Dementia in Sub-Saharan Africa: A Systematic Review and Meta-Analysis (2021)
Journal Article
Ojagbemi, A., Okekunle, A., & Babatunde, O. (2021). Dominant and Modifiable Risk Factors for Dementia in Sub-Saharan Africa: A Systematic Review and Meta-Analysis. Frontiers in Neurology, https://doi.org/10.3389/fneur.2021.627761

Background: Sub-Saharan Africa (SSA) is projected to have a rapid increase in the number of people living with dementia by 2050. Yet, there is currently no robust evidence on the risk factors for dementia in the sub-region that could inform context s... Read More about Dominant and Modifiable Risk Factors for Dementia in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.

Revascularisation strategies in patients with significant left main coronary disease during the COVID-19 pandemic. (2021)
Journal Article
Rashid, M., Mamas, Mohamed, M. O., Curzen, N., de Belder, M., Goodwin, A. T., …Mamas, M. A. (2021). Revascularisation strategies in patients with significant left main coronary disease during the COVID-19 pandemic. Catheterization & Cardiovascular Interventions, 98(7), 1252-1261. https://doi.org/10.1002/ccd.29663

BACKGROUND: There are limited data on the impact of the COVID-19 pandemic on left main (LM) coronary revascularisation activity, choice of revascularisation strategy, and post-procedural outcomes. METHODS: All patients with LM disease (=50% stenosis)... Read More about Revascularisation strategies in patients with significant left main coronary disease during the COVID-19 pandemic..

Developing a model Fracture Liaison Service consultation with patients, carers and clinicians: a Delphi survey to inform content of the iFraP complex consultation intervention. (2021)
Journal Article
Bullock, L., Crawford-Manning, F., Cottrell, E., Fleming, J., Leyland, S., Edwards, J., …Paskins, Z. (2021). Developing a model Fracture Liaison Service consultation with patients, carers and clinicians: a Delphi survey to inform content of the iFraP complex consultation intervention. Archives of Osteoporosis, 16, 1- 17. https://doi.org/10.1007/s11657-021-00913-w

Fracture Liaison Services are recommended to deliver best practice in secondary fracture prevention. This modified Delphi survey, as part of the iFraP (Improving uptake of Fracture Prevention drug Treatments) study, provides consensus regarding tasks... Read More about Developing a model Fracture Liaison Service consultation with patients, carers and clinicians: a Delphi survey to inform content of the iFraP complex consultation intervention..

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study (2021)
Journal Article
Collaborative, C., Collaborative, G., & Parry-Smith, W. (2021). SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study. British Journal of Surgery, 108(9), 1056-1063. https://doi.org/10.1093/bjs/znab101

Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV... Read More about SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.

Development, spread and impact of primary care and musculoskeletal communities of practice to assist rapid translation of evidence into practice (2021)
Journal Article
Stevenson, K., Sarigiovannis, P., Finney, A. G., Cottrell, E., Lewis, R., Edwards, J. J., …Dziedzic, K. S. (2021). Development, spread and impact of primary care and musculoskeletal communities of practice to assist rapid translation of evidence into practice. Musculoskeletal Care, 19(4), 564-569. https://doi.org/10.1002/msc.1552

BACKGROUND: Embedding research into practice is challenging. Barriers include: a shortage of time, lack of understanding of the evidence and a poor support in the clinical setting. A community of practice (CoP) model has been used to address these is... Read More about Development, spread and impact of primary care and musculoskeletal communities of practice to assist rapid translation of evidence into practice.

'Reluctant pioneer': A qualitative study of doctors' experiences as patients with long COVID (2021)
Journal Article
Taylor, A. K., Kingstone, T., Briggs, T. A., O'Donnell, C. A., Atherton, H., Blane, D. N., & Chew‐Graham, C. A. (2021). 'Reluctant pioneer': A qualitative study of doctors' experiences as patients with long COVID. Health Expectations, 24(3), 833-842. https://doi.org/10.1111/hex.13223

BACKGROUND: The coronavirus disease (COVID-19) pandemic has had far-reaching effects upon lives, healthcare systems and society. Some who had an apparently 'mild' COVID-19 infection continue to suffer from persistent symptoms, including chest pain, b... Read More about 'Reluctant pioneer': A qualitative study of doctors' experiences as patients with long COVID.

Onset of comorbidities and flare patterns within pre-existing morbidity clusters in people with gout: 5-year primary care cohort study. (2021)
Journal Article
Bajpai, R., Muller, S., Mallen, C., Watson, L., Richette, P., Hider, S. L., & Roddy, E. (2021). Onset of comorbidities and flare patterns within pre-existing morbidity clusters in people with gout: 5-year primary care cohort study. Rheumatology, 61(1), 407-412. https://doi.org/10.1093/rheumatology/keab283

OBJECTIVE: To investigate the onset of comorbidities and pattern of flares over five years according to baseline comorbidity clusters in people with gout. METHODS: In a prospective primary-care-based cohort study, adults aged =18 years with gout, wer... Read More about Onset of comorbidities and flare patterns within pre-existing morbidity clusters in people with gout: 5-year primary care cohort study..

Postpartum haemorrhage and risk of mental ill health: A population-based longitudinal study using linked primary and secondary care databases (2021)
Journal Article
Parry-Smith, W., Okoth, K., Subramanian, A., Gokhale, K. M., Chandan, J. S., Humpston, C., …Šumilo, D. (2021). Postpartum haemorrhage and risk of mental ill health: A population-based longitudinal study using linked primary and secondary care databases. Journal of Psychiatric Research, 137, 419-425. https://doi.org/10.1016/j.jpsychires.2021.03.022

Exploring why medical students still feel underprepared for clinical practice: a qualitative analysis of an authentic on-call simulation (2021)
Journal Article
Hawkins, N., Younan, H., Fyfe, M., Parekh, R., & McKeown, A. (2021). Exploring why medical students still feel underprepared for clinical practice: a qualitative analysis of an authentic on-call simulation. BMC Medical Education, https://doi.org/10.1186/s12909-021-02605-y

Current research shows that many UK medical graduates continue to feel underprepared to work as a junior doctor. Most research in this field has focused on new graduates and employed the use of retrospective self-rating questionnaires. There remains... Read More about Exploring why medical students still feel underprepared for clinical practice: a qualitative analysis of an authentic on-call simulation.

Sex Differences in Ischemic Stroke Outcomes in Patients With Pulmonary Hypertension. (2021)
Journal Article
Mamas. (2021). Sex Differences in Ischemic Stroke Outcomes in Patients With Pulmonary Hypertension. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, e019341 - ?. https://doi.org/10.1161/JAHA.120.019341

Background The association between systemic hypertension and cerebrovascular disease is well documented. However, the impact of pulmonary hypertension (PH) on acute ischemic stroke outcomes is unknown despite PH being recognized as a risk factor for... Read More about Sex Differences in Ischemic Stroke Outcomes in Patients With Pulmonary Hypertension..

Autologous Matrix Induced Chondrogenesis (AMIC) Compared to Microfractures for Chondral Defects of the Talar Shoulder: A Five-Year Follow-Up Prospective Cohort Study. (2021)
Journal Article
(2021). Autologous Matrix Induced Chondrogenesis (AMIC) Compared to Microfractures for Chondral Defects of the Talar Shoulder: A Five-Year Follow-Up Prospective Cohort Study. Life, 1-9. https://doi.org/10.3390/life11030244

INTRODUCTION: Many procedures are available to manage cartilage defects of the talus, including microfracturing (MFx) and Autologous Matrix Induced Chondrogenesis (AMIC). Whether AMIC or MFx are equivalent for borderline sized defects of the talar sh... Read More about Autologous Matrix Induced Chondrogenesis (AMIC) Compared to Microfractures for Chondral Defects of the Talar Shoulder: A Five-Year Follow-Up Prospective Cohort Study..

Patient experiences of receiving arthroscopic surgery or personalised hip therapy for femoroacetabular impingement in the context of the UK fashion study: a qualitative study (2021)
Journal Article
(2021). Patient experiences of receiving arthroscopic surgery or personalised hip therapy for femoroacetabular impingement in the context of the UK fashion study: a qualitative study. Trials, 211 -?. https://doi.org/10.1186/s13063-021-05151-6

BACKGROUND: UK FASHIoN was a multicentre randomised controlled trial comparing hip arthroscopic surgery (HA) with personalised hip therapy (PHT, physiotherapist-led conservative care), for patients with hip pain attributed to femoroacetabular impinge... Read More about Patient experiences of receiving arthroscopic surgery or personalised hip therapy for femoroacetabular impingement in the context of the UK fashion study: a qualitative study.

What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? (2021)
Journal Article
Mallen. (2021). What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?. Rheumatology, https://doi.org/10.1093/rheumatology/keab254

OBJECTIVES: To examine incidence of treatment changes due to abnormal blood-test results and, to explore rates of treatment changes due to liver, kidney and haematological blood-test abnormalities in autoimmune rheumatic diseases (AIRD) treated with... Read More about What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?.

Single-centre survey of parents regarding the hidden burden of paediatric flexible bronchoscopy. (2021)
Journal Article
Gilchrist. (2021). Single-centre survey of parents regarding the hidden burden of paediatric flexible bronchoscopy. BMJ Paediatrics Open, e000991 - ?. https://doi.org/10.1136/bmjpo-2020-000991

Although paediatric flexible bronchoscopy is safe with relatively few side effects, parents frequently report an associated burden. To assess this, we undertook 25 semi-structured interviews with the parents of children who had recently undergone thi... Read More about Single-centre survey of parents regarding the hidden burden of paediatric flexible bronchoscopy..

Impact of pre-existent vascular and poly-vascular disease on acute myocardial infarction management and outcomes: An analysis of 2 million patients from the National Inpatient Sample. (2021)
Journal Article
Mamas. (2021). Impact of pre-existent vascular and poly-vascular disease on acute myocardial infarction management and outcomes: An analysis of 2 million patients from the National Inpatient Sample. https://doi.org/10.1016/j.ijcard.2020.11.051

BACKGROUND: Patients with pre-existing vascular disease are known to have worse outcomes after acute myocardial infarction (AMI). However, there is limited data for outcomes stratified by type and number of vascular territories involved. METHODS: Usi... Read More about Impact of pre-existent vascular and poly-vascular disease on acute myocardial infarction management and outcomes: An analysis of 2 million patients from the National Inpatient Sample..

Dysregulation of ferroptosis may involve in the development of non-small-cell lung cancer in Xuanwei area (2021)
Journal Article
(2021). Dysregulation of ferroptosis may involve in the development of non-small-cell lung cancer in Xuanwei area. Journal of Cellular and Molecular Medicine, 2872 - 2884. https://doi.org/10.1111/jcmm.16318

The Xuanwei area of Yunnan Province, China, is one of the regions suffering from the highest occurrence and mortality rate of lung cancer in the world. Local residents tend to use bituminous coal as domestic fuel, which causes serious indoor air poll... Read More about Dysregulation of ferroptosis may involve in the development of non-small-cell lung cancer in Xuanwei area.

A Comparative Study of International and Asian Criteria for Overweight or Obesity at Workplaces in Singapore (2021)
Journal Article
Nazeha, N., Sathish, T., Soljak, M., Dunleavy, G., Visvalingam, N., Divakar, U., …Car, J. (2021). A Comparative Study of International and Asian Criteria for Overweight or Obesity at Workplaces in Singapore. Asia-Pacific Journal of Public Health, 33(4), 404-410. https://doi.org/10.1177/1010539521998855

To compare the prevalence of and risk factors associated with overweight or obesity between the international (body mass index [BMI] ≥25 kg/m2) and Asian (BMI ≥23 kg/m2) criteria in a working population in Singapore. This was a cross-sectional analys... Read More about A Comparative Study of International and Asian Criteria for Overweight or Obesity at Workplaces in Singapore.