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Exercise interventions for treating work-related complaints of the arm, neck or shoulder in adults. (2025)
Journal Article
Stubbs, P. W., Mehta, P., Trøstrup, J., Tamminga, S. J., Stynes, S. M., Koes, B. W., & Verhagen, A. P. (2025). Exercise interventions for treating work-related complaints of the arm, neck or shoulder in adults. Cochrane Database of Systematic Reviews, 4(4), 1-18. https://doi.org/10.1002/14651858.CD014643

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of exercise interventions for work-related complaints of the arm, neck or shoulder (CANS) in adults. The outcomes of interest are pain, func... Read More about Exercise interventions for treating work-related complaints of the arm, neck or shoulder in adults..

Temporal species stability underpins the link between biodiversity and human health (2025)
Journal Article
Xu, Q., Qu, B., Zhao, P., Clement, S., Shi, Y., Li, L., Jordan, K. P., & Chen, Y. (2025). Temporal species stability underpins the link between biodiversity and human health. Environmental Research, 278(1 August 2025), Article 121728. https://doi.org/10.1016/j.envres.2025.121728

Biodiversity is known to impact human health, but the complex relationships between species diversity and health outcomes is poorly understood. Measuring the temporal dissimilarity in species composition can be leveraged to understand the stability o... Read More about Temporal species stability underpins the link between biodiversity and human health.

Mercury exposure, pink disease and Young's syndrome: a forgotten public health disaster. (2025)
Journal Article
Brown, M., Hendley, V., & Ahmad, N. (2025). Mercury exposure, pink disease and Young's syndrome: a forgotten public health disaster. BMJ Case Reports, 18(4), e265108. https://doi.org/10.1136/bcr-2025-265108

Pink disease was once a widespread phenomenon, known to physicians throughout the Western world. Its prevalence declined massively once the source, mercury, was identified in several products. In modern medicine, pink disease rarely forms a different... Read More about Mercury exposure, pink disease and Young's syndrome: a forgotten public health disaster..

Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study (2025)
Journal Article
Ashworth, J., Cornwall, N., Harrisson, S., Woodcock, C., Nicholls, E., Lancaster, G., Wathall, S., Laing, L., Helliwell, T., Jowett, S., Kigozi, J., Mallen, C., Avery, A., Knaggs, R., Pincus, T., White, S., & Jinks, C. (2025). Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study. Pilot and Feasibility Studies, 11(1), Article 53. https://doi.org/10.1186/s40814-025-01636-2

Background: Given the poor long-term effectiveness of opioids for persistent non-cancer pain, and their potential for harm, evidence-based interventions to address opioid overprescribing for persistent pain are needed. This study aimed to explore the... Read More about Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study.

Experiences and Perceptions of Self‐Harm in Rural‐Dwelling Adults: A Rapid Review of Qualitative Evidence (2025)
Journal Article
Saunders, K., Nicholls, W., Corp, N., Kingstone, T., Mughal, F., Chew‐Graham, C. A., Southam, J., & Fisher, T. (2025). Experiences and Perceptions of Self‐Harm in Rural‐Dwelling Adults: A Rapid Review of Qualitative Evidence. Health Expectations, 28(3), 1-10. https://doi.org/10.1111/hex.70268

Background: Self‐harm is associated with factors that are relevant to and exacerbated by rurality. Living in rural areas may intensify existing socio‐economic disadvantages linked to service access, employment opportunities, transport conditions and... Read More about Experiences and Perceptions of Self‐Harm in Rural‐Dwelling Adults: A Rapid Review of Qualitative Evidence.

Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care (2025)
Journal Article
Harrisson, S. A., Jinks, C., Cornwall, N., Woodcock, C., Dikomitis, L., Helliwell, T., Higginbottom, A., Lefroy, J., Knaggs, R., Pincus, T., Santar, M., Sillitto, C., Webb, M., White, S., Mallen, C. D., & Ashworth, J. (2025). Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care. Health Expectations, 28(3), Article e70264. https://doi.org/10.1111/hex.70264

Background: Stakeholder involvement is a core element of the Medical Research Council (MRC) framework for developing and evaluating complex interventions, but approaches to involve stakeholders are not well‐reported. We outline how stakeholders contr... Read More about Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care.

Improving healthcare information for young people with ADHD: perspectives from general practice. (2025)
Journal Article
Price, A., Becker, K., Gudka, R., Smith, J., Mughal, F., Melendez-Torres, G. J., Pitchforth, E., & Newlove-Delgado, T. (2025). Improving healthcare information for young people with ADHD: perspectives from general practice. British Journal of General Practice (BJGP), https://doi.org/10.3399/BJGP.2024.0755

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder which can have poor long-term outcomes when unmanaged. Young people aged 16-25 with ADHD are often unable to access specialist healthcare as recommended by UK gui... Read More about Improving healthcare information for young people with ADHD: perspectives from general practice..

Corrigendum to "Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway" [Biomed. Pharmacother. 176 (2024) 116836]. (2025)
Journal Article
Ebrahim, N., Al Saihati, H. A., Alenzi, F. Q. B., El-Sherbiny, M., & Alsabeelah, N. F. (2025). Corrigendum to "Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway" [Biomed. Pharmacother. 176 (2024) 116836]. Biomedicine and Pharmacotherapy, 187(June 2025), Article 118042. https://doi.org/10.1016/j.biopha.2025.118042

Physical Impairments in People With Gout: A Scoping Review (2025)
Journal Article
Kumar, P., Buckley, J., Roddy, E., & Thomas, M. J. (2025). Physical Impairments in People With Gout: A Scoping Review. Musculoskeletal Care, 23(2), 1-28. https://doi.org/10.1002/msc.70103

Introduction: Gout is the most common form of inflammatory arthritis. It is predominantly managed with pharmacological interventions, and physical impairments in people with gout have seldom been studied. We aimed to identify gout‐related physical im... Read More about Physical Impairments in People With Gout: A Scoping Review.

Clinical impact of a poststroke depression screening program (2025)
Journal Article
Chan, L. G., Ng, M. H. S., Chan, O. H., Eu, J. L., & Bajpai, R. (2025). Clinical impact of a poststroke depression screening program. PM&R, 1-8. https://doi.org/10.1002/pmrj.13372

Background
The potential clinical impact of routine proactive detection and early intervention for poststroke depression (PSD) is currently unknown, despite broad evidence of the adverse impact of PSD on stroke outcomes.

Objective
To measure the... Read More about Clinical impact of a poststroke depression screening program.

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer (2025)
Journal Article
Chen, L., Wang, C., Chang, J., Shiau, A., Shieh, G., Tseng, Y., Yen, Y., Huang, T., Cheng, L., Wu, Y., Wu, C., Su, B., & Wu, P. (2025). Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer. Molecular Oncology, 1-20. https://doi.org/10.1002/1878-0261.70035

Elevated expression of prothymosin α (ProT) is frequently observed in cancers, but the underlying molecular mechanism remains poorly understood. Here, we report the clinical relevance of ProT expression and its correlation with lung cancer progressio... Read More about Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer.

Advancing Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion-Mutated Non-small Cell Lung Cancer (NSCLC) Management Through Molecular Diagnostics and Targeted Therapies. (2025)
Journal Article
Giridharan, S., Ansari, J., & Hussain, I. (in press). Advancing Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion-Mutated Non-small Cell Lung Cancer (NSCLC) Management Through Molecular Diagnostics and Targeted Therapies. Cureus, 17(4), Article e82573. https://doi.org/10.7759/cureus.82573

Non-small cell lung cancer (NSCLC) associated with epidermal growth factor receptor (EGFR) mutations has experienced notable therapeutic advancements; however, exon 20 insertion mutations continue to pose a significant challenge, demonstrating resist... Read More about Advancing Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion-Mutated Non-small Cell Lung Cancer (NSCLC) Management Through Molecular Diagnostics and Targeted Therapies..

Impact of obesity on clinical outcomes in patients with high-risk pulmonary embolism: A comparative analysis. (2025)
Journal Article
Shachar, Z., Gatuz, M. V., Folman, A., Barel, M. S., Abu-Fanne, R., Abramov, D., Mamas, M. A., Roguin, A., & Kobo, O. (2025). Impact of obesity on clinical outcomes in patients with high-risk pulmonary embolism: A comparative analysis. International Journal of Cardiology, 58, 101682. https://doi.org/10.1016/j.ijcha.2025.101682

Pulmonary embolism (PE) is a life-threatening cardiovascular condition with increasing global incidence. Obesity is a significant risk factor for PE, although its reported relationship with outcomes is inconsistent. This study aimed to investigate th... Read More about Impact of obesity on clinical outcomes in patients with high-risk pulmonary embolism: A comparative analysis..

A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children (2025)
Journal Article
Twohig, H., Franklin, L., Carroll, W., Corp, N., Jackson, E., Mallen, C., Ruan, B., Yapp, L., Van Der Windt, D., & Smith, J. (2025). A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children. Paediatric Respiratory Reviews, 1-37. https://doi.org/10.1016/j.prrv.2025.04.005

Background
Dry powder inhalers (DPIs) are a lower-carbon option than pressurised metered dose inhalers (pMDIs). However, DPIs require a forceful inhalation to achieve good lung deposition and there is uncertainty as to whether younger children can e... Read More about A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children.

Assessing ChatGPT 4.0’s Capabilities in the United Kingdom Medical Licensing Examination (UKMLA): A Robust Categorical Analysis (2025)
Journal Article
Casals-Farre, O., Baskaran, R., Singh, A., Kaur, H., Ul Hoque, T., de Almeida, A., Coffey, M., & Hassoulas, A. (in press). Assessing ChatGPT 4.0’s Capabilities in the United Kingdom Medical Licensing Examination (UKMLA): A Robust Categorical Analysis. Scientific Reports, 15(1), Article 13031. https://doi.org/10.1038/s41598-025-97327-2

Advances in the various applications of artificial intelligence will have important implications for medical training and practice. The advances in ChatGPT-4 alongside the introduction of the medical licensing assessment (MLA) provide an opportunity... Read More about Assessing ChatGPT 4.0’s Capabilities in the United Kingdom Medical Licensing Examination (UKMLA): A Robust Categorical Analysis.

Primary Care and Linked Secondary Care Encounters for Foot and Ankle Problems in Children and Young People: A Population‐Based Cohort Study in England (2025)
Journal Article
Rezel‐Potts, E., Bowen, C., Dunn, K. M., Jones, C. I., Gulliford, M. C., & Morrison, S. C. (2025). Primary Care and Linked Secondary Care Encounters for Foot and Ankle Problems in Children and Young People: A Population‐Based Cohort Study in England. Journal of Foot and Ankle Research, 18(2), 1-9. https://doi.org/10.1002/jfa2.70046

Background: In the United Kingdom, foot and ankle problems in children and young people are typically seen by the general practitioner in primary care and referred to secondary care or community services for specialist assessment and intervention. Fo... Read More about Primary Care and Linked Secondary Care Encounters for Foot and Ankle Problems in Children and Young People: A Population‐Based Cohort Study in England.

Location of Terminal Care in Pulmonary Hypertension (2025)
Journal Article
Ibrahim, R., Habib, A., Olson, A., Shrourou, F., Pham, H. N., Abdelnabi, M., Neyestanak, M. E., Soin, S., Low, S.-W., Natt, B., Mamas, M. A., Barry, T., Ayoub, C., Arsanjani, R., Rischard, F. P., & Lee, K. (2025). Location of Terminal Care in Pulmonary Hypertension. CJC Open, 7(6), 832-839. https://doi.org/10.1016/j.cjco.2025.03.026

Background
Death locations for individuals in the US is influenced by social factors. Pulmonary hypertension (PH) is an uncommon condition, with a substantial impact on morbidity and mortality. We evaluated the patterns in and impact of demographics... Read More about Location of Terminal Care in Pulmonary Hypertension.

Differential benefit of adjuvant everolimus according to endocrine therapy backbone in the randomized UNIRAD trial. (2025)
Journal Article
Saint-Ghislain, M., Chabaud, S., Dalenc, F., Allouache, D., Cameron, D., Martinez, M., Grenier, J., Barthelemy, P., Brunt, M., Kaluzinski, L., Mailliez, A., Legouffe, E., Hardy-Bessard, A.-C., Giacchetti, S., Mouret-Reynier, M.-A., Canon, J.-L., Bliss, J., Lemonnier, J., Andre, F., Bachelot, T., & Cottu, P. (2025). Differential benefit of adjuvant everolimus according to endocrine therapy backbone in the randomized UNIRAD trial. ESMO Open, 10(5), Article 105050. https://doi.org/10.1016/j.esmoop.2025.105050

The randomized, double-blind UNIRAD trial evaluating the addition of 2 years of everolimus to endocrine therapy in patients with high-risk, early luminal breast cancer failed to demonstrate a benefit. We report the subgroup analyses. We randomly assi... Read More about Differential benefit of adjuvant everolimus according to endocrine therapy backbone in the randomized UNIRAD trial..