Impact of obesity on clinical outcomes in patients with high-risk pulmonary embolism: A comparative analysis.

Shachar, Ziv; Gatuz, Marlon V; Folman, Adam; Barel, Maguli S; Abu-Fanne, Rami; Abramov, Dmitry; Mamas, Mamas A; Roguin, Ariel; Kobo, Ofer

Abstract

Pulmonary embolism (PE) is a life-threatening cardiovascular condition with increasing global incidence. Obesity is a significant risk factor for PE, although its reported relationship with outcomes is inconsistent. This study aimed to investigate the impact of obesity on clinical outcomes in patients with high-risk PE. We conducted a retrospective analysis of US adult patients hospitalized with high-risk PE from 2016 to 2019 using the National Inpatient Sample database. Patients were categorized into three groups based on BMI: non-obese, obese (30 to < 40 kg/m ), and severely obese (≥40 kg/m ). We compared baseline characteristics, in-hospital procedures, and outcomes among these groups. Multivariable logistic regression models assessed the relationship between obesity levels and in-hospital outcomes. Of 752,660 patients with PE, 29,610 (3.9 %) were classified as high-risk. The distribution among BMI categories was: non-obese (77.1 %), obese (8.8 %), and severely obese (14.1 %). Severely obese patients were younger (mean age 55.7 vs. 66.1 years for non-obese, p < 0.001) and more likely to be female (63.2 % vs. 51.4 % for non-obese, p < 0.001). After adjustment, obese and severely obese patients had lower odds of in-hospital mortality (obese: aOR 0.50, p < 0.001; severely obese: aOR 0.69, p < 0.001) and major adverse cardiovascular and cerebrovascular events (obese: aOR 0.50, p < 0.001; severely obese: aOR 0.72, p < 0.001). Our study revealed an "obesity paradox" in high-risk PE patients, with obese and severely obese individuals showing lower mortality and fewer complications despite higher comorbidity rates. These findings emphasize the need for tailored risk assessment and treatment strategies in obese patients with high-risk PE. [Abstract copyright: © 2025 The Authors. Published by Elsevier B.V.]

Citation

Shachar, Z., Gatuz, M. V., Folman, A., Barel, M. S., Abu-Fanne, R., Abramov, D., Mamas, M. A., Roguin, A., & Kobo, O. (2025). Impact of obesity on clinical outcomes in patients with high-risk pulmonary embolism: A comparative analysis. International Journal of Cardiology, 58, 101682. https://doi.org/10.1016/j.ijcha.2025.101682

• Journal Article Type: Article
• Acceptance Date: Apr 9, 2025
• Online Publication Date: Apr 18, 2025
• Publication Date: Apr 18, 2025
• Deposit Date: Jun 4, 2025
• Journal: International journal of cardiology. Heart & vasculature
• Print ISSN: 0167-5273
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 58
• Pages: 101682
• DOI: https://doi.org/10.1016/j.ijcha.2025.101682
• Keywords: Pulmonary embolism, Obesity, Risk factors, Outcomes
• Public URL: https://keele-repository.worktribe.com/output/1242390
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S2352906725000855?via%3Dihub#coi005