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Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial (2025)
Other
Thomas, M. J., Hughes, G., Cooke, K., Butler-Walley, S., Marshall, E., Bowyer, L., Wathall, S., Smith, J., Lawton, S. A., Brammar, J., Burnett, T., Drake, C., Foster, N. E., Hendry, G. J., Holden, M. A., Jaki, T., Joseph, R., Keenan, A.-M., Kigozi, J., Lewis, M., …Roddy, E. (2025). Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial

Plantar heel pain (PHP) is the most common soft tissue foot condition and impairs mobility, physical function, ability to work, and quality of life. Systematic reviews highlight a need for high-quality randomised controlled trials (RCTs) of exercises... Read More about Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial.

Improving primary care services for imprisoned women with severe mental illness (IP-SIS) Protocol Paper (2025)
Other
Roden-Lui, G., Chew-Graham, C. A., Hard, J., Harriott, P., King, H., Mastrocola, E., & Walker, T. Improving primary care services for imprisoned women with severe mental illness (IP-SIS) Protocol Paper

Background
A gap exists in the provision of care for imprisoned women with Severe Mental Illness (SMI), both in prison and on release to mainstream primary care. Women in such settings tend to have complex mental health problems, often with comorbid... Read More about Improving primary care services for imprisoned women with severe mental illness (IP-SIS) Protocol Paper.

Responses to Complex Emotional Needs in UK male prisons: A scoping review protocol v1 (2024)
Other
Lamph, G., Clifford, A., Wyndham, D., Wheatcroft, S., Canvin, K., Hughes, N., Hutton, R., Roberts, J., Rydon-Grange, M., Plant, J., & Lewis, C. (2024). Responses to Complex Emotional Needs in UK male prisons: A scoping review protocol v1

The aim of this review is to examine the scope of the literature and grey literature considering support for complex emotional needs in UK male prisons. The objectives to be completed in order to meet the aim are: i.) answer the review question: What... Read More about Responses to Complex Emotional Needs in UK male prisons: A scoping review protocol v1.

Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study (2024)
Other
Bullock, L., Cherrington, A., Clark, E. M., Fleming, J., Bentley, I., Nicholls, E., Webb, D., Smith, J., Bathers, S., Lewis, S., Horne, R., O'Neill, T. W., Mallen, C. D., Jinks, C., & Paskins, Z. (2024). Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study

Background
High quality shared decision-making (SDM) conversations involve people with or at risk of osteoporosis and clinicians working together to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and v... Read More about Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study.

PHARM-LC: What role can Community Pharmacy play in supporting people with long Covid? Protocol for a mixed methods study (2024)
Other
Kingstone, T., Saunders, K., Fisher, T., Bhamra, S., Briggs, T., Higginbottom, A., Higginson, P., Jones, G., Lokugamage, A., Maidment, I., O'Hara, M., Shaw, M., Advisory Group, P.-L. C., & CHEW-GRAHAM, C. (2024). PHARM-LC: What role can Community Pharmacy play in supporting people with long Covid? Protocol for a mixed methods study

Background
Long Covid is a debilitating multifaceted condition, that is more prevalent in those from deprived areas, females and those with another disorder or disability. Those that live with Long Covid currently must endure a lack of services, sup... Read More about PHARM-LC: What role can Community Pharmacy play in supporting people with long Covid? Protocol for a mixed methods study.

Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention (2024)
Other
Siciliano, M., Bathers, S., Bentley, I., Bullock, L., Cherrington, A., Clark, E., Fleming, J., Jinks, C., Lewis, S., Mallen, C., Nicholls, E., O'Neill, T., Smith, J., Webb, D., Paskins, Z., & Iglesias-Urrutia, C. (2024). Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention

Background
Digital health interventions (DHI) are associated with significant promise. In recent years, the need to assess the value of these healthcare technologies has motivated a debate regarding the suitability of existing economic evaluation me... Read More about Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention.

A prediction algorithm to improve the accuracy of the Gold Standard Framework Surprise Question end-of-life prognostic categories in an acute hospital admission cohort-controlled study. The Proactive Risk-Based and Data-Driven Assessment of Patients at the End of Life (PRADA) (2023)
Other
Singh, B., Kumari-Dewat, N., Ryder, A., Klaire, V., Bennion, G., Jennens, H., Matthews, D., Rayner, S., Ritzenthaler, B., Shears, J., Ahmed, K., Sidhu, M., Viswanath, A., Warren, K., & Parry, E. (2023). A prediction algorithm to improve the accuracy of the Gold Standard Framework Surprise Question end-of-life prognostic categories in an acute hospital admission cohort-controlled study. The Proactive Risk-Based and Data-Driven Assessment of Patients at the End of Life (PRADA)

Objective To determine the accuracy of a clinical data algorithm allocated end-of-life prognosis amongst hospital inpatients.

Method The model allocated a predicted Gold Standard Framework end-of-life prognosis to all acute medical patients admitt... Read More about A prediction algorithm to improve the accuracy of the Gold Standard Framework Surprise Question end-of-life prognostic categories in an acute hospital admission cohort-controlled study. The Proactive Risk-Based and Data-Driven Assessment of Patients at the End of Life (PRADA).

Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth (2022)
Other
Hilaire, C., Benlefki, S., Younes, R., Challuau, D., Bernard-Marissal, N., Scamps, F., Bowerman, M., Kothary, R., Schneider, B., L Schneider, B., & Raoul, C. (2022). Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth

Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are the most common motoneuron diseases affecting adults and infants, respectively. ALS and SMA are both characterized by the selective degeneration of motoneurons. Although differ... Read More about Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth.

Study protocol for the development and internal validation of SPIRIT (Schizophrenia Prediction of Resistance to Treatment): A clinical tool for predicting risk of treatment resistance to anti-psychotics in First Episode Schizophrenia (2022)
Other
Farooq, S., Hattle, M., Dazzan, P., Kingstone, T., Ajnakina, O., Shiers, D., Antonietta Nettis, M., Lawrence, A., Riley, R. D., & van der Windt, D. A. (2022). Study protocol for the development and internal validation of SPIRIT (Schizophrenia Prediction of Resistance to Treatment): A clinical tool for predicting risk of treatment resistance to anti-psychotics in First Episode Schizophrenia

Blood biochemical parameters as predictors of disease severity and mortality in COVID-19 patients- an updated systematic review and meta-analysis (2021)
Other
Majid, A., Mishra, P., Parveen, R., Bajpai, R., Khan, M., & Agarwal, N. (2021). Blood biochemical parameters as predictors of disease severity and mortality in COVID-19 patients- an updated systematic review and meta-analysis

<h4>ABSTRACT</h4> <h4>Background</h4> The outbreak of coronavirus disease 2019 (COVID-19) has been rapidly spreading across the globe and poses a great risk to human health. Patients with abnormalities in laboratory parameters are more susceptible to... Read More about Blood biochemical parameters as predictors of disease severity and mortality in COVID-19 patients- an updated systematic review and meta-analysis.

Association of inflammatory markers with severity of disease and mortality in COVID-19 patients: a systematic review and meta-analysis (2021)
Other
Khan, S., Mishra, P., Parveen, R., Bajpai, R., Khan, M. A., & Agarwal, N. B. (2021). Association of inflammatory markers with severity of disease and mortality in COVID-19 patients: a systematic review and meta-analysis

Literature suggests association of inflammatory markers with the severity and mortality related to COVID-19, but there are varying conclusions available. We aimed to provide an overview of the association of inflammatory markers with the severity and... Read More about Association of inflammatory markers with severity of disease and mortality in COVID-19 patients: a systematic review and meta-analysis.

Effect of lumbopelvic control on landing mechanics and lower extremity muscles' activities in female professional athletes: implications for injury prevention. (2021)
Other
(2021). Effect of lumbopelvic control on landing mechanics and lower extremity muscles' activities in female professional athletes: implications for injury prevention

BACKGROUND: Lumbopelvic control (LPC) has recently been associated with function, kinesiology, and load distribution on the limb. However, poor LPC has not been studied as a risk factor for lower limb injury in sports requiring frequent jump landings... Read More about Effect of lumbopelvic control on landing mechanics and lower extremity muscles' activities in female professional athletes: implications for injury prevention..

Dystrophin regulates peripheral circadian SRF signalling (2021)
Other
Betts, C. A., Jagannath, A., van Westering, T. L., Bowerman, M., Banerjee, S., Meng, J., Falzarano, M. S., Cravo, L., McClorey, G., Meijboom, K. E., Bhomra, A., Fang Lim, W., Rinaldi, C., Counsell, J. R., Chwalenia, K., O’Donovan, E., Saleh, A. F., Gait, M. J., Morgan, J. E., Ferlini, A., …Wood, M. J. (2021). Dystrophin regulates peripheral circadian SRF signalling

Dystrophin is a sarcolemmal protein essential for muscle contraction and maintenance, absence of which leads to the devastating muscle wasting disease Duchenne muscular dystrophy (DMD)[1, 2]. Dystrophin has an actin-binding domain [3–5], which specif... Read More about Dystrophin regulates peripheral circadian SRF signalling.

ICS Material: a new method of managing patients with low back pain (stratified care), improves patients' outcomes, reduces costs and assists in the reduction of global burden (2019)
Other
(2019). ICS Material: a new method of managing patients with low back pain (stratified care), improves patients' outcomes, reduces costs and assists in the reduction of global burden

Good musculoskeletal (MSK) health is integral to a full working life. It supports us with functional mobility and dexterity, balance and co-ordination, and contributes to muscular strength and endurance; essential to nearly all forms of work. It also... Read More about ICS Material: a new method of managing patients with low back pain (stratified care), improves patients' outcomes, reduces costs and assists in the reduction of global burden.