All Outputs (25)

Mixed methods evaluation of using the ‘EMPathicO’ communication skills e-learning in primary care: “<i>a super weapon to make the whole experience a bit better”</i> (2025)
Preprint / Working Paper
Teasdale, E., Dewar-Haggart, R., Pollet, S., Leydon, G. M., Everitt, H., Cross, N., Atherton, H., Becque, T., Bostock, J., Garfield, K., Herbert, A., Howick, J., Little, P., Mallen, C., Morrison, L., Nuttall, J., Ridd, M. J., Robnson, M. E., Stuart, B., Vennick, J., …Bishop, F. L. (2025). Mixed methods evaluation of using the ‘EMPathicO’ communication skills e-learning in primary care: “a super weapon to make the whole experience a bit better”

Objectives To examine primary care practitioners’ experiences and use of EMPathicO e-learning to enhance communication of clinical empathy and realistic optimism.

Design Mixed methods evaluation incorporating thematic analysis of qualitative inter... Read More about Mixed methods evaluation of using the ‘EMPathicO’ communication skills e-learning in primary care: “<i>a super weapon to make the whole experience a bit better”</i>.

Clinical and cost-effectiveness of communication skills e-learning for primary care practitioners on patients' musculoskeletal pain and enablement: the Talking in Primary care (TIP) cluster-randomised controlled trial (2025)
Preprint / Working Paper
Bishop, F. L., Becque, T., Garfield, K., Cross, N., Dewar-Haggart, R., Teasdale, E., Herbert, A., Robinson, M. E., Ridd, M. J., Mallen, C., Clarson, L., Bostock, J., Stuart, B., Morrison, L., Pollet, S., Vennik, J., Atherton, H., Howick, J., Leydon, G. M., Nuttall, J., …Everitt, H. A. (2025). Clinical and cost-effectiveness of communication skills e-learning for primary care practitioners on patients' musculoskeletal pain and enablement: the Talking in Primary care (TIP) cluster-randomised controlled trial

Objectives To determine the effectiveness and cost-effectiveness of a brief communication skills e-learning package on empathy and optimism for practitioners consulting with adult primary care patients presenting with musculoskeletal (MSK) pain.

D... Read More about Clinical and cost-effectiveness of communication skills e-learning for primary care practitioners on patients' musculoskeletal pain and enablement: the Talking in Primary care (TIP) cluster-randomised controlled trial.

The Michael Mason Prize: Development and feasibility testing of a complex intervention to improve adherence to fracture prevention medicine using a person-centred approach (2025)
Preprint / Working Paper
Bullock, L., Tyler, N., Clark, E. M., Thomas, S., Gidlow, C., Bentley, I., Hawarden, A., Peel, N., Gregson, C. L., Ralston, S. H., Protheroe, J., Lefroy, J., O’Neill, T. W., Mallen, C., Clare, J., & Paskins, Z. (in press). The Michael Mason Prize: Development and feasibility testing of a complex intervention to improve adherence to fracture prevention medicine using a person-centred approach

Objectives The improving uptake of Fracture Prevention treatments (iFraP) intervention consists of an osteoporosis decision support tool (DST), clinician skills training, and information resources, to improve shared decision-making (SDM) about, and u... Read More about The Michael Mason Prize: Development and feasibility testing of a complex intervention to improve adherence to fracture prevention medicine using a person-centred approach.

Ethnic and Socioeconomic Variation in Pre-Conception Long-Term Conditions: A Cross-Sectional Electronic Health Record Study of 3.4 Million Pregnancies in Cprd Aurum (2025)
Preprint / Working Paper
Cockburn, N., Singh, M., Wambua, S., Gonzalez-Izquierdo, A., Ing Lee, S., Phillips, K., Elsmore, A., Ilaalagan, R., Holland, R., Hanley, S. J., Laws, E., Hodgetts-Morton, V., Gibbon, M., Judd, N. A., Seymour, R. G., Taylor, B., Singh Chandan, J., Parry-Smith, W., & Nirantharakumar, K. (2025). Ethnic and Socioeconomic Variation in Pre-Conception Long-Term Conditions: A Cross-Sectional Electronic Health Record Study of 3.4 Million Pregnancies in Cprd Aurum

Background: Inequalities in pregnancy outcomes between different ethnic groups and backgrounds of deprivation have been observed in the UK and elsewhere for several decades. Pre-existing long-term health conditions increase risks of adverse outcomes... Read More about Ethnic and Socioeconomic Variation in Pre-Conception Long-Term Conditions: A Cross-Sectional Electronic Health Record Study of 3.4 Million Pregnancies in Cprd Aurum.

Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study. (2024)
Preprint / Working Paper
Ashworth, J., Cornwall, N., Harrisson, S. A., Woodcock, C., Nicholls, E., Lancaster, G., Wathall, S., Laing, L., Helliwell, T., Jowett, S., Kigozi, J., Mallen, C. D., Avery, A., Knaggs, R., Pincus, T., White, S., & Jinks, C. (2024). Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study

Background:

Given the poor long-term effectiveness of opioids for persistent non-cancer pain, and their potential for harm, evidence–based interventions to address opioid overprescribing for persistent pain are needed. This study aimed to explore... Read More about Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study..

A non-specialist worker delivered digital assessment of cognitive development (DEEP) in young children: a longitudinal validation study in rural India (2024)
Preprint / Working Paper
Bhavnani, S., Ranjan, A., Mukherjee, D., Divan, G., Prakash, A., Yadav, A., Lal, C., Gajria, D., Irfan, H., Sharma, K. K., Todkar, S. D., Patel, V., & McCray, G. A non-specialist worker delivered digital assessment of cognitive development (DEEP) in young children: a longitudinal validation study in rural India

Background Cognitive development in early childhood is critical for life-long well-being. Existing cognitive development surveillance tools require lengthy parental interviews and observations of children. Developmental Assessment on an E-Platform (D... Read More about A non-specialist worker delivered digital assessment of cognitive development (DEEP) in young children: a longitudinal validation study in rural India.

Title: Prediction of Functional Disability in Older Chinese Adults Using a Random Survival Forest Model (2024)
Preprint / Working Paper
Shan, Y., Jiang, S., Yu, D., Fan, W., Gao, J., Lu, W., Duan, Y., Zhang, Y., Wang, S., Fu, H., & Wang, C. Title: Prediction of Functional Disability in Older Chinese Adults Using a Random Survival Forest Model

Background
As life expectancy increases, so does the risk of age-related diseases and functional disability, which significantly raises the risk of all-cause mortality in older adults. Individuals with disabilities may die up to 20 years earlier tha... Read More about Title: Prediction of Functional Disability in Older Chinese Adults Using a Random Survival Forest Model.

Association of air pollution from a landfill site with primary care consultation (2024)
Preprint / Working Paper
Jordan, K. P., Muller, S., Usman, M., Bailey, J., Burton, C., Lawton, S. A., Mallen, C. D., Mason, K. J., Wathall, S., & van der Windt, D. A. Association of air pollution from a landfill site with primary care consultation

Background Waste landfill sites are associated with gaseous emissions and this air pollution can cause unpleasant smells (“malodour”). This causes concerns about its impact on the health of the local population. This study assessed change in general... Read More about Association of air pollution from a landfill site with primary care consultation.

Protocol for the Work And Vocational advicE (WAVE) randomised controlled trial testing the addition of vocational advice to usual primary care (Clinical Trials: NCT04543097) (2024)
Preprint / Working Paper
Wynne-Jones, G., Lewis, M., Sowden, G., Madan, I., Walker-Bone, K., Chew-Graham, C., Bromley, K., Jowett, S., Parsons, V., Mansell, G., Cooke, K., Lawton, S., Saunders, B., Pemberton, J., Cooper, C., & Foster, N. Protocol for the Work And Vocational advicE (WAVE) randomised controlled trial testing the addition of vocational advice to usual primary care (Clinical Trials: NCT04543097)

Objectives To investigate the effectiveness of adding a brief vocational advice intervention to usual care in reducing the number of days absent from work over a period of 6 months in adults given a fit note by their general practice.

Design Multi... Read More about Protocol for the Work And Vocational advicE (WAVE) randomised controlled trial testing the addition of vocational advice to usual primary care (Clinical Trials: NCT04543097).

Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype (2024)
Preprint / Working Paper
Ioannou, S., G Kay, A., P Stone, A., Rand, E., Elberfeld, S., Bolton, W., Larson, T., E Crossland, R., Kehoe, O., A Mentlak, D., Wang, X.-N., MacDonald, C., & Genever, P. Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype

Mesenchymal stromal cells (MSCs) are a promising source of therapeutic extracellular vesicles (EVs), however it is not clear how heterogeneity within a non-clonal MSC population will affect the collective EV pool. Here we used immortalised clonal MSC... Read More about Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype.

The OBS UK Dashboard: an Interactive Tool for Representative Trial Site Selection to Facilitate Equality and Diversity in Maternity Research (2024)
Preprint / Working Paper
(2024). The OBS UK Dashboard: an Interactive Tool for Representative Trial Site Selection to Facilitate Equality and Diversity in Maternity Research

Background
Obstetric Bleeding Study UK (award ID:152057) is a NIHR-funded stepped wedge cluster randomised controlled trial of a complex intervention for postpartum haemorrhage. This was developed in Wales and evaluated in a feasibility study, with... Read More about The OBS UK Dashboard: an Interactive Tool for Representative Trial Site Selection to Facilitate Equality and Diversity in Maternity Research.

Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement (2024)
Preprint / Working Paper
Short, E., Adcock, I. M., Al-Sarireh, B., Ager, A., Ajjan, R., Akbar, N., Akeroyd, M. A., Alsaleh, G., Al-Sharbatee, G., Alavian, K., Amoaku, W., Andersen, J., Antoniades, C., Arends, M. J., Astley, S., Atan, D., Attanoos, R., Attems, J., Bain, S., Balaskas, K., …Bentley, B. L. Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement

Protocol for the development and validation of a Rheumatoid Arthritis PredIction moDel using primary care health records (RAPID) (2024)
Preprint / Working Paper
Hammond, B., Baranskaya, A., Adderley, N., Zemedikun, D., d’Elia, A., Falahee, M., Mallen, C., Insch, E., Singh Chandan, J., Nirantharakumar, K., Snell, K., & Raza, K. Protocol for the development and validation of a Rheumatoid Arthritis PredIction moDel using primary care health records (RAPID)

Background Rheumatoid Arthritis (RA) is a chronic rheumatological condition which causes inflammation of both the joint lining and extra-articular sites. It affects around 1% of the UK population and, if not properly treated, can lead joint damage, d... Read More about Protocol for the development and validation of a Rheumatoid Arthritis PredIction moDel using primary care health records (RAPID).

Cost-utility analysis of risk-based stratified primary care for common musculoskeletal pain presentations: a cluster-randomised, controlled trial (2024)
Preprint / Working Paper
Kigozi, J., Hill, J. C., Bromley, K., Lewis, M., Wathall, S., Chudyk, A., Dunn, K. M., Foster, N. E., & Jowett, S. Cost-utility analysis of risk-based stratified primary care for common musculoskeletal pain presentations: a cluster-randomised, controlled trial

Background
Risk-based stratified care (SC) has demonstrated cost-effectiveness versus usual primary care for non-specific low back pain. The STarT MSK trial investigated the cost-effectiveness of risk-based stratified care versus non-stratified usua... Read More about Cost-utility analysis of risk-based stratified primary care for common musculoskeletal pain presentations: a cluster-randomised, controlled trial.

Shifting Geographical Transmission Patterns: Characterizing the 2023 Fatal Dengue Outbreak in Bangladesh (2024)
Preprint / Working Paper
Nayeem Hasan, M., Rahman, M., Fahim Uddin, M., Ali Akbar Ashrafi, S., Rahman, K. M., Kumar Paul, K., Rahman Sarker, M. F., Haque, F., Sharma, A., Papakonstantinou, D., Paudyal, P., Asaduzzaman, M., Zumla, A., & Haider, N. Shifting Geographical Transmission Patterns: Characterizing the 2023 Fatal Dengue Outbreak in Bangladesh

In 2023, Bangladesh experienced its largest and deadliest outbreak of Dengue virus (DENV), reporting the highest-ever recorded annual cases and deaths. We aimed to characterize the geographical transmission of the DENV in Bangladesh. From 1 Jan – 31... Read More about Shifting Geographical Transmission Patterns: Characterizing the 2023 Fatal Dengue Outbreak in Bangladesh.

Automating incidence and prevalence analysis in open cohorts (2024)
Preprint / Working Paper
Cockburn, N., Hammond, B., Ghani, I., Cusworth, S., Acharya, A., Gokhale, K., Thayakaran, R., Crowe, F., Minhas, S., Parry-Smith, W., Taylor, B., Nirantharakumar, K., & Singh Chandan, J. Automating incidence and prevalence analysis in open cohorts

Motivation

Increasingly vast quantities of data support improvement and research in public health, and growth is especially seen in administrative data such as that collected in electronic health records. Patients enter and exit these typically o... Read More about Automating incidence and prevalence analysis in open cohorts.

The relationship between research activity and the performance of English general practices: cross sectional and longitudinal analyses (2024)
Preprint / Working Paper
Gibson, J., Kontopantelis, E., Sutton, M., Boaz, A., Little, P., Mallen, C., McManus, R., Park, S., Usher-Smith, J., & Bower, P. (2024). The relationship between research activity and the performance of English general practices: cross sectional and longitudinal analyses

Introduction
Research activity usually improves outcomes by being translated into practice. However, there is developing evidence that research activity itself may improve the overall performance of health care organisations. However, evidence that... Read More about The relationship between research activity and the performance of English general practices: cross sectional and longitudinal analyses.

Multimorbidity in Older Adults with Depression Study (MODS) (Behavioural Activation to improve physical and mental functioning among older people with multiple long-term conditions): Protocol for a fully powered randomised controlled trial (2024)
Preprint / Working Paper
Ryde, E., Hollingsworth, K., Littlewood, E., Atha, L., Bailey, D., Baker, H., Bosanquet, K., Shearsmith, L., Chew-Graham, C. A., McMillan, D., Baird, K., Coventry, P., Crosland, S., Fairhurst, C., Wang, H.-I., Burke, L., Heeley, J., Hewitt, C., Clegg, A., Gentry, T., …Ekers, D. Multimorbidity in Older Adults with Depression Study (MODS) (Behavioural Activation to improve physical and mental functioning among older people with multiple long-term conditions): Protocol for a fully powered randomised controlled trial

Introduction Older adults (65 years or over) and those with long-term health conditions (LTCs), represent a ‘high risk’ group for depression, with a risk two-to-three times the general population. This can lead to poorer quality of life and be costly... Read More about Multimorbidity in Older Adults with Depression Study (MODS) (Behavioural Activation to improve physical and mental functioning among older people with multiple long-term conditions): Protocol for a fully powered randomised controlled trial.

Monitoring for 5-aminosalicylate toxicity: prognostic model development and validation (2023)
Preprint / Working Paper
Abhishek, A., Nakafero, G., Grainge, M. J., Card, T., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., Stevenson, M. D., & Riley, R. D. Monitoring for 5-aminosalicylate toxicity: prognostic model development and validation

Background and aim To develop and validate a prognostic model for risk-stratified monitoring of 5-aminosalicylate (5-ASA) toxicity.

Methods This nationwide retrospective cohort study used data from the Clinical Practice Research Datalink (CPRD) Au... Read More about Monitoring for 5-aminosalicylate toxicity: prognostic model development and validation.

SupportPrim – A computerized clinical decision support system for stratified care for patients with musculoskeletal pain complaints in general practice - Statistical Analysis Plan (2023)
Preprint / Working Paper
Naterstad Lervik, L. C., Bach, K., Granviken, F., Hill, J. C., Simpsom, M. R., Vasseljen, O., Van der Windt, D. A., & Meisingset, I. SupportPrim – A computerized clinical decision support system for stratified care for patients with musculoskeletal pain complaints in general practice - Statistical Analysis Plan

This is a statistical Analysis Plan (SAP) for “SupportPrim – A computerized clinical decision support system for stratified care for patients with musculoskeletal pain complaints in general practice”. The SAP elaborates the statistics described in th... Read More about SupportPrim – A computerized clinical decision support system for stratified care for patients with musculoskeletal pain complaints in general practice - Statistical Analysis Plan.