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All Outputs (384)

Progress in clinical research in surgery and IDEAL (2018)
Journal Article
(2018). Progress in clinical research in surgery and IDEAL. Lancet, 88-94. https://doi.org/10.1016/S0140-6736%2818%2930102-8

The quality of clinical research in surgery has long attracted criticism. High-quality randomised trials have proved difficult to undertake in surgery, and many surgical treatments have therefore been adopted without adequate supporting evidence of e... Read More about Progress in clinical research in surgery and IDEAL.

Targeting isocitrate lyase for the treatments of tuberculosis (2018)
Presentation / Conference
Bhusal, R., Patel, K., Kwai, B., Bashiri, G., Reynisson, J., & Sperry, J. (2018, July). Targeting isocitrate lyase for the treatments of tuberculosis. Poster presented at 43rd FEBS Congress, Biochemistry Forever, Prague, Czech

Supplement: 43rd FEBS Congress, Biochemistry Forever, Prague, Czech Republic, July 7‐12, 2018

A mixed methods study to evaluate the feasibility of using the Adolescent Diabetes Needs Assessment Tool App in paediatric diabetes care in preparation for a longitudinal cohort study. (2018)
Journal Article
(2018). A mixed methods study to evaluate the feasibility of using the Adolescent Diabetes Needs Assessment Tool App in paediatric diabetes care in preparation for a longitudinal cohort study. Pilot and Feasibility Studies, 13 - ?. https://doi.org/10.1186/s40814-017-0164-5

BACKGROUND: An evaluation study was carried out to determine the feasibility of integrating the Adolescent Diabetes Needs Assessment Tool (ADNAT) App into UK paediatric diabetes care, to ascertain best practice standards and to determine methodologic... Read More about A mixed methods study to evaluate the feasibility of using the Adolescent Diabetes Needs Assessment Tool App in paediatric diabetes care in preparation for a longitudinal cohort study..

A multi-modal recruitment strategy using social media and internet-mediated methods to recruit a multidisciplinary, international sample of clinicians to an online research study. (2018)
Journal Article
McRobert, C. J., Hill, J., Smale, T., Hay, E., & Van Der Windt, D. (2018). A multi-modal recruitment strategy using social media and internet-mediated methods to recruit a multidisciplinary, international sample of clinicians to an online research study. PloS one, 13(7), Article e0200184. https://doi.org/10.1371/journal.pone.0200184

BACKGROUND: Challenges exist in recruiting an international sample of clinicians and researchers to an online survey. Traditional recruitment methods remain relevant but issues such as narrow geographical reach, high cost and time intensity limit wha... Read More about A multi-modal recruitment strategy using social media and internet-mediated methods to recruit a multidisciplinary, international sample of clinicians to an online research study..

Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies (2018)
Journal Article
Evans, P. L., Prior, J. A., Belcher, J., Mallen, C., Hay, C. A., & Roddy, E. (2018). Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies. Arthritis Research and Therapy, 20, Article 136. https://doi.org/10.1186/s13075-018-1612-1

BACKGROUND: Gout treatment remains suboptimal. Identifying populations at risk of developing gout may provide opportunities for prevention. Our aim was to assess the risk of incident gout associated with obesity, hypertension and diuretic use. METHOD... Read More about Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies.

Identification of prognostic factors and assessment methods on the evaluation of non-specific low back pain in a biopsychosocial environment: A scoping review (2018)
Journal Article
(2018). Identification of prognostic factors and assessment methods on the evaluation of non-specific low back pain in a biopsychosocial environment: A scoping review. International Journal of Osteopathic Medicine, 25-34. https://doi.org/10.1016/j.ijosm.2018.07.001

This review lists biopsychosocial factors and assessment methods to use with non-specific low back pain. These should be included in evidence-informed educational interventions. This review supports a biopsychosocial approach in a manual therapy cont... Read More about Identification of prognostic factors and assessment methods on the evaluation of non-specific low back pain in a biopsychosocial environment: A scoping review.

Concussion assessment in cycling: a systematic review and call to action (2018)
Journal Article
Heron, N., & Anderson, R. (2018). Concussion assessment in cycling: a systematic review and call to action

Purpose:Concussion is a recognised risk in road cycling and can have serious health consequences1, especially when mismanaged. Epidemiological studies estimate that concussions account for 4-13% of all cycling injuries2-4and that the in... Read More about Concussion assessment in cycling: a systematic review and call to action.

Exploring what patients think when answering the Interpersonal Skills Questionnaire (ISQ): A ‘think aloud’ study (2018)
Journal Article
Al-Jabr, H., Twigg, M., Saadvandi, R., & Desborough, J. (2019). Exploring what patients think when answering the Interpersonal Skills Questionnaire (ISQ): A ‘think aloud’ study. Research in Social and Administrative Pharmacy, 15(5), 619-622. https://doi.org/10.1016/j.sapharm.2018.07.005

Background The Interpersonal Skills Questionnaire (ISQ) was developed to collect patient feedback on consultation skills of practitioners. However, it has not yet been evaluated with pharmacists. Objective To explore the thinking process of pati... Read More about Exploring what patients think when answering the Interpersonal Skills Questionnaire (ISQ): A ‘think aloud’ study.

Greater improvements in diet quality among overweight participants following a group-based commercial weight loss programme than those receiving support to lose weight in primary care (2018)
Journal Article
Solis-Trapala. (2018). Greater improvements in diet quality among overweight participants following a group-based commercial weight loss programme than those receiving support to lose weight in primary care. Nutrition Journal, https://doi.org/10.1186/s12937-018-0370-x

Background Relatively little is known about dietary changes and their relationships with weight change during behavioural weight loss interventions. In a secondary analysis of data from a multicentre RCT, we investigated whether greater improvements... Read More about Greater improvements in diet quality among overweight participants following a group-based commercial weight loss programme than those receiving support to lose weight in primary care.

Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care. (2018)
Journal Article
Mallen. (2018). Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care. Pilot and Feasibility Studies, 93 - ?. https://doi.org/10.1186/s40814-018-0288-2

Background: Platelet-rich plasma (PRP) is a concentrate of autologous blood growth factors which has been shown to provide some symptomatic relief in early osteoarthritis (OA) of the knee. The objective of this study was to test the feasibility and e... Read More about Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care..

Cognitive and contextual factors to optimise clinical outcomes in tendinopathy (2018)
Journal Article
(2018). Cognitive and contextual factors to optimise clinical outcomes in tendinopathy. British Journal of Sports Medicine, 822-823. https://doi.org/10.1136/bjsports-2017-098064

Tendinopathy, a clinical term used to describe ‘tendon-related pain’, is a heterogeneous clinical presentation, reflected by the wide-ranging pain presentations and functional deficits.1 For this population, load-based exercise is effective; however,... Read More about Cognitive and contextual factors to optimise clinical outcomes in tendinopathy.

Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study (2018)
Journal Article
Mallen, Roddy, Bucknall, Muller, Hider, Helliwell, & Paskins. (2018). Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study. Osteoporosis International, 1659-1664. https://doi.org/10.1007/s00198-018-4491-z

This study aimed to examine fracture risk in patients with late-onset psoriasis. A cohort study was conducted using primary care records from the Clinical Practice Research Datalink. Psoriasis patients had a 10% increased risk of fracture compared to... Read More about Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study.

Hajj: what it means for general practice (2018)
Journal Article
Saad, A., Mughal, F., & Chew-Graham, C. (2018). Hajj: what it means for general practice. British Journal of General Practice (BJGP), https://doi.org/10.3399/bjgpopen18X101493

Annually, about 20 000 British Muslims journey to Saudi Arabia to undertake the Hajj, the greater Muslim pilgrimage.1 The National Travel Health Network and Centre advises intended pilgrims to see their GP 6 weeks prior to travel, to review their hea... Read More about Hajj: what it means for general practice.

Missing Information About Study Funding (2018)
Journal Article
Mason, K. J., Barker, J. N., Smith, C. H., Hampton, P. J., Lunt, M., McElhone, K., …Study Group, T. B. (2018). Missing Information About Study Funding. JAMA Dermatology, 154(7), 852. https://doi.org/10.1001/jamadermatol.2018.2319

In the Original Investigation titled “Comparison of Drug Discontinuation, Effectiveness, and Safety Between Clinical Trial Eligible And Ineligible Patients in BADBIR,”1 published online March 28, 2018, there was information omitted regarding study fu... Read More about Missing Information About Study Funding.

Thromboembolism with Janus Kinase (JAK) Inhibitors for Rheumatoid Arthritis: How Real is the Risk? (2018)
Journal Article
Hider, S. (2018). Thromboembolism with Janus Kinase (JAK) Inhibitors for Rheumatoid Arthritis: How Real is the Risk?. Drug Safety, https://doi.org/10.1007/s40264-018-0651-5

Two different Janus kinase (JAK) inhibitors-baricitinib and tofacitinib-are effective and licensed in active rheumatoid arthritis (RA). There have been recent concerns about potential thromboembolic risks with these drugs. Concerns about baricitinib... Read More about Thromboembolism with Janus Kinase (JAK) Inhibitors for Rheumatoid Arthritis: How Real is the Risk?.

Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials (2018)
Report
Hay, E., Dziedzic, K., Foster, N., Peat, G., van der Windt, D., Bartlam, B., …Croft, P. (2018). Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials. NIHR. PGfAR as project number RP-PG-0407-10386. Secretary of State for Health and Social Care

Background Osteoarthritis (OA) is the most common long-term condition managed in UK general practice. However, care is suboptimal despite evidence that primary care and community-based interventions can reduce OA pain and disability. Objectives Th... Read More about Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials.

Do frailty measures improve prediction of mortality and morbidity following transcatheter aortic valve implantation? An analysis of the UK TAVI registry (2018)
Journal Article
Mamas. (2018). Do frailty measures improve prediction of mortality and morbidity following transcatheter aortic valve implantation? An analysis of the UK TAVI registry. Cardiovascular Medicine, https://doi.org/10.1136/bmjopen-2018-022543

Objectives Previous studies indicate frailty to be associated with poor outcomes following transcatheter aortic valve implantation (TAVI), but there is limited evidence from multicentre registries. The aim was to investigate the independent associat... Read More about Do frailty measures improve prediction of mortality and morbidity following transcatheter aortic valve implantation? An analysis of the UK TAVI registry.