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All Outputs (633)

Racial, ethnic and socioeconomic disparities in patients undergoing left atrial appendage closure (2021)
Journal Article
Sparrow, R., Sanjoy, S., Choi, Y., Elgendy, I. Y., Jneid, H., Villablanca, P. A., …Bagur, R. (2021). Racial, ethnic and socioeconomic disparities in patients undergoing left atrial appendage closure. Heart, 107(24), 1946-1955. https://doi.org/10.1136/heartjnl-2020-318650

OBJECTIVE: This manuscript aims to explore the impact of race/ethnicity and socioeconomic status on in-hospital complication rates after left atrial appendage closure (LAAC). METHODS: The US National Inpatient Sample was used to identify hospitalisat... Read More about Racial, ethnic and socioeconomic disparities in patients undergoing left atrial appendage closure.

Practice Nurses' role extension and diagnostic work in long-term conditions: a qualitative metasynthesis and interview study (2021)
Thesis
Tan, V. A. (2021). Practice Nurses' role extension and diagnostic work in long-term conditions: a qualitative metasynthesis and interview study. (Thesis). Keele University

Background
Role extension is common in primary care in the UK, with assessment, diagnosis and management of some conditions by role extended nurses well established. Practice nurses (PNs) are now considered fundamental to the care of patients with... Read More about Practice Nurses' role extension and diagnostic work in long-term conditions: a qualitative metasynthesis and interview study.

Evaluation of surgical outcomes using administrative hospital data (2021)
Thesis
El-Dhuwaib, Y. (2021). Evaluation of surgical outcomes using administrative hospital data. (Thesis). Keele University

Hospital Episode Statistics (HES) is the main hospital administrative dataset in England. Since the early 1990s HES has been used for research. The aim of the thesis is to evaluate the use of HES data to measure surgical outcomes.

Objectives:
1.... Read More about Evaluation of surgical outcomes using administrative hospital data.

Physical activity in people with osteoarthritis and comorbidity: a multi-method study (2021)
Thesis
McKevitt, S. (2021). Physical activity in people with osteoarthritis and comorbidity: a multi-method study. (Thesis). Keele University

Osteoarthritis (OA) is common and associated with one of the highest comorbidity rates. OA clinical guidelines recommend physical activity (PA) as core treatment, irrespective of comorbidity. However, no current synthesis of the effectiveness of PA f... Read More about Physical activity in people with osteoarthritis and comorbidity: a multi-method study.

Investigating health and work participation in later working life: multi-state modelling of Healthy Working Life Expectancy using national population datasets (2021)
Thesis
Parker, M. E. (2021). Investigating health and work participation in later working life: multi-state modelling of Healthy Working Life Expectancy using national population datasets. (Thesis). Keele University

Introduction
Retirement ages are rising in many countries due to population ageing and increasing life expectancy. It is unclear whether people in later working life (age =50) are able to work for longer due to health conditions and a lack of job op... Read More about Investigating health and work participation in later working life: multi-state modelling of Healthy Working Life Expectancy using national population datasets.

The impact of guidelines on the use of imaging in osteoarthritis: a time trend analysis using electronic health record data (2021)
Thesis
Henry-Blake, C. J. (2021). The impact of guidelines on the use of imaging in osteoarthritis: a time trend analysis using electronic health record data. (Thesis). Keele University

The National Institute for Health and Care Excellence (NICE) suggests there is no role for routine radiography in the diagnosis of osteoarthritis (OA). It is not known how consistent this recommendation is across guidelines, or the impact of guidelin... Read More about The impact of guidelines on the use of imaging in osteoarthritis: a time trend analysis using electronic health record data.

Radial First in ST-Segment-Elevation Myocardial Infarction (2021)
Journal Article
Jolly, S. S., & Nolan, J. (2021). Radial First in ST-Segment-Elevation Myocardial Infarction. Circulation: Cardiovascular Interventions, 14(3), Article ARTN e010595. https://doi.org/10.1161/CIRCINTERVENTIONS.121.010595

As young interventionalists, we recall randomizing patients with ST-segment–elevation myocardial infarction (STEMI) into studies such as the RIVAL trial (the Radial Versus Femoral Access for Coronary Angiography and Intervention) and struggling with... Read More about Radial First in ST-Segment-Elevation Myocardial Infarction.

Non-pharmacological interventions to reduce restrictive practices in adult mental health inpatient settings: the COMPARE systematic mapping review (2021)
Report
Baker, J., Berzins, K., Canvin, K., Benson, I., Kellar, I., Wright, J., …Stewart, D. (2021). Non-pharmacological interventions to reduce restrictive practices in adult mental health inpatient settings: the COMPARE systematic mapping review. National Institute for Health Research (NIHR) - Health Services and Delivery Research (HS&DR) Programme

Objectives
The study aimed to provide a mapping review of non-pharmacological interventions to reduce restrictive practices in adult mental health inpatient settings; classify intervention components using the behaviour change technique taxonomy; ex... Read More about Non-pharmacological interventions to reduce restrictive practices in adult mental health inpatient settings: the COMPARE systematic mapping review.

Identifying predictors of ventral hernia recurrence: systematic review and meta-analysis (2021)
Journal Article
Parker, S. G., Mallett, S., Quinn, L., Wood, C. P. J., Boulton, R. W., Jamshaid, S., …Halligan, S. (2021). Identifying predictors of ventral hernia recurrence: systematic review and meta-analysis. BJS Open, 5(2), 1-9. https://doi.org/10.1093/bjsopen/zraa071

BACKGROUND: Ventra hernias are increasing in prevalence and many recur despite attempted repair. To date, much of the literature is underpowered and divergent. As a result there is limited high quality evidence to inform surgeons succinctly which per... Read More about Identifying predictors of ventral hernia recurrence: systematic review and meta-analysis.

Toward a More Nuanced Interpretation of Statistical Significance in Biomedical Research (2021)
Journal Article
Bajpai, R., & Chaturvedi, H. K. (2021). Toward a More Nuanced Interpretation of Statistical Significance in Biomedical Research. Asian Journal of Oncology, 07, 049-051. https://doi.org/10.1055/s-0041-1727066

Editorial
Statistical significance is the bedrock of evidence-based medicine, crucial for decision-making and framing biomedical science policies. The emergence of complex data in many disciplines, resulting from the analysis of large datasets, has... Read More about Toward a More Nuanced Interpretation of Statistical Significance in Biomedical Research.

Clinical and cost effectiveness of a corticosteroid injection versus exercise therapy for shoulder pain in general practice: protocol for a randomised controlled trial (SIX Study). (2021)
Journal Article
Van Der Windt. (2021). Clinical and cost effectiveness of a corticosteroid injection versus exercise therapy for shoulder pain in general practice: protocol for a randomised controlled trial (SIX Study). BMJ Open, e050101 - ?. https://doi.org/10.1136/bmjopen-2021-050101

INTRODUCTION: Shoulder pain is common and the prognosis is often unfavourable. Dutch guidelines on the treatment of shoulder pain in primary care recommend a corticosteroid injection or a referral to exercise therapy, if initial pain management fails... Read More about Clinical and cost effectiveness of a corticosteroid injection versus exercise therapy for shoulder pain in general practice: protocol for a randomised controlled trial (SIX Study)..

Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. (2021)
Journal Article
Holden, M., Callaghan, M., Felson, D., Birrell, F., Nicholls, E., Jowett, S., …Peat, G. (2021). Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. BMJ Open, 11(3), Article e048196. https://doi.org/10.1136/bmjopen-2020-048196

BACKGROUND: Brace effectiveness for knee osteoarthritis (OA) remains unclear and international guidelines offer conflicting recommendations. Our trial will determine the clinical and cost-effectiveness of adding knee bracing (matched to patients' cli... Read More about Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial..

Individual participant data meta-analysis for external validation, recalibration, and updating of a flexible parametric prognostic model. (2021)
Journal Article
Ensor, J., Snell, K. I. E., Debray, T. P. A., Lambert, P. C., Look, M. P., Mamas, M. A., …Riley, R. D. (2021). Individual participant data meta-analysis for external validation, recalibration, and updating of a flexible parametric prognostic model. Statistics in Medicine, 40(13), 3066-3084. https://doi.org/10.1002/sim.8959

Individual participant data (IPD) from multiple sources allows external validation of a prognostic model across multiple populations. Often this reveals poor calibration, potentially causing poor predictive performance in some populations. However, r... Read More about Individual participant data meta-analysis for external validation, recalibration, and updating of a flexible parametric prognostic model..

Dominant and Modifiable Risk Factors for Dementia in Sub-Saharan Africa: A Systematic Review and Meta-Analysis (2021)
Journal Article
Ojagbemi, A., Okekunle, A., & Babatunde, O. (2021). Dominant and Modifiable Risk Factors for Dementia in Sub-Saharan Africa: A Systematic Review and Meta-Analysis. Frontiers in Neurology, https://doi.org/10.3389/fneur.2021.627761

Background: Sub-Saharan Africa (SSA) is projected to have a rapid increase in the number of people living with dementia by 2050. Yet, there is currently no robust evidence on the risk factors for dementia in the sub-region that could inform context s... Read More about Dominant and Modifiable Risk Factors for Dementia in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.

Revascularisation strategies in patients with significant left main coronary disease during the COVID-19 pandemic. (2021)
Journal Article
Rashid, M., Mamas, Mohamed, M. O., Curzen, N., de Belder, M., Goodwin, A. T., …Mamas, M. A. (2021). Revascularisation strategies in patients with significant left main coronary disease during the COVID-19 pandemic. Catheterization & Cardiovascular Interventions, 98(7), 1252-1261. https://doi.org/10.1002/ccd.29663

BACKGROUND: There are limited data on the impact of the COVID-19 pandemic on left main (LM) coronary revascularisation activity, choice of revascularisation strategy, and post-procedural outcomes. METHODS: All patients with LM disease (=50% stenosis)... Read More about Revascularisation strategies in patients with significant left main coronary disease during the COVID-19 pandemic..

Developing a model Fracture Liaison Service consultation with patients, carers and clinicians: a Delphi survey to inform content of the iFraP complex consultation intervention. (2021)
Journal Article
Bullock, L., Crawford-Manning, F., Cottrell, E., Fleming, J., Leyland, S., Edwards, J., …Paskins, Z. (2021). Developing a model Fracture Liaison Service consultation with patients, carers and clinicians: a Delphi survey to inform content of the iFraP complex consultation intervention. Archives of Osteoporosis, 16, 1- 17. https://doi.org/10.1007/s11657-021-00913-w

Fracture Liaison Services are recommended to deliver best practice in secondary fracture prevention. This modified Delphi survey, as part of the iFraP (Improving uptake of Fracture Prevention drug Treatments) study, provides consensus regarding tasks... Read More about Developing a model Fracture Liaison Service consultation with patients, carers and clinicians: a Delphi survey to inform content of the iFraP complex consultation intervention..

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study (2021)
Journal Article
Collaborative, C., Collaborative, G., & Parry-Smith, W. (2021). SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study. British Journal of Surgery, 108(9), 1056-1063. https://doi.org/10.1093/bjs/znab101

Background
Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.

Methods
The primary outcome was the number needed to vaccinate (NNV... Read More about SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.