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All Outputs (623)

Correction: To what extent are patients involved in researching safety in acute mental healthcare? (Research Involvement and Engagement, (2022), 8, 1, (8), 10.1186/s40900-022-00337-x) (2023)
Journal Article
Brierley-Jones, L., Ramsey, L., Canvin, K., Kendal, S., & Baker, J. (2023). Correction: To what extent are patients involved in researching safety in acute mental healthcare? (Research Involvement and Engagement, (2022), 8, 1, (8), 10.1186/s40900-022-00337-x). Research Involvement and Engagement, 9, Article 65. https://doi.org/10.1186/s40900-023-00469-8

Effectiveness of self-management interventions for long-term conditions in people experiencing socio-economic deprivation in high-income countries: a systematic review and meta-analysis (2023)
Journal Article
Okpako, T., Woodward, A., Walters, K., Davies, N., Stevenson, F., Nimmons, D., …Armstrong, M. (in press). Effectiveness of self-management interventions for long-term conditions in people experiencing socio-economic deprivation in high-income countries: a systematic review and meta-analysis. Journal of Public Health, Article fdad145. https://doi.org/10.1093/pubmed/fdad145

Background Long-term conditions (LTCs) are prevalent in socio-economically deprived populations. Self-management interventions can improve health outcomes, but socio-economically deprived groups have lower participation in them, with potentially lowe... Read More about Effectiveness of self-management interventions for long-term conditions in people experiencing socio-economic deprivation in high-income countries: a systematic review and meta-analysis.

Vitamin D supplementation for improving bone density in vitamin D–deficient children and adolescents: systematic review and individual participant data meta-analysis of randomized controlled trials (2023)
Journal Article
Wu, F., El-Hajj Fuleihan, G., Cai, G., Lamberg-Allardt, C., Viljakainen, H. T., Rahme, M., …Winzenberg, T. (2023). Vitamin D supplementation for improving bone density in vitamin D–deficient children and adolescents: systematic review and individual participant data meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition, 118(3), 498-506. https://doi.org/10.1016/j.ajcnut.2023.05.028

Background Vitamin D supplements are widely used for improving bone health in children and adolescents, but their effects in vitamin D–deficient children are unclear. Objectives This study aimed to examine whether the effect of vitamin D supplem... Read More about Vitamin D supplementation for improving bone density in vitamin D–deficient children and adolescents: systematic review and individual participant data meta-analysis of randomized controlled trials.

Patients’ views and experiences of delayed diagnosis of inflammatory bowel disease: a qualitative study (2023)
Journal Article
Cross, E., Prior, J. A., Farmer, A. D., & Saunders, B. (2023). Patients’ views and experiences of delayed diagnosis of inflammatory bowel disease: a qualitative study. British Journal of General Practice Open (BJGP Open), 7(4), Article BJGPO20230070. https://doi.org/10.3399/BJGPO.2023.0070

Diagnosing inflammatory bowel disease (IBD) can be challenging and patients have been found to experience significant diagnostic delay, which can lead to poorer clinical outcomes. The reasons for this delay are not fully understood, and exploring pat... Read More about Patients’ views and experiences of delayed diagnosis of inflammatory bowel disease: a qualitative study.

Association between troponin level and medium-term mortality in 20 000 hospital patients. (2023)
Journal Article
Hinton, J., Mariathas, M. N., Gabara, L., Allan, R., Nicholas, Z., Kwok, C. S., …Curzen, N. (in press). Association between troponin level and medium-term mortality in 20 000 hospital patients. Heart, heartjnl-2023-322463. https://doi.org/10.1136/heartjnl-2023-322463

Cardiac troponin (cTn) concentrations above the manufacturer recommended upper limit of normal (ULN) are frequently seen in hospital patients without a clinical presentation consistent with type 1 myocardial infarction, and the significance of this i... Read More about Association between troponin level and medium-term mortality in 20 000 hospital patients..

In-Hospital Outcomes of Combined Coronary Revascularization and Transcatheter Aortic Valve Implantation in Inpatient Nationwide Analysis. (2023)
Journal Article
Zghouzi, M., Osman, H., Erdem, S., Ullah, W., Patel, N., Sattar, Y., …Alraies, M. C. (in press). In-Hospital Outcomes of Combined Coronary Revascularization and Transcatheter Aortic Valve Implantation in Inpatient Nationwide Analysis. Current Problems in Cardiology, 49(1), Article 101913. https://doi.org/10.1016/j.cpcardiol.2023.101913

Transcatheter aortic valve implantation (TAVI) is accepted as an alternative to surgery, but data on combined percutaneous coronary interventions (PCI) and TAVI during the same in-hospital stay are still lacking. Using the national inpatient sample (... Read More about In-Hospital Outcomes of Combined Coronary Revascularization and Transcatheter Aortic Valve Implantation in Inpatient Nationwide Analysis..

Characteristics and Outcomes of Patients Who Underwent Coronary Atherectomy in Centers With and Without On-Site Cardiac Surgery (2023)
Journal Article
Dafaalla, M., Rashid, M., Moledina, S., Kinnaird, T., Ludman, P., Curzen, N., …Mamas, M. A. (in press). Characteristics and Outcomes of Patients Who Underwent Coronary Atherectomy in Centers With and Without On-Site Cardiac Surgery. American Journal of Cardiology, 204, 242-248. https://doi.org/10.1016/j.amjcard.2023.07.073

We aimed to describe the clinical characteristics and outcomes of patients who underwent atherectomy at the time of percutaneous coronary intervention in centers with on-site surgical centers (SCs) versus nonsurgical centers (NSCs)... Read More about Characteristics and Outcomes of Patients Who Underwent Coronary Atherectomy in Centers With and Without On-Site Cardiac Surgery.

Self‐directed self‐management interventions to prevent or address distress in young people with long‐term physical conditions: A rapid review (2023)
Journal Article
Corp, N., Bray, L., Chew‐Graham, C. A., Polidano, K., Fisher, T., Farmer, A. D., …Saunders, B. (in press). Self‐directed self‐management interventions to prevent or address distress in young people with long‐term physical conditions: A rapid review. Health Expectations, 10.1111/hex.13845. https://doi.org/10.1111/hex.13845

Comorbid distress in adolescents and young adults with physical long-term conditions (LTCs) is common but can be difficult to identify and manage. Self-directed self-management interventions to reduce distress and improve wellbeing may be beneficial.... Read More about Self‐directed self‐management interventions to prevent or address distress in young people with long‐term physical conditions: A rapid review.

Antipsychotic drug prescribing and mortality in people with dementia before and during the COVID-19 pandemic: a retrospective cohort study in Wales, UK. (2023)
Journal Article
Schnier, C., McCarthy, A., Morales, D. R., Akbari, A., Sofat, R., Dale, C., …Wilkinson, T. (2023). Antipsychotic drug prescribing and mortality in people with dementia before and during the COVID-19 pandemic: a retrospective cohort study in Wales, UK. The Lancet Healthy Longevity, 4(8), e421-e430. https://doi.org/10.1016/S2666-7568%2823%2900105-8

Background Concerns have been raised that antipsychotic drug prescribing, which has been associated with increased mortality in people with dementia, might have increased during the COVID-19 pandemic due to social restrictions imposed to limit the s... Read More about Antipsychotic drug prescribing and mortality in people with dementia before and during the COVID-19 pandemic: a retrospective cohort study in Wales, UK..

Care, Violence, and More-Than-Human Reproductive Ecologies in North India (2023)
Journal Article
Fiks, E. (2023). Care, Violence, and More-Than-Human Reproductive Ecologies in North India. Ethnos, 1-17. https://doi.org/10.1080/00141844.2023.2243398

This paper explores therapeutic interventions for subfertility as a domain where meanings and boundaries of care and violence are constituted. It centres around a fragment of one Rajasthani woman’s reproductive journey contextualised within marriage... Read More about Care, Violence, and More-Than-Human Reproductive Ecologies in North India.

Safeguarding community-centred global health research during crises. (2023)
Journal Article
Agampodi, T., Nuwangi, H., Gunasekara, S., Mallawaarachchi, A., Price, H. P., Dikomitis, L., & Agampodi, S. (2023). Safeguarding community-centred global health research during crises. BMJ Global Health, 8(8), Article e013304. https://doi.org/10.1136/bmjgh-2023-013304

Summary box Global health researchers face multiple challenges in proceeding with research programmes during crises, including ethical and safety questions, equitable participation of community members and the collection of robust data. In Sri La... Read More about Safeguarding community-centred global health research during crises..

Introducing novel key genes and transcription factors associated with rectal cancer response to chemoradiation through co-expression network analysis. (2023)
Journal Article
Afshar, S., Leili, T., Amini, P., & Dinu, I. (2023). Introducing novel key genes and transcription factors associated with rectal cancer response to chemoradiation through co-expression network analysis. Heliyon, 9(8), Article e18869. https://doi.org/10.1016/j.heliyon.2023.e18869

Preoperative radiochemotherapy is a promising therapeutic method for locally advanced rectal cancer patients. However, the response of colorectal cancer (CRC) patients to preoperative radiotherapy varies widely. In this study, we aimed to identify no... Read More about Introducing novel key genes and transcription factors associated with rectal cancer response to chemoradiation through co-expression network analysis..

Clinical Frailty Scale as a predictor of adverse outcomes following aortic valve replacement: a systematic review and meta-analysis (2023)
Journal Article
Prendiville, T., Leahy, A., Gabr, A., Ahmad, F., Afilalo, J., Martin, G. P., …Galvin, R. (2023). Clinical Frailty Scale as a predictor of adverse outcomes following aortic valve replacement: a systematic review and meta-analysis. Open Heart, 10(2), Article e002354. https://doi.org/10.1136/openhrt-2023-002354

Objectives: Assessment of frailty prior to aortic valve intervention is recommended in European and North American valvular heart disease guidelines. However, there is a lack of consensus on how it is best measured. The Clinical Frailty Scale (CFS) i... Read More about Clinical Frailty Scale as a predictor of adverse outcomes following aortic valve replacement: a systematic review and meta-analysis.

Socioeconomic disparities in the management and outcomes of acute myocardial infarction (2023)
Journal Article
Weight, N., Moledina, S., Volgman, A. S., Bagur, R., Wijeysundera, H. C., Sun, L. Y., …Mamas, M. A. (2023). Socioeconomic disparities in the management and outcomes of acute myocardial infarction. Heart, heartjnl-2023-322601. https://doi.org/10.1136/heartjnl-2023-322601

Background: Patients from lower socioeconomic status areas have poorer outcomes following acute myocardial infarction (AMI); however, how ethnicity modifies such socioeconomic disparities is unclear. Methods: Using the UK Myocardial Ischaemia Nat... Read More about Socioeconomic disparities in the management and outcomes of acute myocardial infarction.

Time to Benefit of Sodium-Glucose Cotransporter-2 Inhibitors Among Patients With Heart Failure (2023)
Journal Article
Chen, K., Nie, Z., Shi, R., Yu, D., Wang, Q., Shao, F., …Li, C. (2023). Time to Benefit of Sodium-Glucose Cotransporter-2 Inhibitors Among Patients With Heart Failure. Jama Network Open, 6(8), Article e2330754. https://doi.org/10.1001/jamanetworkopen.2023.30754

IMPORTANCE Emerging evidence has consistently demonstrated that sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of heart failure (HF) hospitalization and cardiovascular (CV) death among patients with HF. However, it remains unclear... Read More about Time to Benefit of Sodium-Glucose Cotransporter-2 Inhibitors Among Patients With Heart Failure.

A culturally adapted manual-assisted problem-solving intervention (CMAP) for adults with a history of self-harm: a multi-centre randomised controlled trial (2023)
Journal Article
Husain, N., Kiran, T., Chaudhry, I. B., Williams, C., Emsley, R., Arshad, U., …Chaudhry, N. (in press). A culturally adapted manual-assisted problem-solving intervention (CMAP) for adults with a history of self-harm: a multi-centre randomised controlled trial. BMC Medicine, 21(1), Article 282. https://doi.org/10.1186/s12916-023-02983-8

Background Self-harm is an important predictor of a suicide death. Culturally appropriate strategies for the prevention of self-harm and suicide are needed but the evidence is very limited from low- and middle-income countries (LMICs). This study ai... Read More about A culturally adapted manual-assisted problem-solving intervention (CMAP) for adults with a history of self-harm: a multi-centre randomised controlled trial.

Alzheimer's Disease: Investigating the neuroprotective role of Polyunsaturated fatty acids against β-Amyloid accumulation using SH-SY5Y cell models (2023)
Thesis
Ali, R. (2023). Alzheimer's Disease: Investigating the neuroprotective role of Polyunsaturated fatty acids against β-Amyloid accumulation using SH-SY5Y cell models. (Thesis). Keele University

Alzheimer’s disease is the most common type of dementia characterised by cognitive impairments such as memory loss as well as behavioural symptoms like depression and aggression. The hallmark of the disease is the accumulation of beta-Amyloid (Aβ) as... Read More about Alzheimer's Disease: Investigating the neuroprotective role of Polyunsaturated fatty acids against β-Amyloid accumulation using SH-SY5Y cell models.

Outcomes of Composite Grafts for Pediatric Fingertip Amputations: A Systematic Review (2023)
Journal Article
Jester, N., Han, S., Singh, M., Rao, A. A., Sokhal, B., Ma, Y., & Jester, A. (in press). Outcomes of Composite Grafts for Pediatric Fingertip Amputations: A Systematic Review. Indian Journal of Plastic Surgery, 56(4), 310-319. https://doi.org/10.1055/s-0043-1771295

Introduction: The aim of this study was to explore the outcomes of composite grafts in fingertip amputations in children as well as the contributing factors that may affect outcomes. Methods: Literature search was conducted across six databases... Read More about Outcomes of Composite Grafts for Pediatric Fingertip Amputations: A Systematic Review.