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All Outputs (623)

Reply (2023)
Journal Article
Cipolletta, E., Tata, L. J., Nakafero, G., Avery, A. J., Mamas, M. A., & Abhishek, A. (in press). Reply. Arthritis & Rheumatology, 75(10), 1868-1869. https://doi.org/10.1002/art.42553

Outcomes of Composite Grafts for Pediatric Fingertip Amputations: A Systematic Review (2023)
Journal Article
Jester, N., Han, S., Singh, M., Rao, A. A., Sokhal, B., Ma, Y., & Jester, A. (in press). Outcomes of Composite Grafts for Pediatric Fingertip Amputations: A Systematic Review. Indian Journal of Plastic Surgery, 56(4), 310-319. https://doi.org/10.1055/s-0043-1771295

Introduction: The aim of this study was to explore the outcomes of composite grafts in fingertip amputations in children as well as the contributing factors that may affect outcomes. Methods: Literature search was conducted across six databases... Read More about Outcomes of Composite Grafts for Pediatric Fingertip Amputations: A Systematic Review.

Cardiovascular outcomes in breast cancer survivors: a systematic review and meta-analysis (2023)
Journal Article
Galimzhanov, A., Istanbuly, S., Tun, H. N., Ozbay, B., Alasnag, M., Ky, B., …Mamas, M. A. (in press). Cardiovascular outcomes in breast cancer survivors: a systematic review and meta-analysis. European Journal of Preventive Cardiology, Article zwad243. https://doi.org/10.1093/eurjpc/zwad243

Aims It is unclear whether the future risk of cardiovascular events in breast cancer (bc) survivors is greater than in the general population. This meta-analysis quantifies the risk of cardiovascular disease development in bc patients, compared to th... Read More about Cardiovascular outcomes in breast cancer survivors: a systematic review and meta-analysis.

AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn2B/- spinal muscular atrophy mice Human Molecular Genetics (2023)
Journal Article
Brown, S., Šoltić, D., Synowsky, S. A., Shirran, S. L., Chilcott, E., Shorrock, H. K., …Fuller, H. (2023). AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn2B/- spinal muscular atrophy mice Human Molecular Genetics. Human Molecular Genetics, Article ddad121. https://doi.org/10.1093/hmg/ddad121

Structural, functional and molecular cardiac defects have been reported in spinal muscular atrophy (SMA) patients and mouse models. Previous quantitative proteomics analyses demonstrated widespread molecular defects in the severe Taiwanese SMA mouse... Read More about AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn2B/- spinal muscular atrophy mice Human Molecular Genetics.

Digital health and inpatient palliative care: a cohort-controlled study (2023)
Report
Singh, B. M., Kumari-Dewat, N., Ryder, A., Parry, E., Klaire, V., Matthews, D., …Warren, K. (2023). Digital health and inpatient palliative care: a cohort-controlled study. BMJ

Objectives End of life has unacceptable levels of hospital admission and death. We aimed to determine the association of a novel digital specific system (Proactive Risk-Based and Data-Driven Assessment of Patients at the End of Life, PRADA) to modify... Read More about Digital health and inpatient palliative care: a cohort-controlled study.

The acceptability of the Fire and Rescue Service working with primary care to improve identification of mental health problems in older adults. A mixed-method qualitative study (2023)
Journal Article
Fisher, T., Chew-Graham, C. A., Corp, N., Farooq, S., Kingston, P., Read, I., …Kingstone, T. (2023). The acceptability of the Fire and Rescue Service working with primary care to improve identification of mental health problems in older adults. A mixed-method qualitative study. British Journal of General Practice Open (BJGP Open), 7(4), Article 0059. https://doi.org/10.3399/bjgpo.2023.0059

Impact of Frailty on Clinical Outcomes in Patients With Atrial Fibrillation Who Underwent Cardiac Ablation Using a Nationwide Database (2023)
Journal Article
Diaz-Arocutipa, C., Carvallo-Castañeda, D., Chumbiauca, M., Mamas, M. A., & Hernandez, A. V. (2023). Impact of Frailty on Clinical Outcomes in Patients With Atrial Fibrillation Who Underwent Cardiac Ablation Using a Nationwide Database. American Journal of Cardiology, 203, 98-104. https://doi.org/10.1016/j.amjcard.2023.07.020

This study aimed to assess the association between frailty and clinical outcomes in patients with atrial fibrillation (AF) who undergo catheter ablation. We conducted a retrospective cohort study using the National Inpatient Sample database from 2017... Read More about Impact of Frailty on Clinical Outcomes in Patients With Atrial Fibrillation Who Underwent Cardiac Ablation Using a Nationwide Database.

1600 COMMUNITY-BASED COMPLEX INTERVENTIONS TO SUSTAIN INDEPENDENCE IN OLDER PEOPLE: SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS (2023)
Conference Proceeding
Crocker, T. F., Lam, N., Ensor, J., Jordão, M., Bajpai, R., Bond, M., …Clegg, A. (2023). 1600 COMMUNITY-BASED COMPLEX INTERVENTIONS TO SUSTAIN INDEPENDENCE IN OLDER PEOPLE: SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS. . https://doi.org/10.1093/ageing/afad104.076

Introduction Sustaining independence is important for older people, but there is insufficient guidance about which community services to implement. Methods Systematic review and network meta-analysis (NMA; PROSPERO CRD42019162195) to synthesise effec... Read More about 1600 COMMUNITY-BASED COMPLEX INTERVENTIONS TO SUSTAIN INDEPENDENCE IN OLDER PEOPLE: SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS.

Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming (2023)
Journal Article
Hyland, M., Mennan, C., Davies, R., Wilson, E., Tonge, D. P., Clayton, A., & Kehoe, O. (2023). Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming. Stem Cell Reviews and Reports, 19, 2391–2406. https://doi.org/10.1007/s12015-023-10586-2

Autoimmune conditions, such as rheumatoid arthritis, are characterised by a loss of immune tolerance, whereby the immune cells attack self-antigens causing pain and inflammation. These conditions can be brought into remission using pharmaceutical tre... Read More about Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming.

Sex‐based treatment and outcomes for coronary bifurcation stenting: A report from the e‐ULTIMASTER registry (2023)
Journal Article
Doolub, G., Iannaccone, M., Rab, T., Routledge, H., Aminian, A., Chevalier, B., …Mamas, M. A. (in press). Sex‐based treatment and outcomes for coronary bifurcation stenting: A report from the e‐ULTIMASTER registry. Catheterization and Cardiovascular Interventions, 102(3), 430-439. https://doi.org/10.1002/ccd.30770

Background Percutaneous coronary intervention (PCI) for bifurcation lesions can be technically challenging and is associated with higher risk. There is little data on sex-based differences in strategy and outcomes in bifurcation PCI. Aims We sou... Read More about Sex‐based treatment and outcomes for coronary bifurcation stenting: A report from the e‐ULTIMASTER registry.

Clinical outcome of open ankle fractures in patients above 70 years of age (2023)
Journal Article
Zahra, W., Seifo, M., Cool, P., Ford, D., & Okoro, T. (2023). Clinical outcome of open ankle fractures in patients above 70 years of age. World Journal of Orthopedics, 14(7), 554-561. https://doi.org/10.5312/wjo.v14.i7.554

Background: Open fractures of the ankle are complex injuries requiring multidisciplinary input and are associated with significant morbidity and mortality. However, data on the clinical outcomes of open ankle fracture management in patients older tha... Read More about Clinical outcome of open ankle fractures in patients above 70 years of age.

Prognostic role of CA‐125 in patients undergoing transcatheter aortic valve replacement: A systematic review and meta‐analysis (2023)
Journal Article
Diaz‐Arocutipa, C., Saucedo‐Chinchay, J., & Mamas, M. A. (in press). Prognostic role of CA‐125 in patients undergoing transcatheter aortic valve replacement: A systematic review and meta‐analysis. Clinical Cardiology, 46(10), 1129-1136. https://doi.org/10.1002/clc.24064

Transcatheter aortic valve replacement (TAVR) has become a widely used therapy for patients with severe aortic stenosis. Carbohydrate antigen 125 (CA‐125) is a promising biomarker in some cardiovascular diseases. This systematic review aims to assess... Read More about Prognostic role of CA‐125 in patients undergoing transcatheter aortic valve replacement: A systematic review and meta‐analysis.

Associations between socioeconomic factors and depression in Sri Lanka: The role of gene-environment interplay (2023)
Journal Article
Badini, I., Jayaweera, K., Pannala, G., Adikari, A., Siribaddana, S., Sumathipala, A., …Zavos, H. M. (2023). Associations between socioeconomic factors and depression in Sri Lanka: The role of gene-environment interplay. Journal of Affective Disorders, 340, 1-9. https://doi.org/10.1016/j.jad.2023.07.084

Background: Low socioeconomic status is a risk factor for depression. The nature and magnitude of associations can differ cross-culturally and is influenced by a range of contextual factors. We examined the aetiology of so-cioeconomic indicators and... Read More about Associations between socioeconomic factors and depression in Sri Lanka: The role of gene-environment interplay.

What competencies do European general practice trainees value the most? A prioritisation exercise using a Delphi-informed approach (2023)
Journal Article
Junge, H., Poppleton, A., Sun, S., Janos, S., & Dupont, F. (in press). What competencies do European general practice trainees value the most? A prioritisation exercise using a Delphi-informed approach. Education for Primary Care, 1-7. https://doi.org/10.1080/14739879.2023.2222718

General Practice has changed over the past decade. Expansion of clinicians' roles may create uncertainty, stress, and overload - particular for those at the start of their career. The WONCA Europe network for medical education, EURACT, has published... Read More about What competencies do European general practice trainees value the most? A prioritisation exercise using a Delphi-informed approach.

Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial (2023)
Journal Article
Farooq, S., Sheikh, S., Dikomitis, L., Haq, M. M. U., Khan, A. J., Sanauddin, N., …Lewis, M. (2023). Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial. BMJ Open, 13(7), Article e072471. https://doi.org/10.1136/bmjopen-2023-072471

Objectives In low/middle-income countries (LMICs), more than half of patients with first-episode psychosis initially seek treatment from traditional and religious healers as their first care. This contributes to an excessively long duration of untrea... Read More about Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial.

Chest wall reconstruction reduces hospital mortality following major chest wall trauma: a retrospective cohort study (2023)
Journal Article
Cheruvu, M., Chubsey, R., Blagojevic-Bucknall, M., & Satur, C. (2023). Chest wall reconstruction reduces hospital mortality following major chest wall trauma: a retrospective cohort study. The Annals of The Royal College of Surgeons of England, 105(6), 489-500. https://doi.org/10.1308/rcsann.2022.0155

Introduction Chest wall reconstruction was introduced for the management of patients with severe chest wall injuries. We undertook a retrospective cohort study to investigate whether the treatment was associated with improved survival compared with... Read More about Chest wall reconstruction reduces hospital mortality following major chest wall trauma: a retrospective cohort study.

ALPINE2: Efficacy and safety of 14-day vs 28-day inhaled aztreonam for Pa eradication in children with cystic fibrosis. (2023)
Journal Article
Gilchrist, F. J., Bui, S., Gartner, S., McColley, S. A., Tiddens, H., Ruiz, G., …Skov, M. (in press). ALPINE2: Efficacy and safety of 14-day vs 28-day inhaled aztreonam for Pa eradication in children with cystic fibrosis. Journal of Cystic Fibrosis, 23(1), 80-86. https://doi.org/10.1016/j.jcf.2023.06.008

Antibiotic eradication therapies recommended for newly isolated Pseudomonas aeruginosa (Pa) in people with cystic fibrosis (pwCF) can be burdensome. ALPINE2 compared the efficacy and safety of a shortened 14-day course of aztreonam for inhalation sol... Read More about ALPINE2: Efficacy and safety of 14-day vs 28-day inhaled aztreonam for Pa eradication in children with cystic fibrosis..