Skip to main content

Research Repository

Advanced Search

All Outputs (623)

A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models. (2023)
Journal Article
Hoolachan, J. M., McCallion, E., Sutton, E. R., Çetin, Ö., Pacheco-Torres, P., Dimitriadi, M., …Bowerman, M. (2023). A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models. Human molecular genetics, ddad192. https://doi.org/10.1093/hmg/ddad192

Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder caused by the reduction of survival of motor neuron (SMN) protein levels. Although three SMN-augmentation therapies are clinically approved that significantly slow down disease progres... Read More about A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models..

Abstract 14815: Sex Differences in Transcatheter Aortic Valve Replacement Outcomes Among Patients With Bicuspid Aortic Stenosis: Insights From the National In-Patient Sample (2023)
Journal Article
Rivera, F. B., Redula, S., Liston, M. B., Ong, E., Bantayan, N. R., Choi, S., …Mamas, M. (2023). Abstract 14815: Sex Differences in Transcatheter Aortic Valve Replacement Outcomes Among Patients With Bicuspid Aortic Stenosis: Insights From the National In-Patient Sample. Circulation, 148(Suppl_1), https://doi.org/10.1161/circ.148.suppl_1.14815

Alcoholic cardiomyopathy mortality and social vulnerability index: A nationwide cross-sectional analysis. (2023)
Journal Article
Shahid, M., Ibrahim, R., Arakelyan, A., Hassan, K., Sainbayar, E., Pham, H. N., & Mamas, M. A. (in press). Alcoholic cardiomyopathy mortality and social vulnerability index: A nationwide cross-sectional analysis. International Journal of Cardiology Cardiovascular Risk and Prevention, 19, Article 200224. https://doi.org/10.1016/j.ijcrp.2023.200224

Social vulnerability index (SVI) plays a pivotal role in the outcomes of cardiovascular diseases and prevalence of alcohol use. We evaluated the impact of the SVI on alcoholic cardiomyopathy (ACM) mortality. Mortality data from 1999 to 2020 and the S... Read More about Alcoholic cardiomyopathy mortality and social vulnerability index: A nationwide cross-sectional analysis..

Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed. (2023)
Journal Article
Levis, B., Snell, K. I., Damen, J. A., Hattle, M., Ensor, J., Dhiman, P., …Riley, R. D. (in press). Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed. Journal of Clinical Epidemiology, S0895-4356(23)00282-2. https://doi.org/10.1016/j.jclinepi.2023.10.022

Risk of bias assessments are important in meta-analyses of both aggregate and individual participant data (IPD). There is limited evidence on whether and how risk of bias of included studies or datasets in IPD meta-analyses (IPDMAs) is assessed. We r... Read More about Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed..

Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer (UK TACT2; CRUK/05/19): quality of life results from a multicentre, phase 3, open-label, randomised, controlled trial. (2023)
Journal Article
Velikova, G., Morden, J. P., Haviland, J. S., Emery, C., Barrett-Lee, P., Earl, H., …Cameron, D. (in press). Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer (UK TACT2; CRUK/05/19): quality of life results from a multicentre, phase 3, open-label, randomised, controlled trial. Lancet Oncology, S1470-2045(23)00460-6. https://doi.org/10.1016/S1470-2045%2823%2900460-6

Adjuvant chemotherapy for patients with early breast cancer improves outcomes but its toxicity affects patients' quality of life (QOL). The UK TACT2 trial investigated whether accelerated epirubicin improves time to recurrence and if oral capecitabin... Read More about Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer (UK TACT2; CRUK/05/19): quality of life results from a multicentre, phase 3, open-label, randomised, controlled trial..

In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation. (2023)
Journal Article
Mogas Barcons, A., Chari, D. M., & Adams, C. (in press). In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation. Alternatives to animal experimentation : a journal for new paths in biomedical science / edited by the Swiss Society ALTEX Edition, 41(2), 202-212. https://doi.org/10.14573/altex.2304171

Effective repair of spinal cord injury sites remains a major clinical challenge. One promising strategy is the implantation of multifunctional bioscaffolds to enhance nerve fibre growth, guide regenerating tissue and modulate scarring/inflammation pr... Read More about In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation..

Predictors of outcome in sciatica patients following an epidural steroid injection: the POiSE prospective observational cohort study protocol (2023)
Journal Article
Stynes, S., Snell, K. I., Riley, R. D., Konstantinou, K., Cherrington, A., Daud, N., …Foster, N. E. (2023). Predictors of outcome in sciatica patients following an epidural steroid injection: the POiSE prospective observational cohort study protocol. BMJ Open, 13(11), Article e077776. https://doi.org/10.1136/bmjopen-2023-077776

Introduction: Sciatica can be very painful and, in most cases, is due to pressure on a spinal nerve root from a disc herniation with associated inflammation. For some patients, the pain persists, and one management option is a spinal epidural steroi... Read More about Predictors of outcome in sciatica patients following an epidural steroid injection: the POiSE prospective observational cohort study protocol.

International Variations in Serum PTH and Calcium Levels and Their Mortality Associations in Peritoneal Dialysis Patients: Results from PDOPPS: TH-PO161 (2023)
Presentation / Conference
Nitta, K., Bieber, B., Karaboyas, A., Johnson, D. W., Kanjanabuch, T., Kim, Y., …Kawanishi, H. (2023, November). International Variations in Serum PTH and Calcium Levels and Their Mortality Associations in Peritoneal Dialysis Patients: Results from PDOPPS: TH-PO161. Poster presented at Kidney Week, Philadelphia, PA

Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies (2023)
Journal Article
Abhishek, A., Stevenson, M. D., Nakafero, G., Grainge, M. J., Evans, I., Alabas, O., …Williams, H. C. (2024). Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies. British Journal of Dermatology, 190(4), 559–564. https://doi.org/10.1093/bjd/ljad430

Background There is no evidence base to support the use of 6-monthly monitoring blood tests for the early detection of liver, blood and renal toxicity during established anti-tumour necrosis factor alpha (TNFα) treatment. Objectives To evaluate... Read More about Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies.

A new measure of exercise adherence: the ATEMPT (Adherence To Exercise for Musculoskeletal Pain Tool) (2023)
Journal Article
Bailey, D. L., Bishop, A., McCray, G., Foster, N. E., & Holden, M. A. (2023). A new measure of exercise adherence: the ATEMPT (Adherence To Exercise for Musculoskeletal Pain Tool). British Journal of Sports Medicine, 58(2), bjsports-2022-106347. https://doi.org/10.1136/bjsports-2022-106347

Objectives: This study aimed to (1) develop a new measure of adherence to exercise for musculoskeletal (MSK) pain (Adherence To Exercise for Musculoskeletal Pain Tool: ATEMPT) based on previously conceptualised domains of exercise adherence, (2) repo... Read More about A new measure of exercise adherence: the ATEMPT (Adherence To Exercise for Musculoskeletal Pain Tool).

Bracing Adolescent Idiopathic Scoliosis (BASIS) study – night-time versus full-time bracing in adolescent idiopathic scoliosis: study protocol for a multicentre, randomized controlled trial (2023)
Journal Article
Swaby, L., Perry, D. C., Walker, K., Hind, D., Mills, A., Jayasuriya, R., …Greenwood, S. (2023). Bracing Adolescent Idiopathic Scoliosis (BASIS) study – night-time versus full-time bracing in adolescent idiopathic scoliosis: study protocol for a multicentre, randomized controlled trial. Bone & Joint Open, 4(11), 873-880. https://doi.org/10.1302/2633-1462.411.bjo-2023-0128

Scoliosis is a lateral curvature of the spine with associated rotation, often causing distress due to appearance. For some curves, there is good evidence to support the use of a spinal brace, worn for 20 to 24 hours a day to minimize the curve, makin... Read More about Bracing Adolescent Idiopathic Scoliosis (BASIS) study – night-time versus full-time bracing in adolescent idiopathic scoliosis: study protocol for a multicentre, randomized controlled trial.

Robust Joint Models of Albumin and All-Cause Mortality in Incident Peritoneal Dialysis Patients: A Dynamic Predictions Perspective Adjusting for Competing Risks (2023)
Presentation / Conference
Damgov, I., Kieser, M., Rutherford, P., Lambie, M., Davies, S. J., Wong, M. G., …Schmitt, C. P. (2023, November). Robust Joint Models of Albumin and All-Cause Mortality in Incident Peritoneal Dialysis Patients: A Dynamic Predictions Perspective Adjusting for Competing Risks. Poster presented at ASN Kidney Week, Philadelphia, PA, USA

Sex Differences in the Clinical Outcomes of Patients with Takotsubo Stress Cardiomyopathy: A Meta-analysis of Observational Studies. (2023)
Journal Article
Abusnina, W., Elhouderi, E., Walters, R. W., Al-Abdouh, A., Mostafa, M. R., Ben-Dor, I., …Mamas, M. A. (in press). Sex Differences in the Clinical Outcomes of Patients with Takotsubo Stress Cardiomyopathy: A Meta-analysis of Observational Studies. The American Journal of Cardiology, 211, 316-325. https://doi.org/10.1016/j.amjcard.2023.10.066

The incidence of takotsubo stress cardiomyopathy (TSCM) in males is low compared to females. Sex-based differences in clinical outcomes of TSCM are not well characterized. The aim of this meta-analysis was to analyze whether sex-based differences are... Read More about Sex Differences in the Clinical Outcomes of Patients with Takotsubo Stress Cardiomyopathy: A Meta-analysis of Observational Studies..

Experiences and care needs of children with long Covid: a qualitative study. (2023)
Journal Article
Faux-Nightingale, A., Saunders, B., Burton, C., Chew-Graham, C. A., Somayajula, G., Twohig, H., & Welsh, V. (2023). Experiences and care needs of children with long Covid: a qualitative study. British Journal of General Practice Open (BJGP Open), 8(1), Article 0143. https://doi.org/10.3399/BJGPO.2023.0143

Long Covid, the patient-preferred term, describes symptoms persisting after an acute episode of Covid-19 infection. Symptoms in children and young people (CYP) can affect daily routine, with broader impacts on education, health-related quality of lif... Read More about Experiences and care needs of children with long Covid: a qualitative study..

CSP2023: 460 Exploring healthcare professionals' perspectives on how community pharmacy could better support people living with osteoarthritis: A qualitative interview study (2023)
Presentation / Conference
Simkins, J., White, S., Babatunde, O., & Holden, M. (2023, November). CSP2023: 460 Exploring healthcare professionals' perspectives on how community pharmacy could better support people living with osteoarthritis: A qualitative interview study. Poster presented at Chartered Society of Physiotherapy (CSP) 2023 Annual Conference, Birmingham Conference and Events Centre, Hill Street, , Birmingham, B5 4EW

Osteoarthritis (OA) is a highly prevalent and painful condition that is commonly managed in primary care by various healthcare professionals (HCPs), including physiotherapists (1). Community pharmacy staff have transferable skills that make them well... Read More about CSP2023: 460 Exploring healthcare professionals' perspectives on how community pharmacy could better support people living with osteoarthritis: A qualitative interview study.

Primary care prescribing of orlistat medication for weight management in adults with type 2 diabetes: an epidemiological study (2023)
Thesis
Ghosal, S. (2023). Primary care prescribing of orlistat medication for weight management in adults with type 2 diabetes: an epidemiological study. (Thesis). Keele University

Introduction The incidence of type 2 Diabetes mellitus (T2DM) is increasing and is a major public health burden. Obesity is one of the main modifiable risk factors for T2DM. However no UK studies have assessed the relationship of orlistat, a medica... Read More about Primary care prescribing of orlistat medication for weight management in adults with type 2 diabetes: an epidemiological study.

Association of frailty status with the causes, characteristics and outcomes of patients with cardiovascular disease using electronic health record data (2023)
Thesis
Sokhal, B. S. (2023). Association of frailty status with the causes, characteristics and outcomes of patients with cardiovascular disease using electronic health record data. (Thesis). Keele University

Introduction Cardiovascular disease (CVD) is the commonest cause of morbidity and mortality worldwide. Frailty is a clinical syndrome of physiological decline, resulting in adverse health outcomes. While the bidirectional relationship between CVD a... Read More about Association of frailty status with the causes, characteristics and outcomes of patients with cardiovascular disease using electronic health record data.