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Can analyses of electronic patient records be independently and externally validated? The effect of statins on the mortality of patients with ischaemic heart disease: a cohort study with nested case-control analysis (2014)
Journal Article
(2014). Can analyses of electronic patient records be independently and externally validated? The effect of statins on the mortality of patients with ischaemic heart disease: a cohort study with nested case-control analysis. BMJ Open, e004952 - e004952. https://doi.org/10.1136/bmjopen-2014-004952

Objective To conduct a fully independent and external validation of a research study based on one electronic health record database, using a different electronic database sampling the same population. Design Using the Clinical Practice Research Da... Read More about Can analyses of electronic patient records be independently and externally validated? The effect of statins on the mortality of patients with ischaemic heart disease: a cohort study with nested case-control analysis.

Gelatin-Based Materials in Ocular Tissue Engineering (2014)
Journal Article
(2014). Gelatin-Based Materials in Ocular Tissue Engineering. Materials, 3106 - 3135. https://doi.org/10.3390/ma7043106

Gelatin has been used for many years in pharmaceutical formulation, cell culture and tissue engineering on account of its excellent biocompatibility, ease of processing and availability at low cost. Over the last decade gelatin has been extensively e... Read More about Gelatin-Based Materials in Ocular Tissue Engineering.

Product ion distributions for the reactions of NO(+) with some physiologically significant aldehydes obtained using a SRI-TOF-MS instrument (2014)
Journal Article
(2014). Product ion distributions for the reactions of NO(+) with some physiologically significant aldehydes obtained using a SRI-TOF-MS instrument. International Journal of Mass Spectrometry, 23 - 31. https://doi.org/10.1016/j.ijms.2014.02.016

Product ion distributions for the reactions of NO(+) with 22 aldehydes involved in human physiology have been determined under the prevailing conditions of a selective reagent ionization time of flight mass spectrometry (SRI-TOF-MS) at an E/N in the... Read More about Product ion distributions for the reactions of NO(+) with some physiologically significant aldehydes obtained using a SRI-TOF-MS instrument.

Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000 (2014)
Journal Article
Anderson, R. F., Yadav, P., Patel, D., Reynisson, J., Tipparaju, S. R., Guise, C. P., …Hay, M. P. (in press). Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000. Organic and Biomolecular Chemistry, 12(21), 3386-3392. https://doi.org/10.1039/c4ob00236a

The radical species underlying the activity of the bioreductive anticancer prodrug, SN30000, have been identified by electron paramagnetic resonance and pulse radiolysis techniques. Spin-trapping experiments indicate both an aryl-type radical and an... Read More about Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.

Nesprins: tissue-specific expression of epsilon and other short isoforms (2014)
Journal Article
(2014). Nesprins: tissue-specific expression of epsilon and other short isoforms. PloS one, e94380 -?. https://doi.org/10.1371/journal.pone.0094380

Nesprin-1-giant and nesprin-2-giant regulate nuclear positioning by the interaction of their C-terminal KASH domains with nuclear membrane SUN proteins and their N-terminal calponin-homology domains with cytoskeletal actin. A number of short isoforms... Read More about Nesprins: tissue-specific expression of epsilon and other short isoforms.

Sustained PDGF-BB release from PHBHHx loaded nanoparticles in 3D hydrogel/stem cell model (2014)
Journal Article
(2014). Sustained PDGF-BB release from PHBHHx loaded nanoparticles in 3D hydrogel/stem cell model. Journal of Biomedical Materials Research Part A, 282 -288. https://doi.org/10.1002/jbm.a.35149

This study aimed to design a growth factor loaded copolyester of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx) nanoparticles containing 3D collagen matrix to achieve growth factor sustained release for long-term stimulation of human mesenchymal s... Read More about Sustained PDGF-BB release from PHBHHx loaded nanoparticles in 3D hydrogel/stem cell model.

Vibrational spectroscopy in stem cell characterisation: is there a niche? (2014)
Journal Article
Sulé-Suso, J., Forsyth, N., Untereiner, V., & Sockalingum, G. (2014). Vibrational spectroscopy in stem cell characterisation: is there a niche?. Trends in Biotechnology, 32(5), 254-262. https://doi.org/10.1016/j.tibtech.2014.03.002

Vibrational spectroscopy using both infrared and Raman spectroscopies has been used in recent years with the aim to aid clinicians in disease diagnosis. More recently, these techniques have been applied to study stem cell differentiation and to deter... Read More about Vibrational spectroscopy in stem cell characterisation: is there a niche?.

Dysregulation of ubiquitin homeostasis and ß-catenin signaling promote spinal muscular atrophy (2014)
Journal Article
Wishart, T., Becker, C., Wirth, B., Gillingwater, T., Parson, S., Skehel, P., …Morris, G. (2014). Dysregulation of ubiquitin homeostasis and ß-catenin signaling promote spinal muscular atrophy. Journal of Clinical Investigation, 1821 -1834. https://doi.org/10.1172/JCI71318

The autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA) results from low levels of survival motor neuron (SMN) protein; however, it is unclear how reduced SMN promotes SMA development. Here, we determined that ubiquitin-depend... Read More about Dysregulation of ubiquitin homeostasis and ß-catenin signaling promote spinal muscular atrophy.

Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders (2014)
Journal Article
Simpson, C. M., Robertson, D. M., Al-Musawi, S. L., Heath, D. A., McNatty, K. P., Ritter, L. J., …Stanton, P. G. (2014). Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders. The Journal of Clinical Endocrinology & Metabolism, 99(4), E615-E624. https://doi.org/10.1210/jc.2013-3949

Context: Growth differentiation factor 9 (GDF9) is a central regulator of folliculogenesis and ovulation rate. Fourteen mutations in human (h) GDF9 have been reported in women with premature ovarian failure or polycystic ovarian syndrome as well as... Read More about Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders.

The Stroke Oxygen Study (SO2S) - a multi-center, study to assess whether routine oxygen treatment in the first 72 hours after a stroke improves long-term outcome: study protocol for a randomized controlled trial. (2014)
Journal Article
Roffe, C., Nevatte, T., Crome, P., Gray, R., Sim, J., Pountain, S., …Handy, P. (2014). The Stroke Oxygen Study (SO2S) - a multi-center, study to assess whether routine oxygen treatment in the first 72 hours after a stroke improves long-term outcome: study protocol for a randomized controlled trial. Trials, 15, Article 99. https://doi.org/10.1186/1745-6215-15-99

BACKGROUND: Mild hypoxia is common in stroke patients and may have significant adverse effects on the ischemic brain after stroke. The use of oxygen treatment is rapidly increasing in European stroke units but is not without side effects. It impedes... Read More about The Stroke Oxygen Study (SO2S) - a multi-center, study to assess whether routine oxygen treatment in the first 72 hours after a stroke improves long-term outcome: study protocol for a randomized controlled trial..

Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: retrospective cohort study (2014)
Journal Article
Weich, S., Pearce, H. L., Croft, P., Singh, S., Crome, I., Bashford, J., & Frisher, M. (2014). Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: retrospective cohort study. BMJ, 348(mar19 5), g1996-g1996. https://doi.org/10.1136/bmj.g1996

Objective To test the hypothesis that people taking anxiolytic and hypnotic drugs are at increased risk of premature mortality, using primary care prescription records and after adjusting for a wide range of potential confounders. Design Retrospec... Read More about Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: retrospective cohort study.

Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice (2014)
Journal Article
Bake, T., Murphy, M., Morgan, D., & Mercer, J. (2014). Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice. Appetite, 77, 60 - 71. https://doi.org/10.1016/j.appet.2014.02.020

Male C57BL/6 mice fed ad libitum on control diet but allowed access to a palatable high fat diet (HFD) for 2?h a day during the mid-dark phase rapidly adapt their feeding behaviour and can consume nearly 80% of their daily caloric intake during this... Read More about Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice.

Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension (2014)
Journal Article
Harris, L. E., Morgan, D. G., & Balthasar, N. (2014). Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension. Physiological Reports, 2(3), e00240-?. https://doi.org/10.1002/phy2.240

Growth hormone secretagogue receptor (GHS-R) signaling has been associated with growth hormone release, increases in food intake and pleiotropic cardiovascular effects. Recent data demonstrated that acute GHS-R antagonism leads to increases in mean a... Read More about Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension.

Benefits and harms of extending the duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stents: a meta-analysis (2014)
Journal Article
(2014). Benefits and harms of extending the duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stents: a meta-analysis. Scientific World Journal, https://doi.org/10.1155/2014/794078

Background. The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) is unclear. Methods. We conducted a systematic review and meta-analysis of randomized controlled trials evaluating risk of adverse eve... Read More about Benefits and harms of extending the duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stents: a meta-analysis.

Label free cell tracking in 3-D tissue engineering constructs with high resolution imaging (2014)
Journal Article
Smith, W., Lam, K., Dempsey, K., Mazzocchi-Jones, D., Richardson, J., & Yang, Y. (2014). Label free cell tracking in 3-D tissue engineering constructs with high resolution imaging. Proceedings of SPIE, https://doi.org/10.1117/12.2039354

Within the field of tissue engineering there is an emphasis on studying 3-D live tissue structures. Consequently, to investigate and identify cellular activities and phenotypes in a 3-D environment for all in vitro experiments, including shape, migra... Read More about Label free cell tracking in 3-D tissue engineering constructs with high resolution imaging.

A comparison of psychotropic medication prescribing patterns in East of England prisons and the general population (2014)
Journal Article
Hassan, L., Senior, J., Frisher, M., Edge, D., & Shaw, J. (2014). A comparison of psychotropic medication prescribing patterns in East of England prisons and the general population. Journal of Psychopharmacology, 28(4), 357-362. https://doi.org/10.1177/0269881114523863

While the prevalence of mental illness is higher in prisons than in the community, less is known about comparative rates of psychotropic medicine prescribing. This is the first study in a decade to determine the prevalence and patterns of psychotropi... Read More about A comparison of psychotropic medication prescribing patterns in East of England prisons and the general population.

Reactions of tertiary propargyl alcohols with sodium halides under oxidative conditions (2014)
Journal Article
Aborways, M. M., & Moran, W. J. (2014). Reactions of tertiary propargyl alcohols with sodium halides under oxidative conditions. Tetrahedron Letters, 55(13), 2127-2129. https://doi.org/10.1016/j.tetlet.2014.02.042

The study of the reactions of tertiary propargyl alcohols with sodium halides under oxidative conditions is presented. With sodium iodide, α-iodoenones were formed, however, with sodium bromide or chloride the α-haloenones were only formed in low yie... Read More about Reactions of tertiary propargyl alcohols with sodium halides under oxidative conditions.

Acute mechanical overload increases IGF-I and MMP-9 mRNA in 3D tissue-engineered skeletal muscle (2014)
Journal Article
(2014). Acute mechanical overload increases IGF-I and MMP-9 mRNA in 3D tissue-engineered skeletal muscle. Biotechnology Letters, 1113 - 1124. https://doi.org/10.1007/s10529-014-1464-y

Skeletal muscle (SkM) is a tissue that responds to mechanical load following both physiological (exercise) or pathophysiological (bed rest) conditions. The heterogeneity of human samples and the experimental and ethical limitations of animal studies... Read More about Acute mechanical overload increases IGF-I and MMP-9 mRNA in 3D tissue-engineered skeletal muscle.

Evidence of redox-active iron formation following aggregation of ferrihydrite and the Alzheimer's disease peptide ß-amyloid. (2014)
Journal Article
Telling, & Everett. (2014). Evidence of redox-active iron formation following aggregation of ferrihydrite and the Alzheimer's disease peptide ß-amyloid. Inorganic Chemistry, 2803 - 2809. https://doi.org/10.1021/ic402406g

Recent work has demonstrated increased levels of redox-active iron biominerals in Alzheimer's disease (AD) tissue. However, the origin, nature, and role of iron in AD pathology remains unclear. Using X-ray absorption, X-ray microspectroscopy, and ele... Read More about Evidence of redox-active iron formation following aggregation of ferrihydrite and the Alzheimer's disease peptide ß-amyloid..