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All Outputs (158)

Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. (2018)
Journal Article
Holmes, A. M., Heylings, J. R., Wan, K., & Moss, G. P. (2019). Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. International Journal of Antimicrobial Agents, 53(4), 500-507. https://doi.org/10.1016/j.ijantimicag.2018.12.012

The aim of this study was to investigate a range of poly(amidoamine) (PAMAM) dendrimer generations against Gram-positive and Gram-negative skin pathogens and to determine any differences in antimicrobial potency for different generations, characteris... Read More about Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens..

The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life (2018)
Journal Article
(2019). The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life. Seminars in Arthritis and Rheumatism, 49(1), 20-26. https://doi.org/10.1016/j.semarthrit.2018.12.006

Objective Treat-to-target in rheumatoid arthritis (RA) recommends targeting remission, with low disease activity (LDA) being an alternative goal. When deciding to target remission or LDA, important considerations are the likelihood of attaining them... Read More about The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life.

Evaluating associations between metabolic health, obesity and depressive symptoms: a prospective analysis of data from the English Longitudinal Study of Ageing (ELSA) with a 2-year follow-up. (2018)
Journal Article
Slater, N., Rowley, C., Venables, R., White, S., & Frisher, M. (2018). Evaluating associations between metabolic health, obesity and depressive symptoms: a prospective analysis of data from the English Longitudinal Study of Ageing (ELSA) with a 2-year follow-up. BMJ Open, 8(12), https://doi.org/10.1136/bmjopen-2018-025394

OBJECTIVES: Conflicting results have been reported when the associations between metabolic health, obesity and depression were examined previously. The primary aim of this study was to determine whether metabolic health or obesity are independently a... Read More about Evaluating associations between metabolic health, obesity and depressive symptoms: a prospective analysis of data from the English Longitudinal Study of Ageing (ELSA) with a 2-year follow-up..

Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database (2018)
Journal Article
Mamas. (2018). Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database. JACC. Cardiovascular interventions, 2480-2491. https://doi.org/10.1016/j.jcin.2018.09.035

Objectives Using the British Cardiovascular Intervention Society percutaneous coronary intervention (PCI) database, temporal trends, predictors, and outcomes of radial access (RA) versus femoral access (FA) for unprotected left main stem percutaneou... Read More about Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database.

ERa PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study. (2018)
Journal Article
(2018). ERa PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study. Journal of Orthopaedic Surgery and Research, 316 - ?. https://doi.org/10.1186/s13018-018-1020-x

BACKGROUND: Posterior tibial tendon (PTT) insufficiency is considered as the main cause of adult acquired flat foot and is three times more frequent in females. High estrogen levels exert a positive effect on the overall collagen synthesis in tendons... Read More about ERa PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study..

Marital status and risk of cardiovascular diseases: A systematic review and meta-analysis (2018)
Journal Article
Wong, C., Kwok, C., Narain, A., Gulati, M., Mihalidou, A., Wu, P., …Mamas, M. (2018). Marital status and risk of cardiovascular diseases: A systematic review and meta-analysis. Heart, 1937-1948. https://doi.org/10.1136/heartjnl-2018-313005

Background The influence of marital status on the incidence of cardiovascular disease (CVD) and prognosis after CVD is inconclusive. We systematically reviewed the literature to determine how marital status influences CVD and prognosis after CVD.... Read More about Marital status and risk of cardiovascular diseases: A systematic review and meta-analysis.

Association of comorbid burden with clinical outcomes after transcatheter aortic valve implantation (2018)
Journal Article
Mamas. (2018). Association of comorbid burden with clinical outcomes after transcatheter aortic valve implantation. Heart, 2058-2066. https://doi.org/10.1136/heartjnl-2018-313356

OBJECTIVES To investigate the association of the CharlsonComorbidity Index (CCI) with clinical outcomes after transcatheter aortic valve implantation (TAVI). BACKGROUND: Patients undergoing TAVI have high comorbid burden; however, there is limite... Read More about Association of comorbid burden with clinical outcomes after transcatheter aortic valve implantation.

Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility? (2018)
Journal Article
Davies. (2018). Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility?. Kidney International, 1050 -1052. https://doi.org/10.1016/j.kint.2018.09.012

Peritoneal dialysis technique survival remains challenging due to peritonitis and long-term alterations to peritoneal membrane function and integrity. Up to now, the development of less bio-incompatible dialysis solutions have not had a major impact... Read More about Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility?.

Disparities in mortality among 25–44-year-olds in England: a longitudinal, population-based study (2018)
Journal Article
(2018). Disparities in mortality among 25–44-year-olds in England: a longitudinal, population-based study. The Lancet Public Health, 567 -575. https://doi.org/10.1016/S2468-2667%2818%2930177-4

Summary Background Since the mid-1990s, excess mortality has increased markedly for adults aged 25–44 years in the north compared with the south of England. We examined the underlying causes of this excess mortality and the contribution of socioecono... Read More about Disparities in mortality among 25–44-year-olds in England: a longitudinal, population-based study.

Ectopic Telomerase Expression Fails to Maintain Chondrogenic Capacity in Three-Dimensional Cultures of Clinically Relevant Cell Types. (2018)
Journal Article
Dale, T. P., & Forsyth, N. R. (in press). Ectopic Telomerase Expression Fails to Maintain Chondrogenic Capacity in Three-Dimensional Cultures of Clinically Relevant Cell Types. BioResearch Open Access, 7(1), 10 - 24. https://doi.org/10.1089/biores.2018.0008

The poor healing capacity of cartilage and lack of effective treatment for associated disease and trauma makes it a strong candidate for a regenerative medicine approach. Potential therapies tested to date, although effective, have met with a number... Read More about Ectopic Telomerase Expression Fails to Maintain Chondrogenic Capacity in Three-Dimensional Cultures of Clinically Relevant Cell Types..

The potential of magnetic hyperthermia for triggering the differentiation of cancer cells (2018)
Journal Article
Moise, S., Byrne, J. M., El Haj, A. J., & Telling, N. D. (2018). The potential of magnetic hyperthermia for triggering the differentiation of cancer cells. Nanoscale, 10(44), 20519-20525. https://doi.org/10.1039/c8nr05946b

Magnetic hyperthermia is a potential technique for cancer therapy that exploits heat generated by magnetic nanoparticles to kill cancerous cells. Many studies have shown that magnetic hyperthermia is effective at killing cancer cells both in vitro an... Read More about The potential of magnetic hyperthermia for triggering the differentiation of cancer cells.

Healthcare professionals' perceptions and perspectives on biosimilar medicines and the barriers and facilitators to their prescribing in UK: a qualitative study. (2018)
Journal Article
(2018). Healthcare professionals' perceptions and perspectives on biosimilar medicines and the barriers and facilitators to their prescribing in UK: a qualitative study. BMJ Open, e023603 - ?. https://doi.org/10.1136/bmjopen-2018-023603

OBJECTIVE: To investigate UK healthcare professionals' perceptions and perspectives towards biosimilar infliximab, etanercept and insulin glargine and the potential barriers and facilitators to their prescribing. DESIGN: A cross-sectional qualitative... Read More about Healthcare professionals' perceptions and perspectives on biosimilar medicines and the barriers and facilitators to their prescribing in UK: a qualitative study..

Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts (2018)
Journal Article
Shoaib, A., Kinnaird, T., Curzen, N., Kontopantelis, E., Ludman, P., de Belder, M., …Mamas, M. (2018). Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts. Circulation: Cardiovascular Interventions, 11(11), https://doi.org/10.1161/circinterventions.118.006824

Background: There are limited data on outcomes of patients with previous CABG presenting with NSTEMI undergoing PCI. We compare clinical characteristics and outcomes in NSTEMI patients undergoing PCI with or without prior CABG surgery in a national c... Read More about Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts.

A Perfusion Culture System for Assessing Bone Marrow Stromal Cell Differentiation on PLGA Scaffolds for Bone Repair (2018)
Journal Article
(2018). A Perfusion Culture System for Assessing Bone Marrow Stromal Cell Differentiation on PLGA Scaffolds for Bone Repair. Frontiers in Bioengineering and Biotechnology, 161 -161. https://doi.org/10.3389/fbioe.2018.00161

Biomaterials development for bone repair is currently hindered by the lack of physiologically relevant in vitro testing systems. Here we describe the novel use of a bi-directional perfusion bioreactor to support the long term culture of human bone ma... Read More about A Perfusion Culture System for Assessing Bone Marrow Stromal Cell Differentiation on PLGA Scaffolds for Bone Repair.

FAST Phase III RCT of Radiotherapy Hypofractionation for Treatment of Early Breast Cancer: 10-Year Results (CRUKE/04/015) (2018)
Journal Article
Brunt, A., Haviland, J., Sydenham, M., Algurafi, H., Alhasso, A., Bliss, P., …Yarnold, J. (2018). FAST Phase III RCT of Radiotherapy Hypofractionation for Treatment of Early Breast Cancer: 10-Year Results (CRUKE/04/015). International Journal of Radiation Oncology - Biology - Physics, 102(5), 1603 -1604. https://doi.org/10.1016/j.ijrobp.2018.08.049

Conference abstract.

Comparative Transcriptome and Methylome Analysis in Human Skeletal Muscle Anabolism, Hypertrophy and Epigenetic Memory (2018)
Journal Article
(2018). Comparative Transcriptome and Methylome Analysis in Human Skeletal Muscle Anabolism, Hypertrophy and Epigenetic Memory. bioRxiv, https://doi.org/10.1101/465708

Transcriptome wide changes in human skeletal muscle after acute (anabolic) and chronic resistance exercise (RE) induced hypertrophy have been extensively determined in the literature. We have also recently undertaken DNA methylome analysis (850,000 +... Read More about Comparative Transcriptome and Methylome Analysis in Human Skeletal Muscle Anabolism, Hypertrophy and Epigenetic Memory.

Improving Shared Decision Making Between Patients and Clinicians: Design and Development of a Virtual Patient Simulation Tool. (2018)
Journal Article
Jacklin, S., Maskrey, N., & Chapman, S. (2018). Improving Shared Decision Making Between Patients and Clinicians: Design and Development of a Virtual Patient Simulation Tool. JMIR Medical Education, e10088 - ?. https://doi.org/10.2196/10088

BACKGROUND: Shared decision making (SDM) involves the formation of a collaborative partnership between the patient and clinician combining both of their expertise in order to benefit decision making. In order for clinicians to be able to carry out th... Read More about Improving Shared Decision Making Between Patients and Clinicians: Design and Development of a Virtual Patient Simulation Tool..

Peer assisted learning in pharmacy: The mentor and student perspective (2018)
Journal Article
Micallef, R., & Slater, N. (2018). Peer assisted learning in pharmacy: The mentor and student perspective. Pharmacy Education, 18,

Introduction: Peer assisted learning (PAL) was introduced into a 2nd year pharmacy cohort (n=160) using older students as mentors. Participation in PAL was voluntary. Aim: This study aims to evaluate the Pharmacy Law PAL sessions, from both the st... Read More about Peer assisted learning in pharmacy: The mentor and student perspective.

Incidence and clinical course of limb dysfunction post cardiac catheterization: a systematic review (2018)
Journal Article
Ayyaz Ul Haq, M., Rashid, M., Gilchrist, I. C., Bertrand, O., Shing Kwok, C., Wai Wong, C., …Mamas, M. A. (2018). Incidence and clinical course of limb dysfunction post cardiac catheterization: a systematic review. Circulation Journal, 82(11), 2736. https://doi.org/10.1253/circj.CJ-18-0389

Background We sought to systematically review the available literature on limb dysfunction after transradial or transfemoral cardiac catheterization. Methods & Results MEDLINE and EMBASE were searched for studies evaluating any transradial or... Read More about Incidence and clinical course of limb dysfunction post cardiac catheterization: a systematic review.