All Outputs (117)

Arthroscopic versus mini-open rotator cuff repair: A meta-analysis (2021)
Journal Article
Migliorini, F., Maffulli, N., Eschweiler, J., Schenker, H., Tingart, M., & Betsch, M. (2023). Arthroscopic versus mini-open rotator cuff repair: A meta-analysis. Surgeon, 21(1), e1-e12. https://doi.org/10.1016/j.surge.2021.11.005

Background An all-arthroscopic rotator cuff repair (ASR) may result in less postoperative pain and better functional outcomes than the mini-open (MOR) approach. This meta-analysis provides an updated assessment of the current literature which compar... Read More about Arthroscopic versus mini-open rotator cuff repair: A meta-analysis.

Return to sport after arthroscopic surgery for femoroacetabular impingement (2021)
Journal Article
Migliorini, F., Baroncini, A., Eschweiler, J., Knobe, M., Tingart, M., & Maffulli, N. (2023). Return to sport after arthroscopic surgery for femoroacetabular impingement. Surgeon, 21(1), 21-30. https://doi.org/10.1016/j.surge.2021.11.006

Background Femoroacetabular impingement (FAI) is common among the active and young population. The present study analysed the rate of return to sport, related influencing factors, and the sport activity level according to the Hip Outcome Score - Spo... Read More about Return to sport after arthroscopic surgery for femoroacetabular impingement.

EAHP European Statements Survey 2018, focusing on Section 1: Introductory Statements and Governance, Section 3: Production and Compounding, and Section 4: Clinical Pharmacy Services (2021)
Journal Article
(2021). EAHP European Statements Survey 2018, focusing on Section 1: Introductory Statements and Governance, Section 3: Production and Compounding, and Section 4: Clinical Pharmacy Services. European Journal of Hospital Pharmacy, 26-32. https://doi.org/10.1136/ejhpharm-2019-002028

Objectives The 2018 EAHP European Statements Survey focused on sections 1, 3 and 4 of the European Statements of Hospital Pharmacy. Statistical data on the level of implementation and on the main barriers to implementation of the Statements were col... Read More about EAHP European Statements Survey 2018, focusing on Section 1: Introductory Statements and Governance, Section 3: Production and Compounding, and Section 4: Clinical Pharmacy Services.

The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM) (2021)
Journal Article
Stedman, M., Rea, R., Duff, C. J., Livingston, M., McLoughlin, K., Wong, L., …Heald, A. H. (2022). The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM). https://doi.org/10.1002/edm2.302

BACKGROUND: Finger prick blood glucose (BG) monitoring remains a mainstay of management in people with type 2 diabetes (T2DM) who take sulphonylurea (SU) drugs or insulin. We recently examined patient experience of BG monitoring in people with type 1... Read More about The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM).

UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines. (2021)
Journal Article
Corrà, F., Crudele, F., Baldassari, F., Bianchi, N., Galasso, M., Minotti, L., …Volinia, S. (2021). UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines. Genes, 12(12), Article 1978. https://doi.org/10.3390/genes12121978

In the human genome, there are about 600 ultra-conserved regions (UCRs), long DNA sequences extremely conserved in vertebrates. We performed a large-scale study to quantify transcribed UCR (T-UCR) and miRNA levels in over 6000 cancer and normal tissu... Read More about UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines..

Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device (2021)
Journal Article
Wragg. (2021). Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device. Molecular Therapy - Methods and Clinical Development, 551-566. https://doi.org/10.1016/j.omtm.2021.10.015

Hemophilia A (HA) is a rare bleeding disorder caused by deficiency/dysfunction of the FVIII protein. As current therapies based on frequent FVIII infusions are not a definitive cure, long-term expression of FVIII in endothelial cells through lentivir... Read More about Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device.

Susceptibility vessel sign as a predictor for recanalization and clinical outcome in acute ischaemic stroke: A systematic review and meta-analysis (2021)
Journal Article
(2021). Susceptibility vessel sign as a predictor for recanalization and clinical outcome in acute ischaemic stroke: A systematic review and meta-analysis. Journal of Clinical Neuroscience, 159 - 165. https://doi.org/10.1016/j.jocn.2021.10.017

Objective To assess the prognostic values of susceptibility vessel sign (SVS) on T2*-weighted MRI using GRE and SWI sequences for recanalization status and clinical outcomes in patients with acute ischaemic stroke undergoing different therapies. Meth... Read More about Susceptibility vessel sign as a predictor for recanalization and clinical outcome in acute ischaemic stroke: A systematic review and meta-analysis.

Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial. (2021)
Journal Article
Roffe. (2021). Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial. Stroke, 1141-1148. https://doi.org/10.1161/STROKEAHA.121.035191

BACKGROUND: Seeking consent rapidly in acute stroke trials is crucial as interventions are time sensitive. We explored the association between consent pathways and time to enrollment in the TICH-2 (Tranexamic Acid in Intracerebral Haemorrhage-2) rand... Read More about Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial..

Advanced Hydrogels for Cartilage Tissue Engineering: Recent Progress and Future Directions (2021)
Journal Article
Hafezi, M., Nouri Khorasani, S., Zare, M., Esmaeely Neisiany, R., & Davoodi, P. (2021). Advanced Hydrogels for Cartilage Tissue Engineering: Recent Progress and Future Directions. Polymers, 13(23), Article 4199. https://doi.org/10.3390/polym13234199

Cartilage is a tension- and load-bearing tissue and has a limited capacity for intrinsic self-healing. While microfracture and arthroplasty are the conventional methods for cartilage repair, these methods are unable to completely heal the damaged tis... Read More about Advanced Hydrogels for Cartilage Tissue Engineering: Recent Progress and Future Directions.

Facile synthesis and biological evaluation of chrysin derivatives (2021)
Journal Article
Omonga, N., Zia, Z., Ghanbour, H., Ragazzon-Smith, A., Foster, H., Hadfield, J., & Ragazzon, P. (2021). Facile synthesis and biological evaluation of chrysin derivatives. Journal of Chemical Research, 1083-1092. https://doi.org/10.1177/17475198211057467

In this paper, novel synthetic methods, including microwave O-alkylation, were used to produce several chrysin derivatives. These compounds were purified, characterised and tested on different cell lines and bacterial strains. From this family, 7-(2,... Read More about Facile synthesis and biological evaluation of chrysin derivatives.

Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain. (2021)
Journal Article
Chen. (2021). Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain. Alzheimer's Research and Therapy, 194 - ?. https://doi.org/10.1186/s13195-021-00935-z

BACKGROUND: Alzheimer's disease (AD) is a progressive, degenerative, and terminal disease without cure. There is an urgent need for a new strategy to treat AD. The aim of this study was to investigate the effects of intermittent hypoxic treatment (IH... Read More about Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain..

Greater trochanteric pain syndrome: focused shockwave therapy versus an ultrasound guided injection: a randomised control trial (2021)
Journal Article
Heaver, C., Pinches, M., Kuiper, J. H., Thomas, G., Lewthwaite, S., Burston, B. J., & Banerjee, R. D. (2023). Greater trochanteric pain syndrome: focused shockwave therapy versus an ultrasound guided injection: a randomised control trial. Hip International, 33(3), 490-499. https://doi.org/10.1177/11207000211060396

Greater trochanteric pain syndrome (GTPS) is a common problem with an incidence of 1.8–5.6 per 1000 population. Physiotherapy, anti-inflammatories, corticosteroid injections and surgery have all been described in the management of GTPS, with limited,... Read More about Greater trochanteric pain syndrome: focused shockwave therapy versus an ultrasound guided injection: a randomised control trial.

Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates (2021)
Journal Article
Reynisson, J., Wieczorek-Błauż, A., Kowalczyk, K., Błauż, A., Makal, A., Pawlędzio, S., …Plażuk, D. (2021). Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates. Dalton Transactions, 51(2), 491-508. https://doi.org/10.1039/d1dt03553c

The incorporation of the ferrocenyl moiety into a bioactive molecule may significantly alter the activity of the resulting conjugate. By applying this strategy, we designed ferrocenyl analogs of monastrol - the first low molecular weight kinesin spin... Read More about Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates.

Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles (2021)
Journal Article
Curtis. (2021). Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles. Nanomaterials, 2976 - 2976. https://doi.org/10.3390/nano11112976

Hybrid iron oxide-gold nanoparticles are of increasing interest for applications in nanomedicine, photonics, energy storage, etc. However, they are often difficult to synthesise without experience or 'know-how'. Additionally, standard protocols do no... Read More about Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles.

Testosterone Therapy: Increase in Hematocrit is Associated with Decreased Mortality (2021)
Journal Article
(2021). Testosterone Therapy: Increase in Hematocrit is Associated with Decreased Mortality. Androgens, 150 - 159. https://doi.org/10.1089/andro.2021.0019

Objective: Testosterone therapy (TTh) may reduce morbidity/mortality in men with adult-onset testosterone deficiency (TD), though some cardiovascular safety concerns remain. Increased hematocrit (HCT), a recognized effect of therapy, may be associate... Read More about Testosterone Therapy: Increase in Hematocrit is Associated with Decreased Mortality.

Case-finding and improving patient outcomes for chronic obstructive pulmonary disease in primary care: the BLISS research programme including cluster RCT (2021)
Journal Article
Adab, P., Jordan, R. E., Fitzmaurice, D., Ayres, J. G., Cheng, K., Cooper, B. G., …Turner, A. (2021). Case-finding and improving patient outcomes for chronic obstructive pulmonary disease in primary care: the BLISS research programme including cluster RCT. Programme Grants for Applied Research, 9(13), 1 - 148. https://doi.org/10.3310/pgfar09130

BackgroundChronic obstructive pulmonary disease is a major contributor to morbidity, mortality and health service costs but is vastly underdiagnosed. Evidence on screening and how best to approach this is not clear. There are also uncertainties aroun... Read More about Case-finding and improving patient outcomes for chronic obstructive pulmonary disease in primary care: the BLISS research programme including cluster RCT.

Bringing ethical dilemmas to life; the use of drama teaching in healthcare education (2021)
Journal Article
Jacklin, S., & Allinson, M. (2021). Bringing ethical dilemmas to life; the use of drama teaching in healthcare education. The Journal of Academic Development and Education, https://doi.org/10.21252/29rw-zt56

Context and objectives Empathy is an important element that underpins a health professional’s ability to handle ethical dilemmas involving patients, with a focus on providing person-centred care. The aim of this project was to evaluate the use of an... Read More about Bringing ethical dilemmas to life; the use of drama teaching in healthcare education.

Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance (2021)
Journal Article
Pearson. (2021). Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance. Molecules, 6581 - 6581. https://doi.org/10.3390/molecules26216581

Glyceryl trinitrate (GTN) is one of the earliest known treatments for angina with a fascinating history that bridges three centuries. However, despite its central role in the nitric oxide (NO) story as a NO-donating compound, establishing the precise... Read More about Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance.

Physoxia alters human mesenchymal stem cell secretome (2021)
Journal Article
(2021). Physoxia alters human mesenchymal stem cell secretome. Journal of Tissue Engineering, https://doi.org/10.1177/20417314211056132

The human mesenchymal stem cell (hMSC) secretome has pleiotropic effects which underpin their therapeutic potential. hMSC serum-free conditioned media (SFCM) has been determined to contain a variety of cytokines with roles in regeneration and suppres... Read More about Physoxia alters human mesenchymal stem cell secretome.

Predictors of postoperative hospital length of stay after total knee arthroplasty. (2021)
Journal Article
(2021). Predictors of postoperative hospital length of stay after total knee arthroplasty. https://doi.org/10.11622/smedj.2021142

INTRODUCTION: To collect and analyse clinical and functional variables of patients undergoing rehabilitation after total knee arthroplasty (TKA), in order to identify which amongst them could influence the post-operative length of hospital stay (LOS)... Read More about Predictors of postoperative hospital length of stay after total knee arthroplasty..