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A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation (2024)
Journal Article
Campbell, K., Naire, S., & Kuiper, J.-H. (2024). A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation. Journal of Theoretical Biology, Article 111874. https://doi.org/10.1016/j.jtbi.2024.111874

Treating bone-cartilage defects is a fundamental clinical problem. The ability of damaged cartilage to self-repair is limited due to its avascularity. Left untreated, these defects can lead to osteoarthritis. Details of osteochondral defect repair ar... Read More about A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation.

Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis (2024)
Journal Article
Echrish, J., Pasca, M.-I., Cabrera, D., Yang, Y., & Harper, A. G. S. (2024). Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis. Biomimetics, 9(6), Article 372. https://doi.org/10.3390/biomimetics9060372

Acute cardiovascular events result from clots caused by the rupture and erosion of atherosclerotic plaques. This paper aimed to produce a functional biomimetic hydrogel of the neointimal layer of the atherosclerotic plaque that can support thrombogen... Read More about Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis.

Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study (2024)
Journal Article
Bullock, L., Manning, F., Hawarden, A., Fleming, J., Leyland, S., Clark, E. M., …Paskins, Z. (in press). Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study. Archives of Osteoporosis, 19(1), Article 50. https://doi.org/10.1007/s11657-024-01410-6

Summary: Interviews and focus groups with patients, FLS clinicians, and GPs identified challenges relating to clinical and shared decision-making about bone health and osteoporosis medicines. Findings will inform the development of the multicomponent... Read More about Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study.

Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1 (2024)
Journal Article
Kuiper, J., Campbell, K., & Naire, S. (in press). Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1. Journal of Theoretical Biology,

Treating bone-cartilage defects is a fundamental clinical problem. The ability of damaged cartilage to self-repair is limited due to its avascularity. Left untreated, these defects can lead to osteoarthritis. Details of osteochondral defect repair ar... Read More about Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1.

Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency (2024)
Journal Article
Haider, K. S., Zitzmann, M., Ramachandran, P., König, C. S., Hackett, G., Haider, A., …Ramachandran, S. (2024). Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency. The aging male : the official journal of the International Society for the Study of the Aging Male, 27(1), Article 2357548. https://doi.org/10.1080/13685538.2024.2357548

Objective We evaluated change (Δ) in AMSS in men with adult-onset testosterone deficiency (TD) on/not on testosterone undecanoate (TU) by analysing a registry of men with adult-onset TD. Methods Analyses were performed using non-parametric stati... Read More about Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency.

Surgical approach on combined chronic patellar tendon and bicruciate knee ligament injury (2024)
Journal Article
Piedade, S. R., Górios, C., Spiezia, F., & Maffulli, N. (in press). Surgical approach on combined chronic patellar tendon and bicruciate knee ligament injury. Journal of Orthopaedic Surgery and Research, 19(1), 319. https://doi.org/10.1186/s13018-024-04724-w

A combined injury of the patellar tendon and both the anterior and posterior cruciate ligaments is disabling. It directly affects knee kinematics and biomechanics, presenting a considerable surgical challenge. In this complex and uncommon injury, dec... Read More about Surgical approach on combined chronic patellar tendon and bicruciate knee ligament injury.

Management of Medial Femorotibial Knee Osteoarthritis in Conjunction with Anterior Cruciate Ligament Deficiency: Technical Note and Literature Review (2024)
Journal Article
Legnani, C., Ventura, A., Mangiavini, L., Maffulli, N., & Peretti, G. M. (in press). Management of Medial Femorotibial Knee Osteoarthritis in Conjunction with Anterior Cruciate Ligament Deficiency: Technical Note and Literature Review. Journal of Clinical Medicine, 13(11), Article 3143. https://doi.org/10.3390/jcm13113143

In recent years, there has been increased interest in the management of medial femorotibial knee osteoarthritis (OA) in conjunction with anterior cruciate ligament (ACL) deficiency. Traditional treatment modalities included conservative therapy, high... Read More about Management of Medial Femorotibial Knee Osteoarthritis in Conjunction with Anterior Cruciate Ligament Deficiency: Technical Note and Literature Review.

Physiotherapeutic and non-conventional approaches in patients with chronic low-back pain: a level I Bayesian network meta-analysis (2024)
Journal Article
Baroncini, A., Maffulli, N., Schäfer, L., Manocchio, N., Bossa, M., Foti, C., …Migliorini, F. (in press). Physiotherapeutic and non-conventional approaches in patients with chronic low-back pain: a level I Bayesian network meta-analysis. Scientific Reports, 14(1), 11546. https://doi.org/10.1038/s41598-024-62276-9

Chronic low back pain (cLBP) is a major cause of disability and healthcare expenditure worldwide. Its prevalence is increasing globally from somatic and psychosocial factors. While non-pharmacological management, and in particular physiotherapy, has... Read More about Physiotherapeutic and non-conventional approaches in patients with chronic low-back pain: a level I Bayesian network meta-analysis.

Copper(II) Complexes with Isomeric Morpholine-Substituted 2-Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both Ribonucleotide Reductase and Tubulin Polymerization: The Morpholine Position Matters (2024)
Journal Article
Milunovic, M. N. M., Ohui, K., Besleaga, I., Petrasheuskaya, T. V., Dömötör, O., Enyedy, É. A., …Arion, V. B. (in press). Copper(II) Complexes with Isomeric Morpholine-Substituted 2-Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both Ribonucleotide Reductase and Tubulin Polymerization: The Morpholine Position Matters. Journal of Medicinal Chemistry, https://doi.org/10.1021/acs.jmedchem.4c00259

The development of copper(II) thiosemicarbazone complexes as potential anticancer agents, possessing dual functionality as inhibitors of R2 ribonucleotide reductase (RNR) and tubulin polymerization by binding at the colchicine site, presents a promis... Read More about Copper(II) Complexes with Isomeric Morpholine-Substituted 2-Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both Ribonucleotide Reductase and Tubulin Polymerization: The Morpholine Position Matters.

Better outcomes using suture button compared to screw fixation in talofibular syndesmotic injuries of the ankle: a level I evidence-based meta-analysis. (2024)
Journal Article
Migliorini, F., Maffulli, N., Cocconi, F., Schäfer, L., Bell, A., Katusic, D., & Vaishya, R. (in press). Better outcomes using suture button compared to screw fixation in talofibular syndesmotic injuries of the ankle: a level I evidence-based meta-analysis. Archives of Orthopaedic and Trauma Surgery, https://doi.org/10.1007/s00402-024-05354-x

The present meta-analysis evaluated current level I clinical trials which compared the use of a suture button (SB) versus syndesmotic screw (SS) fixation techniques for syndesmosis injuries of the ankle. The outcomes of interest were to compare patie... Read More about Better outcomes using suture button compared to screw fixation in talofibular syndesmotic injuries of the ankle: a level I evidence-based meta-analysis..

Deciphering the Molecular Mechanisms behind Drug Resistance in Ovarian Cancer to Unlock Efficient Treatment Options (2024)
Journal Article
Nunes, M., Bartosch, C., Abreu, M. H., Richardson, A., Almeida, R., & Ricardo, S. (in press). Deciphering the Molecular Mechanisms behind Drug Resistance in Ovarian Cancer to Unlock Efficient Treatment Options. Cells, 13(9), Article 786. https://doi.org/10.3390/cells13090786

Ovarian cancer is a highly lethal form of gynecological cancer. This disease often goes undetected until advanced stages, resulting in high morbidity and mortality rates. Unfortunately, many patients experience relapse and succumb to the disease due... Read More about Deciphering the Molecular Mechanisms behind Drug Resistance in Ovarian Cancer to Unlock Efficient Treatment Options.

Update on the intriguing roles of AQP4 expression and redistribution in the progression and treatment of glioma (2024)
Journal Article
Chen, R., Lan, Y., & Zou, S. (in press). Update on the intriguing roles of AQP4 expression and redistribution in the progression and treatment of glioma. Annals of Medicine,

Aquaporin 4 (AQP4) isabundant in the human brain and has an important role in brain homeostatsis and diseases. AQP4 expression has been found to be associated with glioma malignancies. However, the complete understanding of the biological processes... Read More about Update on the intriguing roles of AQP4 expression and redistribution in the progression and treatment of glioma.

Return to Sport at Preinjury Level is Common After Surgical Treatment of SLAP Lesions: A Systematic Review and a Meta-analysis. (2024)
Journal Article
Gregori, P., Maffulli, N., Abboud, J., Za, P., Giurazza, G., Papalia, G. F., …Franceschetti, E. (in press). Return to Sport at Preinjury Level is Common After Surgical Treatment of SLAP Lesions: A Systematic Review and a Meta-analysis. Sports Medicine and Arthroscopy Review, 32(1), 2-11. https://doi.org/10.1097/JSA.0000000000000383

Patients undergoing surgery for Superior-Labrum-anterior-to-posterior (SLAP) lesions are often worried about their return to sport performance. This systematic review determined the rate of return to sport and return to sport at the previous level (R... Read More about Return to Sport at Preinjury Level is Common After Surgical Treatment of SLAP Lesions: A Systematic Review and a Meta-analysis..

Carbon Reduction Impact from Synchronising PrescriptionS (CRISPS): A pilot study (2024)
Journal Article
Cork, T., & White, S. (2024). Carbon Reduction Impact from Synchronising PrescriptionS (CRISPS): A pilot study. International Journal of Pharmacy Practice, 32(Supplement_1), i12-i13. https://doi.org/10.1093/ijpp/riae013.016

Introduction Synchronising the dates of patients’ repeat prescriptions can reduce monthly community pharmacy visits or home deliveries, which may improve patients’ adherence to medicines.[1] It should also reduce carbon dioxide (CO2) emissions associ... Read More about Carbon Reduction Impact from Synchronising PrescriptionS (CRISPS): A pilot study.

Long head of biceps tendon augmentation for massive rotator cuff tears improves clinical results regardless of the number of tendons involved (2024)
Journal Article
Savarese, E., Aicale, R., Torsiello, E., Bernardini, G., & Maffulli, N. (in press). Long head of biceps tendon augmentation for massive rotator cuff tears improves clinical results regardless of the number of tendons involved. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1002/ksa.12184

Purpose Management of massive rotator cuff tears (MRCTs) remains debated, and various arthroscopic and open techniques have been described for their management. Nevertheless, the optimal strategy remains unclear. The present study evaluated the clin... Read More about Long head of biceps tendon augmentation for massive rotator cuff tears improves clinical results regardless of the number of tendons involved.

Predictors of success of pharmacological management in patients with chronic lower back pain: systematic review (2024)
Journal Article
Baroncini, A., Maffulli, N., Mian, M., Vaishya, R., Simeone, F., & Migliorini, F. (in press). Predictors of success of pharmacological management in patients with chronic lower back pain: systematic review. Journal of Orthopaedic Surgery and Research, 19(1), Article 248. https://doi.org/10.1186/s13018-024-04741-9

Background Conservative management is recommended as the first therapeutic step in chronic low back pain (LBP), but there is no available evidence regarding the possible effect of patients’ baseline characteristics on the therapeutic outcomes. A sys... Read More about Predictors of success of pharmacological management in patients with chronic lower back pain: systematic review.

Designing a primary care pharmacist-led review for people treated with opioids for persistent pain: a multi-method qualitative study (2024)
Journal Article
Woodcock, C., Cornwall, N., Dikomitis, L., Harrisson, S. A., White, S., Helliwell, T., …Jinks, C. (2024). Designing a primary care pharmacist-led review for people treated with opioids for persistent pain: a multi-method qualitative study. British Journal of General Practice Open (BJGP Open), Article BJGPO.2023.0221. https://doi.org/10.3399/BJGPO.2023.0221

Background Opioids are frequently prescribed for persistent non-cancer pain despite limited evidence of long-term effectiveness and risk of harm. Evidence-based interventions to address inappropriate opioid prescribing are lacking. Aim To explore... Read More about Designing a primary care pharmacist-led review for people treated with opioids for persistent pain: a multi-method qualitative study.

Hospital corridors as lived spaces: The reconfiguration of social boundaries during the early stages of the Covid pandemic (2024)
Journal Article
Faux-Nightingale, A., Kelemen, M., Lilley, S., Robinson, K., & Stewart, C. (2024). Hospital corridors as lived spaces: The reconfiguration of social boundaries during the early stages of the Covid pandemic. Sociology of Health & Illness, https://doi.org/10.1111/1467-9566.13777

This article explores the meanings and uses of a hospital corridor through 98 diary entries produced by the staff of an English specialist hospital during the early stages of the COVID‐19 pandemic. Drawing on Lefebvre's (1991, The production of space... Read More about Hospital corridors as lived spaces: The reconfiguration of social boundaries during the early stages of the Covid pandemic.

The Increased Dissolution and Oral Absorption of Itraconazole by Nanocrystals with an Endogenous Small-Molecule Surfactant as a Stabilizer (2024)
Journal Article
Chang, S., Yang, Q., Liu, J., Yin, L., Han, J., Zong, L., & Pu, X. (in press). The Increased Dissolution and Oral Absorption of Itraconazole by Nanocrystals with an Endogenous Small-Molecule Surfactant as a Stabilizer. Molecules, 29(8), Article 1769. https://doi.org/10.3390/molecules29081769

The aim of this study was to develop cholic-acid-stabilized itraconazole nanosuspensions (ITZ-Nanos) with the objective of enhancing drug dissolution and oral absorption. A laboratory-scale microprecipitation–high-pressure homogenization method was e... Read More about The Increased Dissolution and Oral Absorption of Itraconazole by Nanocrystals with an Endogenous Small-Molecule Surfactant as a Stabilizer.