All Outputs (1775)

Crystallization kinetics and soft magnetic properties in metalloid-free (Fe, Co)90Zr10 amorphous and nanocrystalline alloys (2014)
Journal Article
Blázquez, J., Ipus, J., Conde, C., Cabrera, D., Franco, V., & Conde, A. (2014). Crystallization kinetics and soft magnetic properties in metalloid-free (Fe, Co)90Zr10 amorphous and nanocrystalline alloys. Journal of Alloys and Compounds, 615, S213-S216. https://doi.org/10.1016/j.jallcom.2014.01.095

Microstructure and magnetic properties of metalloid-free (Fe100−xCox)90Zr10 amorphous and nanocrystalline alloys were characterized. Devitrification of these amorphous alloys occurs in two overlapped transformations leading to the formation of α-Fe(C... Read More about Crystallization kinetics and soft magnetic properties in metalloid-free (Fe, Co)90Zr10 amorphous and nanocrystalline alloys.

Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells. (2014)
Journal Article
Wright, K., & Roberts, S. (2014). Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells. Spine Journal, 1722 - 1733. https://doi.org/10.1016/j.spinee.2014.01.021

BACKGROUND CONTEXT: Transplantation of bone marrow cells into spinal cord lesions promotes functional recovery in animal models, and recent clinical trials suggest possible recovery also in humans. The mechanisms responsible for these improvements ar... Read More about Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells..

Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy (2014)
Journal Article
Jenkins, S., Pickard, M., Khong, M., Smith, H., Mann, C., Emes, R., & Chari, D. (2014). Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy. ACS chemical neuroscience, 51 -63. https://doi.org/10.1021/cn400167n

Corticosteroid (CS) therapy is used widely in the treatment of a range of pathologies, but can delay production of myelin, the insulating sheath around central nervous system nerve fibers. The cellular targets of CS action are not fully understood, t... Read More about Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy.

Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53. (2014)
Journal Article
Akram, K. M., Lomas, N. J., Forsyth, N. R., & Spiteri, M. A. (2014). Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53. International Journal of Clinical and Experimental Pathology, 7(2), 552-564

Idiopathic pulmonary fibrosis (IPF) is a progressive, debilitating, and fatal lung disease of unknown aetiology with no current cure. The pathogenesis of IPF remains unclear but repeated alveolar epithelial cell (AEC) injuries and subsequent apoptosi... Read More about Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53..

Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development (2014)
Journal Article
Sudiman, J., Ritter, L. J., Feil, D. K., Wang, X., Chan, K., Mottershead, D. G., …Gilchrist, R. B. (2014). Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development. Journal of Assisted Reproduction and Genetics, 31(3), 295-306. https://doi.org/10.1007/s10815-013-0152-5

Purpose We hypothesised that varying native oocyte-secreted factor (OSF) exposure or using different recombinant OSF peptides would have differential effects on post-in vitro maturation (IVM) embryo and fetal development. Methods Mouse cumulus o... Read More about Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development.

Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas (2014)
Journal Article
Jain, H., Richardson, A., Meyer-Hermann, M., & Byrne, H. (2014). Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas. PloS one, e81582 - ?. https://doi.org/10.1371/journal.pone.0081582

Platinum drug-resistance in ovarian cancers mediated by anti-apoptotic proteins such as Bcl-xL is a major factor contributing to the chemotherapeutic resistance of recurrent disease. Consequently, concurrent inhibition of Bcl-xL in combination with c... Read More about Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas.

Multidrug and optimal heart failure therapy prescribing in older general practice populations: a clinical data linkage study (2014)
Journal Article
(2014). Multidrug and optimal heart failure therapy prescribing in older general practice populations: a clinical data linkage study. BMJ Open, e003698 - ?. https://doi.org/10.1136/bmjopen-2013-003698

OBJECTIVE: To investigate multidrug therapy in the cardiovascular disease (CVD) population and whether it was associated with suboptimal drug prescribing in heart failure (HF). DESIGN: A population-based cross-sectional clinical data linkage study. S... Read More about Multidrug and optimal heart failure therapy prescribing in older general practice populations: a clinical data linkage study.

Late diagnosis among our ageing HIV population: a cohort study (2014)
Journal Article
(2014). Late diagnosis among our ageing HIV population: a cohort study. Journal of the International AIDS Society, 19692 -?. https://doi.org/10.7448/IAS.17.4.19692

INTRODUCTION: With the advent of combined antiretroviral therapy (cART), more people infected with HIV are living into older age; 22% of adults receiving care in the UK are aged over 50 years [1]. Age influences HIV infection; the likelihood of seroc... Read More about Late diagnosis among our ageing HIV population: a cohort study.

The early use of botulinum toxin in post-stroke spasticity: study protocol for a randomised controlled trial (2014)
Journal Article
(2014). The early use of botulinum toxin in post-stroke spasticity: study protocol for a randomised controlled trial. Trials, 12 -?. https://doi.org/10.1186/1745-6215-15-12

BACKGROUND: Patients surviving stroke but who have significant impairment of function in the affected arm are at more risk of developing pain, stiffness and contractures. The abnormal muscle activity, associated with post-stroke spasticity, is though... Read More about The early use of botulinum toxin in post-stroke spasticity: study protocol for a randomised controlled trial.

Incidence of psychoses among drug dependent patients in primary care with no psychiatric history: a retrospective observational matched-cohort study (2013)
Journal Article
Frisher, M., Martino, O. I., Bashford, J., Crome, I., & Croft, P. (in press). Incidence of psychoses among drug dependent patients in primary care with no psychiatric history: a retrospective observational matched-cohort study. The European Journal of Psychiatry, 27(4), 240-247. https://doi.org/10.4321/s0213-61632013000400002

Background and Objectives: While several studies have indicated a link between illicit drug use and the development of psychosis, the confounding role of pre-existing psychiatric illness is unclear. This study controls for this factor to a greater ex... Read More about Incidence of psychoses among drug dependent patients in primary care with no psychiatric history: a retrospective observational matched-cohort study.

aV ß5 and CD44 are oxygen-regulated human embryonic stem cell attachment factors (2013)
Journal Article
(2013). aV ß5 and CD44 are oxygen-regulated human embryonic stem cell attachment factors. BioMed Research International, 729281 - ?. https://doi.org/10.1155/2013/729281

Human embryonic stem cells (hESCs) have great potential for clinical therapeutic use. However, relatively little is known of the mechanisms which dictate their specificity of adhesion to substrates through adhesion proteins including integrins. Previ... Read More about aV ß5 and CD44 are oxygen-regulated human embryonic stem cell attachment factors.

A novel semi-supervised methodology for extracting tumor type-specific MRS sources in human brain data (2013)
Journal Article
(2013). A novel semi-supervised methodology for extracting tumor type-specific MRS sources in human brain data. PloS one, e83773 - e83773. https://doi.org/10.1371/journal.pone.0083773

Background: The clinical investigation of human brain tumors often starts with a non-invasive imaging study, providing information about the tumor extent and location, but little insight into the biochemistry of the analyzed tissue. Magnetic Resonanc... Read More about A novel semi-supervised methodology for extracting tumor type-specific MRS sources in human brain data.

Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro (2013)
Journal Article
(2013). Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro. NeuroReport, 1041 -1046. https://doi.org/10.1097/WNR.0000000000000071

Factors controlling proliferation and differentiation are crucial in advancement of neural cell-based experimental neurodegenerative therapies. In this regard, nicotinamide has been shown to determine the fate of neural cells, enhance neuralization,... Read More about Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro.

Biosynthesis of Zinc Substituted Magnetite Nanoparticles with Enhanced Magnetic Properties (2013)
Journal Article
Byrne, T. M., Coker, V. S., Cespedes, E., Wincott, P. L., Vaughan, D. J., Pattrick, R. A. D., …Telling, N. D. (2014). Biosynthesis of Zinc Substituted Magnetite Nanoparticles with Enhanced Magnetic Properties. Advanced functional materials, 24(17), 2518-2529. https://doi.org/10.1002/adfm.201303230

The magnetic moments of magnetite nanoparticles are dramatically enhanced through the addition of zinc in a microbiologically driven synthesis procedure. The particles are produced through the reduction of Fe(III)-compounds containing Zn(II) by the i... Read More about Biosynthesis of Zinc Substituted Magnetite Nanoparticles with Enhanced Magnetic Properties.

The development of thieno[2,3-b]pyridine analogues as anticancer agents applying in silico methods (2013)
Journal Article
Arabshahi, H. J., Leung, E., Barker, D., & Reynisson, J. (2014). The development of thieno[2,3-b]pyridine analogues as anticancer agents applying in silico methods. MedChemComm, 5(2), 186. https://doi.org/10.1039/c3md00320e

The chemical space surrounding a class of thieno[2,3-b]pyridines was investigated by testing their commercially available derivatives against the NCI60 panel of human tumour cell lines. The results from the nineteen analogues revealed that ortho- and... Read More about The development of thieno[2,3-b]pyridine analogues as anticancer agents applying in silico methods.

Effects of a specific MCHR1 antagonist (GW803430) on energy budget and glucose metabolism in diet‐induced obese mice (2013)
Journal Article
Zhang, L., Sinclair, R., Selman, C., Mitchell, S., Morgan, D., Clapham, J. C., & Speakman, J. R. (2014). Effects of a specific MCHR1 antagonist (GW803430) on energy budget and glucose metabolism in diet‐induced obese mice. Obesity, 22(3), 681-690. https://doi.org/10.1002/oby.20418

Objective The melanin-concentrating hormone (MCH) is a centrally acting peptide implicated in the regulation of energy homeostasis and body weight, although its role in glucose homeostasis is uncertain. Our objective was to determine effects of MCHR... Read More about Effects of a specific MCHR1 antagonist (GW803430) on energy budget and glucose metabolism in diet‐induced obese mice.

CuI-catalyzed cycloisomerization of propargyl amides (2013)
Journal Article
Moran, W., & Alhalib, A. (2014). CuI-catalyzed cycloisomerization of propargyl amides. Organic and Biomolecular Chemistry, 12(5), 795-800. https://doi.org/10.1039/c3ob42030b

The synthesis of substituted dihydrooxazoles by the CuI-catalyzed cycloisomerization of terminal propargyl amides is reported. The reaction has been shown to have good substrate scope and experiments to delineate the mechanism have been performed. Su... Read More about CuI-catalyzed cycloisomerization of propargyl amides.

Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival (2013)
Journal Article
Davies, S. (2013). Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival. Journal of the American Society of Nephrology, 2071 - 2080. https://doi.org/10.1681/ASN.2013030314

Systemic inflammation, as evidenced by elevated inflammatory cytokines, is a feature of advanced renal failure and predicts worse survival. Dialysate IL-6 concentrations associate with variability in peritoneal small solute transport rate (PSTR), whi... Read More about Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival.

The effects of surgical lengthening of hamstring muscles in children with cerebral palsy – The consequences of pre-operative muscle length measurement (2013)
Journal Article
Laracca, E., Stewart, C., Postans, N., & Roberts, A. (2014). The effects of surgical lengthening of hamstring muscles in children with cerebral palsy – The consequences of pre-operative muscle length measurement. Gait and Posture, 39(3), 847-851. https://doi.org/10.1016/j.gaitpost.2013.11.010

The effect of a thieno[2,3-b]pyridine PLC-γ inhibitor on the proliferation, morphology, migration and cell cycle of breast cancer cells (2013)
Journal Article
Leung, E., Hung, J. M., Barker, D., & Reynisson, J. (in press). The effect of a thieno[2,3-b]pyridine PLC-γ inhibitor on the proliferation, morphology, migration and cell cycle of breast cancer cells. MedChemComm, 5(1), 99-106. https://doi.org/10.1039/c3md00290j

3-Amino-N-(3-chlorophenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (compound 1) is a putative phosphoinositide specific-phospholipase C-γ (PLC-γ) enzyme inhibitor. This enzyme is a plausible anticancer target linked to cell motil... Read More about The effect of a thieno[2,3-b]pyridine PLC-γ inhibitor on the proliferation, morphology, migration and cell cycle of breast cancer cells.