All Outputs (1775)

Killer bee molecules: antimicrobial peptides as effector molecules to target sporogonic stages of Plasmodium (2013)
Journal Article
(2013). Killer bee molecules: antimicrobial peptides as effector molecules to target sporogonic stages of Plasmodium. PLOS pathogens a peer-reviewed open-access journal published by the Public Library of Science, e1003790 -?. https://doi.org/10.1371/journal.ppat.1003790

A new generation of strategies is evolving that aim to block malaria transmission by employing genetically modified vectors or mosquito pathogens or symbionts that express anti-parasite molecules. Whilst transgenic technologies have advanced rapidly,... Read More about Killer bee molecules: antimicrobial peptides as effector molecules to target sporogonic stages of Plasmodium.

Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor. (2013)
Journal Article
Fisher, N., Hilton-Bolt, T., G Edwards, M., J Haxton, K., McKenzie, M., Allin, S. M., & Richardson, A. (2014). Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor. ACS medicinal chemistry letters, 5(1), 34-39. https://doi.org/10.1021/ml4003106

Autotaxin is an extracellular phospholipase D that catalyzes the hydrolysis of lysophosphatidyl choline (LPC) to bioactive lipid lysophosphatidic acid (LPA). LPA has been implicated in many pathological processes relevant to cancer, including cell mi... Read More about Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor..

Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases (2013)
Journal Article
Fuller, H. R., Humphrey, E. L., & Morris, G. E. (2013). Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases. Future Medicinal Chemistry, 5(17), 2091-2101. https://doi.org/10.4155/fmc.13.165

There are several lines of laboratory-based evidence emerging to suggest that purified polyphenol compounds such as resveratrol, found naturally in red grapes, epigallocatechin galate from green tea and curcumin from turmeric, might be useful for the... Read More about Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases.

Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method (2013)
Journal Article
Guan, G., Li, C., Ling, Y., Yang, Y., Vorstius, J. B., Keatch, R. P., …Huang, Z. (2013). Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method. Journal of Biomedical Optics, 18(11), 111417. https://doi.org/10.1117/1.jbo.18.11.111417

Damage of collagen fibers in tendons is often directly related to changes in a tendon’s mechanical properties. Direct quantitative elasticity measurement of tendons will provide important information in tendon dysfunction diagnosis and treatment asse... Read More about Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method.

Rilpivirine inhibits drug transporters ABCB1, SLC22A1, and SLC22A2 in vitro (2013)
Journal Article
(2013). Rilpivirine inhibits drug transporters ABCB1, SLC22A1, and SLC22A2 in vitro. Antimicrobial Agents and Chemotherapy, 5612-5618. https://doi.org/10.1128/AAC.01421-13

Rilpivirine is a nonnucleoside reverse transcriptase inhibitor approved for treatment of HIV-1 infection in antiretroviral-naive adult patients. Potential interactions with drug transporters have not been fully investigated. Transport by and inhibiti... Read More about Rilpivirine inhibits drug transporters ABCB1, SLC22A1, and SLC22A2 in vitro.

Ponseti casting for club foot – above- or below-knee?: A prospective randomised clinical trial (2013)
Journal Article
Maripuri, S. N., Gallacher, P. D., Bridgens, J., Kuiper, J. H., & Kiely, N. T. (2013). Ponseti casting for club foot – above- or below-knee?: A prospective randomised clinical trial. The Bone & Joint Journal, 95-B(11), 1570-1574. https://doi.org/10.1302/0301-620x.95b11.31899

We undertook a randomised clinical trial to compare treatment times and failure rates between above- and below-knee Ponseti casting groups. Eligible children with idiopathic clubfoot, treated using the Ponseti method, were randomised to either below-... Read More about Ponseti casting for club foot – above- or below-knee?: A prospective randomised clinical trial.

Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases (2013)
Journal Article
Wright, K. T., Mennan, C., Fox, H., Richardson, J. B., Banerjee, R., & Roberts, S. (2013). Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases. Regenerative Medicine, 8(6), 699 - 709. https://doi.org/10.2217/rme.13.67

AIM: Autologous chondrocyte implantation (ACI) is used worldwide for the treatment of cartilage defects. This study has aimed to assess for the first time the cells that are contained within human ACI repair tissues several years post-treatment. We h... Read More about Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases.

Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO2 silica dispersion technology (2013)
Journal Article
Guan, J., Han, J., Zhang, D., Chu, C., Liu, H., Sun, J., …Zhang, T. (2014). Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO2 silica dispersion technology. European Journal of Pharmaceutics and Biopharmaceutics, 86(3), 376-382. https://doi.org/10.1016/j.ejpb.2013.10.008

The aim of this study was to design a silica-supported solid dispersion of a water-insoluble drug, glyburide, to increase its dissolution rate and oral absorption using supercritical fluid (SCF) technology. DSC and PXRD results indicated that the enc... Read More about Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO2 silica dispersion technology.

Bristol girls dance project (BGDP): protocol for a cluster randomised controlled trial of an after-school dance programme to increase physical activity among 11–12 year old girls (2013)
Journal Article
(2013). Bristol girls dance project (BGDP): protocol for a cluster randomised controlled trial of an after-school dance programme to increase physical activity among 11–12 year old girls. BMC Public Health, https://doi.org/10.1186/1471-2458-13-1003

Background Many children do not meet current UK physical activity (PA) guidelines. Girls are less active than boys throughout childhood, and the age-related decline in PA, particularly from early adolescence, is steeper for girls than for boys. Danc... Read More about Bristol girls dance project (BGDP): protocol for a cluster randomised controlled trial of an after-school dance programme to increase physical activity among 11–12 year old girls.

A histological comparison of the repair tissue formed when using either Chondrogide® or periosteum during autologous chondrocyte implantation (2013)
Journal Article
McCarthy, H., & Roberts, S. (2013). A histological comparison of the repair tissue formed when using either Chondrogide® or periosteum during autologous chondrocyte implantation. Osteoarthritis and Cartilage, 21(12), 2048-2057. https://doi.org/10.1016/j.joca.2013.10.004

Objective In this study, we compare the clinical and histological outcome between periosteum and Chondrogide® during autologous chondrocyte implantation (ACI). Method This study consisted of 88 patients having received ACI in the knee; 33 treate... Read More about A histological comparison of the repair tissue formed when using either Chondrogide® or periosteum during autologous chondrocyte implantation.

Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells--a rheumatoid arthritis mouse model (2013)
Journal Article
El Haj, A., Kehoe, O., Morris, R., & Markides, H. (2013). Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells--a rheumatoid arthritis mouse model. Stem Cell Research and Therapy, 126 -?. https://doi.org/10.1186/scrt337

INTRODUCTION: The application of mesenchymal stem cells (MSCs) in treating rheumatoid arthritis (RA) has been made possible by the immunosuppressive and differentiation abilities of these cells. A non-invasive means of assessing cell integration and... Read More about Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells--a rheumatoid arthritis mouse model.

Disadvantaged former miners’ perspectives on smoking cessation: A qualitative study (2013)
Journal Article
White, S., & Baird, W. (2013). Disadvantaged former miners’ perspectives on smoking cessation: A qualitative study. Health Education Journal, 72(6), 755-760. https://doi.org/10.1177/0017896912468817

Objective: To explore disadvantaged former miners’ perspectives in north Derbyshire, United Kingdom (UK) on smoking and smoking cessation. Methods: In-depth, audiotaped interviews with 16 disadvantaged former miners who smoked or had stopped smoki... Read More about Disadvantaged former miners’ perspectives on smoking cessation: A qualitative study.

Pericellular Ca(2+) recycling potentiates thrombin-evoked Ca(2+) signals in human platelets. (2013)
Journal Article
Sage, S., Pugh, N., Farndale, R., & Harper, A. (2013). Pericellular Ca(2+) recycling potentiates thrombin-evoked Ca(2+) signals in human platelets. https://doi.org/10.1002/phy2.85

We have previously demonstrated that Na(+)/Ca(2+) exchangers (NCXs) potentiate Ca(2+) signaling evoked by thapsigargin in human platelets, via their ability to modulate the secretion of autocoids from dense granules. This link was confirmed in platel... Read More about Pericellular Ca(2+) recycling potentiates thrombin-evoked Ca(2+) signals in human platelets..

Association of glycation gap with mortality and vascular complications in diabetes (2013)
Journal Article
(2013). Association of glycation gap with mortality and vascular complications in diabetes. Diabetes Care, 3247 -3253. https://doi.org/10.2337/dc12-1040

OBJECTIVE: The "glycation gap" (G-gap), an essentially unproven concept, is an empiric measure of disagreement between HbA1c and fructosamine, the two indirect estimates of glycemic control. Its association with demographic features and key clinical... Read More about Association of glycation gap with mortality and vascular complications in diabetes.

Teaching clinical reasoning to medical students (2013)
Journal Article
(2013). Teaching clinical reasoning to medical students. Clinical Teacher, 308 - 312. https://doi.org/10.1111/tct.12043

BACKGROUND: Keele Medical School's new curriculum includes a 5-week course to extend medical students' consultation skills beyond those historically required for competent inductive diagnosis. CONTEXT: Clinical reasoning is a core skill for the pract... Read More about Teaching clinical reasoning to medical students.

Abstract A085: miR-222/221 in aggressive breast cancer (2013)
Journal Article
Di Leva, G., Piovan, C., Cheung, D., Briskin, D., Kumar, A., Nuovo, G., …Croce, C. (2013). Abstract A085: miR-222/221 in aggressive breast cancer. Molecular Cancer Research, 11(10_Supplement), A085-A085. https://doi.org/10.1158/1557-3125.advbc-a085

MicroRNAs (miRNAs) are small non coding RNAs that regulate gene expression at post-transcriptional level through translational inhibition and/or degradation of mRNA target genes. Recent evidence points to a widespread role for miRNAs in the initiatio... Read More about Abstract A085: miR-222/221 in aggressive breast cancer.

Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury (2013)
Journal Article
Weightman, A., Jenkins, S., Pickard, M., Chari, D., & Yang, Y. (2014). Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury. Nanomedicine: Nanotechnology, Biology and Medicine, 10(2), 291-295. https://doi.org/10.1016/j.nano.2013.09.001

Non-neuronal cells of the central nervous system (CNS), termed “neuroglia,” play critical roles in neural regeneration; therefore, replacement of glial populations via implantable nanofabricated devices (providing a growth-permissive niche) is a prom... Read More about Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury.

Receptor-targeted, magneto-mechanical stimulation of osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (2013)
Journal Article
(2013). Receptor-targeted, magneto-mechanical stimulation of osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. International Journal of Molecular Sciences, 19276 - 19293. https://doi.org/10.3390/ijms140919276

Mechanical cues are employed to promote stem cell differentiation and functional tissue formation in tissue engineering and regenerative medicine. We have developed a Magnetic Force Bioreactor (MFB) that delivers highly targeted local forces to cells... Read More about Receptor-targeted, magneto-mechanical stimulation of osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.

A microscopic and macroscopic study of aging collagen on its molecular structure, mechanical properties, and cellular response (2013)
Journal Article
Wilson, S. L., Guilbert, M., Sulé‐Suso, J., Torbet, J., Jeannesson, P., Sockalingum, G. D., & Yang, Y. (2014). A microscopic and macroscopic study of aging collagen on its molecular structure, mechanical properties, and cellular response. FASEB Journal, 28(1), 14-25. https://doi.org/10.1096/fj.13-227579

During aging, collagen structure changes, detrimentally affecting tissues' biophysical and biomechanical properties due to an accumulation of advanced glycation end-products (AGEs). In this investigation, we conducted a parallel study of microscopic... Read More about A microscopic and macroscopic study of aging collagen on its molecular structure, mechanical properties, and cellular response.

Corneal Stromal Cell Plasticity: In Vitro Regulation of Cell Phenotype Through Cell-Cell Interactions in a Three-Dimensional Model (2013)
Journal Article
Wilson, S. L., Yang, Y., & El Haj, A. J. (2014). Corneal Stromal Cell Plasticity: In Vitro Regulation of Cell Phenotype Through Cell-Cell Interactions in a Three-Dimensional Model. Tissue engineering. Part A, 20(1-2), 225-238. https://doi.org/10.1089/ten.tea.2013.0167

In vivo, epithelial cells are connected both anatomically and functionally with stromal keratocytes. Co-culturing aims at recapturing this cellular anatomy and functionality by bringing together two or more cell types within the same culture environm... Read More about Corneal Stromal Cell Plasticity: In Vitro Regulation of Cell Phenotype Through Cell-Cell Interactions in a Three-Dimensional Model.