All Outputs (114)

A facile in vitro model to study rapid mineralization in bone tissues (2014)
Journal Article
Yang, Y. (2014). A facile in vitro model to study rapid mineralization in bone tissues. BioMedical Engineering OnLine, 136 - ?. https://doi.org/10.1186/1475-925X-13-136

BACKGROUND: Mineralization in bone tissue involves stepwise cell-cell and cell-ECM interaction. Regulation of osteoblast culture microenvironments can tailor osteoblast proliferation and mineralization rate, and the quality and/or quantity of the fin... Read More about A facile in vitro model to study rapid mineralization in bone tissues.

Fit for purpose? A qualitative study of key stakeholders’ perspectives on pharmaceutical needs assessments. (2014)
Presentation / Conference
Hamilton, J., Cork, T., Zaman, H., & White, S. (2014, September). Fit for purpose? A qualitative study of key stakeholders’ perspectives on pharmaceutical needs assessments. Poster presented at Royal Pharmaceutical Society (RPS), Annual Conference 2014, ICC Birmingham UK

PNAs were introduced in 2004, revised by Primary Care Trusts (PCTs) between 2009 and 2011 and, since April 2013, are in the process of being reviewed again by the new Health and Wellbeing Boards (HWBs) for completion in 2015. A previous questionnaire... Read More about Fit for purpose? A qualitative study of key stakeholders’ perspectives on pharmaceutical needs assessments..

Daylight robbery: Hospitals admissions for childhood asthma in English regions are inversely associated with hours of sunshine (2014)
Presentation / Conference
Carroll, W., Saunders, A., Ismail, K., Farrell, W., Emes, R., & Fryer, A. (2014, September). Daylight robbery: Hospitals admissions for childhood asthma in English regions are inversely associated with hours of sunshine. Presented at 22nd Annual Congress, Munich, Germany

Background: Vitamin D is implicated in the expression of childhood asthma but it is difficult to pick apart cause and effect from observational data. If lack of vitamin D is secondary to a sedentary lifestyle then weather patterns should not effect a... Read More about Daylight robbery: Hospitals admissions for childhood asthma in English regions are inversely associated with hours of sunshine.

Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy (2014)
Journal Article
Guilbert, M., Eklouh-Molinier, C., Wehbe, K., Sulé-Suso, J., Yang, Y., Cinque, G., …Sockalingum, G. D. (2014). Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy. Journal of Biomedical Optics, 19(11), 111612. https://doi.org/10.1117/1.jbo.19.11.111612

We report here on a first study using synchrotron radiation-based Fourier transform infrared microspectroscopy and imaging to investigate HT1080 human fibrosarcoma cells grown onto different-aged type I collagen networks. Spectral images were analy... Read More about Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy.

Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives (2014)
Journal Article
Hung, J. M., Arabshahi, H. J., Leung, E., Reynisson, J., & Barker, D. (2014). Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives. European Journal of Medicinal Chemistry, 86, 420-437. https://doi.org/10.1016/j.ejmech.2014.09.001

Forty seven thieno[2,3-b]pyridines-2-carboxamides, furo[2,3-b]pyridines-2-carboxamides and tetrahydrothieno[2,3-b]quinolones-2-carboxamides derivatives were synthesized and tested for their antiproliferative activity against the NCI-60 cell lines. Th... Read More about Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives.

Diagnosis and management of Neuro-Behçet's disease: international consensus recommendations. (2014)
Journal Article
(2014). Diagnosis and management of Neuro-Behçet's disease: international consensus recommendations. Journal of Neurology, 1662 - 1676. https://doi.org/10.1007/s00415-013-7209-3

Neuro-Behçet's disease (NBD) is one of the more serious manifestations of Behçet's disease (BD), which is a relapsing inflammatory multisystem disease with an interesting epidemiology. Though NBD is relatively uncommon, being potentially treatable, n... Read More about Diagnosis and management of Neuro-Behçet's disease: international consensus recommendations..

Optimizing nanomedicine pharmacokinetics using physiologically based pharmacokinetics modelling (2014)
Journal Article
(2014). Optimizing nanomedicine pharmacokinetics using physiologically based pharmacokinetics modelling. British Journal of Pharmacology, 3963-3979. https://doi.org/10.1111/bph.12604

The delivery of therapeutic agents is characterized by numerous challenges including poor absorption, low penetration in target tissues and non-specific dissemination in organs, leading to toxicity or poor drug exposure. Several nanomedicine strategi... Read More about Optimizing nanomedicine pharmacokinetics using physiologically based pharmacokinetics modelling.

The effect of a phospholipase C gamma inhibitor on the proliferation and phenotype of Du145 prostate cancer cells (2014)
Presentation / Conference
Muzinic, N. R., Mastelic, A., Markotic, A., Culic, V. C., Ross, A., Vuica-Ross, M., …Reynisson, J. (2014, August). The effect of a phospholipase C gamma inhibitor on the proliferation and phenotype of Du145 prostate cancer cells. Poster presented at FEBS EMBO 2014 Conference, Paris, France

Introduction: Prostate cancer remains the second most common cause of cancer related death among men, highlighting the need for new therapies. Many cancer cellular functions have been dis-covered to be regulated by phospholipase C (PLC) gamma activat... Read More about The effect of a phospholipase C gamma inhibitor on the proliferation and phenotype of Du145 prostate cancer cells.

Pharmacy students’ perceptions on interacting with people with mental health problems: a qualitative study (2014)
Conference Proceeding
Sidhu, J., Zamanb, H., & White, S. (2014). Pharmacy students’ perceptions on interacting with people with mental health problems: a qualitative study.

Previous research suggests that pharmacy workplace contact and the mental health content of undergraduate pharmacy education may not improve students’ negative attitudes towards people with mental health problems.1 However, studies have not explored... Read More about Pharmacy students’ perceptions on interacting with people with mental health problems: a qualitative study.

Bacterially synthesized ferrite nanoparticles for magnetic hyperthermia applications (2014)
Journal Article
Céspedes, E., Byrne, J. M., Farrow, N., Moise, S., Coker, V. S., Bencsik, M., …Telling, N. D. (in press). Bacterially synthesized ferrite nanoparticles for magnetic hyperthermia applications. Nanoscale, 6(21), 12958-12970. https://doi.org/10.1039/c4nr03004d

Magnetic hyperthermia uses AC stimulation of magnetic nanoparticles to generate heat for cancer cell destruction. Whilst nanoparticles produced inside magnetotactic bacteria have shown amongst the highest reported heating to date, these particles are... Read More about Bacterially synthesized ferrite nanoparticles for magnetic hyperthermia applications.

Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15 (2014)
Journal Article
Reader, K. L., Mottershead, D. G., Martin, G. A., Gilchrist, R. B., Heath, D. A., McNatty, K. P., & Juengel, J. L. (2016). Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15. Reproduction, Fertility and Development, 28(4), 491. https://doi.org/10.1071/rd14099

Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) act synergistically to regulate granulosa cell proliferation and steroid production in several species. Several non-Sma and mothers against decapentaplegic (SMAD) signal... Read More about Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15.

Modulation of Magnetic Heating via Dipolar Magnetic Interactions in Monodisperse and Crystalline Iron Oxide Nanoparticles (2014)
Journal Article
Salas, G., Camarero, J., Cabrera, D., Takacs, H., Varela, M., Ludwig, R., …Teran, F. J. (2014). Modulation of Magnetic Heating via Dipolar Magnetic Interactions in Monodisperse and Crystalline Iron Oxide Nanoparticles. Journal of Physical Chemistry C, 118(34), 19985-19994. https://doi.org/10.1021/jp5041234

In the pursuit of controlling the heat exposure mediated by magnetic nanoparticles, we provide new guidelines for tailoring magnetic relaxation processes via dipolar interactions. For this purpose, highly crystalline and monodisperse magnetic iron ox... Read More about Modulation of Magnetic Heating via Dipolar Magnetic Interactions in Monodisperse and Crystalline Iron Oxide Nanoparticles.

Product ion distributions for the reactions of NO(+) with some physiologically significant volatile organosulfur and organoselenium compounds obtained using a selective reagent ionization time-of-flight mass spectrometer (2014)
Journal Article
(2014). Product ion distributions for the reactions of NO(+) with some physiologically significant volatile organosulfur and organoselenium compounds obtained using a selective reagent ionization time-of-flight mass spectrometer. Rapid communications in mass spectrometry RCM, 1683 - 1690. https://doi.org/10.1002/rcm.6947

RATIONALE: The reactions of NO(+) with volatile organic compounds (VOCs) in Selective Reagent Ionization Time-of-Flight Mass Spectrometry (SRI-TOF-MS) reactors are relatively poorly known, inhibiting their use for trace gas analysis. The rationale fo... Read More about Product ion distributions for the reactions of NO(+) with some physiologically significant volatile organosulfur and organoselenium compounds obtained using a selective reagent ionization time-of-flight mass spectrometer.

A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication (2014)
Journal Article
(2014). A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication. Journal of Antimicrobial Chemotherapy, 3275-3281. https://doi.org/10.1093/jac/dku312

Objectives Recent clinical data have suggested high raltegravir concentrations in gut tissue after oral administration, with implications for treatment and prevention. We have used in silico, in vitro, ex vivo and in vivo models to further investiga... Read More about A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication.

Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis (2014)
Journal Article
Mamas. (2014). Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis. Open Heart, e000092 -?. https://doi.org/10.1136/openhrt-2014-000092

OBJECTIVE: The objective of this study is to evaluate the efficacy and safety of renal denervation in patients with resistant hypertension. METHODS: We searched MEDLINE and EMBASE for studies that evaluated the use of catheter-based renal sympathetic... Read More about Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis.

Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges (2014)
Journal Article
Jenkins, S., Yiu, H., Rosseinsky, M., & Chari, D. (2014). Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges. Molecular and Cellular Therapies, https://doi.org/10.1186/2052-8426-2-23

Oligodendrocyte precursor cells (OPCs) have shown high promise as a transplant population to promote regeneration in the central nervous system, specifically, for the production of myelin - the protective sheath around nerve fibers. While clinical tr... Read More about Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges.

Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists (2014)
Journal Article
McCoull, W., Barton, P., Brown, A. J., Bowker, S. S., Cameron, J., Clarke, D. S., …Morgan, D. (2014). Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists. Journal of Medicinal Chemistry, 57(14), 6128 - 6140

Ghrelin plays a major physiological role in the control of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offer utility as antiobesity agents by lowering the set-point for hunger between meals. We identif... Read More about Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists.

Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence (2014)
Journal Article
Mottershead. (2014). Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence. PloS one, https://doi.org/10.1371/journal.pone.0103563

Developmental competence of in vitro matured (IVM) oocytes needs to be improved and this can potentially be achieved by adding recombinant bone morphogenetic protein 15 (BMP15) or growth differentiation factor (GDF9) to IVM. The aim of this study was... Read More about Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence.

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice (2014)
Journal Article
Chen, R. L., Ogunshola, O. O., Yeoh, K. K., Jani, A., Papadakis, M., Nagel, S., …Buchan, A. M. (2014). HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice. Journal of Neurochemistry, 131(2), 177-189. https://doi.org/10.1111/jnc.12804

This study investigated the effects of 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetic acid (IOX3), a selective small molecule inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylases, on mouse brains subject to transient focal cerebra... Read More about HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.

Anti-ovarian cancer activities of alkaloids from Triclisia subcordata olive (Menispermecaea) (2014)
Conference Proceeding
Uche, F., Li, W., Richardson, A., & Greenhough, T. Anti-ovarian cancer activities of alkaloids from Triclisia subcordata olive (Menispermecaea). . https://doi.org/10.1055/s-0034-1382585

This study investigates the anticancer activities of Triclisia subcordata, identifies and elucidates the structure(s) of the bioactive anticancer compound. The evaluation of anticancer activity was done by in vitro sulforhodamine B dye method using A... Read More about Anti-ovarian cancer activities of alkaloids from Triclisia subcordata olive (Menispermecaea).