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A Pilot Study of Ion - Molecule Reactions at Temperatures Relevant to the Atmosphere of Titan (2016)
Journal Article
(2016). A Pilot Study of Ion - Molecule Reactions at Temperatures Relevant to the Atmosphere of Titan. Origins of Life and Evolution of Biospheres, 533-538. https://doi.org/10.1007/s11084-016-9499-9

Reliable theoretical models of the chemical kinetics of the ionosphere of Saturn's moon, Titan, is highly dependent on the precision of the rates of the reactions of ambient ions with hydrocarbon molecules at relevant temperatures. A Variable Tempera... Read More about A Pilot Study of Ion - Molecule Reactions at Temperatures Relevant to the Atmosphere of Titan.

Does skeletal muscle have an 'epi'-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise (2016)
Journal Article
(2016). Does skeletal muscle have an 'epi'-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise. Aging cell, 603 - 616. https://doi.org/10.1111/acel.12486

Skeletal muscle mass, quality and adaptability are fundamental in promoting muscle performance, maintaining metabolic function and supporting longevity and healthspan. Skeletal muscle is programmable and can ‘remember’ early-life metabolic stimuli af... Read More about Does skeletal muscle have an 'epi'-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise.

Staying connected: structural integration at the intervertebral disc–vertebra interface of human lumbar spines (2016)
Journal Article
(2016). Staying connected: structural integration at the intervertebral disc–vertebra interface of human lumbar spines. European Spine Journal, 248 -258. https://doi.org/10.1007/s00586-016-4560-y

Purpose To investigate the microscopic fibrous integration between the intervertebral disc, cartilage endplates and vertebral endplates in human lumbar spines of varying degrees of degeneration using differential interference contrast (DIC) optics.... Read More about Staying connected: structural integration at the intervertebral disc–vertebra interface of human lumbar spines.

Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells (2016)
Journal Article
Abed, M., Abdullah, M., & Richardson, A. (2016). Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells. Journal of Ovarian Research, 25 - ?. https://doi.org/10.1186/s13048-016-0234-y

BACKGROUND: BH3 mimetics are a class of drugs that antagonize the Bcl-2 family of apoptosis inhibitors. We have previously shown that these compounds can potentiate the activity of carboplatin against several ovarian cancer cell lines. However, recen... Read More about Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells.

L-glutamine Improves Skeletal Muscle Cell Differentiation and Prevents Myotube Atrophy After Cytokine (TNF-alpha) Stress Via Reduced p38 MAPK Signal Transduction (2016)
Journal Article
(2016). L-glutamine Improves Skeletal Muscle Cell Differentiation and Prevents Myotube Atrophy After Cytokine (TNF-alpha) Stress Via Reduced p38 MAPK Signal Transduction. Journal of Cellular Physiology, 2720 - 2732. https://doi.org/10.1002/jcp.25380

Tumour Necrosis Factor-Alpha (TNF-a) is chronically elevated in conditions where skeletal muscle loss occurs. As l-glutamine can dampen the effects of inflamed environments, we investigated the role of l-glutamine in both differentiating C2C12 myobla... Read More about L-glutamine Improves Skeletal Muscle Cell Differentiation and Prevents Myotube Atrophy After Cytokine (TNF-alpha) Stress Via Reduced p38 MAPK Signal Transduction.

Hydration Free Energy as a Molecular Descriptor in Drug Design: A Feasibility Study (2016)
Journal Article
Zafar, A., & Reynisson, J. (2016). Hydration Free Energy as a Molecular Descriptor in Drug Design: A Feasibility Study. Molecular Informatics, 35(5), 207-214. https://doi.org/10.1002/minf.201501035

In this work the idea was investigated whether calculated hydration energy (ΔGhyd) can be used as a molecular descriptor in defining promising regions of chemical space for drug design. Calculating ΔGhyd using the Density Solvation Model (SMD) in con... Read More about Hydration Free Energy as a Molecular Descriptor in Drug Design: A Feasibility Study.

Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. (2016)
Journal Article
Garcia, J., Wright, K., Roberts, S., Herman Kuiper, J., Mangham, C., Richardson, J., & Mennan, C. (2016). Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. Scientific reports, 6, 24295 -?. https://doi.org/10.1038/srep24295

The infrapatellar fat pad (FP) and synovial fluid (SF) in the knee serve as reservoirs of mesenchymal stromal cells (MSCs) with potential therapeutic benefit. We determined the influence of the donor on the phenotype of donor matched FP and SF derive... Read More about Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus..

MRSI-based molecular imaging of therapy response to temozolomide in preclinical glioblastoma using source analysis (2016)
Journal Article
(2016). MRSI-based molecular imaging of therapy response to temozolomide in preclinical glioblastoma using source analysis. NMR in Biomedicine, 732-743. https://doi.org/10.1002/nbm.3521

Characterization of glioblastoma (GB) response to treatment is a key factor for improving patients' survival and prognosis. MRI and magnetic resonance spectroscopic imaging (MRSI) provide morphologic and metabolic profiles of GB but usually fail to p... Read More about MRSI-based molecular imaging of therapy response to temozolomide in preclinical glioblastoma using source analysis.

Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial (2016)
Journal Article
Roffe. (2016). Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial. International Journal of Stroke, 683-694. https://doi.org/10.1177/1747493016641960

Rationale Outcome after intracerebral hemorrhage remains poor. Tranexamic acid is easy to administer, readily available, inexpensive, and effective in other hemorrhagic conditions. Aim This randomized trial aims to test the hypothesis that intra... Read More about Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial.

Outcomes following primary percutaneous coronary intervention in patients with previous coronary artery bypass surgery (2016)
Journal Article
Mamas. (2016). Outcomes following primary percutaneous coronary intervention in patients with previous coronary artery bypass surgery. Circulation: Cardiovascular Interventions, https://doi.org/10.1161/circinterventions.115.003151

Background: There are limited data on outcomes of patients with previous coronary artery bypass grafting (CABG) presenting with ST-segment elevation myocardial infarction (STEMI) and undergoing primary percutaneous coronary intervention (PPCI). We re... Read More about Outcomes following primary percutaneous coronary intervention in patients with previous coronary artery bypass surgery.

Acute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3-week regimen delivered in the UK FAST-Forward Trial (2016)
Journal Article
Brunt, A. M., Wheatley, D., Yarnold, J., Somaiah, N., Kelly, S., Harnett, A., …Bliss, J. M. (2016). Acute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3-week regimen delivered in the UK FAST-Forward Trial. Radiotherapy and Oncology, 120(1), 114-118. https://doi.org/10.1016/j.radonc.2016.02.027

BACKGROUND AND PURPOSE: FAST-Forward is a phase 3 clinical trial testing a 1-week course of whole breast radiotherapy against the UK standard 3-week regimen after primary surgery for early breast cancer. Two acute skin toxicity substudies were undert... Read More about Acute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3-week regimen delivered in the UK FAST-Forward Trial.

Islet-intrinsic effects of CFTR mutation (2016)
Journal Article
Harper. (2016). Islet-intrinsic effects of CFTR mutation. Diabetologia, 1350-1355. https://doi.org/10.1007/s00125-016-3936-1

Cystic fibrosis-related diabetes (CFRD) is the most significant extra-pulmonary comorbidity in cystic fibrosis (CF) patients, and accelerates lung decline. In addition to the traditional view that CFRD is a consequence of fibrotic destruction of the... Read More about Islet-intrinsic effects of CFTR mutation.

Current management of pregnancy-related low back pain: a national cross-sectional survey of UK physiotherapists (2016)
Journal Article
(2016). Current management of pregnancy-related low back pain: a national cross-sectional survey of UK physiotherapists. Physiotherapy, 102(1), 78-85. https://doi.org/10.1016/j.physio.2015.02.003

BACKGROUND: Pregnancy-related low back pain (LBP) is very common. Evidence from a systematic review supports the use of exercise and acupuncture, although little is known about the care received by women with pregnancy-related back pain in the UK. OB... Read More about Current management of pregnancy-related low back pain: a national cross-sectional survey of UK physiotherapists.

Two case reports of the successful eradication of new isolates of Burkholderia cepacia complex in children with cystic fibrosis. (2016)
Journal Article
(2016). Two case reports of the successful eradication of new isolates of Burkholderia cepacia complex in children with cystic fibrosis. BMC Pharmacology and Toxicology, 14 - ?. https://doi.org/10.1186/s40360-016-0054-0

BACKGROUND: Chronic infection with Burkholderia cepacia complex (BCC) has a detrimental effect on morbidity and mortality for patients with cystic fibrosis (CF). It is therefore logical to attempt to eradicate new isolates however there is a paucity... Read More about Two case reports of the successful eradication of new isolates of Burkholderia cepacia complex in children with cystic fibrosis..

Liquid crystalline ordered collagen substrates for applications in tissue engineering (2016)
Journal Article
(2016). Liquid crystalline ordered collagen substrates for applications in tissue engineering. ACS Biomaterials Science and Engineering, 625-633. https://doi.org/10.1021/acsbiomaterials.6b00030

This report describes methods for fabricating substrates with anisotropic order from a single solution of high concentration collagen. By exploiting the intrinsic property of collagen to behave as a cholesteric liquid crystal, we demonstrate first th... Read More about Liquid crystalline ordered collagen substrates for applications in tissue engineering.

Post-stroke dysphagia: A review and design considerations for future trials (2016)
Journal Article
Roffe. (2016). Post-stroke dysphagia: A review and design considerations for future trials. International Journal of Stroke, 399 - 411. https://doi.org/10.1177/1747493016639057

Post-stroke dysphagia (a difficulty in swallowing after a stroke) is a common and expensive complication of acute stroke and is associated with increased mortality, morbidity, and institutionalization due in part to aspiration, pneumonia, and malnutr... Read More about Post-stroke dysphagia: A review and design considerations for future trials.

A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain (2016)
Journal Article
Wong, S. S., Østergaard, S., Hall, G., Li, C., Williams, P. M., Stennicke, H., & Emsley, J. (2016). A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain. Blood, 127(23), 2915-2923. https://doi.org/10.1182/blood-2015-10-676122

Factor XI (FXI) is the zymogen of FXIa, which cleaves FIX in the intrinsic pathway of coagulation. FXI is known to exist as a dimer and interacts with multiple proteins via its 4 apple domains in the “saucer section” of the enzyme; however, to date,... Read More about A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.