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Obesity does not affect the size of infrapatellar fat pad adipocytes: implications for the pathogenesis of knee osteoarthritis (2016)
Journal Article
Garcia, J., Wei, W., Runhaar, J., Wright, K., Mennan, C., Roberts, S., …Bastiaansen-Jenniskens, Y. (2016). Obesity does not affect the size of infrapatellar fat pad adipocytes: implications for the pathogenesis of knee osteoarthritis. Osteoarthritis and Cartilage, 24(S1), S334-S335. https://doi.org/10.1016/j.joca.2016.01.599

Purpose: Obesity is known to be a risk factor for the development of osteoarthritis (OA). Obesity is accompanied by adipocyte hypertrophy and elevated inflammation in subcutaneous and visceral adipose tissue. The infrapatellar fat pad (IPFP) is an ad... Read More about Obesity does not affect the size of infrapatellar fat pad adipocytes: implications for the pathogenesis of knee osteoarthritis.

OCT as a convenient tool to assess the quality and application of organotypic retinal samples (2016)
Journal Article
Gater, R., Khoshnaw, N., Nguyen, D., El Haj, A. J., & Yang, Y. (2016). OCT as a convenient tool to assess the quality and application of organotypic retinal samples. Proceedings of SPIE, 9707, https://doi.org/10.1117/12.2213509

Eye diseases such as macular degeneration and glaucoma have profound consequences on the quality of human life. Without treatment, these diseases can lead to loss of sight. To develop better treatments for retinal diseases, including cell therapies a... Read More about OCT as a convenient tool to assess the quality and application of organotypic retinal samples.

Explaining inequalities in receipt of care in the older patient with acute coronary syndrome (2016)
Journal Article
Mamas. (2016). Explaining inequalities in receipt of care in the older patient with acute coronary syndrome. European Heart Journal - Quality of Care and Clinical Outcomes, 59-61. https://doi.org/10.1093/ehjqcco/qcw011

The world's population is ageing and patients with acute coronary syndromes (ACS) are presenting later in life such that a third or more are now aged =70.1 ACS mortality rates are higher in older patients,1 and absolute benefits of treatment are, the... Read More about Explaining inequalities in receipt of care in the older patient with acute coronary syndrome.

Effects of inter- and intra-aggregate magnetic dipolar interactions on the magnetic heating efficiency of iron oxide nanoparticles (2016)
Journal Article
Ovejero, J. G., Cabrera, D., Carrey, J., Valdivielso, T., Salas, G., & Teran, F. J. (in press). Effects of inter- and intra-aggregate magnetic dipolar interactions on the magnetic heating efficiency of iron oxide nanoparticles. Physical Chemistry Chemical Physics, 18(16), 10954-10963. https://doi.org/10.1039/c6cp00468g

Iron oxide nanoparticles have found an increasing number of biomedical applications as sensing or trapping platforms and therapeutic and/or diagnostic agents. Most of these applications are based on their magnetic properties, which may vary depending... Read More about Effects of inter- and intra-aggregate magnetic dipolar interactions on the magnetic heating efficiency of iron oxide nanoparticles.

Anti-epileptic drugs and bone loss: phenytoin reduces pro-collagen I and alters the electrophoretic mobility of osteonectin in cultured bone cells (2016)
Journal Article
Wilson, E., Garton, M., & Fuller, H. (2016). Anti-epileptic drugs and bone loss: phenytoin reduces pro-collagen I and alters the electrophoretic mobility of osteonectin in cultured bone cells. Epilepsy Research, 97-101. https://doi.org/10.1016/j.eplepsyres.2016.03.002

Phenytoin is an antiepileptic drug used in the management of partial and tonic-clonic seizures. In previous studies we have shown that valproate, another antiepileptic drug, reduced the amount of two key bone proteins, pro-collagen I and osteonectin... Read More about Anti-epileptic drugs and bone loss: phenytoin reduces pro-collagen I and alters the electrophoretic mobility of osteonectin in cultured bone cells.

An audit on the use of chaperones during intimate patient examinations (2016)
Journal Article
(2016). An audit on the use of chaperones during intimate patient examinations. https://doi.org/10.1016/j.amsu.2016.03.005

Background The general medical council stipulate all intimate examinations should be chaperoned, and their identity documented within patients' notes. We decided to audit our surgical unit for compliance to these guidelines. Methods A prospectiv... Read More about An audit on the use of chaperones during intimate patient examinations.

Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. (2016)
Journal Article
Bhattacharjee, A., McCarthy, H. S., Tins, B., Roberts, S., Kuiper, J. H., Harrison, P. E., & Richardson, J. B. (2016). Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. American Journal of Sports Medicine, 44(5), 1249 - 1259. https://doi.org/10.1177/0363546516631739

BACKGROUND: Structural and functional outcome of bone graft with first- or second-generation autologous chondrocyte implantation (ACI) in treating cartilage and subchondral bone defect has not been reported previously. PURPOSE: To evaluate the outcom... Read More about Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee..

Sequences of Regressions Distinguish Nonmechanical from Mechanical Associations between Metabolic Factors, Body Composition, and Bone in Healthy Postmenopausal Women (2016)
Journal Article
Solis-Trapala. (2016). Sequences of Regressions Distinguish Nonmechanical from Mechanical Associations between Metabolic Factors, Body Composition, and Bone in Healthy Postmenopausal Women. The Journal of Nutrition, 846-854. https://doi.org/10.3945/jn.115.224485

Background: There is increasing recognition of complex interrelations between the endocrine functions of bone and fat tissues or organs. Objective: The objective was to describe nonmechanical and mechanical links between metabolic factors, body co... Read More about Sequences of Regressions Distinguish Nonmechanical from Mechanical Associations between Metabolic Factors, Body Composition, and Bone in Healthy Postmenopausal Women.

Pigtail catheter "propping" for MitraClip percutaneous transcatheter mitral valve repair. (2016)
Journal Article
(2016). Pigtail catheter "propping" for MitraClip percutaneous transcatheter mitral valve repair. Catheterization & Cardiovascular Interventions, 316-318. https://doi.org/10.1002/ccd.26288

In recent years percutaneous therapy has emerged as a feasible and effective option for the treatment of mitral regurgitation, particularly in cases where the risks of conventional cardiac surgery are prohibitively high. To date the most widely used... Read More about Pigtail catheter "propping" for MitraClip percutaneous transcatheter mitral valve repair..

The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization. (2016)
Journal Article
Stamelos, V. A., Fisher, N., Bamrah, H., Voisey, C., Price, J. C., Farrell, W. E., …Richardson, A. (in press). The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization. PloS one, e0150696 - ?. https://doi.org/10.1371/journal.pone.0150696

Obatoclax belongs to a class of compounds known as BH3 mimetics which function as antagonists of Bcl-2 family apoptosis regulators. It has undergone extensive preclinical and clinical evaluation as a cancer therapeutic. Despite this, it is clear that... Read More about The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization..

Mesenchymal stem cell derived products attenuate cytokine-induced apoptosis in pancreatic beta cells (2016)
Presentation / Conference
Al Azzawi, B., Merkhan, M. M., Kelly, C., & Forsyth, N. (2016, March). Mesenchymal stem cell derived products attenuate cytokine-induced apoptosis in pancreatic beta cells. Poster presented at Abstracts of the Diabetes UK Professional Conference 2016, Scottish Exhibition and Conference Centre, Glasgow, Scotland

Aims:Cytokine-driven beta cell apoptosis is central to Type 1diabetes. Mesenchymal stem cells (MSCs) are multipotent cellswith significant immunomodulatory capacity, which counteractautoimmunityand enhance islet engraftment and survival. The aimof th... Read More about Mesenchymal stem cell derived products attenuate cytokine-induced apoptosis in pancreatic beta cells.

EAHP European Statements baseline survey 2015: results (2016)
Journal Article
(2016). EAHP European Statements baseline survey 2015: results. European Journal of Hospital Pharmacy, 69 - 75. https://doi.org/10.1136/ejhpharm-2016-000889

Objectives The European Statements baseline survey was designed to give an insight to how well the European Statements of Hospital Pharmacy (the Statements) are being implemented and to help inform the European Association of Hospital Pharmacists (EA... Read More about EAHP European Statements baseline survey 2015: results.

Alternative tension band technique for olecranon fractures: A biomechanical study (2016)
Journal Article
Singh, S., Kuiper, J., Behzadian, A., Madhusudhan, T., & Sinha, A. (2016). Alternative tension band technique for olecranon fractures: A biomechanical study. Injury, 47(2), 294-295. https://doi.org/10.1016/j.injury.2015.12.008

Objectives: To investigate whether an alternative tension band wire technique will produce greater compression and less displacement at olecranon (elbow) fracture sites compared to a standard figure of eight tension band technique. Olecranon fracture... Read More about Alternative tension band technique for olecranon fractures: A biomechanical study.

Modelling conditions and health care processes in electronic health records: an application to severe mental illness with the clinical practice research datalink (2016)
Journal Article
(2016). Modelling conditions and health care processes in electronic health records: an application to severe mental illness with the clinical practice research datalink. PloS one, https://doi.org/10.1371/journal.pone.0146715

Background The use of Electronic Health Records databases for medical research has become mainstream. In the UK, increasing use of Primary Care Databases is largely driven by almost complete computerisation and uniform standards within the National... Read More about Modelling conditions and health care processes in electronic health records: an application to severe mental illness with the clinical practice research datalink.

EAHP European Statements baseline survey 2015: methodology (2016)
Journal Article
(2016). EAHP European Statements baseline survey 2015: methodology. European Journal of Hospital Pharmacy, 65 -68. https://doi.org/10.1136/ejhpharm-2016-000893

The European Statements of Hospital Pharmacy are a set of hospital pharmacy practice standards published by the European Association of Hospital Pharmacists (EAHP) for European health systems to ensure safe, effective and optimal use of medicines in... Read More about EAHP European Statements baseline survey 2015: methodology.

EAHP European Statements baseline survey 2015: first steps on the implementation journey (2016)
Journal Article
(2016). EAHP European Statements baseline survey 2015: first steps on the implementation journey. European Journal of Hospital Pharmacy, 76 -79. https://doi.org/10.1136/ejhpharm-2016-000892

An implementation plan was developed in conjunction with the publication of the European Statements of Hospital Pharmacy. Subsequently a baseline survey on the status of the Statements was conducted with specific questions on awareness, capability an... Read More about EAHP European Statements baseline survey 2015: first steps on the implementation journey.

Automated Electrophysiological and Pharmacological Evaluation of Human Pluripotent Stem Cell-Derived Cardiomyocytes (2016)
Journal Article
Rajamohan, D., Kalra, S., Duc Hoang, M., George, V., Staniforth, A., Russell, H., …Denning, C. (2016). Automated Electrophysiological and Pharmacological Evaluation of Human Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cells and Development, 25(6), 439-452. https://doi.org/10.1089/scd.2015.0253

Automated planar patch clamp systems are widely used in drug evaluation studies because of their ability to provide accurate, reliable, and reproducible data in a high-throughput manner. Typically, CHO and HEK tumorigenic cell lines overexpressing si... Read More about Automated Electrophysiological and Pharmacological Evaluation of Human Pluripotent Stem Cell-Derived Cardiomyocytes.

A Tailor-Made Synthetic Polymer for Cell Encapsulation: Design Rationale, Synthesis, Chemical-Physics and Biological Characterizations (2016)
Journal Article
Gerges, I., Tamplenizza, M., Rossi, E., Tocchio, A., Martello, F., Recordati, C., …Lenardi, C. (2016). A Tailor-Made Synthetic Polymer for Cell Encapsulation: Design Rationale, Synthesis, Chemical-Physics and Biological Characterizations. Macromolecular Bioscience, 16(6), 870-881. https://doi.org/10.1002/mabi.201500386

This study presents a custom-made in situ gelling polymeric precursor for cell encapsulation. Composed of poly((2-hydroxyethyl)methacrylate-co-(3-aminopropyl)methacrylamide) (P(HEMA-co-APM) mother backbone and RGD-mimicking poly(amidoamine) (PAA) moi... Read More about A Tailor-Made Synthetic Polymer for Cell Encapsulation: Design Rationale, Synthesis, Chemical-Physics and Biological Characterizations.

Abstract P4-10-14: Breast reconstruction changes coping mechanisms in breast cancer survivorship (2016)
Journal Article
Lake, B., Fuller, H., Rastall, S., & Usman, T. (2016). Abstract P4-10-14: Breast reconstruction changes coping mechanisms in breast cancer survivorship. Cancer Research, 76(4_Supplement), P4-10-14-P4-10-14. https://doi.org/10.1158/1538-7445.sabcs15-p4-10-14

Introduction Cancer survivorship is the process of living through and beyond cancer; a key part is how a patient copes with their diagnosis. Breast cancer is the most common malignancy of women worldwide and is known to be a severe stressor. Resea... Read More about Abstract P4-10-14: Breast reconstruction changes coping mechanisms in breast cancer survivorship.