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Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis (2016)
Journal Article
Mamas, Rashid, M., & Nolan, J. (2016). Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis. Heart, https://doi.org/10.1136/heartjnl-2015-308956

Abstract Objective: First-degree atrioventricular block is frequently encountered in clinical practice and is generally considered a benign process. However, there is emerging evidence that prolonged PR interval may be associated with adverse outcome... Read More about Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis.

Temporal Analyses of the Response of Intervertebral Disc Cells and Mesenchymal Stem Cells to Nutrient Deprivation (2016)
Journal Article
Wright, K., & Roberts, S. (2016). Temporal Analyses of the Response of Intervertebral Disc Cells and Mesenchymal Stem Cells to Nutrient Deprivation. Stem Cells International, 5415901 - ?

Much emphasis has been placed recently on the repair of degenerate discs using implanted cells, such as disc cells or bone marrow derived mesenchymal stem cells (MSCs). This study examines the temporal response of bovine and human nucleus pulposus (N... Read More about Temporal Analyses of the Response of Intervertebral Disc Cells and Mesenchymal Stem Cells to Nutrient Deprivation.

A multinational cross-sectional survey of the management of patient medication adherence by European Healthcare Professionals (2016)
Journal Article
(2016). A multinational cross-sectional survey of the management of patient medication adherence by European Healthcare Professionals. BMJ Open, e009610. https://doi.org/10.1136/bmjopen-2015-009610

Objectives To examine which interventions healthcare professionals use to support patients with taking medicines and their perceptions about the effectiveness of those actions. Design Cross-sectional multinational study. Setting Online surve... Read More about A multinational cross-sectional survey of the management of patient medication adherence by European Healthcare Professionals.

Endocytotic potential governs magnetic particle loading in dividing neural cells: studying modes of particle inheritance. (2016)
Journal Article
Tickle, J., Jenkins, S., Polyak, B., Pickard, M., & Chari, D. (2016). Endocytotic potential governs magnetic particle loading in dividing neural cells: studying modes of particle inheritance. Nanomedicine, 345 - 358. https://doi.org/10.2217/nnm.15.202

AIM: To achieve high and sustained magnetic particle loading in a proliferative and endocytotically active neural transplant population (astrocytes) through tailored magnetite content in polymeric iron oxide particles. MATERIALS & METHODS: MPs of var... Read More about Endocytotic potential governs magnetic particle loading in dividing neural cells: studying modes of particle inheritance..

Bile duct reconstruction following laparoscopic cholecystectomy in England (2016)
Journal Article
(2016). Bile duct reconstruction following laparoscopic cholecystectomy in England. Surgical Endoscopy, 3516- 3525. https://doi.org/10.1007/s00464-015-4641-8

Objectives To determine the incidence of bile duct reconstruction (BDR) following laparoscopic cholecystectomy (LC) and to identify associated risk factors. Background Major bile duct injury (BDI) requiring reconstruction is a serious complicati... Read More about Bile duct reconstruction following laparoscopic cholecystectomy in England.

Habitual chocolate consumption and the risk of incident heart failure among healthy men and women (2016)
Journal Article
Mamas. (2016). Habitual chocolate consumption and the risk of incident heart failure among healthy men and women. Nutrition, Metabolism and Cardiovascular Diseases, 722-734. https://doi.org/10.1016/j.numecd.2016.01.003

Background: We aimed to examine the association between chocolate intake and the risk of incident heart failure in a UK general population. We conducted a systematic review and meta-analysis to quantify this association. Methods and results: We used... Read More about Habitual chocolate consumption and the risk of incident heart failure among healthy men and women.

Habitual chocolate consumption and the risk of incident heart failure among healthy men and women (2016)
Journal Article
Mamas. (2016). Habitual chocolate consumption and the risk of incident heart failure among healthy men and women. Nutrition, Metabolism and Cardiovascular Diseases, 722 -734. https://doi.org/10.1016/j.numecd.2016.01.003

BACKGROUND: We aimed to examine the association between chocolate intake and the risk of incident heart failure in a UK general population. We conducted a systematic review and meta-analysis to quantify this association. METHODS AND RESULTS: We used... Read More about Habitual chocolate consumption and the risk of incident heart failure among healthy men and women.

Synthesis and cytotoxicity of thieno[2,3-b]quinoline-2-carboxamide and cycloalkyl[b]thieno[3,2-e]pyridine-2-carboxamide derivatives (2016)
Journal Article
Leung, E., Pilkington, L. I., van Rensburg, M., Jeon, C. Y., Song, M., Arabshahi, H. J., …Barker, D. (2016). Synthesis and cytotoxicity of thieno[2,3-b]quinoline-2-carboxamide and cycloalkyl[b]thieno[3,2-e]pyridine-2-carboxamide derivatives. Bioorganic and Medicinal Chemistry, 24(5), 1142-1154. https://doi.org/10.1016/j.bmc.2016.01.047

Seventy nine derivatives of thieno[2,3-b]quinolines, tetrahydrothieno[2,3-b]quinoline, dihydrocyclopenta[b]thieno[3,2-e]pyridine, cyclohepta[b]thieno[3,2-e]pyridine and hexahydrocycloocta[b]thieno[3,2-e]pyridine were either synthesized or obtained co... Read More about Synthesis and cytotoxicity of thieno[2,3-b]quinoline-2-carboxamide and cycloalkyl[b]thieno[3,2-e]pyridine-2-carboxamide derivatives.

Longitudinal bioimpedance vector plots add little value to fluid management of peritoneal dialysis patients (2016)
Journal Article
Tan, B. K., Yu, Z., Fang, W., Lin, A., Ni, Z., Qian, J., …Davies, S. J. (2016). Longitudinal bioimpedance vector plots add little value to fluid management of peritoneal dialysis patients. Kidney International, 89(2), https://doi.org/10.1038/ki.2015.294

Bioimpedance (BI) has the potential to enable better management of fluid balance, which can worsen over time on peritoneal dialysis (PD) due to loss of residual kidney function and progressive muscle wasting. We undertook a prospective, randomized, o... Read More about Longitudinal bioimpedance vector plots add little value to fluid management of peritoneal dialysis patients.

Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches (2016)
Journal Article
(2016). Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches. International Journal of Molecular Sciences, 128 - 128. https://doi.org/10.3390/ijms17010128

The tissue turnover of unperturbed adult lung is remarkably slow. However, after injury or insult, a specialised group of facultative lung progenitors become activated to replenish damaged tissue through a reparative process called regeneration. Disr... Read More about Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches.

The influence of hydrostatic pressure on tissue engineered bone development (2016)
Journal Article
(2016). The influence of hydrostatic pressure on tissue engineered bone development. Journal of Theoretical Biology, https://doi.org/10.1016/j.jtbi.2015.12.020

The hydrostatic pressure stimulation of an appropriately cell–seeded porous scaffold within a bioreactor is a promising method for engineering bone tissue external to the body. We propose a mathematical model, and employ a suite of candidate constitu... Read More about The influence of hydrostatic pressure on tissue engineered bone development.

How well are national guidelines relating to the general sales of aspirin and paracetamol, adhered to by retail stores: a mystery shopper study. (2016)
Journal Article
(2016). How well are national guidelines relating to the general sales of aspirin and paracetamol, adhered to by retail stores: a mystery shopper study. BMJ Open, e010081 - ?. https://doi.org/10.1136/bmjopen-2015-010081

OBJECTIVE: To determine whether non-pharmaceutical retail outlets are aboding to the current Medicines and Healthcare products Regulatory Agency (MHRA) national guidelines for over-the-counter (OTC) sales of aspirin and paracetamol. METHODS: Stages 1... Read More about How well are national guidelines relating to the general sales of aspirin and paracetamol, adhered to by retail stores: a mystery shopper study..

"Sometimes we can't fix things": a qualitative study of health care professionals' perceptions of end of life care for patients with heart failure (2016)
Journal Article
(2016). "Sometimes we can't fix things": a qualitative study of health care professionals' perceptions of end of life care for patients with heart failure. BMC Palliative Care, https://doi.org/10.1186/s12904-016-0074-y

Background: Although heart failure has a worse prognosis than some cancers, patients often have restricted access to well-developed end of life (EoL) models of care. Studies show that patients with advanced heart failure may have a poor understanding... Read More about "Sometimes we can't fix things": a qualitative study of health care professionals' perceptions of end of life care for patients with heart failure.

Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice (2016)
Journal Article
Mamas. (2016). Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice. Cardiology in Review, https://doi.org/10.1097/CRD.0000000000000097

Disease of the proximal left anterior descending (LAD) artery is a common pathological finding often combined with disease in other coronary arteries. In this article we review specifically the evidence (and the guidelines arising from the data) for... Read More about Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice.

Impact of operator volume for percutaneous coronary intervention (PCI) on clinical outcomes: what do the numbers say? (2016)
Journal Article
Mamas, M., & Rashid, M. (2016). Impact of operator volume for percutaneous coronary intervention (PCI) on clinical outcomes: what do the numbers say?. European Heart Journal, 16-22. https://doi.org/10.1093/ehjqcco/qcv030

The impact of operator and centre volume on clinical outcomes and quality of care has been of considerable debate in recent years in a number of surgical- and procedural-based specialities. A relationship between higher volumes at both the institutio... Read More about Impact of operator volume for percutaneous coronary intervention (PCI) on clinical outcomes: what do the numbers say?.

Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development (2016)
Journal Article
Fuller, H., Mandefro, B., Shirran, S., Gross, A., Kaus, A., Botting, C., …Sareen, S. (2016). Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development. Frontiers in Cellular Neuroscience, https://doi.org/10.3389/fncel.2015.00506

Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced... Read More about Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development.

Support vector regression to estimate the permeability enhancement of potential transdermal enhancers (2016)
Journal Article
Moss. (2016). Support vector regression to estimate the permeability enhancement of potential transdermal enhancers. Journal of Pharmacy and Pharmacology, 170-184. https://doi.org/10.1111/jphp.12508

Objectives Searching for chemicals that will safely enhance transdermal drug delivery is a significant challenge. This study applies support vector regression (SVR) for the first time to estimating the optimal formulation design of transdermal hydro... Read More about Support vector regression to estimate the permeability enhancement of potential transdermal enhancers.

'Stealth' nanoparticles evade neural immune cells but also evade all major brain cell populations: Implications for PEG-based neurotherapeutics (2016)
Journal Article
Jenkins, S., Weinberg, D., Al-Shakli, A., Fernandes, A., Yiu, H., Telling, N., …Chari, D. (2016). 'Stealth' nanoparticles evade neural immune cells but also evade all major brain cell populations: Implications for PEG-based neurotherapeutics. Journal of Controlled Release, 224, 136-145. https://doi.org/10.1016/j.jconrel.2016.01.013

Surface engineering to control cell behavior is of high interest across the chemical engineering, drug delivery and biomaterial communities. Defined chemical strategies are necessary to tailor nanoscale protein interactions/adsorption, enabling contr... Read More about 'Stealth' nanoparticles evade neural immune cells but also evade all major brain cell populations: Implications for PEG-based neurotherapeutics.

Lessons learnt from a primary care asthma improvement project. (2016)
Journal Article
(2016). Lessons learnt from a primary care asthma improvement project. npj Primary Care Respiratory Medicine, 15075 - ?. https://doi.org/10.1038/npjpcrm.2015.75

Asthma is a very common disease that can occur at any age. In the UK and in many other countries it is mainly managed in primary care. The published evidence suggests that the key to improving diagnosis and management lies in better training and educ... Read More about Lessons learnt from a primary care asthma improvement project..