All Outputs (243)

Commonality amid diversity: multi-study proteomic identification of conserved disease mechanisms in spinal muscular atrophy (2016)
Journal Article
Fuller, H., Wishart, T., & Gillingwater, T. (2016). Commonality amid diversity: multi-study proteomic identification of conserved disease mechanisms in spinal muscular atrophy. Neuromuscular Disorders, 560-569. https://doi.org/10.1016/j.nmd.2016.06.004

The neuromuscular disease spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality, resulting from low levels of full-length survival motor neuron (SMN) protein. Despite having a good understanding of the underlying genetics of SM... Read More about Commonality amid diversity: multi-study proteomic identification of conserved disease mechanisms in spinal muscular atrophy.

Brief Encounter or Indecent Proposal?: achieve gold-standard research grant management, and avoid feeling used (2016)
Presentation / Conference
(2016, June). Brief Encounter or Indecent Proposal?: achieve gold-standard research grant management, and avoid feeling used. Presented at ARMA Annual Conference, Birmingham

Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake (2016)
Journal Article
Weightman, A. P., Jenkins, S. I., & Chari, D. M. (2016). Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake. Nano Research, 9(8), 2384-2397. https://doi.org/10.1007/s12274-016-1125-7

Development of nanoparticle (NP) based therapies to promote regeneration in sites of central nervous system (CNS; i.e. brain and spinal cord) pathology relies critically on the availability of experimental models that offer biologically valid predict... Read More about Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake.

EU Falsified Medicines Directive mandatory requirements for secondary care: A concise review (2016)
Journal Article
(2016). EU Falsified Medicines Directive mandatory requirements for secondary care: A concise review. Journal of Generic Medicines, 95-101. https://doi.org/10.1177/1741134316643358

Since the publication of the Falsified Medicines Directive in 2011 and the subsequent delegated regulation in February 2016, there has been much discussion surrounding the level of Falsified Medicines Directive compliance required by secondary care i... Read More about EU Falsified Medicines Directive mandatory requirements for secondary care: A concise review.

Fingerprint of Tiger Balm® By Thermal Desorption Gas Chromatography Mass Spectrometry (2016)
Journal Article
Aldulaimi, O. A., & Li, W. W. (2016). Fingerprint of Tiger Balm® By Thermal Desorption Gas Chromatography Mass Spectrometry. Pharmacognosy Journal, 230-233. https://doi.org/10.5530/pj.2016.3.9

Introduction: Tiger Balm® is a blend of volatile oils used for many years in control of muscle cramps and headache. Objectives: To establish a quick and accurate method of analysis for Tiger Balm®. Materials and Methods: GC-MS and TD GC-MS were used... Read More about Fingerprint of Tiger Balm® By Thermal Desorption Gas Chromatography Mass Spectrometry.

Association between osteoarthritis and cardiovascular disease: systematic review and meta-analysis (2016)
Journal Article
Mamas. (2016). Association between osteoarthritis and cardiovascular disease: systematic review and meta-analysis. European Journal of Preventive Cardiology, 938-946. https://doi.org/10.1177/2047487315610663

Background To examine for a possible relationship between osteoarthritis and cardiovascular disease. Design A systematic review and meta-analysis. Methods Published and unpublished literature from: MEDLINE, EMBASE, CINAHL, the Cochrane Libra... Read More about Association between osteoarthritis and cardiovascular disease: systematic review and meta-analysis.

Anomalous origin of the left coronary artery from the pulmonary artery: case report and review (2016)
Journal Article
(2016). Anomalous origin of the left coronary artery from the pulmonary artery: case report and review. https://doi.org/10.5837/bjc.2016.022

Anomalous origin of the left coronary artery from the pulmonary artery is a rare congenital condition that proves to be fatal in most individuals during childhood due to significant left ventricular ischaemia. However, there are case reports of indiv... Read More about Anomalous origin of the left coronary artery from the pulmonary artery: case report and review.

The importance of interactions between atrial fibrillation and heart failure (2016)
Journal Article
Mamas. (2016). The importance of interactions between atrial fibrillation and heart failure. Clinical Medicine, 272 -276. https://doi.org/10.7861/clinmedicine.16-3-272

Heart failure (HF) and atrial fibrillation (AF) are among the commonest cardiovascular conditions encountered in clinical practice and frequently coexist. Over the last decade, they have evolved into global cardiovascular epidemics. This, in turn, ha... Read More about The importance of interactions between atrial fibrillation and heart failure.

Adherence with oral chemotherapy in a cancer unit in Northern Ireland (2016)
Journal Article
Doyle, C., White, S., & Mills, L. (2016). Adherence with oral chemotherapy in a cancer unit in Northern Ireland. Journal of Medicines Optimisation, 2(2), 28 - 33

Introduction Studies in Chronic Myeloid Leukaemia (CML) have shown that adherence to oral chemotherapy is fundamental in achieving good responses where better adherence (>90%) is critical in achieving a major molecular response. The aims of this s... Read More about Adherence with oral chemotherapy in a cancer unit in Northern Ireland.

Identification of anticancer agents based on the thieno[2,3-b]pyridine and 1H-pyrazole molecular scaffolds (2016)
Journal Article
Eurtivong, C., Reynisdóttir, I., Kuczma, S., Furkert, D. P., Brimble, M. A., & Reynisson, J. (2016). Identification of anticancer agents based on the thieno[2,3-b]pyridine and 1H-pyrazole molecular scaffolds. Bioorganic and Medicinal Chemistry, 24(16), 3521-3526. https://doi.org/10.1016/j.bmc.2016.05.061

Structural similarity search of commercially available analogues of thieno[2,3-b]pyridine and 1H-pyrazole derivatives, known anticancer agents, resulted in 717 hits. These were docked into the phosphoinositide specific-phospholipase C (PLC) binding p... Read More about Identification of anticancer agents based on the thieno[2,3-b]pyridine and 1H-pyrazole molecular scaffolds.

Meta-analysis of the prognostic impact of anemia in patients undergoing percutaneous coronary intervention (2016)
Journal Article
Mamas, & Nolan. (2016). Meta-analysis of the prognostic impact of anemia in patients undergoing percutaneous coronary intervention. American Journal of Cardiology, 610-620. https://doi.org/10.1016/j.amjcard.2016.05.059

Anemia is common in patients undergoing percutaneous coronary intervention (PCI), and current guidelines fail to offer recommendations for its management. This review aims to examine the relation between baseline anemia and mortality, major adverse c... Read More about Meta-analysis of the prognostic impact of anemia in patients undergoing percutaneous coronary intervention.

Testosterone Undecanoate improves Sexual Function in Men with Type 2 diabetes and Severe Hypogonadism: Results from a 30 week randomized placebo controlled study. (2016)
Journal Article
(2016). Testosterone Undecanoate improves Sexual Function in Men with Type 2 diabetes and Severe Hypogonadism: Results from a 30 week randomized placebo controlled study. BJU International, 804-813. https://doi.org/10.1111/bju.13516

OBJECTIVE: To evaluate the Sexual Function response to 30 weeks treatment with Long Acting Testosterone Undecanoate (TU) or Placebo (P) 199 men with type 2 diabetes and either severe or mild hypogonadism. PATIENTS AND METHODS: Men with hypogonadism (... Read More about Testosterone Undecanoate improves Sexual Function in Men with Type 2 diabetes and Severe Hypogonadism: Results from a 30 week randomized placebo controlled study..

Mesenchymal stromal cells from human umbilical cords display poor chondrogenic potential in scaffold-free three dimensional cultures. (2016)
Journal Article
Islam, A., Hansen, A., Mennan, C., & Martinez-Zubiaurre, I. (2016). Mesenchymal stromal cells from human umbilical cords display poor chondrogenic potential in scaffold-free three dimensional cultures. European cells & materials, 407 - 424. https://doi.org/10.22203/eCM.v031a26

Many researchers world over are currently investigating the suitability of stromal cells harvested from foetal tissues for allogeneic cell transplantation therapies or for tissue engineering purposes. In this study, we have investigated the chondroge... Read More about Mesenchymal stromal cells from human umbilical cords display poor chondrogenic potential in scaffold-free three dimensional cultures..

Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer (2016)
Journal Article
Wu. (2016). Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer. Oncotarget, 30844-30858. https://doi.org/10.18632/oncotarget.9602

Cancer cells initially characterized as sensitive to chemotherapy may acquire resistance to chemotherapy and lead to tumor recurrence through the expansion of drug-resistant population. Acquisition of drug resistance to conventional chemotherapy is a... Read More about Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer.

Heart Failure Association of the European Society of Cardiology heart failure nurse curriculum. (2016)
Journal Article
(2016). Heart Failure Association of the European Society of Cardiology heart failure nurse curriculum. European Journal of Heart Failure, 736-743. https://doi.org/10.1002/ejhf.568

Recent advances in care and management of heart failure have improved outcome, largely as a result of the developing evidence basis for medications, implantable devices and the organization of heart failure follow-up. Such developments have also incr... Read More about Heart Failure Association of the European Society of Cardiology heart failure nurse curriculum..

Fuel for the work required: A practical approach to amalgamating train-low paradigms for endurance athletes (2016)
Journal Article
(2016). Fuel for the work required: A practical approach to amalgamating train-low paradigms for endurance athletes. Physiological Reports, https://doi.org/10.14814/phy2.12803

Using an amalgamation of previously studied “train-low” paradigms, we tested the effects of reduced carbohydrate (CHO) but high leucine availability on cell-signaling responses associated with exercise-induced regulation of mitochondrial biogenesis a... Read More about Fuel for the work required: A practical approach to amalgamating train-low paradigms for endurance athletes.

Effects of transthyretin on thyroxine and ß-amyloid removal from cerebrospinal fluid in mice. (2016)
Journal Article
Chen, R., Chen, C. P., & Preston, J. E. (2016). Effects of transthyretin on thyroxine and ß-amyloid removal from cerebrospinal fluid in mice. Clinical and Experimental Pharmacology and Physiology, 43(9), 844-850. https://doi.org/10.1111/1440-1681.12598

Transthyretin (TTR) is a binding protein for the thyroid hormone thyroxine (T4 ), retinol and ß-amyloid peptide. TTR aids the transfer of T4 from the blood to the cerebrospinal fluid (CSF), but also prevents T4 loss from the blood-CSF barrier. It is... Read More about Effects of transthyretin on thyroxine and ß-amyloid removal from cerebrospinal fluid in mice..

Status of selected ion flow tube MS: accomplishments and challenges in breath analysis and other areas (2016)
Journal Article
(2016). Status of selected ion flow tube MS: accomplishments and challenges in breath analysis and other areas. Bioanalysis, 1183 -1201. https://doi.org/10.4155/bio-2016-0038

This article reflects our observations of recent accomplishments made using selected ion flow tube MS (SIFT-MS). Only brief descriptions are given of SIFT-MS as an analytical method and of the recent extensions to the underpinning analytical ion chem... Read More about Status of selected ion flow tube MS: accomplishments and challenges in breath analysis and other areas.

Development of a tool to predict outcome of Autologous Chondrocyte Implantation (2016)
Journal Article
Kuiper. (2016). Development of a tool to predict outcome of Autologous Chondrocyte Implantation. Cartilage, 119-130. https://doi.org/10.1177/1947603516650002

Objective. The study had 2 objectives: first, to evaluate the success of autologous chondrocyte implantation (ACI) in terms of incidence of surgical re-intervention, including arthroplasty, and investigate predictors of successful treatment outcome... Read More about Development of a tool to predict outcome of Autologous Chondrocyte Implantation.

Breath concentration of acetic acid vapour is elevated in patients with cystic fibrosis (2016)
Journal Article
(2016). Breath concentration of acetic acid vapour is elevated in patients with cystic fibrosis. Journal of Breath Research, 021002 -?. https://doi.org/10.1088/1752-7155/10/2/021002

A study has been carried out of the volatile organic compounds present in the exhaled breath of 58 cystic fibrosis (CF) patients. An important observation is that the acetic acid vapour concentration measured by selected ion flow tube mass spectromet... Read More about Breath concentration of acetic acid vapour is elevated in patients with cystic fibrosis.