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Point-of-care measurements reveal release of purines into venous blood of stroke patients (2019)
Journal Article
Roffe. (2019). Point-of-care measurements reveal release of purines into venous blood of stroke patients. Purinergic Signalling, 237-246. https://doi.org/10.1007/s11302-019-09647-4

Stroke is a leading cause of death and disability. Here, we examine whether point-of-care measurement of the purines, adenosine, inosine and hypoxanthine, which are downstream metabolites of ATP, has potential to assist the diagnosis of stroke. In a... Read More about Point-of-care measurements reveal release of purines into venous blood of stroke patients.

“Dynamic knee valgus” – are we measuring what we think we’re measuring? An evaluation of static and functional knee calibration methods for application in gait and clinical screening tests of the overhead squat and hurdle step. (2019)
Journal Article
Philp, F., Leboeuf, F., Pandyan, A., & Stewart, C. (2019). “Dynamic knee valgus” – are we measuring what we think we’re measuring? An evaluation of static and functional knee calibration methods for application in gait and clinical screening tests of the overhead squat and hurdle step. Gait and Posture, 70, 298-304. https://doi.org/10.1016/j.gaitpost.2019.03.006

Background Dynamic “knee valgus” has been identified as a risk factor for significant knee injuries, however, the limits and sources of error associated with existing 3D motion analysis methods have not been well established. Research question W... Read More about “Dynamic knee valgus” – are we measuring what we think we’re measuring? An evaluation of static and functional knee calibration methods for application in gait and clinical screening tests of the overhead squat and hurdle step..

Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death (2019)
Journal Article
Lim, J., Dobson, J., Subramanian, M., Miaskowski, A., & Jenkins, S. (2019). Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death. Applied Physics A, https://doi.org/10.1007/s00339-019-2510-3

The manipulation of magnetic nanoparticles (MNPs) using an external magnetic field, has been successfully demonstrated in various biomedical applications. Some have utilised this non-invasive external stimulus and there is an potential to build on th... Read More about Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death.

Low failure rate at short term for 40?mm heads and second generation triple annealed HCLPE liners in hybrid Hip Replacements (2019)
Journal Article
Kuiper. (2019). Low failure rate at short term for 40?mm heads and second generation triple annealed HCLPE liners in hybrid Hip Replacements. Journal of Clinical Orthopaedics and Trauma, 350-357. https://doi.org/10.1016/j.jcot.2017.12.008

Introduction 40?mm large diameter heads offer the advantages of lesser dislocation rates and better stability while highly cross linked polyethylene have lower wear rates than ultra high molecular weight polyethylene. Studies of the survivorship of... Read More about Low failure rate at short term for 40?mm heads and second generation triple annealed HCLPE liners in hybrid Hip Replacements.

PCSK9 Inhibitors in Diabetic Dyslipidemia (2019)
Book Chapter
(2019). PCSK9 Inhibitors in Diabetic Dyslipidemia. In RSSDI Diabetes Update 2018 (374-378). https://doi.org/10.5005/jp/books/18092_77

The association between cardiovascular disease (CVD) risk and raised serum total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) has been demonstrated in epidemiology1 and intervention trials showing significant decreases in CVD foll... Read More about PCSK9 Inhibitors in Diabetic Dyslipidemia.

Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death (2019)
Journal Article
Lambie, M., Teece, L., Johnson, D. W., Petrie, M., Mactier, R., Solis-Trapala, I., …Davies, S. J. (2019). Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death. Nephrology Dialysis Transplantation, 1585-1591. https://doi.org/10.1093/ndt/gfz034

Background Risk of Encapsulating Peritoneal Sclerosis (EPS) is strongly associated with the duration of peritoneal dialysis (PD), such that patients who have been on PD for some time may consider elective transfer to haemodialysis to mitigate risk o... Read More about Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death.

Mauritian Endemic Medicinal Plant Extracts Induce G2/M Phase Cell Cycle Arrest and Growth Inhibition of Oesophageal Squamous Cell Carcinoma in Vitro (2019)
Journal Article
Rummun, N., Hughes, R., Beesoo, R., Li, W., Aldulaimi, O., Macleod, K., …Neergheen-Bhujun, V. (2019). Mauritian Endemic Medicinal Plant Extracts Induce G2/M Phase Cell Cycle Arrest and Growth Inhibition of Oesophageal Squamous Cell Carcinoma in Vitro

Terrestrial plants have contributed massively to the development of modern oncologic drugs. Despite the wide acceptance of Mauritian endemic flowering plants in traditional medicine, scientific evidence of their chemotherapeutic potential is lacking.... Read More about Mauritian Endemic Medicinal Plant Extracts Induce G2/M Phase Cell Cycle Arrest and Growth Inhibition of Oesophageal Squamous Cell Carcinoma in Vitro.

Striking lung cancer response to self-administration of cannabidiol: a case report and literature review (2019)
Journal Article
Sule-Suso, J., Watson, N., van Pittius, D., & Jegannathen, A. (2019). Striking lung cancer response to self-administration of cannabidiol: a case report and literature review. SAGE Open Medical Case Reports, https://doi.org/10.1177/2050313X19832160

In spite of new drugs, lung cancer is associated with a very poor prognosis. Whilst targeted therapies are improving outcomes, it is not uncommon for many patients to have only a partial response, and relapse during follow up. Thus, new drugs or re-e... Read More about Striking lung cancer response to self-administration of cannabidiol: a case report and literature review.

International Variations in Peritoneal Dialysis Utilization and Implications for Practice (2019)
Journal Article
Davies. (2019). International Variations in Peritoneal Dialysis Utilization and Implications for Practice. American Journal of Kidney Diseases, https://doi.org/10.1053/j.ajkd.2018.12.033

In many countries, the use of peritoneal dialysis (PD) remains low despite arguments that support its greater use, including dialysis treatment away from hospital settings, avoidance of central venous catheters, and potential health economic advantag... Read More about International Variations in Peritoneal Dialysis Utilization and Implications for Practice.

Combined ascorbic acid and T3 produce better healing compared to bone marrow mesenchymal stem cells in an Achilles tendon injury rat model: a proof of concept study. (2019)
Journal Article
(2019). Combined ascorbic acid and T3 produce better healing compared to bone marrow mesenchymal stem cells in an Achilles tendon injury rat model: a proof of concept study. Journal of Orthopaedic Surgery and Research, 54 - ?. https://doi.org/10.1186/s13018-019-1098-9

BACKGROUND: This pilot study aimed to ascertain whether the local application of ascorbic acid (AA), of T3, and of rat (r) bone marrow mesenchymal stem cells (BMSCs), alone or in all possible combinations, promoted healing after an Achilles tendon in... Read More about Combined ascorbic acid and T3 produce better healing compared to bone marrow mesenchymal stem cells in an Achilles tendon injury rat model: a proof of concept study..

Dynamic Culture Substrates That Mimic the Topography of the Epidermal-Dermal Junction (2019)
Journal Article
Yang. (2019). Dynamic Culture Substrates That Mimic the Topography of the Epidermal-Dermal Junction. Tissue Engineering Part A, 214 - 223. https://doi.org/10.1089/ten.tea.2018.0125

The junction between the epidermal and dermal layers of human skin undulates, the width and depth of the undulations varying with age and disease. We previously showed that when primary human epidermal keratinocytes are seeded on collagen-coated undu... Read More about Dynamic Culture Substrates That Mimic the Topography of the Epidermal-Dermal Junction.

Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro (2019)
Journal Article
Mottershead. (2019). Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro. Endocrinology, 160(4), 853-862. https://doi.org/10.1210/en.2018-01026

The oocyte-secreted factors bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) interact functionally and it is hypothesised that this interaction may be mediated by formation of a GDF9:BMP15 heterodimer, termed cumulin.... Read More about Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro.

Early readmissions after isolated coronary artery bypass grafting. (2019)
Journal Article
Mamas. (2019). Early readmissions after isolated coronary artery bypass grafting. International Journal of Clinical Practice, e13319 - ?. https://doi.org/10.1111/ijcp.13319

Since its introduction, coronary artery bypass grafting (CABG) has been the revascularisation intervention of choice in patients with complex coronary artery disease [1]. CABG is the most common cardiac surgical procedure [3]. Those reshospitalised w... Read More about Early readmissions after isolated coronary artery bypass grafting..

Relative survival and excess mortality following primary percutaneous coronary intervention for ST-elevation myocardial infarction (2019)
Journal Article
Mamas. (2019). Relative survival and excess mortality following primary percutaneous coronary intervention for ST-elevation myocardial infarction. European Heart Journal: Acute Cardiovascular Care, 68-77. https://doi.org/10.1177/2048872617710790

Background: High survival rates are commonly reported following primary percutaneous coronary intervention for ST-elevation myocardial infarction, with most contemporary studies reporting overall survival. Aims: The aim of this study was to d... Read More about Relative survival and excess mortality following primary percutaneous coronary intervention for ST-elevation myocardial infarction.

Breast reconstruction affects coping mechanisms in breast cancer survivors. (2019)
Journal Article
Lake, B., Fuller, H., Rastall, S., & Usman, T. (2019). Breast reconstruction affects coping mechanisms in breast cancer survivors. Indian Journal of Surgery, 43-50. https://doi.org/10.1007/s12262-017-1712-1

Coping strategies used by women with breast cancer are vital for adjustment to their disease. Whilst it is clear that factors such as age at diagnosis, social support and ethnicity can influence coping mechanisms, there is currently no information ab... Read More about Breast reconstruction affects coping mechanisms in breast cancer survivors..

Discharge Against Medical Advice after Hospitalization for Acute Myocardial Infarction (2019)
Journal Article
Mamas. (2019). Discharge Against Medical Advice after Hospitalization for Acute Myocardial Infarction. Heart, 315-321. https://doi.org/10.1136/heartjnl-2018-313671

Background Discharge against medical advice (AMA) occurs infrequently but is associated with poor outcomes. There are limited descriptions of discharges AMA in national cohorts of patients with acute myocardial infarction (AMI). This study aims to e... Read More about Discharge Against Medical Advice after Hospitalization for Acute Myocardial Infarction.

Nanoparticle-Based Imaging of Clinical Transplant Populations Encapsulated in Protective Polymer Matrices (2019)
Journal Article
Adams, C., Delaney, A., Carwardine, D., Tickle, J., Granger, N., & Chari, D. (2019). Nanoparticle-Based Imaging of Clinical Transplant Populations Encapsulated in Protective Polymer Matrices. Macromolecular Bioscience, 19, e1800389. https://doi.org/10.1002/mabi.201800389

A recent clinical trial proves that autologous olfactory mucosal cell (OMC) transplantation improves locomotion in dogs with naturally occurring spinal injuries comparable to human lesions. However, not all dogs respond to the treatment, likely due t... Read More about Nanoparticle-Based Imaging of Clinical Transplant Populations Encapsulated in Protective Polymer Matrices.

Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon’s Capsule + Conjunctival ModelFibrosis Response Within a 3D Tenon’s + Conjunctival Model (2019)
Journal Article
Gater, R., Ipek, T., Sadiq, S., Nguyen, D., Jones, L., El Haj, A., & Yang, Y. (2019). Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon’s Capsule + Conjunctival ModelFibrosis Response Within a 3D Tenon’s + Conjunctival Model. Investigative ophthalmology & visual science, 60(2), 605 -614. https://doi.org/10.1167/iovs.18-25335

Surgical techniques such as trabeculectomy aim to treat glaucoma by making an incision into the scleral tissue, to create an alternative drainage pathway for aqueous to flow into the sub-Tenon’s/subconjunctival space. However, tissue fibrosis and wou... Read More about Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon’s Capsule + Conjunctival ModelFibrosis Response Within a 3D Tenon’s + Conjunctival Model.