All Outputs (136)

Determining the ideal osteotomy for stemless total shoulder replacement – a cadaveric study (2021)
Journal Article
McClelland, D., Blackwell, J. R., O’Beirne, S., Grocott, N. E., & Ogrodnik, P. (2022). Determining the ideal osteotomy for stemless total shoulder replacement – a cadaveric study. Journal of Shoulder and Elbow Surgery, 31(2), 413-419. https://doi.org/10.1016/j.jse.2021.08.018

Hypothesis: To determine the angle of osteotomy that produces a circular humeral cut surface.
Methods: 49 cadaveric shoulders, from 25 cadavers, underwent sequential humeral head osteotomy from 180 degrees (vertical, in line with the humeral diaphys... Read More about Determining the ideal osteotomy for stemless total shoulder replacement – a cadaveric study.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes (2021)
Journal Article
Alexander, S. P. H., Fabbro, D., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., …Wong, S. S. (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. British Journal of Pharmacology, 178(S1), S313 - S411. https://doi.org/10.1111/bph.15542

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select... Read More about THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes.

Altered Acute Phase Response (APR) signalling following cartilage harvest can be identified in the plasma of ‘non-Responder’ Patients to Autologous Chondrocyte Implantation (2021)
Presentation / Conference
Hulme. (2021, September). Altered Acute Phase Response (APR) signalling following cartilage harvest can be identified in the plasma of ‘non-Responder’ Patients to Autologous Chondrocyte Implantation. Presented at British Orthopaedic Research Society (BORS) 2021, Virtual (Hosted by Imperial College London)

3D Biomimetic Scaffold for Growth Factor Controlled Delivery: An In-Vitro Study of Tenogenic Events on Wharton's Jelly Mesenchymal Stem Cells. (2021)
Journal Article
Camilla Ciardulli, M., Lovecchio, J., Scala, P., Pavel Lamparelli, E., Dale, T., Giudice, V., …Della Porta, G. (2021). 3D Biomimetic Scaffold for Growth Factor Controlled Delivery: An In-Vitro Study of Tenogenic Events on Wharton's Jelly Mesenchymal Stem Cells. Pharmaceutics, 13(9), https://doi.org/10.3390/pharmaceutics13091448

The present work described a bio-functionalized 3D fibrous construct, as an interactive teno-inductive graft model to study tenogenic potential events of human mesenchymal stem cells collected from Wharton's Jelly (hWJ-MSCs). The 3D-biomimetic and bi... Read More about 3D Biomimetic Scaffold for Growth Factor Controlled Delivery: An In-Vitro Study of Tenogenic Events on Wharton's Jelly Mesenchymal Stem Cells..

Establishing the acceptability and usability of an animated virtual patient simulation. (2021)
Journal Article
Lucy Richardson, C., Chapman, S., & White, S. (2021). Establishing the acceptability and usability of an animated virtual patient simulation. Exploratory Research in Clinical and Social Pharmacy, 4, Article 100069. https://doi.org/10.1016/j.rcsop.2021.100069

Background: An animated, video-based, virtual patient (VP) has been developed to allow pharmacists to learn how, and practice how, to advise patients taking non-vitamin K oral anticoagulants, a group of high-risk medicines. VPs are well-established r... Read More about Establishing the acceptability and usability of an animated virtual patient simulation..

Complex ruptures of the quadriceps tendon: a systematic review of surgical procedures and outcomes. (2021)
Journal Article
(2021). Complex ruptures of the quadriceps tendon: a systematic review of surgical procedures and outcomes. https://doi.org/10.1186/s13018-021-02696-9

BACKGROUND: Chronic ruptures, ruptures following total knee arthroplasty (TKA), and re-ruptures of the quadriceps tendon (QT) are rare. A systematic review of the current literature was conducted on their treatment and outcome to provide evidence-bas... Read More about Complex ruptures of the quadriceps tendon: a systematic review of surgical procedures and outcomes..

Surgical management of focal chondral defects of the knee: a Bayesian network meta-analysis. (2021)
Journal Article
(2021). Surgical management of focal chondral defects of the knee: a Bayesian network meta-analysis. Journal of Orthopaedic Surgery and Research, 543 - ?. https://doi.org/10.1186/s13018-021-02684-z

BACKGROUND: Focal chondral defects of the knee are common. Several surgical techniques have been proposed for the management of chondral defects: microfractures (MFX), osteochondral autograft transplantation (OAT), autologous matrix-induced chondroge... Read More about Surgical management of focal chondral defects of the knee: a Bayesian network meta-analysis..

Implementation and evaluation of a good prescribing tip email to reduce junior doctors' prescribing errors (2021)
Journal Article
(2021). Implementation and evaluation of a good prescribing tip email to reduce junior doctors' prescribing errors. Journal of Patient Safety and Risk Management, 214 - 220. https://doi.org/10.1177/25160435211036672

Background Prescribing errors are common, occurring in 7% of in-patient medication orders in UK hospitals. Foundation Year 1 (F1) doctors have reported a lack of feedback on prescribing as a cause of errors. Aim To evaluate the effect of implementing... Read More about Implementation and evaluation of a good prescribing tip email to reduce junior doctors' prescribing errors.

Testosterone Therapy in Adult-Onset Testosterone Deficiency: Hematocrit and Hemoglobin Changes (2021)
Journal Article
(2021). Testosterone Therapy in Adult-Onset Testosterone Deficiency: Hematocrit and Hemoglobin Changes. Androgens, 141 - 149. https://doi.org/10.1089/andro.2021.0013

Objective: Hematocrit (HCT)/hemoglobin (Hb) ratio in (%/g/dL) is around 3, with high fidelity between measured and derived Hb (applying the conversion using HCT) in various pathologies. We examined changes in HCT and Hb values and HCT/Hb, compared wi... Read More about Testosterone Therapy in Adult-Onset Testosterone Deficiency: Hematocrit and Hemoglobin Changes.

Cross-cultural adaptation of the Victorian institute of sports assessment - Hamstrings (VISA-H) questionnaire for Spanish speaking athletes with proximal hamstring tendinopathy. (2021)
Journal Article
(2021). Cross-cultural adaptation of the Victorian institute of sports assessment - Hamstrings (VISA-H) questionnaire for Spanish speaking athletes with proximal hamstring tendinopathy. Physical Therapy in Sport, 50 - 57. https://doi.org/10.1016/j.ptsp.2021.06.009

OBJECTIVE: To cross-culturally adapt and validate the Victorian Institute of Sports Assessment - Hamstrings (VISA-H) scale into Spanish. DESIGN: Clinical measurement study (psychometric analysis). SETTING: Sports clubs and physiotherapy clinics. PART... Read More about Cross-cultural adaptation of the Victorian institute of sports assessment - Hamstrings (VISA-H) questionnaire for Spanish speaking athletes with proximal hamstring tendinopathy..

Insulin resistance in cardiovascular disease, uremia, and peritoneal dialysis. (2021)
Journal Article
Lambie, & Davies. (2021). Insulin resistance in cardiovascular disease, uremia, and peritoneal dialysis. Trends in Endocrinology and Metabolism, 721 - 730. https://doi.org/10.1016/j.tem.2021.06.001

Diabetic nephropathy is highly correlated with the occurrence of other complications of type 1 diabetes (T1D) and type 2 diabetes (T2D) mellitus; for example, hypertension with cardiovascular disease (CVD) being the most frequent cause of death in pa... Read More about Insulin resistance in cardiovascular disease, uremia, and peritoneal dialysis..

Correction for Jeon et al., A set of NF-κB–regulated microRNAs induces acquired TRAIL resistance in Lung cancer (2021)
Journal Article
Jeon, Y., Middleton, J., Kim, T., Laganà, A., Piovan, C., Secchiero, P., …Croce, A. C. M. (2021). Correction for Jeon et al., A set of NF-κB–regulated microRNAs induces acquired TRAIL resistance in Lung cancer. Proceedings of the National Academy of Sciences of the United States of America, 118(36), https://doi.org/10.1073/pnas.2113288118

An evaluation into the refusal of essential shared care agreements: Aripiprazole (2021)
Conference Proceeding
Tolley, L., Azar, M., Singh, G., Gunnell, K. A., Campbell, A., & White, S. (2021). An evaluation into the refusal of essential shared care agreements: Aripiprazole.

Measuring the educational benefits of using a virtual patient to practice pharmacist-patient consultations (2021)
Journal Article
Richardson, C. L., White, S., & Chapman, S. (2021). Measuring the educational benefits of using a virtual patient to practice pharmacist-patient consultations. Pharmacy Education, 382 - 389. https://doi.org/10.46542/pe.2021.211.382389

<jats:p>Objective: Virtual patients (VPs) are a method of simulating clinical practice however little is known about their use by healthcare professionals. This study explores if, and how, one VP is educationally beneficial for pharmacists and pre-re... Read More about Measuring the educational benefits of using a virtual patient to practice pharmacist-patient consultations.

Tailoring Therapeutic Responses via Engineering Microenvironments with a Novel Synthetic Fluid Gel (2021)
Journal Article
(2021). Tailoring Therapeutic Responses via Engineering Microenvironments with a Novel Synthetic Fluid Gel. Advanced healthcare materials, 1 - 12. https://doi.org/10.1002/adhm.202100622

This study reports the first fully synthetic fluid gel (SyMGels) using a simple poly(ethylene glycol) polymer. Fluid gels are an interesting class of materials: structured during gelation via shear-confinement to form microparticulate suspensions, th... Read More about Tailoring Therapeutic Responses via Engineering Microenvironments with a Novel Synthetic Fluid Gel.

Reducing risks associated with medicines and lifestyle in a residential care population with intellectual disabilities: evaluation of a pharmacy review initiative in England (2021)
Journal Article
Thayer, N., White, S., Islam, J., Jones, W., Kenzie, S., & Kullu, R. (2021). Reducing risks associated with medicines and lifestyle in a residential care population with intellectual disabilities: evaluation of a pharmacy review initiative in England. BMJ Open, 11(8), Article e046630. https://doi.org/10.1136/bmjopen-2020-046630

OBJECTIVES: A collaborative service initiative involving community pharmacists and a specialist mental health pharmacist was developed to provide pharmacist reviews for care home residents with intellectual disabilities (IDs). This study aimed to cha... Read More about Reducing risks associated with medicines and lifestyle in a residential care population with intellectual disabilities: evaluation of a pharmacy review initiative in England.

Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi Study (2021)
Journal Article
Kuiper. (2021). Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi Study. Surgeries, 286 - 302. https://doi.org/10.3390/surgeries2030029

<jats:p>A range of surgical techniques have been developed for the repair or regeneration of lesioned cartilage in the human knee and a corresponding array of scoring systems have been created to assess their outcomes. The published literature displa... Read More about Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi Study.

Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model. (2021)
Journal Article
McCarthy, H., Perry, J., Mennan, C., & Wright, K. (2021). Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model. Cells, 1-16. https://doi.org/10.3390/cells10081999

Human umbilical cord (hUC)- or bone marrow (hBM)-derived mesenchymal stromal cells (MSCs) were evaluated as an allogeneic source of cells for cartilage repair. We aimed to determine if they could enhance healing of chondral defects with or without th... Read More about Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model..

An evaluation into the refusal of essential shared care agreements: Aripiprazole (2021)
Journal Article
Tolley, L., Azar, M., Singh, G., Gunnell, K., Campbell, A., & White, S. (2021). An evaluation into the refusal of essential shared care agreements: Aripiprazole. Pharmacoepidemiology and Drug Safety, 30(S2), 4

Introduction: Essential Shared Care Agreements (ESCAs) are written agreements which allow for coherent transfer of prescribing between primary and secondary care services. This study focuses on one UK NHS Trust which uses ESCAs for atypical antipsych... Read More about An evaluation into the refusal of essential shared care agreements: Aripiprazole.

Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature. (2021)
Journal Article
(2021). Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature

The COVID-19 pandemic has markedly impacted on cultural, political, and economic structures all over the world. Several aspects of its pathogenesis and related clinical consequences have not yet been elucidated. Infection rates, as well morbidity and... Read More about Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature..