Skip to main content

Research Repository

Advanced Search

All Outputs (135)

Development of a novel 3D gut-microbiota model for the assessment of absorption and metabolism of health supplements and therapeutic drugs (2021)
Thesis
Alansari, R. H. A. (2021). Development of a novel 3D gut-microbiota model for the assessment of absorption and metabolism of health supplements and therapeutic drugs. (Thesis). Keele University

The human body hosts a vast number of microorganisms such as bacteria, archaea, and viruses that are colonised inside and outside the body. This combination of microorganisms living within the human body is known as microbiota. The human microbiota v... Read More about Development of a novel 3D gut-microbiota model for the assessment of absorption and metabolism of health supplements and therapeutic drugs.

An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. (2021)
Journal Article
Wright, K., Roberts, S., & Kuiper, J. (2021). An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. Cells, https://doi.org/10.3390/cells10081903

Chondrocyte-based cartilage repair strategies, such as articular chondrocyte implantation, are widely used, but few studies addressed the communication between native subchondral bone cells and the transplanted chondrocytes. An indirect co-culture mo... Read More about An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans..

Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions (2021)
Journal Article
Barnes, N. G., Ahmed Mal Ullah, A. A., Ragazzon, P. A., Charafi, N., & Hadfield, J. A. (2021). Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions. ChemistrySelect, 6(28), 7082 - 7086. https://doi.org/10.1002/slct.202101960

Combretastatin A-4 (CA4) is a potent anti-mitotic and vascular disrupting agent. Organic chemists have been working to optimize the synthesis of CA4 for the past 3 decades, with methods requiring hazardous solvents and harsh reaction conditions. Here... Read More about Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions.

Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model. (2021)
Journal Article
(2021). Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model. Cells, https://doi.org/10.3390/cells10071776

The ovine critical-sized defect model provides a robust preclinical model for testing tissue-engineered constructs for use in the treatment of non-union bone fractures and severe trauma. A critical question in cell-based therapies is understanding th... Read More about Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model..

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition. (2021)
Journal Article
Reynisson. (2021). New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition. Biomolecules, https://doi.org/10.3390/biom11070973

Usnic acid (UA) is a secondary metabolite of lichens that exhibits a wide range of biological activities. Previously, we found that UA derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1 (TDP1). It can remove covalent complex DNA-... Read More about New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition..

Rectal Hypersensitivity in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis (2021)
Journal Article
(2021). Rectal Hypersensitivity in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. Crohn's & Colitis 360, https://doi.org/10.1093/crocol/otab041

Abstract Abdominal pain is a key symptom of inflammatory bowel disease (IBD), particularly in active IBD, but also occurs in patients with quiescent disease suggesting that mechanisms other than active inflammation may be responsible. Putative hypoth... Read More about Rectal Hypersensitivity in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.

The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins (2021)
Thesis
Njoroge, W. (2021). The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins. (Thesis). Keele University

Cardiovascular disease (CVD) has been identified as the leading cause of mortality in westernised society. The triggering factor for the majority of cardiovascular diseases is atherosclerosis, defined as an accumulation of fatty materials in the vasc... Read More about The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins.

Experiences of patients and healthcare workers in the NHS pre- and post- Covid-19 (2021)
Thesis
Faux-Nightingale, A. H. (2021). Experiences of patients and healthcare workers in the NHS pre- and post- Covid-19. (Thesis). Keele University

This project assesses the benefit that qualitative investigation of experience brings to healthcare research. It does this through: Phase One - Understanding the factors affecting AFO compliance in children with CP People with cerebral palsy (CP)... Read More about Experiences of patients and healthcare workers in the NHS pre- and post- Covid-19.

Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019) (2021)
Journal Article
Goenaga Infante, H., Warren, J., Chalmers, J., Dent, G., Todoli, J. L., Collingwood, J., …Craston, D. (2021). Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019). Pure and Applied Chemistry, 93(6), 647 - 776. https://doi.org/10.1515/pac-2019-0203

Recommendations are given concerning the terminology of concepts and methods used in spectroscopy in analytical chemistry, covering nuclear magnetic resonance spectroscopy, atomic spectroscopy, and vibrational spectroscopy.

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs. (2021)
Journal Article
Reynisson, J. (2021). Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs. Oncology and Therapy,

Cancer chemotherapy sensitizers hold the key to maximizing the potential of standard anticancer treatments. We have a long-standing interest in developing and validating inhibitors of the DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (TDP1) as ch... Read More about Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs..

Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells. (2021)
Journal Article
Reynisson. (2021). Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells. Medicines, https://doi.org/10.3390/medicines8070032

The adhesion of cancer cells to vascular endothelium is a critical process in hematogenous metastasis and might be similar to the recruitment of leukocytes at the site of inflammation. It is mediated by E-selectin and its ligands, of which the most s... Read More about Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells..

Haemoglobin and transfusions in elderly patients with hip fractures: the effect of a dedicated orthogeriatrician. (2021)
Journal Article
(2021). Haemoglobin and transfusions in elderly patients with hip fractures: the effect of a dedicated orthogeriatrician. Journal of Orthopaedic Surgery and Research, https://doi.org/10.1186/s13018-021-02524-0

BACKGROUND: Hip fractures are common in elderly patients, in whom it is important to monitor blood loss; however, unnecessary transfusions should be avoided. The primary objective of this study was to assess whether the employment of a dedicated orth... Read More about Haemoglobin and transfusions in elderly patients with hip fractures: the effect of a dedicated orthogeriatrician..

Prevention of retention of vaginal swabs and tampons with novel device system (2021)
Presentation / Conference
Desai, A., Ogrodnik, P., Desai, K., & Mapunde, V. (2021, June). Prevention of retention of vaginal swabs and tampons with novel device system. Presented at RCOG Virtual World Congress 2021

Objective Vaginal swabs, tampons are the single most common cause of retained objects reported annually and are currently classed as 'Never events'. They can cause significant morbidity - serious physical-psychological, infection, secondary PPH, seps... Read More about Prevention of retention of vaginal swabs and tampons with novel device system.

Biogenic metallic elements in the human brain? (2021)
Journal Article
Everett, J., Lermyte, F., Brooks, J., Tjendana-Tjhin, V., Plascencia-Villa, G., Hands-Portman, I., …Telling, N. D. (2021). Biogenic metallic elements in the human brain?. Science Advances, 7(24), https://doi.org/10.1126/sciadv.abf6707

The chemistry of copper and iron plays a critical role in normal brain function. A variety of enzymes and proteins containing positively charged Cu+, Cu2+, Fe2+, and Fe3+ control key processes, catalyzing oxidative metabolism and neurotransmitter and... Read More about Biogenic metallic elements in the human brain?.

Experiential learning in public health: evaluation of a health promotion campaign assessment for pharmacy students (2021)
Journal Article
White, S., Gifford, A., & Frisher, M. (2021). Experiential learning in public health: evaluation of a health promotion campaign assessment for pharmacy students. Pharmacy Education, 21(1), 56 - 64. https://doi.org/10.46542/pe.2021.211.5664

Description: Students in small groups designed, delivered and evaluated real-life health promotion campaigns in the local community. A peer assessed component was included from the fifth cohort onwards. Evaluation: Six successive cohorts of pharmacy... Read More about Experiential learning in public health: evaluation of a health promotion campaign assessment for pharmacy students.

Does statin-treated hyperlipidemia affect rotator cuff healing or muscle fatty infiltration after rotator cuff repair? (2021)
Journal Article
Amit, P., Kuiper, J. H., James, S., & Snow, M. (2021). Does statin-treated hyperlipidemia affect rotator cuff healing or muscle fatty infiltration after rotator cuff repair?. Journal of Shoulder and Elbow Surgery, 2465-2474. https://doi.org/10.1016/j.jse.2021.05.014

PURPOSE: Hyperlipidemia is linked to poor tendon to bone healing and progression of fatty infiltration after rotator cuff repair. Statins effectively treat hyperlipidemia, but it is unknown if they have any potential detrimental effects following rot... Read More about Does statin-treated hyperlipidemia affect rotator cuff healing or muscle fatty infiltration after rotator cuff repair?.

Use of Pulmonary Computed Tomography for Evaluating Suspected Stroke-Associated Pneumonia (2021)
Journal Article
Roffe. (2021). Use of Pulmonary Computed Tomography for Evaluating Suspected Stroke-Associated Pneumonia. Journal of Stroke and Cerebrovascular Diseases, 1-8. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105757

Objectives Accurate and timely diagnosis of pneumonia complicating stroke remains challenging and the diagnostic accuracy of chest X-ray (CXR) in the setting of stroke-associated pneumonia (SAP) is uncertain. The overall objective of this study was t... Read More about Use of Pulmonary Computed Tomography for Evaluating Suspected Stroke-Associated Pneumonia.

Potential of biomarkers during pharmacological therapy setting for postmenopausal osteoporosis: a systematic review. (2021)
Journal Article
(2021). Potential of biomarkers during pharmacological therapy setting for postmenopausal osteoporosis: a systematic review. Journal of Orthopaedic Surgery and Research, 1- 13. https://doi.org/10.1186/s13018-021-02497-0

BACKGROUND: Biochemical markers of bone turnover (BTMs), such as the bone alkaline phosphatase (bALP), procollagen type I N propeptide (PINP), serum cross-linked C-telopeptides of type I collagen (bCTx), and urinary cross-linked N-telopeptides of typ... Read More about Potential of biomarkers during pharmacological therapy setting for postmenopausal osteoporosis: a systematic review..