All Outputs (101)

Computational study on the iodobenzene-catalyzed oxidative cyclization of a δ-alkynyl β-ketoester (2022)
Journal Article
Butt, S. E., Rodríguez, A., Sotiropoulos, J., & Moran, W. J. (in press). Computational study on the iodobenzene-catalyzed oxidative cyclization of a δ-alkynyl β-ketoester. Arkivoc, 2022(7), 19-26. https://doi.org/10.24820/ark.5550190.p011.745

The iodobenzene-catalyzed oxidative cyclization of a δ-alkynyl β-ketoester has been investigated by density functional theory (DFT) calculations at the CPCM(acetonitrile)/B3LYP/6-311++G(d,p)//B3LYP/SDD(I) levels. Three different mechanisms were consi... Read More about Computational study on the iodobenzene-catalyzed oxidative cyclization of a δ-alkynyl β-ketoester.

Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice (2022)
Journal Article
Allinson, M., Black, P., & White, S. (2022). Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice. American journal of pharmaceutical education, 86(5), Article 8643. https://doi.org/10.5688/ajpe8643

Objective. For many UK pharmacy students there are minimal opportunities to learn, or be exposed to, different ways of dealing with ethical and professional dilemmas in real life practice during undergraduate education. This study aimed to explore th... Read More about Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice.

Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells (2022)
Journal Article
Kitchen, Li, & Reynisson. (2022). Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells. https://doi.org/10.1016/j.prmcm.2022.100074

Inappropriate DNA methylation of tumour suppressor genes can affect their expression and function, and as such, DNA methylation has been a promising target for anti-cancer therapy. In gynaecological malignancy, ovarian cancer has the highest associat... Read More about Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells.

Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan. (2022)
Journal Article
Reynisson. (2022). Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan. Molecules, https://doi.org/10.3390/molecules27113374

Inhibiting tyrosyl-DNA phosphodiesterase 1 (TDP1) is a promising strategy for increasing the effectiveness of existing antitumor therapy since it can remove the DNA lesions caused by anticancer drugs, which form covalent complexes with topoisomerase... Read More about Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan..

Superparamagnetic-blocked state transition under alternating magnetic fields: towards determining the magnetic anisotropy in magnetic suspensions (2022)
Journal Article
Cabrera, D., Yoshida, T., Rincón-Domínguez, T., Cuñado, J., Salas, G., Bollero, A., …Teran, F. J. (2022). Superparamagnetic-blocked state transition under alternating magnetic fields: towards determining the magnetic anisotropy in magnetic suspensions. Nanoscale, 14(24), 8789-8796. https://doi.org/10.1039/D2NR00808D

The potential of magnetic nanoparticles for acting as efficient catalysts, imaging tracers or heating mediators relays on their superparamagnetic behaviour under alternating magnetic fields. In spite of the relevance of this magnetic phenomenon, the... Read More about Superparamagnetic-blocked state transition under alternating magnetic fields: towards determining the magnetic anisotropy in magnetic suspensions.

An international survey mapping practice and barriers for upper-limb assessments in movement analysis. (2022)
Journal Article
Philp, F., Freeman, R., & Stewart, C. (2022). An international survey mapping practice and barriers for upper-limb assessments in movement analysis. Gait and Posture, 96, 93 - 101. https://doi.org/10.1016/j.gaitpost.2022.05.018

BACKGROUND: Upper-limb movement analysis could improve our understanding of function, pathological mechanisms and inform rehabilitation and surgical decision-making. Despite the potential benefits, the use of clinical upper-limb motion analysis is no... Read More about An international survey mapping practice and barriers for upper-limb assessments in movement analysis..

Cost-Effectiveness Analysis of a Medial Meniscus Replacement Prosthesis for the Treatment of Patients with Medial Compartment Pain in the United Kingdom (2022)
Journal Article
Javanbakht, M., Mashayekhi, A., Carlson, A., Moloney, E., Snow, M., Murray, J., & Spalding, T. (2022). Cost-Effectiveness Analysis of a Medial Meniscus Replacement Prosthesis for the Treatment of Patients with Medial Compartment Pain in the United Kingdom. PharmacoEconomics, 6(5), 681-696. https://doi.org/10.1007/s41669-022-00336-4

Background The most common intra-articular knee injury is a meniscal tear, which commonly occurs secondary to trauma following twisting or hyperflexion. Treatment options for meniscal tears can either be surgical or non-surgical, and range from rest,... Read More about Cost-Effectiveness Analysis of a Medial Meniscus Replacement Prosthesis for the Treatment of Patients with Medial Compartment Pain in the United Kingdom.

Evaluating the Feasibility and Reliability of Remotely Delivering and Scoring the North Star Ambulatory Assessment in Ambulant Patients with Duchenne Muscular Dystrophy (2022)
Journal Article
Kuiper. (2022). Evaluating the Feasibility and Reliability of Remotely Delivering and Scoring the North Star Ambulatory Assessment in Ambulant Patients with Duchenne Muscular Dystrophy. Children, 728 - 728. https://doi.org/10.3390/children9050728

Objective: The North Star Ambulatory Assessment (NSAA) is a validated 17-item functional rating scale and widely used to assess motor function in boys with Duchenne muscular dystrophy (DMD). The SARS-CoV-2 pandemic and subsequent Government 'lockdown... Read More about Evaluating the Feasibility and Reliability of Remotely Delivering and Scoring the North Star Ambulatory Assessment in Ambulant Patients with Duchenne Muscular Dystrophy.

Do these three popular anti-ageing skincare ingredients work? Here’s what the evidence says (2022)
Digital Artefact
Wong, S. S., & Grazier, N. (2022). Do these three popular anti-ageing skincare ingredients work? Here’s what the evidence says. [Blog Style Article]

Osteoarthritis in Athletes Versus Nonathletes: A Systematic Review (2022)
Journal Article
Migliorini, F., Marsilio, E., Torsiello, E., Pintore, A., Oliva, F., & Maffulli, N. (2022). Osteoarthritis in Athletes Versus Nonathletes: A Systematic Review. Sports Medicine and Arthroscopy Review, 30(2), 78-86. https://doi.org/10.1097/jsa.0000000000000339

Introduction: Joint overload and sport-related injuries may accelerate the development of osteoarthritis (OA). A systematic review of the literature was performed to establish the risk of athletes to develop premature OA compared with nonathletes. Ma... Read More about Osteoarthritis in Athletes Versus Nonathletes: A Systematic Review.

Intensive Physical Activity Increases the Risk of Knee and Hip Arthroplasty: A Systematic Review (2022)
Journal Article
Migliorini, F., Pintore, A., Torsiello, E., Oliva, F., Spiezia, F., & Maffulli, N. (2022). Intensive Physical Activity Increases the Risk of Knee and Hip Arthroplasty: A Systematic Review. Sports Medicine and Arthroscopy Review, 30(2), 111-116. https://doi.org/10.1097/jsa.0000000000000340

Purpose: The present study investigated the type of sport and activity level of athletes before they underwent knee and/or hip arthroplasty for osteoarthritis (OA), and compared them with a control group of subjects who did not undergo knee and hip a... Read More about Intensive Physical Activity Increases the Risk of Knee and Hip Arthroplasty: A Systematic Review.

Osteoarthritis of the Knee in Middle-age Athletes: Many Measures are Practiced, but Lack Sound Scientific Evidence (2022)
Journal Article
Quaranta, M., Riccio, I., Oliva, F., & Maffulli, N. (2022). Osteoarthritis of the Knee in Middle-age Athletes: Many Measures are Practiced, but Lack Sound Scientific Evidence. Sports Medicine and Arthroscopy Review, 30(2), 102-110. https://doi.org/10.1097/jsa.0000000000000341

Osteoarthritis of the knee generally affects individuals from the fifth decade, the typical age of middle-age athletes. In the early stages, management is conservative and multidisciplinary. It is advisable to avoid sports with high risk of trauma, b... Read More about Osteoarthritis of the Knee in Middle-age Athletes: Many Measures are Practiced, but Lack Sound Scientific Evidence.

The Influence of Athletes’ Age in the Onset of Osteoarthritis: A Systematic Review (2022)
Journal Article
Migliorini, F., Vecchio, G., Pintore, A., Oliva, F., & Maffulli, N. (2022). The Influence of Athletes’ Age in the Onset of Osteoarthritis: A Systematic Review. Sports Medicine and Arthroscopy Review, 30(2), 97-101. https://doi.org/10.1097/jsa.0000000000000345

Purpose: Whether sport participation is a risk factor for osteoarthritis (OA) development or progression is controversial. Mechanical overload, injuries, genetics, and acquired disorders concur to the onset of OA, with high variability between sports... Read More about The Influence of Athletes’ Age in the Onset of Osteoarthritis: A Systematic Review.

The Association Between Sex and Osteoarthritis in the Physically Active Population: A Systematic Review (2022)
Journal Article
Migliorini, F., Torsiello, E., La Padula, G., Oliva, F., & Maffulli, N. (2022). The Association Between Sex and Osteoarthritis in the Physically Active Population: A Systematic Review. Sports Medicine and Arthroscopy Review, 30(2), 87-91. https://doi.org/10.1097/jsa.0000000000000346

Purpose: Intense sporting activity and certain types of work increase the risk of early osteoarthritis (OA). OA can be idiopathic or associated to certain predisposing factors: female sex, obesity, history of joint injury, and joint overuse. The role... Read More about The Association Between Sex and Osteoarthritis in the Physically Active Population: A Systematic Review.

Elderly Runners and Osteoarthritis: A Systematic Review (2022)
Journal Article
Migliorini, F., Marsilio, E., Oliva, F., Hildebrand, F., & Maffulli, N. (2022). Elderly Runners and Osteoarthritis: A Systematic Review. Sports Medicine and Arthroscopy Review, 30(2), 92-96. https://doi.org/10.1097/jsa.0000000000000347

Purpose: The impact of running on the onset of osteoarthritis (OA) is controversial. This study compared the incidence of OA in elderly runners versus nonrunners. Material and Methods: This systematic review was conducted according to the PRISMA guid... Read More about Elderly Runners and Osteoarthritis: A Systematic Review.

P181 Musculoskeletal pain and prognosis of acute coronary syndrome and cerebrovascular accident: a linked electronic health record cohort study (2022)
Journal Article
Mason, K. J., Jordan, K. P., Achana, F. A., Bailey, J., Chen, Y., Frisher, M., …Edwards, J. J. (2022). P181 Musculoskeletal pain and prognosis of acute coronary syndrome and cerebrovascular accident: a linked electronic health record cohort study. Rheumatology, 61(S1), https://doi.org/10.1093/rheumatology/keac133.180

Abstract Background/Aims There is some evidence of an increased risk of cardiovascular disease in patients with painful musculoskeletal conditions, but it is unclear if musculoskeletal pain also worsens its prognosis. The aim was to determine whethe... Read More about P181 Musculoskeletal pain and prognosis of acute coronary syndrome and cerebrovascular accident: a linked electronic health record cohort study.

Correction: MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. (2022)
Journal Article
Garofalo, M., Jeon, Y., Nuovo, G. J., Middleton, J., Secchiero, P., Joshi, P., …Croce, C. M. (2022). Correction: MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. PloS one, e0267628 - ?. https://doi.org/10.1371/journal.pone.0267628

[This corrects the article DOI: 10.1371/journal.pone.0067581.].

In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants-Systematic Review and Meta-Analysis. (2022)
Journal Article
Kaur Sandhu, A., Yang, Y., & Li, W. (2022). In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants-Systematic Review and Meta-Analysis. ACS Biomaterials Science and Engineering, 1749-1762. https://doi.org/10.1021/acsbiomaterials.1c01307

Biomaterial-associated infection is difficult to detect and brings consequences that can lead to morbidity and mortality. Bacteria can adhere to the implant surface, grow, and form biofilms. Antimicrobial peptides (AMPs) can target and kill bacterial... Read More about In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants-Systematic Review and Meta-Analysis..

SUCCESSFUL ISOLATION AND CULTURE OF MULTIPOTENTIAL DISTAL AIRWAY STEM CELLS FROM COPD PATIENTS (2022)
Journal Article
Dale. (2022). SUCCESSFUL ISOLATION AND CULTURE OF MULTIPOTENTIAL DISTAL AIRWAY STEM CELLS FROM COPD PATIENTS. Tissue engineering. Part A, S451 - S452

Chronic Obstructive Pulmonary Disease (COPD) presents a significant, incurable, worldwide health burden, identifying it as a prospective regenerative medicine target. Sourcing cells for lung therapies is challenging; progress has been made in culturi... Read More about SUCCESSFUL ISOLATION AND CULTURE OF MULTIPOTENTIAL DISTAL AIRWAY STEM CELLS FROM COPD PATIENTS.

Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture (2022)
Journal Article
Chen, R., Ahmed, M. A., & Forsyth, N. R. (2022). Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture. Biomolecules, 12(4), 541 - 541. https://doi.org/10.3390/biom12040541

Cells respond to reduced oxygen availability predominately by activation of the hypoxia-inducible factor (HIF) pathway. HIF activation upregulates hundreds of genes that help cells survive in the reduced oxygen environment. The aim of this study is t... Read More about Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture.