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Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches (2017)
Journal Article
McIntyre, P. J., Collins, P. M., Vrzal, L., Birchall, K., Arnold, L. H., Mpamhanga, C., …Bayliss, R. (2017). Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches. ACS chemical biology, 12(11), 2906-2914. https://doi.org/10.1021/acschembio.7b00537

A new observation of Ovummuridae, from the mid-Silurian (Wenlock) strata of Wenlock Edge, Shropshire, UK: A preliminary report (2017)
Journal Article
(2017). A new observation of Ovummuridae, from the mid-Silurian (Wenlock) strata of Wenlock Edge, Shropshire, UK: A preliminary report

Calcareous microfossils belonging to the family Ovummuridae Munnecke, Servais and Vachard, 2000, are described for the first time from the Silurian strata of Wenlock Edge, Shropshire, UK. This occurrence increases the known palaeogeographical range o... Read More about A new observation of Ovummuridae, from the mid-Silurian (Wenlock) strata of Wenlock Edge, Shropshire, UK: A preliminary report.

Natural attenuation of chlorinated ethenes in hyporheic zones: a review of key biogeochemical processes and in-situ transformation potential (2017)
Journal Article
(2017). Natural attenuation of chlorinated ethenes in hyporheic zones: a review of key biogeochemical processes and in-situ transformation potential. Water Research, 362-382. https://doi.org/10.1016/j.watres.2017.10.059

Chlorinated ethenes (CEs) are legacy contaminants whose chemical footprint is expected to persist in aquifers around the world for many decades to come. These organohalides have been reported in river systems with concerning prevalence and are though... Read More about Natural attenuation of chlorinated ethenes in hyporheic zones: a review of key biogeochemical processes and in-situ transformation potential.

The SuperWASP catalogue of 4963 RR Lyr stars: identification of 983 Blazhko effect candidates (2017)
Journal Article
Greer, P., Payne, S., Norton, A., Maxted, P., Smalley, B., West, R., …Kolb, U. (2017). The SuperWASP catalogue of 4963 RR Lyr stars: identification of 983 Blazhko effect candidates. Astronomy & Astrophysics, A11. https://doi.org/10.1051/0004-6361/201630296

Aims. We set out to compile a catalogue of RRab pulsating variables in the SuperWASP archive and identify candidate Blazhko effect objects within this catalogue. We analysed their light curves and power spectra for correlations in their common charac... Read More about The SuperWASP catalogue of 4963 RR Lyr stars: identification of 983 Blazhko effect candidates.

Natural attenuation of chlorinated ethenes in hyporheic zones: a review of key biogeochemical processes and in-situ transformation potential (2017)
Journal Article
(2017). Natural attenuation of chlorinated ethenes in hyporheic zones: a review of key biogeochemical processes and in-situ transformation potential. Water Research, https://doi.org/10.1016/j.watres.2017.10.059

Chlorinated ethenes (CEs) are legacy contaminants whose chemical footprint is expected to persist in aquifers around the world for many decades to come. These organohalides have been reported in river systems with concerning prevalence and are though... Read More about Natural attenuation of chlorinated ethenes in hyporheic zones: a review of key biogeochemical processes and in-situ transformation potential.

Demolinguistics, internet and big data (2017)
Journal Article
Sorolla, N., Nobajas, À., & Gras, J. M. I. (2017). Demolinguistics, internet and big data

L’article revisa les novetats que aporten a la demolingüística les noves dades massives disponibles amb la proliferació d’Internet, i sobretot de les plataformes digitals de xarxes socials. Explora els avantatges i inconvenients d’aquesta nova font d... Read More about Demolinguistics, internet and big data.

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion (2017)
Journal Article
Russo. (2017). Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion. Science, 518 - 522. https://doi.org/10.1126/science.aan1478

Proteases of the malaria parasite Plasmodium falciparum have long been investigated as drug targets. The P. falciparum genome encodes 10 aspartic proteases called plasmepsins, which are involved in diverse cellular processes. Most have been studied e... Read More about Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.

Co-Occurrence and Characteristics of Patients With Axial Spondyloarthritis Who Meet Criteria for Fibromyalgia Results From a UK National Register (2017)
Journal Article
(2017). Co-Occurrence and Characteristics of Patients With Axial Spondyloarthritis Who Meet Criteria for Fibromyalgia Results From a UK National Register. Arthritis and Rheumatology, 2144 - 2150. https://doi.org/10.1002/art.40185

Objective. To estimate the proportion of patients with axial spondyloarthritis (SpA) in a UK national biologics registry who met criteria for fibromyalgia (FM), and to delineate the characteristics of these patients. Methods. Two cohorts of patients... Read More about Co-Occurrence and Characteristics of Patients With Axial Spondyloarthritis Who Meet Criteria for Fibromyalgia Results From a UK National Register.

Determining geophysical responses from burials in graveyards and cemeteries (2017)
Journal Article
Dick, H. C., Pringle, J. K., Wisniewski, K. D., Goodwin, J., van der Putten, R., Evans, G. T., …Hansen, J. D. (2017). Determining geophysical responses from burials in graveyards and cemeteries. Geophysics, 82(6), B245 - B255 (11). https://doi.org/10.1190/geo2016-0440.1

Graveyards and cemeteries around the world are being increasingly designated as full. There is a growing requirement to identify burial spaces or to exhume and then re-inter burials if necessary. Near-surface geophysical methods offer a potentially n... Read More about Determining geophysical responses from burials in graveyards and cemeteries.

Are all online hotel prices created dynamic?: An empirical assessment (2017)
Journal Article
(2017). Are all online hotel prices created dynamic?: An empirical assessment. International Journal of Hospitality Management, 163-173. https://doi.org/10.1016/j.ijhm.2017.09.001

Understanding how tourist firms set their online prices is important given their growing reliance on Online Travel Agencies (OTA). The article investigates whether the narrative of a pervasive presence of dynamic pricing provides a realistic descript... Read More about Are all online hotel prices created dynamic?: An empirical assessment.

Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U (2017)
Journal Article
Yang, X., Wang, C. C., Lee, W. Y. W., Trovik, J., Chung, T. K. H., & Kwong, J. (2018). Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U. Cancer Letters, 413, 23-34. https://doi.org/10.1016/j.canlet.2017.10.028

Endometrioid endometrial carcinoma (EEC) is one of the common causes of cancer-related mortality in women. Mounting evidences suggest that long noncoding RNAs (lncRNAs) function in multiple cancers. In this study, we discovered that HAND2-AS1, a lncR... Read More about Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U.

Involvement of the a/ß Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5) (2017)
Journal Article
Hasan, A. M., & Dent, G. (2017). Involvement of the a/ß Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5). American Journal of Immunology, 209-215. https://doi.org/10.3844/ajisp.2017.209.215

Eosinophils are the principal effector cells for allergic inflammation in a variety of diseases, in which they contribute to tissue damage and remodelling processes via the secretion of cytotoxic granular proteins and cytokines. The intracellular mec... Read More about Involvement of the a/ß Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5).

Irreversible mixing by unstable periodic orbits in buoyancy dominated stratified turbulence (2017)
Journal Article
(2017). Irreversible mixing by unstable periodic orbits in buoyancy dominated stratified turbulence. Journal of Fluid Mechanics, https://doi.org/10.1017/jfm.2017.695

We consider turbulence driven by a large-scale horizontal shear in Kolmogorov flow (i.e. with sinusoidal body forcing) and a background linear stable stratification with buoyancy frequency N-B(2) imposed in the third, vertical direction in a fluid wi... Read More about Irreversible mixing by unstable periodic orbits in buoyancy dominated stratified turbulence.

Supramolecular coordination polymers using a close to ‘V-shaped’ fluorescent 4-amino-1,8-naphthalimide Tröger's base scaffold (2017)
Journal Article
Shanmugaraju, S., Hawes, C. S., Savyasachi, A. J., Blasco, S., Kitchen, J. A., & Gunnlaugsson, T. (in press). Supramolecular coordination polymers using a close to ‘V-shaped’ fluorescent 4-amino-1,8-naphthalimide Tröger's base scaffold. Chemical Communications, 53(93), 12512-12515. https://doi.org/10.1039/c7cc07333j

A V-shaped 4-amino-1,8-naphthalimide derived dipyridyl ligand comprising the Tröger's base structural motif has been synthesised and subsequently used in the formation of two new supramolecular coordination polymers.

Differential Drug Survival of Second-Line Biologic Therapies in Patients with Psoriasis: Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR). (2017)
Journal Article
Iskandar, I. Y., Warren, R. B., Lunt, M., Mason, K. J., Evans, I., McElhone, K., …Griffiths, C. E. (2018). Differential Drug Survival of Second-Line Biologic Therapies in Patients with Psoriasis: Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR). Journal of Investigative Dermatology, 138(4), 775 - 784. https://doi.org/10.1016/j.jid.2017.09.044

Little is known about the drug survival of second-line biologic therapies for psoriasis in routine clinical practice. We assessed drug survival of second-line biologic therapies and estimated the risk of recurrent discontinuation due to adverse event... Read More about Differential Drug Survival of Second-Line Biologic Therapies in Patients with Psoriasis: Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR)..

A randomised trial of the influence of racial stereotype bias on examiners’ scores, feedback and recollections in undergraduate clinical exams (2017)
Journal Article
Yeates. (2017). A randomised trial of the influence of racial stereotype bias on examiners’ scores, feedback and recollections in undergraduate clinical exams. BMC Medicine, 179 -?. https://doi.org/10.1186/s12916-017-0943-0

Asian medical students and doctors receive lower scores on average than their white counterparts in examinations in the UK and internationally (a phenomenon known as “differential attainment”). This could be due to examiner bias or to social, psychol... Read More about A randomised trial of the influence of racial stereotype bias on examiners’ scores, feedback and recollections in undergraduate clinical exams.

The Use of Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry and Metabonomic Profiling to Differentiate Between Normally Slaughtered and Dead On Arrival Poultry Meat (2017)
Journal Article
Thompson. (2017). The Use of Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry and Metabonomic Profiling to Differentiate Between Normally Slaughtered and Dead On Arrival Poultry Meat. Analytical Chemistry, 12131-12136. https://doi.org/10.1021/acs.analchem.7b02749

Metabonomic profiling techniques, with established quality control methods, have been used to detect subtle metabolic differences in tissue that could aid in the discovery of fraud within the food industry. Liquid chromatography quadrupole time-of-fl... Read More about The Use of Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry and Metabonomic Profiling to Differentiate Between Normally Slaughtered and Dead On Arrival Poultry Meat.

Different communication strategies for disclosing a diagnosis of schizophrenia and related disorders. (2017)
Journal Article
Farooq, S., Johal, R. K., Ziff, C., & Naeem, F. (2017). Different communication strategies for disclosing a diagnosis of schizophrenia and related disorders. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD011707.pub2

BACKGROUND: Delivering the diagnosis of a serious illness is an important skill in most fields of medicine, including mental health. Research has found that communication skills can impact on a person's recall and understanding of the diagnosis, trea... Read More about Different communication strategies for disclosing a diagnosis of schizophrenia and related disorders..