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Very Deep inside the SN 1987A Core Ejecta: Molecular Structures Seen in 3D (2017)
Journal Article
Abellán, F. J., Indebetouw, R., Marcaide, J. M., Gabler, M., Fransson, C., Spyromilio, J., …Woosley, S. E. (in press). Very Deep inside the SN 1987A Core Ejecta: Molecular Structures Seen in 3D. Astrophysical Journal Letters, 842(2), L24. https://doi.org/10.3847/2041-8213/aa784c

Most massive stars end their lives in core-collapse supernova explosions and enrich the interstellar medium with explosively nucleosynthesized elements. Following core collapse, the explosion is subject to instabilities as the shock propagates outwar... Read More about Very Deep inside the SN 1987A Core Ejecta: Molecular Structures Seen in 3D.

A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFa-TGFa-EGFR. (2017)
Journal Article
Kwong. (2017). A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFa-TGFa-EGFR. Oncogene, 3576 - 3587. https://doi.org/10.1038/onc.2016.509

Peritoneum is the most common site for ovarian cancer metastasis. Here we investigate how cancer epigenetics regulates reciprocal tumor-stromal interactions in peritoneal metastasis of ovarian cancer. Firstly, we find that omental stromal fibroblasts... Read More about A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFa-TGFa-EGFR..

Predicting risk of undiagnosed COPD: development and validation of the TargetCOPD score. (2017)
Journal Article
(2017). Predicting risk of undiagnosed COPD: development and validation of the TargetCOPD score. European Respiratory Journal, https://doi.org/10.1183/13993003.02191-2016

Chronic obstructive pulmonary disease (COPD) is greatly underdiagnosed worldwide and more efficient methods of case-finding are required. We developed and externally validated a risk score to identify undiagnosed COPD using primary care records.We co... Read More about Predicting risk of undiagnosed COPD: development and validation of the TargetCOPD score..

Recurring sets of recurring starspots on exoplanet-host Qatar-2 (2017)
Journal Article
Močnik, T., Southworth, J., & Hellier, C. (2017). Recurring sets of recurring starspots on exoplanet-host Qatar-2. Monthly Notices of the Royal Astronomical Society, 471(1), 394-403. https://doi.org/10.1093/mnras/stx1557

We announce the detection of recurring sets of recurring starspot occultation events in the short-cadence K2 light curve of Qatar-2, a K dwarf star transited every 1.34 d by a hot Jupiter. In total, we detect 34 individual starspot occultation events... Read More about Recurring sets of recurring starspots on exoplanet-host Qatar-2.

Effective treatment options for musculoskeletal pain in primary care: A systematic overview of current evidence (2017)
Journal Article
Babatunde, O., Jordan, J., Van Der Windt, D., Hill, J., Foster, N. E., & Protheroe, J. (2017). Effective treatment options for musculoskeletal pain in primary care: A systematic overview of current evidence. PLoS ONE, 12(6), Article e0178621. https://doi.org/10.1371/journal.pone.0178621

Background & aims Musculoskeletal pain, the most common cause of disability globally, is most frequently managed in primary care. People with musculoskeletal pain in different body regions share similar characteristics, prognosis, and may respond to... Read More about Effective treatment options for musculoskeletal pain in primary care: A systematic overview of current evidence.

The Influence of Buyers' Time Orientation on Online Shopping Behavior: A Typology (2017)
Journal Article
(2017). The Influence of Buyers' Time Orientation on Online Shopping Behavior: A Typology. International Journal of Electronic Commerce, 299-333. https://doi.org/10.1080/10864415.2016.1319206

This research investigates the influence of buyers’ time orientations (measured as polychronic–monochronic and past–future time orientations) on four major variables of online shopping: trust, social interaction, browsing, and locus of control, which... Read More about The Influence of Buyers' Time Orientation on Online Shopping Behavior: A Typology.

KCC3 loss-of-function contributes to Andermann syndrome by inducing activity-dependent neuromuscular junction defects. (2017)
Journal Article
Bowerman, M., Salsac, C., Bernard, V., Soulard, C., Dionne, A., Coque, E., …Scamps, F. (2017). KCC3 loss-of-function contributes to Andermann syndrome by inducing activity-dependent neuromuscular junction defects. Neurobiology of Disease, 106, 35 - 48. https://doi.org/10.1016/j.nbd.2017.06.013

Loss-of-function mutations in the potassium-chloride cotransporter KCC3 lead to Andermann syndrome, a severe sensorimotor neuropathy characterized by areflexia, amyotrophy and locomotor abnormalities. The molecular events responsible for axonal loss... Read More about KCC3 loss-of-function contributes to Andermann syndrome by inducing activity-dependent neuromuscular junction defects..

Management of shoulder pain by UK general practitioners (GPs): a national survey (2017)
Journal Article
Roddy, & Van Der Windt. (2017). Management of shoulder pain by UK general practitioners (GPs): a national survey. BMJ Open, e015711 -?. https://doi.org/10.1136/bmjopen-2016-015711

OBJECTIVES: Studies in Canada, the USA and Australia suggested low confidence among general practitioners (GPs) in diagnosing and managing shoulder pain, with frequent use of investigations. There are no comparable studies in the UK; our objective wa... Read More about Management of shoulder pain by UK general practitioners (GPs): a national survey.

Knowledge, attitude and practice of healthcare professionals towards infliximab and insulin glargine biosimilars: result of a UK web-based survey (2017)
Journal Article
Chapman, S. R., Fitzpatrick, R. W., & Aladul, M. I. (2017). Knowledge, attitude and practice of healthcare professionals towards infliximab and insulin glargine biosimilars: result of a UK web-based survey. BMJ Open, 7(6), e016730 - ?. https://doi.org/10.1136/bmjopen-2017-016730

OBJECTIVE: To investigate healthcare professionals' knowledge and attitudes towards infliximab and insulin glargine biosimilars and the factors influencing their prescribing. Then, to compare healthcare professionals' attitudes with the utilisation o... Read More about Knowledge, attitude and practice of healthcare professionals towards infliximab and insulin glargine biosimilars: result of a UK web-based survey.

Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design. (2017)
Journal Article
Richardson, J. B., Wright, K. T., Wales, J., Herman Kuiper, J., McCarthy, H. S., Gallacher, P., …Roberts, S. (2017). Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design. Regenerative Medicine, 12(5), 493-501. https://doi.org/10.2217/rme-2017-0032

AIM: The main aim of this trial is to test the safety and efficacy of autologous stromal/stem cells, chondrocytes or the two combined in the treatment of knee cartilage defects. PATIENTS & METHODS: Patients with symptomatic chondral/osteochondral def... Read More about Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design..

Single-molecule Analysis Reveals that DNA Replication Dynamics Vary Across the Course of Schizogony in the Malaria Parasite Plasmodium falciparum (2017)
Journal Article
(2017). Single-molecule Analysis Reveals that DNA Replication Dynamics Vary Across the Course of Schizogony in the Malaria Parasite Plasmodium falciparum. Scientific reports, https://doi.org/10.1038/s41598-017-04407-z

The mechanics of DNA replication and cell cycling are well-characterized in model organisms, but less is known about these basic aspects of cell biology in early-diverging Apicomplexan parasites, which do not divide by canonical binary fission but un... Read More about Single-molecule Analysis Reveals that DNA Replication Dynamics Vary Across the Course of Schizogony in the Malaria Parasite Plasmodium falciparum.

Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity (2017)
Journal Article
Werther, R., Hallinan, J. P., Lambert, A. R., Havens, K., Pogson, M., Jarjour, J., …Stoddard, B. L. (2017). Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity. Nucleic acids research, 8621 - 8634. https://doi.org/10.1093/nar/gkx544

The retargeting of protein-DNA specificity, outside of extremely modular DNA binding proteins such as TAL effectors, has generally proved to be quite challenging. Here, we describe structural analyses of five different extensively retargeted variants... Read More about Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity.

3D hydrodynamic simulations of carbon burning in massive stars (2017)
Journal Article
Cristini, A., Meakin, C., Hirschi, R., Arnett, D., Georgy, C., Viallet, M., & Walkington, I. (2017). 3D hydrodynamic simulations of carbon burning in massive stars. Monthly Notices of the Royal Astronomical Society, 471(1), 279 -300. https://doi.org/10.1093/mnras/stx1535

We present the first detailed 3D hydrodynamic implicit large eddy simulations of turbulent convection of carbon burning in massive stars. Simulations begin with radial profiles mapped from a carbon-burning shell within a 15M circle dot 1D stellar evo... Read More about 3D hydrodynamic simulations of carbon burning in massive stars.

Association between characteristics of pain and stiffness and the functional status of patients with incident polymyalgia rheumatica from primary care (2017)
Journal Article
Cawley, A., Prior, J., Muller, S., Helliwell, T., Hider, S., Dasgupta, B., …Mallen, C. (2017). Association between characteristics of pain and stiffness and the functional status of patients with incident polymyalgia rheumatica from primary care. Clinical Rheumatology, 37(6), 1639-1644. https://doi.org/10.1007/s10067-017-3730-6

This paper aims to examine the relationship between different characteristics of pain and stiffness and the functional status of patients with newly diagnosed polymyalgia rheumatica (PMR). Baseline analysis of an inception cohort study was conducted.... Read More about Association between characteristics of pain and stiffness and the functional status of patients with incident polymyalgia rheumatica from primary care.

The disjuncture between confidence and cooperation: Police contact amongst Polish migrants and established residents (2017)
Journal Article
Griffiths, C. (2018). The disjuncture between confidence and cooperation: Police contact amongst Polish migrants and established residents. European Journal of Criminology, 15(2), 197-216. https://doi.org/10.1177/1477370817712962

Trust and confidence in such criminal justice institutions as the police is considered crucial for the successful functioning of society and to allow for greater voluntary compliance and cooperation with institutions of control. There is a plethora o... Read More about The disjuncture between confidence and cooperation: Police contact amongst Polish migrants and established residents.