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ALMA reveals the aftermath of a white dwarf-brown dwarf merger in CK Vulpeculae (2018)
Journal Article
Eyres, S. P. S., Evans, A., Zijlstra, A., Avison, A., Gehrz, R. D., Hajduk, M., …Wagner, R. M. (2018). ALMA reveals the aftermath of a white dwarf-brown dwarf merger in CK Vulpeculae. Monthly Notices of the Royal Astronomical Society, 481(4), 4931-4939. https://doi.org/10.1093/mnras/sty2554

We present Atacama Large Millimeter–Submillimeter Array (ALMA) observations of CK Vulpeculae which is identified with ‘Nova Vulpeculae 1670’. They trace obscuring dust in the inner regions of the associated nebulosity. The dust forms two cocoons, eac... Read More about ALMA reveals the aftermath of a white dwarf-brown dwarf merger in CK Vulpeculae.

Association of Same-Day Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes (2018)
Journal Article
Mamas. (2018). Association of Same-Day Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes. JAMA Cardiology, https://doi.org/10.1001/jamacardio.2018.3029

Importance Same-day discharge (SDD) after elective percutaneous coronary intervention (PCI) is associated with lower costs and preferred by patients. However, to our knowledge, contemporary patterns of SDD after elective PCI with respect to the inci... Read More about Association of Same-Day Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes.

Engineering CRISPR guide RNA riboswitches for in vivo applications (2018)
Journal Article
Galizi, R., & Jaramillo, A. (2018). Engineering CRISPR guide RNA riboswitches for in vivo applications. Current Opinion in Biotechnology, 103 - 113. https://doi.org/10.1016/j.copbio.2018.08.007

CRISPR-based genome editing provides a simple and scalable toolbox for a variety of therapeutic and biotechnology applications. Whilst the fundamental properties of CRISPR proved easily transferable from the native prokaryotic hosts to eukaryotic and... Read More about Engineering CRISPR guide RNA riboswitches for in vivo applications.

The Gaia-ESO Survey: the origin and evolution of s-process elements (2018)
Journal Article
Jeffries. (2018). The Gaia-ESO Survey: the origin and evolution of s-process elements. Astronomy & Astrophysics, https://doi.org/10.1051/0004-6361/201832841

Context. Several works have found an increase of the abundances of the s-process neutron-capture elements in the youngest Galactic stellar populations. These trends provide important constraints on stellar and Galactic evolution and they need to be c... Read More about The Gaia-ESO Survey: the origin and evolution of s-process elements.

A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes (2018)
Journal Article
Kyrou, K., M Hammond, A., Galizi, R., Kranjc, N., Burt, A., K Beaghton, A., …Crisanti, A. (2018). A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes. Nature Biotechnology, 1062 - 1066. https://doi.org/10.1038/nbt.4245

In the human malaria vector Anopheles gambiae, the gene doublesex (Agdsx) encodes two alternatively spliced transcripts, dsx-female (AgdsxF) and dsx-male (AgdsxM), that control differentiation of the two sexes. The female transcript, unlike the male,... Read More about A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes.

Low-metallicity CO+He WD post-merger models for RCB stars and their connection to pre-solar low-density graphite grains (2018)
Journal Article
(2018). Low-metallicity CO+He WD post-merger models for RCB stars and their connection to pre-solar low-density graphite grains. Monthly Notices of the Royal Astronomical Society, https://doi.org/10.1093/mnras/sty2606

R Coronae Borealis stars are predominantly metal-poor, near-solar mass hydrogen-deficient carbon-rich supergiants, that have evolved from mergers of carbon-oxygen and helium white dwarf systems. They have some of the lowest 16O/18O ratios measured in... Read More about Low-metallicity CO+He WD post-merger models for RCB stars and their connection to pre-solar low-density graphite grains.

Post-disaster tourism: building resilience through community-led approaches in the aftermath of the 2011 disasters in Japan (2018)
Journal Article
(2018). Post-disaster tourism: building resilience through community-led approaches in the aftermath of the 2011 disasters in Japan. Journal of Sustainable Tourism, 1766-1783. https://doi.org/10.1080/09669582.2018.1511720

Post-disaster tourism is often perceived as a form of Dark Tourism associated with death, loss and destruction. In Japan, the term Dark Tourism has gained prominence following the 2011 Great East Japan Earthquake and Tsunami. This paper focuses on a... Read More about Post-disaster tourism: building resilience through community-led approaches in the aftermath of the 2011 disasters in Japan.

'For the Protection of all the People’: Æthelflæd and her Burhs in Northwest Mercia (2018)
Journal Article
Blake, M., & Sargent, A. (2018). 'For the Protection of all the People’: Æthelflæd and her Burhs in Northwest Mercia. Midland History, 43(2), 120-154. https://doi.org/10.1080/0047729X.2018.1519141

The fortifications, or burhs, constructed between 910 and 915 by Æthelflæd, Lady of the Mercians, across much of the western Midlands have often been understood as part of a broader programme initiated by her brother Edward, king of the Anglo-Saxons,... Read More about 'For the Protection of all the People’: Æthelflæd and her Burhs in Northwest Mercia.

A Novel PAA Derivative with Enhanced Drug Efficacy in Pancreatic Cancer Cell Lines (2018)
Journal Article
Alsuraifi, A., Kong Thoo Lin, P., Curtis, A., Lamprou, D., & Hoskins, C. (2018). A Novel PAA Derivative with Enhanced Drug Efficacy in Pancreatic Cancer Cell Lines. Pharmaceuticals, https://doi.org/10.3390/ph11040091

Nanoparticles have been shown to be effective drug carriers in cancer therapy. Pancreatic cancer forms dense tumours which are often resistant to drug molecules. In order to overcome such multidrug resistance, new drug entities, novel delivery system... Read More about A Novel PAA Derivative with Enhanced Drug Efficacy in Pancreatic Cancer Cell Lines.

Factors associated with physiotherapists' preference for MRI in primary care patients with low back and leg pain (2018)
Journal Article
Ely, S., Stynes, S., Ogollah, R., Foster, N. E., & Konstantinou, K. (2018). Factors associated with physiotherapists' preference for MRI in primary care patients with low back and leg pain. Musculoskeletal Science and Practice, 38, 46-52. https://doi.org/10.1016/j.msksp.2018.09.003

Background Criticisms about overuse of MRI in low back pain are well documented. Yet, with the exception of suspicion of serious pathology, little is known about factors that influence clinicians' preference for magnetic resonance imaging (MRI) at f... Read More about Factors associated with physiotherapists' preference for MRI in primary care patients with low back and leg pain.

Overwinter survival and post-release movements of translocated water voles: implications for current mitigation guidance (2018)
Journal Article
(2018). Overwinter survival and post-release movements of translocated water voles: implications for current mitigation guidance. European Journal of Wildlife Research, https://doi.org/10.1007/s10344-018-1216-8

Translocation is currently used as a last resort mitigation strategy for water voles (Arvicola amphibius) in the UK (Dean et al. 2016), where populations have undergone widespread declines during the past century. To increase the chances of success,... Read More about Overwinter survival and post-release movements of translocated water voles: implications for current mitigation guidance.

Seasonal aggravation of acne in summers and the effect of temperature and humidity in a study in a tropical setting (2018)
Journal Article
Narang, I., Sardana, K., Bajpai, R., & Garg, V. K. (2019). Seasonal aggravation of acne in summers and the effect of temperature and humidity in a study in a tropical setting. Journal of Cosmetic Dermatology, 18(4), 1098-1104. https://doi.org/10.1111/jocd.12777

Summary Background Effect of seasonality on acne and acne flare has varied interpretations depending on the geographical area of study. In tropical areas, factors like high temperature and humidity may cause acne flares. Aims To assess the seasonal v... Read More about Seasonal aggravation of acne in summers and the effect of temperature and humidity in a study in a tropical setting.

Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone (2018)
Journal Article
O'Brien, M., Weber, A., Hardy, G., & Ley, S. (2018). Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone. Tetrahedron, 5319 - 5329. https://doi.org/10.1016/j.tet.2018.06.041

A mannitol derived 2,3-butanediacetal ethyl ketone displays high levels of diastereoselectivity in boron and titanium mediated aldol reactions with a range of aliphatic and aromatic aldehydes to afford syn aldol products in high yield. The stereochem... Read More about Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone.

Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model. (2018)
Journal Article
Owida, H., Rutter, A., Cinque, G., Kuiper, N., Sule-Suso, J., & Yang, Y. (2018). Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model. Analyst, 5979-5986. https://doi.org/10.1039/c8an01272e

Isolated and monolayer expanded chondrocytes are not the ideal cell form to produce a cartilage matrix. In articular cartilage, each chondrocyte is surrounded by a 2-4 µm thick collagen VI-rich pericellular matrix (PCM) forming a chondron. Freshly ex... Read More about Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model..

Policing football crowds in Sweden (2018)
Journal Article
Stott, C., Havelund, J., & Williams, N. (2018). Policing football crowds in Sweden. Journal of Scandinavian Studies in Criminology and Crime Prevention, https://doi.org/10.1080/14043858.2018.1513679

The policing football crowds in Sweden is underpinned by a national coordination approach based upon a set of conflict reducing principles and supported by crowd theory (Reicher et al., 2004). The approach is referred to as the Special Police Tactic... Read More about Policing football crowds in Sweden.

Screening of the cervical spine in sub-acromial shoulder pain: a systematic review (2018)
Journal Article
(2018). Screening of the cervical spine in sub-acromial shoulder pain: a systematic review. Shoulder and Elbow,

Background Sub-acromial shoulder pain (SASP) is a common clinical presentation with much diagnostic uncertainty. Some of this uncertainty relates to the involvement of the cervical spine as a source or contribution to SASP. Currently, there is no ac... Read More about Screening of the cervical spine in sub-acromial shoulder pain: a systematic review.

The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1. (2018)
Journal Article
(2018). The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1. Cell chemical biology, 1107-1116. https://doi.org/10.1016/j.chembiol.2018.06.001

The polo kinase family are important oncology targets that act in regulating entry into and progression through mitosis. Structure-guided discovery of a new class of inhibitors of Polo-like kinase 1 (PLK1) catalytic activity that interact with Cys67... Read More about The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1..

A new quality of life wound checklist: the patient voice in wound care (2018)
Journal Article
Green, J., Green, L., Corcoran, P., & Read, S. (2018). A new quality of life wound checklist: the patient voice in wound care. Wounds UK, 14(4), 40-45

Wounds are expensive; to the NHS as a whole, to local Trusts who provide wound care services with increasingly tightening budgets, to teams within predominantly primary care who deliver the care required and, lastly, but not least, to the patient and... Read More about A new quality of life wound checklist: the patient voice in wound care.

Changes in human intervertebral disc biochemical composition and bony end plates between middle and old age (2018)
Journal Article
Martins, D., de Medeiros, V., Wajchenberg, M., Paredes-Gamero, E., Andrade De Lima, M., Reginato, R., …Faloppa, F. (2018). Changes in human intervertebral disc biochemical composition and bony end plates between middle and old age. PloS one, 13, e0203932--e0203932. https://doi.org/10.1371/journal.pone.0203932

Objective This study evaluates molecular, nutritional and biochemical alterations in human intervertebral discs between middle and old age. Methods Twenty-eight human lumbar intervertebral discs from donors were evaluated and separated into two... Read More about Changes in human intervertebral disc biochemical composition and bony end plates between middle and old age.