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Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. (2018)
Journal Article
Holmes, A. M., Heylings, J. R., Wan, K., & Moss, G. P. (2019). Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. International Journal of Antimicrobial Agents, 53(4), 500-507. https://doi.org/10.1016/j.ijantimicag.2018.12.012

The aim of this study was to investigate a range of poly(amidoamine) (PAMAM) dendrimer generations against Gram-positive and Gram-negative skin pathogens and to determine any differences in antimicrobial potency for different generations, characteris... Read More about Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens..

Prevalence of foot pain across an international consortium of population based cohorts. (2018)
Journal Article
Gates, L. S., Arden, N. K., Hannan, M. T., Roddy, E., Gill, T. K., Hill, C. L., …Golightly, Y. M. (2019). Prevalence of foot pain across an international consortium of population based cohorts. Arthritis Care and Research, 71(5), 661-670. https://doi.org/10.1002/acr.23829

OBJECTIVE: Despite the potential burden of foot pain, some of the most fundamental epidemiological questions surrounding the foot remain poorly explored. The prevalence of foot pain has proved difficult to compare across existing studies due to var... Read More about Prevalence of foot pain across an international consortium of population based cohorts..

Evaluating associations between metabolic health, obesity and depressive symptoms: a prospective analysis of data from the English Longitudinal Study of Ageing (ELSA) with a 2-year follow-up. (2018)
Journal Article
Slater, N., Rowley, C., Venables, R., White, S., & Frisher, M. (2018). Evaluating associations between metabolic health, obesity and depressive symptoms: a prospective analysis of data from the English Longitudinal Study of Ageing (ELSA) with a 2-year follow-up. BMJ Open, 8(12), https://doi.org/10.1136/bmjopen-2018-025394

OBJECTIVES: Conflicting results have been reported when the associations between metabolic health, obesity and depression were examined previously. The primary aim of this study was to determine whether metabolic health or obesity are independently a... Read More about Evaluating associations between metabolic health, obesity and depressive symptoms: a prospective analysis of data from the English Longitudinal Study of Ageing (ELSA) with a 2-year follow-up..

The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life (2018)
Journal Article
(2019). The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life. Seminars in Arthritis and Rheumatism, 49(1), 20-26. https://doi.org/10.1016/j.semarthrit.2018.12.006

Objective Treat-to-target in rheumatoid arthritis (RA) recommends targeting remission, with low disease activity (LDA) being an alternative goal. When deciding to target remission or LDA, important considerations are the likelihood of attaining them... Read More about The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life.

Exploring the reversible host-guest chemistry of a crystalline octanuclear Ag(I) metallosupramolecular macrocycle formed from a simple pyrazinylpyridine ligand (2018)
Journal Article
Hawes, C. S. (2018). Exploring the reversible host-guest chemistry of a crystalline octanuclear Ag(I) metallosupramolecular macrocycle formed from a simple pyrazinylpyridine ligand. Dalton Transactions, 17266-17275. https://doi.org/10.1039/C8DT04583F

Here we report the synthesis of two new 2-(2-pyrazinyl)pyridine ligands, and explore their coordination chemistry with Cu(ii) and Ag(i) ions, leading to the discovery of metallosupramolecular architectures of surprising complexity. Differing only in... Read More about Exploring the reversible host-guest chemistry of a crystalline octanuclear Ag(I) metallosupramolecular macrocycle formed from a simple pyrazinylpyridine ligand.

Molecular tools and genetic markers for the generation of transgenic sexing strains in Anopheline mosquitoes. (2018)
Journal Article
Bernardini, F., Elaine Haghighat-Khah, R., Galizi, R., Marc Hammond, A., Nolan, T., & Crisanti, A. (2018). Molecular tools and genetic markers for the generation of transgenic sexing strains in Anopheline mosquitoes. Parasites and Vectors, 660 - ?. https://doi.org/10.1186/s13071-018-3207-8

Malaria is a serious global health burden, affecting more than 200 million people each year in over 90 countries, predominantly in Africa, Asia and the Americas. Since the year 2000, a concerted effort to combat malaria has reduced its incidence by m... Read More about Molecular tools and genetic markers for the generation of transgenic sexing strains in Anopheline mosquitoes..

A perspective on the need and current status of efficient sex separation methods for mosquito genetic control. (2018)
Journal Article
(2018). A perspective on the need and current status of efficient sex separation methods for mosquito genetic control. Parasites and Vectors, 654 - ?. https://doi.org/10.1186/s13071-018-3222-9

Major efforts are currently underway to develop novel, complementary methods to combat mosquito-borne diseases. Mosquito genetic control strategies (GCSs) have become an increasingly important area of research on account of their species-specificity,... Read More about A perspective on the need and current status of efficient sex separation methods for mosquito genetic control..

Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database (2018)
Journal Article
Mamas. (2018). Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database. JACC. Cardiovascular interventions, 2480-2491. https://doi.org/10.1016/j.jcin.2018.09.035

Objectives Using the British Cardiovascular Intervention Society percutaneous coronary intervention (PCI) database, temporal trends, predictors, and outcomes of radial access (RA) versus femoral access (FA) for unprotected left main stem percutaneou... Read More about Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database.

Playing in the UEFA Europa League Does Not Adversely Affect English Premier League or La Liga Performance (2018)
Journal Article
Stephens, R., Bosworth, G., & Shepherd, T. A. (2018). Playing in the UEFA Europa League Does Not Adversely Affect English Premier League or La Liga Performance. Journal of Functional Morphology and Kinesiology, 4(1 (Special Issue Sport Psychology)), https://doi.org/10.3390/jfmk4010002

Purpose: This article presents data challenging the widely held but untested view that concurrently playing mid-week Union of European Football Associations (UEFA) Europa League matches adversely affects domestic league performance. Method: Over... Read More about Playing in the UEFA Europa League Does Not Adversely Affect English Premier League or La Liga Performance.

Can the STarT Back Tool predict health-related quality of life and work ability after an acute/subacute episode with back or neck pain? A psychometric validation study in primary care. (2018)
Journal Article
Hill, J. (2018). Can the STarT Back Tool predict health-related quality of life and work ability after an acute/subacute episode with back or neck pain? A psychometric validation study in primary care. BMJ Open, https://doi.org/10.1136/bmjopen-2018-021748

OBJECTIVES: The predictive ability of the STarT Back Tool (SBT) has not yet been examined among acute/subacute back and/or neck pain in a primary care setting in respect to health-related quality of life (HRQoL) and work ability outcomes. The aim of... Read More about Can the STarT Back Tool predict health-related quality of life and work ability after an acute/subacute episode with back or neck pain? A psychometric validation study in primary care..

The microRNA-183/96/182 Cluster is Essential for Stereociliary Bundle Formation and Function of Cochlear Sensory Hair Cells (2018)
Journal Article
Geng, R., Furness, D. N., Muraleedharan, C. K., Zhang, J., Dabdoub, A., Lin, V., & Xu, S. (2018). The microRNA-183/96/182 Cluster is Essential for Stereociliary Bundle Formation and Function of Cochlear Sensory Hair Cells. Scientific reports, 8, 18022 - ?. https://doi.org/10.1038/s41598-018-36894-z

The microRNA (miR)-183/96/182 cluster plays important roles in the development and functions of sensory organs, including the inner ear. Point-mutations in the seed sequence of miR-96 result in non-syndromic hearing loss in both mice and humans. Howe... Read More about The microRNA-183/96/182 Cluster is Essential for Stereociliary Bundle Formation and Function of Cochlear Sensory Hair Cells.

Infestation by Myzus persicae Increases Susceptibility of Brassica napus cv. "Canard" to Rhizoctonia solani AG 2-1 (2018)
Journal Article
Drizou, F., Bruce, T. J. A., Ray, R. V., & Graham, N. S. (2018). Infestation by Myzus persicae Increases Susceptibility of Brassica napus cv. "Canard" to Rhizoctonia solani AG 2-1. Frontiers in Plant Science, 9, Article ARTN 1903. https://doi.org/10.3389/fpls.2018.01903

Activation of plant defense pathways can be influenced by the presence of different species of attacking organisms. Understanding the complicated interactions triggering plant defense mechanisms is of great interest as it may allow the development of... Read More about Infestation by Myzus persicae Increases Susceptibility of Brassica napus cv. "Canard" to Rhizoctonia solani AG 2-1.

Developing a video-based method to compare and adjust examiner effects in fully nested OSCEs (2018)
Journal Article
Yeates, P., Cope, N., Hawarden, A., Bradshaw, H., McCray, G., & Homer, M. (2019). Developing a video-based method to compare and adjust examiner effects in fully nested OSCEs. Medical Education, 53(3), 250-263. https://doi.org/10.1111/medu.13783

Background: Whilst averaging across multiple examiners judgements reduces unwanted overall score variability in Objective Structured Clinical Examinations (OSCE), designs involving several parallel circuits of the OSCE require that different examin... Read More about Developing a video-based method to compare and adjust examiner effects in fully nested OSCEs.

NGTS-2b: An inflated hot-Jupiter transiting a bright F-dwarf (2018)
Journal Article
Raynard, L., Goad, M. R., Gillen, E., Nielsen, L. D., Watson, C. A., Thompson, A. P. G., …Wheatley, P. J. (2018). NGTS-2b: An inflated hot-Jupiter transiting a bright F-dwarf. Monthly Notices of the Royal Astronomical Society, 481(4), 4960-4970. https://doi.org/10.1093/mnras/sty2581

We report the discovery of NGTS-2b, an inflated hot-Jupiter transiting a bright F5V star (2MASS J14202949 - 3112074; Teff = 6478+94-89 K), discovered as part of the Next Generation Transit Survey (NGTS). The planet is in a P = 4.51?d orbit with mass... Read More about NGTS-2b: An inflated hot-Jupiter transiting a bright F-dwarf.

Effect on hospital length of stay of tourniquet use during internal fixation of ankle fracture: randomized controlled trial (2018)
Journal Article
Sim, J., Grocott, N., Majeed, H., & McClelland, D. (2019). Effect on hospital length of stay of tourniquet use during internal fixation of ankle fracture: randomized controlled trial. Journal of Foot and Ankle Surgery, 58(1), 114-118. https://doi.org/10.1053/j.jfas.2018.08.023

Approximately 50% of ankle fractures require internal fixation. A tourniquet is often employed to create a bloodless operative field, but its effect on hospital length of stay (LOS) is unclear. This paper reports a parallel-group observer-blinded ran... Read More about Effect on hospital length of stay of tourniquet use during internal fixation of ankle fracture: randomized controlled trial.

HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis (2018)
Journal Article
Dand, N., Duckworth, M., Baudry, D., Russell, A., Curtis, C. J., Hyuck Lee, S., …Study Group, B. (2019). HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis. Journal of Allergy and Clinical Immunology, 143(6), 2120-2130. https://doi.org/10.1016/j.jaci.2018.11.038

BACKGROUND: Biologic therapies can be highly effective for the treatment of severe psoriasis, but response for individual patients can vary according to drug. Predictive biomarkers to guide treatment selection could improve patient outcomes and treat... Read More about HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis.

Insect population trends and the IUCN Red List process (2018)
Journal Article
Fox, R., Harrower, C. A., Bell, J. R., Shortall, C. R., Middlebrook, I., & Wilson, R. J. (2018). Insect population trends and the IUCN Red List process. Journal of Insect Conservation, 23, 269–278. https://doi.org/10.1007/s10841-018-0117-1

Reliable assessment of extinction risk is a key factor in the preparation of Red Lists and in prioritizing biodiversity conservation. Temporal population trends can provide important evidence for such assessments, but imperfect sampling (observation... Read More about Insect population trends and the IUCN Red List process.