All Outputs (1405)

Early Last Interglacial ocean warming drove substantial ice mass loss from Antarctica. (2020)
Journal Article
(2020). Early Last Interglacial ocean warming drove substantial ice mass loss from Antarctica. Proceedings of the National Academy of Sciences of the United States of America, 3996-4006. https://doi.org/10.1073/pnas.1902469117

The future response of the Antarctic ice sheet to rising temperatures remains highly uncertain. A useful period for assessing the sensitivity of Antarctica to warming is the Last Interglacial (LIG) (129 to 116 ky), which experienced warmer polar temp... Read More about Early Last Interglacial ocean warming drove substantial ice mass loss from Antarctica..

Early Last Interglacial ocean warming drove substantial ice mass loss from Antarctica (2020)
Journal Article
(2020). Early Last Interglacial ocean warming drove substantial ice mass loss from Antarctica. Proceedings of the National Academy of Sciences of the United States of America, 3996-4006. https://doi.org/10.5194/egusphere-egu2020-12771

The future response of the Antarctic ice sheet to rising temperatures remains highly uncertain. A useful period for assessing the sensitivity of Antarctica to warming is the Last Interglacial (LIG; 129-116 kyr), which experienced warmer polar tempera... Read More about Early Last Interglacial ocean warming drove substantial ice mass loss from Antarctica.

Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched cohort study (2020)
Journal Article
Mallen. (2020). Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched cohort study. Rheumatology, https://doi.org/10.1093/rheumatology/keaa044

Objective Statins are reported to have a potential benefit on progression of OA and on disease activity in RA, but existing evidence is conflicting. Our objective was to examine whether statins associate with reduction in the risk for joint replacem... Read More about Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched cohort study.

A second-order asymptotic model for Rayleigh waves on a linearly elastic half plane (2020)
Journal Article
Wootton, P. T., Prikazchikov, D., & Kaplunov, J. (2020). A second-order asymptotic model for Rayleigh waves on a linearly elastic half plane. IMA Journal of Applied Mathematics, 85(1), 113 - 131. https://doi.org/10.1093/imamat/hxz037

We derive a second-order correction to an existing leading-order model for surface waves in linear elasticity. The same hyperbolic–elliptic equation form is obtained with a correction term added to the surface boundary condition. The validity of the... Read More about A second-order asymptotic model for Rayleigh waves on a linearly elastic half plane.

Managing loneliness: a qualitative study of older people's views. (2020)
Journal Article
Chew-Graham. (2020). Managing loneliness: a qualitative study of older people's views. Aging and Mental Health, 1 - 8. https://doi.org/10.1080/13607863.2020.1729337

Engaging with older people who self-identify as lonely may help professionals in mental health and other services understand how they deal with loneliness. The evidence-base for effective interventions to address loneliness is inconclusive. This stud... Read More about Managing loneliness: a qualitative study of older people's views..

Schopenhauer on Christ, Suffering and the Negation of the Will (2020)
Journal Article
Head. (2020). Schopenhauer on Christ, Suffering and the Negation of the Will. International Journal of Philosophical Studies, https://doi.org/10.1080/09672559.2020.1732444

This paper seeks to illuminate Schopenhauer’s notion of the negation or denial of the will by investigating the figure of the saint within his philosophy. We argue that various discussions in Schopenhauer’s works of the possible role of Christ as exe... Read More about Schopenhauer on Christ, Suffering and the Negation of the Will.

Deregulation and institutional conversion in the Greek hotel industry: an employment relations model in transition (2020)
Journal Article
Papadopoulos, O., & Lyddon, D. (2020). Deregulation and institutional conversion in the Greek hotel industry: an employment relations model in transition. Industrial Relations Journal, 51(1-2), 92-109. https://doi.org/10.1111/irj.12282

Before the debt crisis of 2010 forced Greece into almost permanent austerity, its hotel workers enjoyed wages and conditions (through a sector collective agreement) similar to those in other economic sectors. This was against the international trend... Read More about Deregulation and institutional conversion in the Greek hotel industry: an employment relations model in transition.

Screening for thyroid disease in patients with type 2 diabetes mellitus: An evaluation of current practice (2020)
Journal Article
Palit, T., Heald, A. H., Fryer, A. A., & Duff, C. J. (2020). Screening for thyroid disease in patients with type 2 diabetes mellitus: An evaluation of current practice. Annals of Clinical Biochemistry, 57(3), 242-245. https://doi.org/10.1177/0004563220910772

Background United Kingdom national guidelines do not recommend routine testing for thyroid disease in people with type 2 diabetes mellitus (T2DM). However, some studies suggest an increased risk of thyroid dysfunction in T2DM. The aim of this study... Read More about Screening for thyroid disease in patients with type 2 diabetes mellitus: An evaluation of current practice.

Rotator cuff disorders: a survey of current (2018) Italian physiotherapy practice (2020)
Journal Article
Brindisino, F., Matteuzzi, I., Bury, J., McCreesh, K., & Littlewood, C. (2020). Rotator cuff disorders: a survey of current (2018) Italian physiotherapy practice. Physiotherapy Practice and Research, 41(1), 11-22. https://doi.org/10.3233/PPR-190141

BACKGROUND Shoulder pain is a common musculoskeletal complaint and disorders of the rotator cuff (RC) are widely regarded as the most common cause. Where clinical care is required, physiotherapists play an integral role. Previous studies have report... Read More about Rotator cuff disorders: a survey of current (2018) Italian physiotherapy practice.

Enamel thickness and growth rates in modern human permanent first molars over a 2000 year period in Britain (2020)
Journal Article
Aris, C., Mahoney, P., O'Hara, M. C., & Deter, C. (2020). Enamel thickness and growth rates in modern human permanent first molars over a 2000 year period in Britain. American Journal of Physical Anthropology, 173(1), 141-157. https://doi.org/10.1002/ajpa.24026

Objectives This study explores variation and trends in first molar enamel thickness and daily enamel secretion rates over a 2000 year period in Britain. Methods Permanent first molars (n = 89) from the Roman, Anglo-Saxon, and Medieval periods, a... Read More about Enamel thickness and growth rates in modern human permanent first molars over a 2000 year period in Britain.

Cathepsin B-associated Activation of Amyloidogenic Pathway in Murine Mucopolysaccharidosis Type I Brain Cortex (2020)
Journal Article
Viana, G. M., Gonzalez, E. A., Palacio Alvarez, M. M., Cavalheiro, R. P., do Nascimento, C. C., Baldo, G., …Nader, H. B. (2020). Cathepsin B-associated Activation of Amyloidogenic Pathway in Murine Mucopolysaccharidosis Type I Brain Cortex. International Journal of Molecular Sciences, 21, https://doi.org/10.3390/ijms21041459

Mucopolysaccharidosis type I (MPS I) is caused by genetic deficiency of alpha-l-iduronidase and impairment of lysosomal catabolism of heparan sulfate and dermatan sulfate. In the brain, these substrates accumulate in the lysosomes of neurons and glia... Read More about Cathepsin B-associated Activation of Amyloidogenic Pathway in Murine Mucopolysaccharidosis Type I Brain Cortex.

The Formation of a 70 M ? Black Hole at High Metallicity (2020)
Journal Article
Hirschi. (2020). The Formation of a 70 M ? Black Hole at High Metallicity. Astrophysical Journal, 113 -113. https://doi.org/10.3847/1538-4357/ab6d77

A 70 black hole (BH) was discovered in the Milky Way disk in a long-period detached binary system (LB-1) with a high-metallicity 8 B star companion. Current consensus on the formation of BHs from high-metallicity stars limits the BH mass to be below... Read More about The Formation of a 70 M ? Black Hole at High Metallicity.

STarT back tool retained its predicting abilities in patients with acute and sub-acute low back pain after a transcultural adaptation and validation to Hebrew (2020)
Journal Article
Hill, J. (2020). STarT back tool retained its predicting abilities in patients with acute and sub-acute low back pain after a transcultural adaptation and validation to Hebrew. Musculoskeletal Science and Practice, 102134 -102134. https://doi.org/10.1016/j.msksp.2020.102134

Background The STarT Back Screening Tool (SBT) distributes low back pain (LBP) patients into three prognostic groups for stratified care. This approach has demonstrated beneficial clinical and cost-effectiveness. Objectives To translate and validate... Read More about STarT back tool retained its predicting abilities in patients with acute and sub-acute low back pain after a transcultural adaptation and validation to Hebrew.

Prognostic significance of early urinary catheterization after acute stroke: Secondary analyses of the international HeadPoST trial (2020)
Journal Article
Ouyang, M., Billot, L., Song, L., Wang, X., Roffe, C., Arima, H., …Anderson, C. S. (2021). Prognostic significance of early urinary catheterization after acute stroke: Secondary analyses of the international HeadPoST trial. International Journal of Stroke, 16(2), 200-206. https://doi.org/10.1177/1747493020908140

Background An indwelling urinary catheter (IUC) is often inserted to manage bladder dysfunction, but its impact on prognosis is uncertain. We aimed to determine the association of IUC use on clinical outcomes after acute stroke in the international,... Read More about Prognostic significance of early urinary catheterization after acute stroke: Secondary analyses of the international HeadPoST trial.

Supportive care for end-stage kidney disease: an integral part of kidney services across a range of income settings around the world. (2020)
Journal Article
Davies. (2020). Supportive care for end-stage kidney disease: an integral part of kidney services across a range of income settings around the world. Kidney International Supplements, e86 - e94. https://doi.org/10.1016/j.kisu.2019.11.008

A key component of treatment for all people with advanced kidney disease is supportive care, which aims to improve quality of life and can be provided alongside therapies intended to prolong life, such as dialysis. This article addresses the key cons... Read More about Supportive care for end-stage kidney disease: an integral part of kidney services across a range of income settings around the world..

Development, synthesis and biological investigation of a novel class of potent PC-PLC inhibitors. (2020)
Journal Article
Reynisson. (2020). Development, synthesis and biological investigation of a novel class of potent PC-PLC inhibitors. European Journal of Medicinal Chemistry, https://doi.org/10.1016/j.ejmech.2020.112162

Phospholipases are enzymes that are involved in the hydrolysis of acyl and phosphate esters of phospholipids, generating secondary messengers that have implications in various cellular processes including proliferation, differentiation and motility.... Read More about Development, synthesis and biological investigation of a novel class of potent PC-PLC inhibitors..

Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications (2020)
Journal Article
Finch, L., Harris, S., Solomou, G., Sen, J., Tzerakis, N., Emes, R. D., …Chari, D. M. (2020). Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications. Journal of Controlled Release, 321, 553-563. https://doi.org/10.1016/j.jconrel.2020.02.028

High transplant cell loss is a major barrier to translation of stem cell therapy for pathologies of the brain and spinal cord. Encapsulated delivery of stem cells in biomaterials for cell therapy is gaining popularity but experimental research has ov... Read More about Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications.

Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis (2020)
Journal Article
Perry, J., McCarthy, H., Bou-Gharios, G., van't Hof, R., Milner, P., Mennan, C., & Roberts, S. (2020). Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis. Osteoarthritis and Cartilage Open, 2(2), 100044 - 100044. https://doi.org/10.1016/j.ocarto.2020.100044

Objective This study investigated the effect of hUC-MSCs on osteoarthritis (OA) progression in a xenogeneic model. Design Male, 10 week-old C57Bl/6 mice underwent sham surgery (n=15) or partial medial meniscectomy (PMM;n=76). 5x105 hUC-MSCs (from 3 d... Read More about Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis.

Use of the nominal group technique to identify UK stakeholder views of the measures and domains used in the assessment of therapeutic exercise adherence for patients with musculoskeletal disorders. (2020)
Journal Article
Mallett, R., McLean, S., Holden, M. A., Potia, T., Gee, M., & Haywood, K. (2020). Use of the nominal group technique to identify UK stakeholder views of the measures and domains used in the assessment of therapeutic exercise adherence for patients with musculoskeletal disorders. BMJ Open, 10(2), https://doi.org/10.1136/bmjopen-2019-031591

Objectives The objective was to the undertake nominal group technique (NGT) to evaluate current exercise adherence measures and isolated domains to develop stakeholder consensus on the domains to include in the measurement of therapeutic exercise adh... Read More about Use of the nominal group technique to identify UK stakeholder views of the measures and domains used in the assessment of therapeutic exercise adherence for patients with musculoskeletal disorders..

Foot orthoses for people with rheumatoid arthritis, involving quantitative and qualitative outcomes: protocol for a randomised controlled trial. (2020)
Journal Article
Ramos-Petersen, L., Nester, C., Gijon-Nogueron, G., & Ortega-Avila, A. (2020). Foot orthoses for people with rheumatoid arthritis, involving quantitative and qualitative outcomes: protocol for a randomised controlled trial. BMJ Open, 10, e036433. https://doi.org/10.1136/bmjopen-2019-036433

INTRODUCTION: Rheumatoid arthritis (RA) involves changes to foot structure and function, and there is an association between RA and foot pain. This pain affects those patient's physical activity and experience of daily living. While there is clinical... Read More about Foot orthoses for people with rheumatoid arthritis, involving quantitative and qualitative outcomes: protocol for a randomised controlled trial..