All Outputs (84)

Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype (2024)
Preprint / Working Paper
Ioannou, S., G Kay, A., P Stone, A., Rand, E., Elberfeld, S., Bolton, W., Larson, T., E Crossland, R., Kehoe, O., A Mentlak, D., Wang, X.-N., MacDonald, C., & Genever, P. Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype

Mesenchymal stromal cells (MSCs) are a promising source of therapeutic extracellular vesicles (EVs), however it is not clear how heterogeneity within a non-clonal MSC population will affect the collective EV pool. Here we used immortalised clonal MSC... Read More about Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype.

Within-host competition sparks pathogen molecular evolution and perpetual microbiota dysbiosis (2024)
Preprint / Working Paper
Stevens, E., Li, J., Hector, T., Drew, G., Hoang, K., Greenrod, S., Paterson, S., & King, K. Within-host competition sparks pathogen molecular evolution and perpetual microbiota dysbiosis

Pathogens newly invading a host must compete with resident microbiota. This within-host microbial warfare could lead to more severe disease outcomes or constrain the evolution of virulence. Using experimental evolution of a widespread pathogen (Staph... Read More about Within-host competition sparks pathogen molecular evolution and perpetual microbiota dysbiosis.

EWOCS-II: X-ray properties of the Wolf-Rayet stars in the young Galactic super star cluster Westerlund 1 (2024)
Preprint / Working Paper
Anastasopoulou, K., Guarcello, M., Flaccomio, E., Sciortino, S., Benatti, S., De Becker, M., Wright, N., Drake, J., Albacete-Colombo, J., Andersen, M., Argiroffi, C., Bayo, A., Castellanos, R., Gennaro, M., Grebel, E., Miceli, M., Najarro, F., Negueruela, I., Prisinzano, L., Ritchie, B., …Zeidler, P. EWOCS-II: X-ray properties of the Wolf-Rayet stars in the young Galactic super star cluster Westerlund 1

We present the most comprehensive and deepest X-ray study to date of the properties of the richest Wolf-Rayet (WR) population observed in a single stellar cluster, Westerlund 1 (Wd1). This work is based on 36 Chandra observations obtained from the "E... Read More about EWOCS-II: X-ray properties of the Wolf-Rayet stars in the young Galactic super star cluster Westerlund 1.

Using Diverse Local Optima for Setting Kernel Parameters in Support Vector Regression: Forecasting Emerging Market Credit Spreads (2024)
Preprint / Working Paper
Anderson, G., & Audzeyeva, A. Using Diverse Local Optima for Setting Kernel Parameters in Support Vector Regression: Forecasting Emerging Market Credit Spreads

We propose a novel approach for determining support vector regression (SVR) kernel parameters in the presence of multiple local optima. In contrast to existing approaches focusing on identifying a single "best" tuning parameter setting, an impractica... Read More about Using Diverse Local Optima for Setting Kernel Parameters in Support Vector Regression: Forecasting Emerging Market Credit Spreads.

The OBS UK Dashboard: an Interactive Tool for Representative Trial Site Selection to Facilitate Equality and Diversity in Maternity Research (2024)
Preprint / Working Paper
(2024). The OBS UK Dashboard: an Interactive Tool for Representative Trial Site Selection to Facilitate Equality and Diversity in Maternity Research

Background
Obstetric Bleeding Study UK (award ID:152057) is a NIHR-funded stepped wedge cluster randomised controlled trial of a complex intervention for postpartum haemorrhage. This was developed in Wales and evaluated in a feasibility study, with... Read More about The OBS UK Dashboard: an Interactive Tool for Representative Trial Site Selection to Facilitate Equality and Diversity in Maternity Research.

Quantitative evidence for relational care approaches to assessing and managing self-harm and suicide risk in inpatient mental health and emergency department settings: a scoping review (2024)
Preprint / Working Paper
Griffiths, J. L., Foye, U., Stuart, R., Jarvis, R., Chipp, B., Griffiths, R., Jeynes, T., Mitchell, L., Parker, J., Rowan Olive, R., Quirke, K., Baker, J., Brennan, G., Lamph, G., McKeown, M., Lloyd-Evans, B., Trevillion, K., & Simpson, A. Quantitative evidence for relational care approaches to assessing and managing self-harm and suicide risk in inpatient mental health and emergency department settings: a scoping review

There is an over-reliance on structured risk assessments and restrictive practices for managing self-harm and suicidality in inpatient mental health and emergency department (ED) settings, despite a lack of supporting evidence. Alternative ‘relationa... Read More about Quantitative evidence for relational care approaches to assessing and managing self-harm and suicide risk in inpatient mental health and emergency department settings: a scoping review.

First Light And Reionisation Epoch Simulations (FLARES) XVI: Size Evolution of Massive Dusty Galaxies at Cosmic Dawn from UV to IR (2024)
Preprint / Working Paper
Punyasheel, P., Vijayan, A. P., Greve, T. R., Roper, W. J., Algera, H., Gillman, S., Gullberg, B., Irodotou, D., Lovell, C. C., Seeyave, L. T., Thomas, P. A., & Wilkins, S. M. First Light And Reionisation Epoch Simulations (FLARES) XVI: Size Evolution of Massive Dusty Galaxies at Cosmic Dawn from UV to IR

We use the First Light And Reionisation Epoch Simulations (FLARES) to study the evolution of the rest-frame ultraviolet (UV) and far-infrared (FIR) sizes for a statistical sample of massive ($\gtrsim10^{9}$M$_{\odot}$) high redshift galaxies (z $\in$... Read More about First Light And Reionisation Epoch Simulations (FLARES) XVI: Size Evolution of Massive Dusty Galaxies at Cosmic Dawn from UV to IR.

Scanning the skies for migrants: Conservation-focused opportunities for a pan-European automated telemetry network (2024)
Preprint / Working Paper
Mitchell, L., Brust, V., Karwinkel, T., Åkesson, S., Kishkinev, D., Norevik, G., Szep, T., Hedenström, A., Lagerveld, S., Helm, B., & Schmaljohann, H. Scanning the skies for migrants: Conservation-focused opportunities for a pan-European automated telemetry network

Accelerated biodiversity loss during the Anthropocene has destabilised functional links within and between ecosystems. Migratory species that cross different ecosystems on their repeated journeys between breeding and non-breeding sites are particular... Read More about Scanning the skies for migrants: Conservation-focused opportunities for a pan-European automated telemetry network.

Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement (2024)
Preprint / Working Paper
Short, E., Adcock, I. M., Al-Sarireh, B., Ager, A., Ajjan, R., Akbar, N., Akeroyd, M. A., Alsaleh, G., Al-Sharbatee, G., Alavian, K., Amoaku, W., Andersen, J., Antoniades, C., Arends, M. J., Astley, S., Atan, D., Attanoos, R., Attems, J., Bain, S., Balaskas, K., …Bentley, B. L. Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement

3D simulations of convective shell Neon-burning in a massive star (2024)
Preprint / Working Paper
Georgy, C., Rizzuti, F., Hirschi, R., Varma, V., D. Arnett, W., Meakin, C., Mocak, M., StJ. Murphy, A., & Rauscher, T. 3D simulations of convective shell Neon-burning in a massive star

The treatment of convection remains a major weakness in the modelling of stellar evolution with one-dimensional (1D) codes. The ever increasing computing power makes now possible to simulate in 3D part of a star for a fraction of its life, allowing u... Read More about 3D simulations of convective shell Neon-burning in a massive star.

DISRUPTIONS IN LIVELIHOODS, HEALTHCARE ACCESS AND HEALTH OUTCOMES IN WEST AFRICA DURING EMERGING INFECTIOUS DISEASE OUTBREAKS (2024)
Preprint / Working Paper
Ansumana, R., Bockarie, A. S., Konneh, M., Haider, N., Cadmus, E., Korvah, A., Fayiah, J., Waka-Metzger, Y. K., George, A. M., Mallah, G., Lamin, J. M., Dar, O., Mayhew, S., Bah, D., Bilivigoi, P., Maggasouba, N., Cadmus, S., & Alders, R. DISRUPTIONS IN LIVELIHOODS, HEALTHCARE ACCESS AND HEALTH OUTCOMES IN WEST AFRICA DURING EMERGING INFECTIOUS DISEASE OUTBREAKS

Background Outbreaks of infectious diseases like Ebola virus disease, Lassa fever, and COVID-19 have severely strained infrastructural systems and social services across West Africa. We investigated the disruptions caused by emerging outbreaks on acc... Read More about DISRUPTIONS IN LIVELIHOODS, HEALTHCARE ACCESS AND HEALTH OUTCOMES IN WEST AFRICA DURING EMERGING INFECTIOUS DISEASE OUTBREAKS.

Protocol for the development and validation of a Rheumatoid Arthritis PredIction moDel using primary care health records (RAPID) (2024)
Preprint / Working Paper
Hammond, B., Baranskaya, A., Adderley, N., Zemedikun, D., d’Elia, A., Falahee, M., Mallen, C., Insch, E., Singh Chandan, J., Nirantharakumar, K., Snell, K., & Raza, K. Protocol for the development and validation of a Rheumatoid Arthritis PredIction moDel using primary care health records (RAPID)

Background Rheumatoid Arthritis (RA) is a chronic rheumatological condition which causes inflammation of both the joint lining and extra-articular sites. It affects around 1% of the UK population and, if not properly treated, can lead joint damage, d... Read More about Protocol for the development and validation of a Rheumatoid Arthritis PredIction moDel using primary care health records (RAPID).

Cost-utility analysis of risk-based stratified primary care for common musculoskeletal pain presentations: a cluster-randomised, controlled trial (2024)
Preprint / Working Paper
Kigozi, J., Hill, J. C., Bromley, K., Lewis, M., Wathall, S., Chudyk, A., Dunn, K. M., Foster, N. E., & Jowett, S. Cost-utility analysis of risk-based stratified primary care for common musculoskeletal pain presentations: a cluster-randomised, controlled trial

Background
Risk-based stratified care (SC) has demonstrated cost-effectiveness versus usual primary care for non-specific low back pain. The STarT MSK trial investigated the cost-effectiveness of risk-based stratified care versus non-stratified usua... Read More about Cost-utility analysis of risk-based stratified primary care for common musculoskeletal pain presentations: a cluster-randomised, controlled trial.

Shifting Geographical Transmission Patterns: Characterizing the 2023 Fatal Dengue Outbreak in Bangladesh (2024)
Preprint / Working Paper
Nayeem Hasan, M., Rahman, M., Fahim Uddin, M., Ali Akbar Ashrafi, S., Rahman, K. M., Kumar Paul, K., Rahman Sarker, M. F., Haque, F., Sharma, A., Papakonstantinou, D., Paudyal, P., Asaduzzaman, M., Zumla, A., & Haider, N. Shifting Geographical Transmission Patterns: Characterizing the 2023 Fatal Dengue Outbreak in Bangladesh

In 2023, Bangladesh experienced its largest and deadliest outbreak of Dengue virus (DENV), reporting the highest-ever recorded annual cases and deaths. We aimed to characterize the geographical transmission of the DENV in Bangladesh. From 1 Jan – 31... Read More about Shifting Geographical Transmission Patterns: Characterizing the 2023 Fatal Dengue Outbreak in Bangladesh.

Automating incidence and prevalence analysis in open cohorts (2024)
Preprint / Working Paper
Cockburn, N., Hammond, B., Ghani, I., Cusworth, S., Acharya, A., Gokhale, K., Thayakaran, R., Crowe, F., Minhas, S., Parry-Smith, W., Taylor, B., Nirantharakumar, K., & Singh Chandan, J. Automating incidence and prevalence analysis in open cohorts

Motivation

Increasingly vast quantities of data support improvement and research in public health, and growth is especially seen in administrative data such as that collected in electronic health records. Patients enter and exit these typically o... Read More about Automating incidence and prevalence analysis in open cohorts.

The relationship between research activity and the performance of English general practices: cross sectional and longitudinal analyses (2024)
Preprint / Working Paper
Gibson, J., Kontopantelis, E., Sutton, M., Boaz, A., Little, P., Mallen, C., McManus, R., Park, S., Usher-Smith, J., & Bower, P. (2024). The relationship between research activity and the performance of English general practices: cross sectional and longitudinal analyses

Introduction
Research activity usually improves outcomes by being translated into practice. However, there is developing evidence that research activity itself may improve the overall performance of health care organisations. However, evidence that... Read More about The relationship between research activity and the performance of English general practices: cross sectional and longitudinal analyses.

Multimorbidity in Older Adults with Depression Study (MODS) (Behavioural Activation to improve physical and mental functioning among older people with multiple long-term conditions): Protocol for a fully powered randomised controlled trial (2024)
Preprint / Working Paper
Ryde, E., Hollingsworth, K., Littlewood, E., Atha, L., Bailey, D., Baker, H., Bosanquet, K., Shearsmith, L., Chew-Graham, C. A., McMillan, D., Baird, K., Coventry, P., Crosland, S., Fairhurst, C., Wang, H.-I., Burke, L., Heeley, J., Hewitt, C., Clegg, A., Gentry, T., …Ekers, D. Multimorbidity in Older Adults with Depression Study (MODS) (Behavioural Activation to improve physical and mental functioning among older people with multiple long-term conditions): Protocol for a fully powered randomised controlled trial

Introduction Older adults (65 years or over) and those with long-term health conditions (LTCs), represent a ‘high risk’ group for depression, with a risk two-to-three times the general population. This can lead to poorer quality of life and be costly... Read More about Multimorbidity in Older Adults with Depression Study (MODS) (Behavioural Activation to improve physical and mental functioning among older people with multiple long-term conditions): Protocol for a fully powered randomised controlled trial.

Monitoring for 5-aminosalicylate toxicity: prognostic model development and validation (2023)
Preprint / Working Paper
Abhishek, A., Nakafero, G., Grainge, M. J., Card, T., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., Stevenson, M. D., & Riley, R. D. Monitoring for 5-aminosalicylate toxicity: prognostic model development and validation

Background and aim To develop and validate a prognostic model for risk-stratified monitoring of 5-aminosalicylate (5-ASA) toxicity.

Methods This nationwide retrospective cohort study used data from the Clinical Practice Research Datalink (CPRD) Au... Read More about Monitoring for 5-aminosalicylate toxicity: prognostic model development and validation.

SupportPrim – A computerized clinical decision support system for stratified care for patients with musculoskeletal pain complaints in general practice - Statistical Analysis Plan (2023)
Preprint / Working Paper
Naterstad Lervik, L. C., Bach, K., Granviken, F., Hill, J. C., Simpsom, M. R., Vasseljen, O., Van der Windt, D. A., & Meisingset, I. SupportPrim – A computerized clinical decision support system for stratified care for patients with musculoskeletal pain complaints in general practice - Statistical Analysis Plan

This is a statistical Analysis Plan (SAP) for “SupportPrim – A computerized clinical decision support system for stratified care for patients with musculoskeletal pain complaints in general practice”. The SAP elaborates the statistics described in th... Read More about SupportPrim – A computerized clinical decision support system for stratified care for patients with musculoskeletal pain complaints in general practice - Statistical Analysis Plan.

Uptake, safety, and effectiveness of inactivated influenza vaccine in patients with inflammatory bowel disease: a nationwide study in the UK using data from the Clinical Practice Research Datalink (2023)
Preprint / Working Paper
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (2023). Uptake, safety, and effectiveness of inactivated influenza vaccine in patients with inflammatory bowel disease: a nationwide study in the UK using data from the Clinical Practice Research Datalink

Objective We investigated UK wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), the association between vaccination against influenza and IBD flare, and the effectiveness of IIV in preventing morbidity an... Read More about Uptake, safety, and effectiveness of inactivated influenza vaccine in patients with inflammatory bowel disease: a nationwide study in the UK using data from the Clinical Practice Research Datalink.