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All Outputs (60)

From quarks to cognition: in pursuit of a complete micropsychist theory of consciousness (2022)
Thesis
Hibbert, B. J. (2022). From quarks to cognition: in pursuit of a complete micropsychist theory of consciousness. (Thesis). Keele University

Despite having received a recent resurgence of interest, Panpsychism remains a worldview afflicted by various explanatory shortfalls. Chiefly, the literature is yet to provide a ‘proper’ panpsychist theory of consciousness with the potential to expla... Read More about From quarks to cognition: in pursuit of a complete micropsychist theory of consciousness.

User-centred design of bedside clinical guidelines for mobile devices (2022)
Thesis
Mitchell, J. A. (2022). User-centred design of bedside clinical guidelines for mobile devices. (Thesis). Keele University

Local point of care clinical guidelines exist in numerous formats and cover a variety of clinical information, normally created on a national and local level. They are generally available as basic web pages, PDFs or documents. Despite widespread avai... Read More about User-centred design of bedside clinical guidelines for mobile devices.

Neuroevolution of bipedal locomotion: algorithmic, balance penalty and morphological improvements for improved robustness and performance (2022)
Thesis
Jackson, B. (2022). Neuroevolution of bipedal locomotion: algorithmic, balance penalty and morphological improvements for improved robustness and performance. (Thesis). Keele University

Bipedalism is theorised to have emerged in humans in order to enable endurance running and tool use via the hands. It is one of the most complex styles of locomotion, with agents typically having a high center of mass and two feet very close together... Read More about Neuroevolution of bipedal locomotion: algorithmic, balance penalty and morphological improvements for improved robustness and performance.

An in vitro study of the modulation of astrocytes in the blood brain barrier during human cerebral malaria (2022)
Thesis
Ogbolosingha, A. J. (2022). An in vitro study of the modulation of astrocytes in the blood brain barrier during human cerebral malaria. (Thesis). Keele University

Cerebral malaria (CM) is the most life-threatening complication of Plasmodium falciparum (Pf) infection. A key hallmark of CM is the sequestration of Pf infected red blood cells (PRBC) to the human brain endothelial cells (HBEC) of the blood brain ba... Read More about An in vitro study of the modulation of astrocytes in the blood brain barrier during human cerebral malaria.

Activation of Hypoxia Inducible Factor pathway for neuroprotection in in vitro models of ischaemic stroke (2022)
Thesis
Singh, A. (2022). Activation of Hypoxia Inducible Factor pathway for neuroprotection in in vitro models of ischaemic stroke. (Thesis). Keele University

Ischaemic stroke is the most common form of stroke, accounting for appropriate 87% of all strokes. Reperfusion is the only immediate treatment option following ischaemic stroke, however, this option is only applicable to a small percentage of patient... Read More about Activation of Hypoxia Inducible Factor pathway for neuroprotection in in vitro models of ischaemic stroke.

Impulsive-compulsive behaviours in Parkinson’s disease: a behavioural, neuroimaging and neurophysiological investigation (2022)
Thesis
Martini, A. (2022). Impulsive-compulsive behaviours in Parkinson’s disease: a behavioural, neuroimaging and neurophysiological investigation. (Thesis). Keele University

Background: Persons with Parkinson’s (PwP) may develop Impulsivecompulsive behaviours (ICBs) as side-effect of dopamine replacement therapy (DRT). The unresolved question addressed by this thesis is why only some PwP develop ICBs. This is an importan... Read More about Impulsive-compulsive behaviours in Parkinson’s disease: a behavioural, neuroimaging and neurophysiological investigation.

Radical idealism and empirical metaphysics in the work of Mary Baker Eddy (2022)
Thesis
Sheldon, N. D. (2022). Radical idealism and empirical metaphysics in the work of Mary Baker Eddy. (Thesis). Keele University

The nineteenth-century American, Mary Baker Eddy, is well known in the United States for having founded the religion Christian Science, but she is not generally regarded as philosopher, let alone an original one. This dissertation argues that she is... Read More about Radical idealism and empirical metaphysics in the work of Mary Baker Eddy.

Military logistics and supply during the British Civil Wars, 1638–1653 (2022)
Thesis
Price, G. W. (2022). Military logistics and supply during the British Civil Wars, 1638–1653. (Thesis). Keele University

The aim of this thesis is to analyse the logistics and supply systems of the armies during the British Civil Wars at an operational level. Current historical works have neglected to fully evaluate the events of the British Civil Wars with respect to... Read More about Military logistics and supply during the British Civil Wars, 1638–1653.

Examining the self-representation of hijab fashion bloggers as a postfeminist phenomenon: discourses of empowerment and their limitations (2022)
Thesis
Mora, L. (2022). Examining the self-representation of hijab fashion bloggers as a postfeminist phenomenon: discourses of empowerment and their limitations. (Thesis). Keele University

In the last decade, hijab fashion bloggers on Instagram have gained remarkable levels of popularity among young Muslim women. While scholars have recognised the importance of describing and celebrating the empowering sides of hijab fashion as a subcu... Read More about Examining the self-representation of hijab fashion bloggers as a postfeminist phenomenon: discourses of empowerment and their limitations.

Cell models to evaluate oligodendrocyte lineage cell growth on biomaterials (2022)
Thesis
Chowdhury, F. (2022). Cell models to evaluate oligodendrocyte lineage cell growth on biomaterials. (Thesis). Keele University

Oligodendrocyte lineage and neuronal cells are essential neural populations required for axonal remyelination after spinal cord injury (SCI). Injection of an exogenous cell population into the site of neural injury has posed translational barriers, s... Read More about Cell models to evaluate oligodendrocyte lineage cell growth on biomaterials.

The opportunities and challenges of governing mobility in the rural-urban fringe - a study of Warrington, UK (2022)
Thesis
Peacock, A. J. (2022). The opportunities and challenges of governing mobility in the rural-urban fringe - a study of Warrington, UK. (Thesis). Keele University

The rural-urban fringe is a complex space, yet one increasingly being viewed as a unique, positive opportunity space (Scott et al., 2013). It is characterised by a flexible, contextspecific spatial form and is subject to governance pressures by both... Read More about The opportunities and challenges of governing mobility in the rural-urban fringe - a study of Warrington, UK.

Chemical synthesis and biological evaluation of 4'-thionucleosides (2022)
Thesis
Guinan, M. (2022). Chemical synthesis and biological evaluation of 4'-thionucleosides. (Thesis). Keele University

Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers and viruses. Several such compounds, including Sofosbuvir and Gemcitabine are the go-to option in first line treatments. Ho... Read More about Chemical synthesis and biological evaluation of 4'-thionucleosides.

A transcriptomic-based drug repositioning approach for the identification of novel muscle-specific therapies for spinal muscular atrophy (2022)
Thesis
Hoolachan, J. M. (2022). A transcriptomic-based drug repositioning approach for the identification of novel muscle-specific therapies for spinal muscular atrophy. (Thesis). Keele University

Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder (NMD) caused by depleted survival of motor neuron (SMN) levels and characterised by neuronal degeneration and progressive muscle atrophy. Although three approved SMN-depen... Read More about A transcriptomic-based drug repositioning approach for the identification of novel muscle-specific therapies for spinal muscular atrophy.

Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica (2022)
Thesis
Twohig, H. J. (2022). Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica. (Thesis). Keele University

Background
Polymyalgia rheumatica (PMR) causes pain, stiffness and disability in older adults. Measuring the impact of the condition from the patient’s perspective is vital to highquality research and patient-centred care, yet there are no validated... Read More about Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica.

In our own image: materialism’s impoverished image of humanity and what this means for our technological future (2022)
Thesis
Brayford, K. M. (2022). In our own image: materialism’s impoverished image of humanity and what this means for our technological future. (Thesis). Keele University

In this thesis, I seek to temper the commonly held faith in our technological endeavours. Recently this has taken the form of seeking to create humanlike technologies. In part one, I argue that progress in this is derailed by the image of humanity ad... Read More about In our own image: materialism’s impoverished image of humanity and what this means for our technological future.

Use of nanoparticles to improve the therapeutic index of navitoclax (2022)
Thesis
Alrosan, K. J. J. A. (2022). Use of nanoparticles to improve the therapeutic index of navitoclax. (Thesis). Keele University

Ovarian cancer is considered a major health problem in women. The chemotherapeutic drugs that are used often are inadequate due to the development of drug resistance. This s related to many causes, and one of them is an evasion of apoptosis. One of t... Read More about Use of nanoparticles to improve the therapeutic index of navitoclax.

Gravitonicity: towards a model of the ‘Gravitation’ in Music (2022)
Thesis
Shufflebotham, J. D. (2022). Gravitonicity: towards a model of the ‘Gravitation’ in Music. (Thesis). Keele University

This research develops a model of the ‘gravitation’ in Music. In the literature on the ‘gravitational’ properties of melody and harmony, two sub-metaphors are apparent: ‘distance’ and ‘motion’. Gravitation and Music’s ‘gravitation’ are, therefore, fu... Read More about Gravitonicity: towards a model of the ‘Gravitation’ in Music.

Polypharmacy in atrial fibrillation: An analysis of prospective outcomes using the Clinical Practice Research Datalink (CPRD) (2022)
Thesis
Scott, N. (2022). Polypharmacy in atrial fibrillation: An analysis of prospective outcomes using the Clinical Practice Research Datalink (CPRD). (Thesis). Keele University

Objectives: Observational studies of polypharmacy and the risk of death or ischaemic stroke in individuals with atrial fibrillation (AF) have produced inconsistent findings. The reason for this variation may be due to differences in study designs and... Read More about Polypharmacy in atrial fibrillation: An analysis of prospective outcomes using the Clinical Practice Research Datalink (CPRD).

A novel scaffold for cell-based lung tissue engineering (2022)
Thesis
Kyoseva, A. Y. (2022). A novel scaffold for cell-based lung tissue engineering. (Thesis). Keele University

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and numbers are rising. Tissue engineering approaches have the potential to improve lung function and treat diseases such as COPD. Our aim is to investigate a... Read More about A novel scaffold for cell-based lung tissue engineering.