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12 Transcatheter versus surgical approach for severe aortic stenosis with concomitant coronary artery disease: a systematic review and meta-analysis of early and mid-term outcomes (2020)
Presentation / Conference
Kotronias, R., Bray, J., Scarsini, R., Rajasundaram, S., Terentes-Printzios, D., De Maria, G. L., …Bannning, A. (2020, July). 12 Transcatheter versus surgical approach for severe aortic stenosis with concomitant coronary artery disease: a systematic review and meta-analysis of early and mid-term outcomes. Paper presented at Abstracts from the British Cardiovascular Society Annual Conference 2020

Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1. (2020)
Journal Article
Reynisson. (2020). Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1. Molecules, https://doi.org/10.3390/molecules25153496

Two novel structural types of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors with hexahydroisobenzofuran 11 and 3-oxabicyclo [3.3.1]nonane 12 scaffolds were discovered. These monoterpene-derived compounds were synthesized through preliminary isome... Read More about Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1..

Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents (2020)
Thesis
Abdulrahman, M. F. A. (2020). Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents. (Thesis). Keele University

The rate-limiting step for oral absorption of hydrophobic drugs and solubility is the drug dissolution rate in the GI fluids. Several novel and traditional methods have been used to improve the solubility rates of poorly water soluble drugs. The prof... Read More about Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents.

Understanding gender and its relation to the philosophy of personal identity (2020)
Thesis
McCarthy, J. (2020). Understanding gender and its relation to the philosophy of personal identity. (Thesis). Keele University

The aim of this thesis is to establish that there is no metaphysical account of personal identity that requires us to regard gender as essential to our identities. I shall begin by examining forms of essentialism as well as rejections of essentialism... Read More about Understanding gender and its relation to the philosophy of personal identity.

The United Kingdom in the European Community: The diplomacy of the UK government towards the Single European Act, 1984-5 (2020)
Thesis
Bienek, C. J. (2020). The United Kingdom in the European Community: The diplomacy of the UK government towards the Single European Act, 1984-5. (Thesis). Keele University

This dissertation examines the policy making of the United Kingdom towards the Single European Act (SEA) from June 1984 to December 1985. The SEA codified the practice of foreign policy coordination and began a process of liberalising the Single Mark... Read More about The United Kingdom in the European Community: The diplomacy of the UK government towards the Single European Act, 1984-5.

Structural characterisation of human immunoglobulin G Fc fragment and its interaction with heparin (2020)
Thesis
Earps, H. F. (2020). Structural characterisation of human immunoglobulin G Fc fragment and its interaction with heparin. (Thesis). Keele University

Human immunoglobulin (Ig) G is the most commonly found class of antibody in the human body and is involved in pathogen recognition as a part of the adaptive and innate immune response. Recognition occurs through the fragment antibody binding (FAB) re... Read More about Structural characterisation of human immunoglobulin G Fc fragment and its interaction with heparin.

Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways (2020)
Thesis
Šoltić, D. (2020). Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways. (Thesis). Keele University

Spinal muscular atrophy (SMA) is a debilitating genetic disorder, characterised by homozygous loss of the survival of motor neuron 1 (SMN1) gene, resulting in insufficient levels of ubiquitously expressed survival of motor neuron (SMN) protein. The t... Read More about Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways.

Self-management support for people with Multiple Sclerosis (2020)
Thesis
Al Abbad, B. K. N. (2020). Self-management support for people with Multiple Sclerosis. (Thesis). Keele University

Background Self-management programmes help people with long term conditions, such as Multiple Sclerosis (MS), manage symptoms, and contain utilization of health-care resources. However, the optimum level and type of support for people with MS (PwMS... Read More about Self-management support for people with Multiple Sclerosis.

Enabling teachers to promote incremental theories of intelligence in young children: an intervention and an instrument (2020)
Thesis
Garnett, N. J. (2020). Enabling teachers to promote incremental theories of intelligence in young children: an intervention and an instrument. (Thesis). Keele University

The primary focus of this thesis was to translate the rich ‘implicit theories of intelligence’ framework into an accessible intervention to allow teachers to promote growth mindsets in their pupils. A growth mindset is an implicit belief that one can... Read More about Enabling teachers to promote incremental theories of intelligence in young children: an intervention and an instrument.

Mathematical modelling of cartilage and bone defect healing after cell implantation (2020)
Thesis
Campbell, K. (2020). Mathematical modelling of cartilage and bone defect healing after cell implantation. (Thesis). Keele University

This thesis is concerned with mathematically modelling the regeneration of cartilage and cartilage-bone defects. Defects of the bone-cartilage unit, namely chondral and osteochondral defects, are a leading cause of osteoarthritis, the most common typ... Read More about Mathematical modelling of cartilage and bone defect healing after cell implantation.

A critical race theory analysis of the reflections of Black West African adults on their education in English schools (2020)
Thesis
Tambi, T. M. (2020). A critical race theory analysis of the reflections of Black West African adults on their education in English schools. (Thesis). Keele University

Educational research relating to students of black and minority ethnic (BME) backgrounds in England often contains a disproportionately high coverage of issues of underachievement at the expense of the educational experiences of the students. Much of... Read More about A critical race theory analysis of the reflections of Black West African adults on their education in English schools.

Developing the Scientific Reporting Skills of Chemistry Students (2020)
Book Chapter
Capel, N., McGarvey, D., Beaumont, K., Hancock, L., Haxton, K., Jones, R., …Plana, D. (2020). Developing the Scientific Reporting Skills of Chemistry Students. In On Your Marks: Learner-Focused Feedback Practices and Feedback Literacy. Advance HE

The publication contains a diverse range of expertise in assessment and feedback, bringing together experts in a number of disciplines to present ideas on learner-centred feedback. The main goal of the collection is to showcase learner-focused fee... Read More about Developing the Scientific Reporting Skills of Chemistry Students.

Adoption of same day discharge following elective left main stem percutaneous coronary intervention. (2020)
Journal Article
Mamas, & Rashid. (2020). Adoption of same day discharge following elective left main stem percutaneous coronary intervention. International Journal of Cardiology, https://doi.org/10.1016/j.ijcard.2020.07.038

BACKGROUND: This study sought to investigate the safety and feasibility of same day discharge (SDD) practice and compare clinical outcomes to patients admitted for overnight stay (ON) undergoing elective left main stem (LMS) percutaneous coronary int... Read More about Adoption of same day discharge following elective left main stem percutaneous coronary intervention..

Patient response, treatments and mortality for acute myocardial infarction during the COVID-19 pandemic. (2020)
Journal Article
Rashid, & Mamas. (2020). Patient response, treatments and mortality for acute myocardial infarction during the COVID-19 pandemic. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcaa062

AIM: COVID-19 might have affected the care and outcomes of hospitalised acute myocardial infarction (AMI). We aimed to determine whether the COVID-19 pandemic changed patient response, hospital treatment and mortality from AMI. METHODS AND RESULTS: A... Read More about Patient response, treatments and mortality for acute myocardial infarction during the COVID-19 pandemic..

Association between long-term pulse pressure trajectories and risk of end-stage renal diseases in incident malignant hypertensive nephropathy (2020)
Journal Article
Zhuang, Y., Ding, C., Xu, Y., Ding, Z., & Yu, D. (2021). Association between long-term pulse pressure trajectories and risk of end-stage renal diseases in incident malignant hypertensive nephropathy. Blood Pressure Monitoring, 26(1), 14-21. https://doi.org/10.1097/MBP.0000000000000477

Objective The trajectories of pulse pressure (PP) might affect the prognosis of malignant hypertensive nephropathy (MHN). We aimed to describe the association between PP trajectories and the future risk of end-stage renal disease and to identify and... Read More about Association between long-term pulse pressure trajectories and risk of end-stage renal diseases in incident malignant hypertensive nephropathy.

Association between long-term pulse pressure trajectories and risk of end-stage renal diseases in incident malignant hypertensive nephropathy (2020)
Journal Article
Zhuang, Y., Ding, C., Xu, Y., Ding, Z., & Yu, D. (2020). Association between long-term pulse pressure trajectories and risk of end-stage renal diseases in incident malignant hypertensive nephropathy. Blood Pressure Monitoring, https://doi.org/10.1097/MBP.0000000000000477

Objective The trajectories of pulse pressure (PP) might affect the prognosis of malignant hypertensive nephropathy (MHN). We aimed to describe the association between PP trajectories and the future risk of end-stage renal disease and to identify and... Read More about Association between long-term pulse pressure trajectories and risk of end-stage renal diseases in incident malignant hypertensive nephropathy.

Possible Drivers of the 2019 Dengue Outbreak in Bangladesh: The Need for a Robust Community-Level Surveillance System (2020)
Journal Article
Haider, N., Kock, R., Benfield, C., & Ahsan, A. (2021). Possible Drivers of the 2019 Dengue Outbreak in Bangladesh: The Need for a Robust Community-Level Surveillance System. Journal of Medical Entomology, 58(1), 37-39. https://doi.org/10.1093/jme/tjaa150

Bangladesh experienced its largest dengue virus (DENV) outbreak in 2019, with 101,354 patients admitted to hospital with either laboratory-confirmed or clinical diagnosis. By contrast, the cumulative number of dengue patients admitted to hospitals in... Read More about Possible Drivers of the 2019 Dengue Outbreak in Bangladesh: The Need for a Robust Community-Level Surveillance System.

Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts (2020)
Journal Article
(2020). Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts. Scientific reports, 12681 -?. https://doi.org/10.1038/s41598-020-69526-6

We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural-geographic regions. A classical twin design was applied to pooled data from 28 cohorts representing 16 countries and including 193,518 t... Read More about Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts.