All Outputs (654)

IMPACT OF RELIGION ON FRAMING AND CARING FOR DEMENTIA AMONG MUSLIM ARABS IN QATAR: A QUALITATIVE STUDY (2024)
Presentation / Conference Contribution
Daher-Nashif, S., Hammad, S., & Kane, T. IMPACT OF RELIGION ON FRAMING AND CARING FOR DEMENTIA AMONG MUSLIM ARABS IN QATAR: A QUALITATIVE STUDY. Presented at GSA 2024 Annual Scientific Meeting, “The Fortitude Factor”

Studies have examined how religion plays a major role in framing mental disorders and in shaping caregiving practices. This presentation sheds light on dementia care among Muslim Arabs in Qatar. The presentation will examine how old age and dementia... Read More about IMPACT OF RELIGION ON FRAMING AND CARING FOR DEMENTIA AMONG MUSLIM ARABS IN QATAR: A QUALITATIVE STUDY.

A consensus process to develop a model of care for patients with alcohol use disorder in the general medical setting (2024)
Presentation / Conference Contribution
Sinclair, J., Uhm, S., King, M., Foote, G., Kalk, N., Canvin, K., Case, P., & Philipps, T. (2024, November). A consensus process to develop a model of care for patients with alcohol use disorder in the general medical setting. Presented at SSA Annual Conference, Newcastle upon Tyne, UK

Background and aim

The rise in alcohol-related harm is reflected in increased hospital admissions in non-treatment-seeking people. There is a limited evidence base for what might constitute effective, high-quality care in general medical settings.... Read More about A consensus process to develop a model of care for patients with alcohol use disorder in the general medical setting.

Understanding chromotropic materials with combined insitu Neutron Diffraction and Raman Spectroscopy (2024)
Thesis
Dugmore, S. K. Understanding chromotropic materials with combined insitu Neutron Diffraction and Raman Spectroscopy. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1012545

In recent years, in many fields of scientific research, the multi-technique approach has grown into a robust method for the experimental characterisation of complex materials. The combination of diffraction, spectroscopy and other non-destructive tec... Read More about Understanding chromotropic materials with combined insitu Neutron Diffraction and Raman Spectroscopy.

Defining optimal interventions for Perinatal Anxiety (PNA) in a primary care population: a multi-methods study (2024)
Thesis
Silverwood, V. A. Defining optimal interventions for Perinatal Anxiety (PNA) in a primary care population: a multi-methods study. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1015697

Introduction
Perinatal anxiety (PNA) occurs during pregnancy and up to 12 months postpartum. PNA affects approximately 21% of women worldwide and can have a negative impact on mothers, children and their families. The National Institute for Health... Read More about Defining optimal interventions for Perinatal Anxiety (PNA) in a primary care population: a multi-methods study.

How does organisational culture facilitate uptake of home dialysis? An ethnographic study of kidney centres in England (2024)
Journal Article
Allen, K., Shaw, K. L., Spry, J. L., Dikomitis, L., Coyle, D., Damery, S., Fotheringham, J., Lambie, M., Williams, I. P., & Davies, S. (2024). How does organisational culture facilitate uptake of home dialysis? An ethnographic study of kidney centres in England. BMJ Open, 14(12), https://doi.org/10.1136/bmjopen-2024-085754

Objective: The proportion of people having home dialysis for kidney disease varies considerably by treating centre, socioeconomic deprivation levels in the area and to some extent ethnicity. This study aimed to gain in-depth insights into cultural an... Read More about How does organisational culture facilitate uptake of home dialysis? An ethnographic study of kidney centres in England.

Cardiovascular-Liver-Metabolic Health: Recommendations in Screening, Diagnosis, and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease in Cardiovascular Disease via Modified Delphi Approach. (2024)
Journal Article
Chew, N. W. S., Mehta, A., Goh, R. S. J., Zhang, A., Chen, Y., Chong, B., Chew, H. S. J., Shabbir, A., Brown, A., Dimitriadis, G. K., Huang, D. Q., Foo, R., le Roux, C. W., Figtree, G. A., Fudim, M., Pandey, A., Mamas, M. A., Hausenloy, D. J., Richards, A. M., Nicholls, S. J., …Sperling, L. S. (2025). Cardiovascular-Liver-Metabolic Health: Recommendations in Screening, Diagnosis, and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease in Cardiovascular Disease via Modified Delphi Approach. Circulation, 151(1), 98-119. https://doi.org/10.1161/CIRCULATIONAHA.124.070535

There is a new awareness of the widespread nature of metabolic dysfunction-associated steatotic liver disease (MASLD) and its connection to cardiovascular disease (CVD). This has catalyzed collaboration between cardiologists, hepatologists, endocrino... Read More about Cardiovascular-Liver-Metabolic Health: Recommendations in Screening, Diagnosis, and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease in Cardiovascular Disease via Modified Delphi Approach..

Genotype‐Guided Asthma Treatment Reduces Exacerbations in Children: Meta‐Analysis of Two RCTs (2024)
Journal Article
Slob, E. M. A., Vijverberg, S. J. H., Ruffles, T., Noij, L. C. E., Biermann, J., Brouwer, A. F. J., van den Brink, K., de Bruin‐Kok, A., Van Ewijk, B. E., Haarman, E., Hammer, S. C., Hashimoto, S., Hogarth, F., Jones, C. J., Kamps, A. W. A., Kersten, E. T. G., de Kleer, I., Lipworth, B. J., Littleford, R., Mérelle, M., …Maitland‐van der Zee, A. H. (in press). Genotype‐Guided Asthma Treatment Reduces Exacerbations in Children: Meta‐Analysis of Two RCTs. Allergy, https://doi.org/10.1111/all.16438

Background: Long‐acting beta2‐agonists (LABA) in combination with inhaled corticosteroids (ICS) are commonly used to treat asthma, however, some children lack response to the addition of LABA. This might be partially due to the presence of the Arg16G... Read More about Genotype‐Guided Asthma Treatment Reduces Exacerbations in Children: Meta‐Analysis of Two RCTs.

How do patients determine when their inhaler is empty? Insights from an analysis of returned inhalers and a patient survey. (2024)
Journal Article
Murphy, A. C., Carroll, W., Gotsell, M., Potter, C., Quint, J. K., & Malone, R. (in press). How do patients determine when their inhaler is empty? Insights from an analysis of returned inhalers and a patient survey. BMJ Open Respiratory Research, 11(1), e002579. https://doi.org/10.1136/bmjresp-2024-002579

Inhalers are widely used for the management of asthma and chronic obstructive pulmonary disease. However, there is little knowledge about the extent to which an inhaler is used and when it is disposed of, despite the implications for an individual's... Read More about How do patients determine when their inhaler is empty? Insights from an analysis of returned inhalers and a patient survey..

Editor's Choice – Delays to Revascularisation and Outcomes of Non-Elective Admissions for Chronic Limb Threatening Ischaemia: a UK Population Based Cohort Study (2024)
Journal Article
Birmpili, P., Li, Q., Johal, A. S., Atkins, E., Waton, S., Pherwani, A. D., Williams, R., Chetter, I., Boyle, J. R., & Cromwell, D. A. (2024). Editor's Choice – Delays to Revascularisation and Outcomes of Non-Elective Admissions for Chronic Limb Threatening Ischaemia: a UK Population Based Cohort Study. European Journal of Vascular and Endovascular Surgery, 69(4), 640-648. https://doi.org/10.1016/j.ejvs.2024.12.038

Objective
Major amputation and death are significant outcomes after lower limb revascularisation for chronic limb threatening ischaemia (CLTI), but there is limited evidence on their association with the timing of revascularisation. The aim of this... Read More about Editor's Choice – Delays to Revascularisation and Outcomes of Non-Elective Admissions for Chronic Limb Threatening Ischaemia: a UK Population Based Cohort Study.

Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study. (2024)
Preprint / Working Paper
Ashworth, J., Cornwall, N., Harrisson, S. A., Woodcock, C., Nicholls, E., Lancaster, G., Wathall, S., Laing, L., Helliwell, T., Jowett, S., Kigozi, J., Mallen, C. D., Avery, A., Knaggs, R., Pincus, T., White, S., & Jinks, C. (2024). Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study

Background:

Given the poor long-term effectiveness of opioids for persistent non-cancer pain, and their potential for harm, evidence–based interventions to address opioid overprescribing for persistent pain are needed. This study aimed to explore... Read More about Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study..

Supporting the drive for net zero by decarbonising general practice – A longitudinal study protocol [version 1; peer review: awaiting peer review] (2024)
Journal Article
Raquel Nunes, A., Atherton, H., Dahlmann, F., Eccles, A., Geddes, O., Gregg, M., Jowett, S., Karaba, F., Nelson, L., Spencer, R., Twohig, H., & Dale, J. (2024). Supporting the drive for net zero by decarbonising general practice – A longitudinal study protocol [version 1; peer review: awaiting peer review]. NIHR Open Research, 1-11. https://doi.org/10.3310/nihropenres.13833.1

Introduction
The urgency to address climate change and reduce carbon emissions in healthcare, highlighted in the United Kingdom (UK) by the 'Delivering a 'Net Zero' National Health Service (NHS)' report, emphasises the need for healthcare organisati... Read More about Supporting the drive for net zero by decarbonising general practice – A longitudinal study protocol [version 1; peer review: awaiting peer review].

Cardiovascular diseases in patients with cancer: A comprehensive review of epidemiological trends, cardiac complications, and prognostic implications (2024)
Journal Article
Alshahrani, A. A., Kontopantelis, E., Morgan, C., Ravindrarajah, R., Martin, G. P., & Mamas, M. A. (in press). Cardiovascular diseases in patients with cancer: A comprehensive review of epidemiological trends, cardiac complications, and prognostic implications. Chinese Medical Journal, https://doi.org/10.1097/cm9.0000000000003419

This article provides an overview of the current evidence on the epidemiology, overlapping risk factors, and pathophysiology of cardiovascular disease (CVD) in patients with cancer. It explores the cardiotoxic effects of anticancer therapy and their... Read More about Cardiovascular diseases in patients with cancer: A comprehensive review of epidemiological trends, cardiac complications, and prognostic implications.

Evaluating the use of electromyography in UK and European gait laboratories for the assessment of cerebral palsy and other neurological and musculoskeletal conditions (2024)
Journal Article
Shepherd, H., Reeves, J., & Stewart, C. (in press). Evaluating the use of electromyography in UK and European gait laboratories for the assessment of cerebral palsy and other neurological and musculoskeletal conditions. Gait & Posture, 117, 143-152. https://doi.org/10.1016/j.gaitpost.2024.12.018

Background
Electromyography (EMG) can estimate the magnitude and timing of muscle activation during walking in those with gait disorders. Despite the potential of EMG use in assessment and clinical decision-making... Read More about Evaluating the use of electromyography in UK and European gait laboratories for the assessment of cerebral palsy and other neurological and musculoskeletal conditions.

The Impact of Age and Sex on Fasting Plasma Glucose and Glycated Haemoglobin (HbA1c) in the Non-diabetes Population. (2024)
Journal Article
Stedman, M., Heald, A. H., Holland, D., Halsall, I., Green, L., Wu, P., Patel, K., Scargill, J., Gibson, M., Hanna, F. W. F., & Fryer, A. A. (in press). The Impact of Age and Sex on Fasting Plasma Glucose and Glycated Haemoglobin (HbA1c) in the Non-diabetes Population. Diabetes Therapy, https://doi.org/10.1007/s13300-024-01680-w

We previously reported sex differences in the distribution of glycated haemoglobin (HbA1c) for men/women aged < 50 years vs older individuals, with implications for delayed diabetes diagnosis. Here, we explored whether this pattern was also seen in m...

Responses to Complex Emotional Needs in UK male prisons: A scoping review protocol v1 (2024)
Other
Lamph, G., Clifford, A., Wyndham, D., Wheatcroft, S., Canvin, K., Hughes, N., Hutton, R., Roberts, J., Rydon-Grange, M., Plant, J., & Lewis, C. (2024). Responses to Complex Emotional Needs in UK male prisons: A scoping review protocol v1

The aim of this review is to examine the scope of the literature and grey literature considering support for complex emotional needs in UK male prisons. The objectives to be completed in order to meet the aim are: i.) answer the review question: What... Read More about Responses to Complex Emotional Needs in UK male prisons: A scoping review protocol v1.

Correction: Addressing disparities in the long-term mortality risk in individuals with non-ST segment myocardial infarction (NSTEMI) by diabetes mellitus status: a nationwide cohort study. (2024)
Journal Article
Cole, A., Weight, N., Misra, S., Grapsa, J., Rutter, M. K., Siudak, Z., Moledina, S., Kontopantelis, E., Khunti, K., & Mamas, M. A. (in press). Correction: Addressing disparities in the long-term mortality risk in individuals with non-ST segment myocardial infarction (NSTEMI) by diabetes mellitus status: a nationwide cohort study. Diabetologia, https://doi.org/10.1007/s00125-024-06337-8

Psoriatic Arthritis Priority Setting Partnership: patient- and clinician-informed considerations for future UK health service delivery. (2024)
Journal Article
James, L., Hailey, L., Bundy, C., Burstow, H., Chandler, D., Cowper, R., Helliwell, P., Joannes, L., Kelly, A., Kennedy, B., Kinsella, S., McAteer, H., Mukherjee, S., Packham, J., Wise, E., Young, H., Dures, E., & Coates, L. C. (in press). Psoriatic Arthritis Priority Setting Partnership: patient- and clinician-informed considerations for future UK health service delivery. Rheumatology, 1-6. https://doi.org/10.1093/rheumatology/keae680

Little is known about the ideal service delivery model and shortcomings in patient experiences in the NHS for patients with Psoriatic Arthritis (PsA). To identify unmet needs perceived within the current health service delivery model for PsA from the... Read More about Psoriatic Arthritis Priority Setting Partnership: patient- and clinician-informed considerations for future UK health service delivery..

Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review] (2024)
Journal Article
Imantalab, D., Singh Sokhal, B., Prasanna Kumar Menon, S., Kalra, S., Muller, S., & Mallen, C. (2024). Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review]. NIHR Open Research, 1-14. https://doi.org/10.3310/nihropenres.13786.1

Motor Neurone Disease (MND) is a neurodegenerative condition affecting motor neurons in spinal cord and brainstem, leading to a reduced life expectancy. This study describes demographic trends in MND-associated mortality in the United States over a 2... Read More about Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review].

Rising mortality rates linked to type‐2 diabetes and obesity in the United States: An observational analysis from 1999 to 2022 (2024)
Journal Article
Ahmed, M., Nofal, A., Shafiq, A., Javaid, H., Ahsan, A., Nadeem, Z. A., Ahmed, R., Alam, M., Mamas, M. A., Fudim, M., & Fonarow, G. C. (in press). Rising mortality rates linked to type‐2 diabetes and obesity in the United States: An observational analysis from 1999 to 2022. Journal of Diabetes Investigation, https://doi.org/10.1111/jdi.14386

Background: The prevalence of type 2 diabetes (T2D) and obesity are increasing in the United States. However, population‐level data for mortality trends due to T2D and obesity are limited. This study aims to assess these death trends among adults in... Read More about Rising mortality rates linked to type‐2 diabetes and obesity in the United States: An observational analysis from 1999 to 2022.

A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides (2024)
Journal Article
Shen, Z., Simard, M., Brand, D., Andrei, V., Al-Khader, A., Oumlil, F., Trevers, K., Butters, T., Haefliger, S., Kara, E., Amary, F., Tirabosco, R., Cool, P., Royle, G., Hawkins, M. A., Flanagan, A. M., & Collins-Fekete, C.-A. (in press). A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides. Communications Biology, 7(1), 1674. https://doi.org/10.1038/s42003-024-07398-6

Mitotic activity is an important feature for grading several cancer types. However, counting mitotic figures (cells in division) is a time-consuming and laborious task prone to inter-observer variation. Inaccurate recognition of MFs can lead to incor... Read More about A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides.