All Outputs (17)

Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation. (2022)
Journal Article

OBJECTIVE: In vitro maturation (IVM) and cryopreservation of oocytes are two important parts of assisted reproductive technology (ART), but their efficacy is low. This study aimed to improve the quality of in vitro vitrified-warmed maturated oocytes... Read More about Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation..

Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation (2022)
Journal Article

Objective: In vitro maturation (IVM) and cryopreservation of oocytes are two important parts of assisted reproductive technology (ART), but their efficacy is low. This study aimed to improve the quality of in vitro vitrified-warmed maturated oocytes... Read More about Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation.

Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM. (2022)
Journal Article

PURPOSE: In vitro maturation (IVM) is a technology that generates mature oocytes following culture of immature cumulus-oocyte complexes (COC) in vitro. IVM is characterized by minimal patient stimulation, making it attractive for certain patient grou... Read More about Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM..

Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro (2019)
Journal Article

Meeting abstract, from the 35th Annual Meeting of the European Society of Human Reproduction and Embryology.

Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro (2019)
Journal Article

The oocyte-secreted factors bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) interact functionally and it is hypothesised that this interaction may be mediated by formation of a GDF9:BMP15 heterodimer, termed cumulin.... Read More about Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro.

Seminal fluid factors regulate activin A and follistatin synthesis in female cervical epithelial cells (2015)
Journal Article

Background: Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency. Using a rat model that recapitulates features of human ESCC,... Read More about Seminal fluid factors regulate activin A and follistatin synthesis in female cervical epithelial cells.

Promotion of EGF receptor signaling improves the quality of low developmental competence oocytes (2015)
Journal Article

Oocytes acquire developmental competence with progressive folliculogenesis. Cumulus oocyte complexes (COCs) from small antral follicles have inherent low competence and are poorly responsive to amphiregulin (AREG) which normally mediates oocyte matur... Read More about Promotion of EGF receptor signaling improves the quality of low developmental competence oocytes.

Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone (2015)
Journal Article

The developmental competence of cumulus oocyte complexes (COCs) can be increased during in vitro oocyte maturation with the addition of exogenous oocyte-secreted factors, such as bone morphogenetic protein 15 (BMP15), in combination with hormones. FS... Read More about Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone.

Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15 (2014)
Journal Article

Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) act synergistically to regulate granulosa cell proliferation and steroid production in several species. Several non-Sma and mothers against decapentaplegic (SMAD) signal... Read More about Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15.

Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence (2014)
Journal Article

Developmental competence of in vitro matured (IVM) oocytes needs to be improved and this can potentially be achieved by adding recombinant bone morphogenetic protein 15 (BMP15) or growth differentiation factor (GDF9) to IVM. The aim of this study was... Read More about Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence.

Mouse GDF9 decreases KITL gene expression in human granulosa cells (2014)
Journal Article

Kit ligand (KITL) is an important granulosa cell-derived growth factor in ovarian folliculogenesis, but its expression and function in human granulosa cells are currently poorly understood. Based on studies performed in animal models, it was hypothes... Read More about Mouse GDF9 decreases KITL gene expression in human granulosa cells.

Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders (2014)
Journal Article

Context: Growth differentiation factor 9 (GDF9) is a central regulator of folliculogenesis and ovulation rate. Fourteen mutations in human (h) GDF9 have been reported in women with premature ovarian failure or polycystic ovarian syndrome as well as... Read More about Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders.

Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply (2014)
Journal Article

This study assessed the participation of amphiregulin (AREG) and bone morphogenetic protein 15 (BMP15) during maturation of bovine cumulus-oocyte complexes (COCs) on cumulus cell function and their impact on subsequent embryo development. AREG treatm... Read More about Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply.

Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development (2014)
Journal Article

Purpose We hypothesised that varying native oocyte-secreted factor (OSF) exposure or using different recombinant OSF peptides would have differential effects on post-in vitro maturation (IVM) embryo and fetal development. Methods Mouse cumulus o... Read More about Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development.

Growth differentiation factor 9: bone morphogenetic protein 15 synergism and the potential involvement of heterodimerization (2013)
Journal Article

Oocyte-Secreted Factors in Domestic Animals (2013)
Book Chapter

Summary This chapter contains sections titled: Introduction Historical Background Localization and Specificity Structure and Genetic Diversity of Gdf9 and Bmp15 Signalling Mechanisms of Gdf9 and Bmp15 Roles of Oocyte-Secreted Factors Manipula... Read More about Oocyte-Secreted Factors in Domestic Animals.

Smad signalling in the ovary (2006)
Journal Article

It has now been a decade since the first discovery of the intracellular Smad proteins, the downstream signalling molecules of one of the most important growth factor families in the animal kingdom, the transforming growth factor beta (TGF-beta) super... Read More about Smad signalling in the ovary.