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The future of peritoneal dialysis (2024)
Journal Article
Davies, S. (in press). The future of peritoneal dialysis. Clinical Kidney Journal, 17(Supplement_2), 9-18. https://doi.org/10.1093/ckj/sfae277

Peritoneal dialysis (PD), long established as the leading form of home dialysis, has comparatively good 5-year outcomes and cost-utility analyses have consistently demonstrated benefits to both patients and payers. Future improvements should still be... Read More about The future of peritoneal dialysis.

Establishing a peritoneal dialysis technique survival core outcome measure: A standardised outcomes in nephrology-peritoneal dialysis consensus workshop report (2024)
Journal Article
Elphick, E. H., Manera, K. E., Viecelli, A. K., Craig, J. C., Cho, Y., Ju, A., …Lambie, M. (in press). Establishing a peritoneal dialysis technique survival core outcome measure: A standardised outcomes in nephrology-peritoneal dialysis consensus workshop report. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, https://doi.org/10.1177/08968608241287684

Background Technique survival, also reported with negative connotations as technique failure or transfer from peritoneal dialysis to haemodialysis, has been identified by patients, caregivers and health professionals as a critically important outcome... Read More about Establishing a peritoneal dialysis technique survival core outcome measure: A standardised outcomes in nephrology-peritoneal dialysis consensus workshop report.

Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients (2024)
Journal Article
Johal, N., Sharma, R., Belcher, J., Coyle, D., Lindley, E. J., Keane, D., …Davies, S. J. (in press). Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients. BMC Nephrology, 25(1), Article 398. https://doi.org/10.1186/s12882-024-03837-y

Introduction: Fluid assessment and management is a key aspect of good dialysis care and is affected by patient-level characteristics and potentially centre-level practices. In this secondary analysis of the BISTRO trial we wished to establish whether... Read More about Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients.

Dynamic Prediction of Cardiovascular Events in Incident Patients on Peritoneal Dialysis with Multivariate Joint Models Adjusting for Phosphate, Albumin, and Calcium Trajectories and Competing Risks (2024)
Presentation / Conference
Damgov, I., Kieser, M., Davies, S. J., Wong, M. G., Pollock, C. A., Johnson, D. W., & Schmitt, C. P. (2024, October). Dynamic Prediction of Cardiovascular Events in Incident Patients on Peritoneal Dialysis with Multivariate Joint Models Adjusting for Phosphate, Albumin, and Calcium Trajectories and Competing Risks. Poster presented at Kidney Week, San Diego, CA

Preparing for responsive management versus preparing for renal dialysis in multimorbid older people with advanced chronic kidney disease (Prepare for Kidney Care): Study protocol for a randomised controlled trial. (2024)
Journal Article
Worthington, J., Soundy, A., Frost, J., Rooshenas, L., MacNeill, S. J., Realpe Rojas, A., …Caskey, F. J. (2024). Preparing for responsive management versus preparing for renal dialysis in multimorbid older people with advanced chronic kidney disease (Prepare for Kidney Care): Study protocol for a randomised controlled trial. Trials, 25(1), 1-19. https://doi.org/10.1186/s13063-024-08509-8

Background: Chronic kidney disease (CKD) prevalence is steadily increasing, in part due to increased multimorbidity in our aging global population. When progression to kidney failure cannot be avoided, people need unbiased information to inform decis... Read More about Preparing for responsive management versus preparing for renal dialysis in multimorbid older people with advanced chronic kidney disease (Prepare for Kidney Care): Study protocol for a randomised controlled trial..

Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial (2024)
Journal Article
Belcher, J., Coyle, D., Lindley, E. J., Keane, D., Caskey, F. J., Dasgupta, I., …Davies, S. J. (in press). Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial. Kidney360, https://doi.org/10.34067/KID.0000000596

Preservation of residual kidney function (RKF) in dialysis patients has been associated with improved survival. RKF in the BISTRO trial was relatively well preserved and here we describe its association with survival during the trial and extended fol... Read More about Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial.

Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT (2024)
Journal Article
Zanganeh, M., Belcher, J., Fotheringham, J., Coyle, D., Lindley, E. J., Keane, D. F., …Andronis, L. (in press). Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT. Health Technology Assessment, 1-45. https://doi.org/10.3310/jypr4287

Background
The BioImpedance Spectroscopy to maintain Renal Output randomised controlled trial investigated the effect of bioimpedance spectroscopy added to a standardised fluid management protocol on the risk of anuria and preservation of residual k... Read More about Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT.

Rationale and design of ELIXIR, a randomized, controlled trial to evaluate efficacy and safety of XyloCore, a glucose-sparing solution for peritoneal dialysis. (2024)
Journal Article
Bonomini, M., Davies, S., Kleophas, W., Lambie, M., Reboldi, G., Liberato, L. D., …Arduini, A. (2024). Rationale and design of ELIXIR, a randomized, controlled trial to evaluate efficacy and safety of XyloCore, a glucose-sparing solution for peritoneal dialysis. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, https://doi.org/10.1177/08968608241274106

Peritoneal dialysis adoption and technique survival is affected by limitations related to peritoneal membrane longevity and metabolic alterations. Indeed, almost all peritoneal dialysis fluids exploit glucose as an osmotic agent that rapidly diffuses... Read More about Rationale and design of ELIXIR, a randomized, controlled trial to evaluate efficacy and safety of XyloCore, a glucose-sparing solution for peritoneal dialysis..

Impact of Chronic Kidney Disease on the Processes of Care and Long-Term Mortality of Non-ST-Segment-Elevation Myocardial Infarction: A Nationwide Cohort Study and Long-Term Follow-Up. (2024)
Journal Article
Weight, N., Moledina, S., Ullah, M., Wijeysundera, H. C., Davies, S., Chew, N. W. S., …Mamas, M. A. (in press). Impact of Chronic Kidney Disease on the Processes of Care and Long-Term Mortality of Non-ST-Segment-Elevation Myocardial Infarction: A Nationwide Cohort Study and Long-Term Follow-Up. Journal of the American Heart Association, 13(16), Article e032671. https://doi.org/10.1161/JAHA.123.032671

A growing population of patients with chronic kidney disease (CKD) presents with non-ST-segment-elevation myocardial infarction, although little is known about their longer-term mortality. Using the MINAP (Myocardial Ischaemia National Audit Project)... Read More about Impact of Chronic Kidney Disease on the Processes of Care and Long-Term Mortality of Non-ST-Segment-Elevation Myocardial Infarction: A Nationwide Cohort Study and Long-Term Follow-Up..

#1248 Sex specific associations between fat free mass and weight with mortality: sequences of regressions analyses from the UK Biobank cohort (2024)
Presentation / Conference
Tabinor, M., Potts, J., Ferro, C. J., Davies, S., & Solis-Trapala, I. (2024, May). #1248 Sex specific associations between fat free mass and weight with mortality: sequences of regressions analyses from the UK Biobank cohort. Presented at 61st ERA Congress, Stockholm, Sweden

Background and Aims There is growing evidence that muscle mass (MM) loss, observed in long term conditions (LTCs), including chronic kidney disease (CKD), is associated with mortality. This study aimed to explore the direct association between MM and... Read More about #1248 Sex specific associations between fat free mass and weight with mortality: sequences of regressions analyses from the UK Biobank cohort.

#2796 Divergent associations between mortality and different measures of renal function after adjustment for body composition: results from the UK Biobank (2024)
Presentation / Conference
Tabinor, M., Potts, J., Ferro, C. J., Davies, S., & Solis-Trapala, I. (2024, May). #2796 Divergent associations between mortality and different measures of renal function after adjustment for body composition: results from the UK Biobank. Presented at 61st ERA Congress, Stockholm, Sweden

Background and Aims There is data suggesting estimated glomerular filtration rate using Cystatin-C (eGFRCystatin-C) is superior to the creatinine-based (eGFRCreat) method when assessing associations between renal function and mortality (Lees et al. 2... Read More about #2796 Divergent associations between mortality and different measures of renal function after adjustment for body composition: results from the UK Biobank.

#2832 Lean tissue mass is associated with mortality across different stages of chronic kidney disease: a systematic review and meta-analysis (2024)
Presentation / Conference
Tabinor, M., Elphick, E., Stephens, C., Wall, N., Ul Hussain, A., Shah, R., …Davies, S. (2024, May). #2832 Lean tissue mass is associated with mortality across different stages of chronic kidney disease: a systematic review and meta-analysis. Presented at 61st ERA Congress, Stockholm, Sweden

Background and Aims Loss of lean tissue mass (LLTM) commonly occurs in multiple long-term conditions (LTC), including chronic kidney disease (CKD), and is thought to be associated with adverse outcomes including mortality, frailty surrogates and poor... Read More about #2832 Lean tissue mass is associated with mortality across different stages of chronic kidney disease: a systematic review and meta-analysis.

Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England (2024)
Journal Article
Damery, S., Lambie, M., Williams, I., Coyle, D., Fotheringham, J., Solis-Trapala, I., …Davies, S. J. (in press). Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, https://doi.org/10.1177/08968608241232200

Background:
Disparities in home dialysis uptake across England suggest inequity and unexplained variation in access. We surveyed staff at all English kidney centres to identify patterns in service organisation/delivery and explore correlations with... Read More about Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England.

The Point-of-Care Peritoneal Dialysis System Early Evaluation Study (POC-PDEE): A pilot proof-of-principal study of the Ellen Medical Devices Point-of-Care affordable peritoneal dialysis system. (2024)
Journal Article
Talbot, B., Davies, S., Burman, J., Ritchie, A., Snelling, P., Lynch, S., …Knight, J. (in press). The Point-of-Care Peritoneal Dialysis System Early Evaluation Study (POC-PDEE): A pilot proof-of-principal study of the Ellen Medical Devices Point-of-Care affordable peritoneal dialysis system. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, https://doi.org/10.1177/08968608231209850

The global unmet need for kidney replacement therapy means that millions of people die every year as they cannot afford treatment. Peritoneal dialysis (PD) offers comparable survival to haemodialysis and is often more affordable, but one barrier to i... Read More about The Point-of-Care Peritoneal Dialysis System Early Evaluation Study (POC-PDEE): A pilot proof-of-principal study of the Ellen Medical Devices Point-of-Care affordable peritoneal dialysis system..

Effects of Empagliflozin on Fluid Overload, Weight and Blood Pressure in Chronic Kidney Disease (2023)
Journal Article
Mayne, K. J., Staplin, N., Keane, D. F., Wanner, C., Brenner, S., Cejka, V., …Herrington, W. G. (2023). Effects of Empagliflozin on Fluid Overload, Weight and Blood Pressure in Chronic Kidney Disease. Journal of the American Society of Nephrology, 35(2), 202-215. https://doi.org/10.1681/asn.0000000000000271

BACKGROUND: Chronic kidney disease (CKD) is associated with fluid excess which can be estimated by bioimpedance spectroscopy. We aimed to assess effects of sodium glucose co-transporter 2 inhibition on bioimpedance-derived “Fluid Overload” and adipos... Read More about Effects of Empagliflozin on Fluid Overload, Weight and Blood Pressure in Chronic Kidney Disease.

Providing environmentally sustainable nephrology care: focus in Low- and Middle-Income Countries. (2023)
Journal Article
Luyckx, V. A., Alasfar, S., Bajpai, D., Atwater, C. E., Knight, J., Talbot, B., …Niang, A. (2024). Providing environmentally sustainable nephrology care: focus in Low- and Middle-Income Countries. Kidney International, 105(2), 259-268. https://doi.org/10.1016/j.kint.2023.09.034

Healthcare on a global scale significantly contributes to carbon emissions, with high-income countries being the primary culprits. Within healthcare, dialysis plays a significant role as a major source of emissions. Low- and middle-income countries h... Read More about Providing environmentally sustainable nephrology care: focus in Low- and Middle-Income Countries..

Robust Joint Models of Albumin and All-Cause Mortality in Incident Peritoneal Dialysis Patients: A Dynamic Predictions Perspective Adjusting for Competing Risks (2023)
Presentation / Conference
Damgov, I., Kieser, M., Rutherford, P., Lambie, M., Davies, S. J., Wong, M. G., …Schmitt, C. P. (2023, November). Robust Joint Models of Albumin and All-Cause Mortality in Incident Peritoneal Dialysis Patients: A Dynamic Predictions Perspective Adjusting for Competing Risks. Poster presented at ASN Kidney Week, Philadelphia, PA, USA

Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis (2023)
Journal Article
Istanbuly, O., Belcher, J., Tabinor, M., Solis-Trapala, I., Lambie, M., & Davies, S. J. (in press). Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis. BMC Nephrology, 24(1), Article 312. https://doi.org/10.1186/s12882-023-03370-4

Background: Systemic inflammation, measured as circulating Interleukin-6 (IL-6) levels, is associated with cardiovascular and all-cause mortality in chronic kidney disease. However, this has not been convincingly demonstrated in a systematic review o... Read More about Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis.