All Outputs (124)

Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England (2024)
Journal Article

Background: Disparities in home dialysis uptake across England suggest inequity and unexplained variation in access. We surveyed staff at all English kidney centres to identify patterns in service organisation/delivery and explore correlations with h... Read More about Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England.

The Point-of-Care Peritoneal Dialysis System Early Evaluation Study (POC-PDEE): A pilot proof-of-principal study of the Ellen Medical Devices Point-of-Care affordable peritoneal dialysis system. (2024)
Journal Article

The global unmet need for kidney replacement therapy means that millions of people die every year as they cannot afford treatment. Peritoneal dialysis (PD) offers comparable survival to haemodialysis and is often more affordable, but one barrier to i... Read More about The Point-of-Care Peritoneal Dialysis System Early Evaluation Study (POC-PDEE): A pilot proof-of-principal study of the Ellen Medical Devices Point-of-Care affordable peritoneal dialysis system..

Emerging Approaches for Optimizing Fluid Management with Peritoneal Dialysis (2023)
Journal Article

Effects of Empagliflozin on Fluid Overload, Weight and Blood Pressure in Chronic Kidney Disease (2023)
Journal Article

BACKGROUND: Chronic kidney disease (CKD) is associated with fluid excess which can be estimated by bioimpedance spectroscopy. We aimed to assess effects of sodium glucose co-transporter 2 inhibition on bioimpedance-derived “Fluid Overload” and adipos... Read More about Effects of Empagliflozin on Fluid Overload, Weight and Blood Pressure in Chronic Kidney Disease.

Providing environmentally sustainable nephrology care: focus in Low- and Middle-Income Countries. (2023)
Journal Article

Healthcare on a global scale significantly contributes to carbon emissions, with high-income countries being the primary culprits. Within healthcare, dialysis plays a significant role as a major source of emissions. Low- and middle-income countries h... Read More about Providing environmentally sustainable nephrology care: focus in Low- and Middle-Income Countries..

Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis (2023)
Journal Article

Background: Systemic inflammation, measured as circulating Interleukin-6 (IL-6) levels, is associated with cardiovascular and all-cause mortality in chronic kidney disease. However, this has not been convincingly demonstrated in a systematic review o... Read More about Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis.

Catheter Event Rates in Medical Compared to Surgical Peritoneal Dialysis Catheter Insertion (2023)
Journal Article

How patient, center, and insertion technique factors interact needs to be understood when designing peritoneal dialysis (PD) catheter insertion pathways. We undertook a prospective cohort study in 44 UK centers enrolling participants planned for firs... Read More about Catheter Event Rates in Medical Compared to Surgical Peritoneal Dialysis Catheter Insertion.

An update on absolute and relative indications for dialysis treatment modalities (2023)
Journal Article

Background Choosing a dialysis modality is an important decision for people to make as their kidney failure progresses. In doing so, their options should be informed by any absolute or relative indications that may favour one modality over another. M... Read More about An update on absolute and relative indications for dialysis treatment modalities.

The Peritoneal Membrane and its Role in Peritoneal Dialysis. (2023)
Journal Article

A healthy and functional peritoneal membrane is key to achieve sufficient ultrafiltration and to restore fluid balance, a major component of high-quality prescription in patients treated with peritoneal dialysis (PD). Variability in membrane function... Read More about The Peritoneal Membrane and its Role in Peritoneal Dialysis..

Bio-impedance spectroscopy added to a fluid management protocol does not improve preservation of residual kidney function in incident hemodialysis patients in a randomized controlled trial (2023)
Journal Article

Avoiding excessive dialysis-associated volume depletion may help preserve residual kidney function (RKF). To establish whether knowledge of the estimated normally hydrated weight from bioimpedance measurements (BI-NHW) when setting the post-hemodialy... Read More about Bio-impedance spectroscopy added to a fluid management protocol does not improve preservation of residual kidney function in incident hemodialysis patients in a randomized controlled trial.

Volume management in hemodialysis – a moving target (2023)
Journal Article

CKD-Associated Cardiovascular Mortality in the United States: Temporal Trends From 1999 to 2020. (2023)
Journal Article

RATIONALE & OBJECTIVE: Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular (CV) mortality, but there are limited data on temporal trends disaggregated by sex, race, and urban/rural status in this population. STUDY DESI... Read More about CKD-Associated Cardiovascular Mortality in the United States: Temporal Trends From 1999 to 2020..

Home dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. (2023)
Journal Article

Home dialysis modalities (home hemodialysis [HD] and peritoneal dialysis [PD]) are associated with greater patient autonomy and treatment satisfaction compared with in-center modalities, yet the level of home-dialysis use worldwide is low. Reasons fo... Read More about Home dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference..

IMPROVE-PD Finder: A Web-Based Platform to Search and Share Peritoneal Dialysis Biobank, Registry, and Clinical Trial Metadata (2023)
Journal Article

Peritoneal dialysis (PD) is a life-sustaining kidney replacement therapy for the increasing number of people with permanent kidney failure across all age groups worldwide. Although PD potentially offers socioeconomic and performance benefits over hem... Read More about IMPROVE-PD Finder: A Web-Based Platform to Search and Share Peritoneal Dialysis Biobank, Registry, and Clinical Trial Metadata.

Salt and Water Balance (2022)
Book Chapter

Achieving salt and water balance is fundamental to optimizing fluid status, one of the key objectives of peritoneal dialysis (PD) treatment. The relative importance of salt and water management to patient outcomes was historically underestimated by e... Read More about Salt and Water Balance.

Monitoring residual kidney function in haemodialysis patients using timed urine collections: validation of the use of estimated blood results to calculate GFR (2022)
Journal Article

OBJECTIVE: With growing recognition of the benefits of preserving residual kidney function (RKF) and use of incremental treatment regimes, the incentive to measure residual clearance in haemodialysis patients is increasing. Interdialytic urine collec... Read More about Monitoring residual kidney function in haemodialysis patients using timed urine collections: validation of the use of estimated blood results to calculate GFR.

Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle (2022)
Journal Article

INTRODUCTION: Use of home dialysis by centres in the UK varies considerably and is decreasing despite attempts to encourage greater use. Knowing what drives this unwarranted variation requires in-depth understanding of centre cultural and organisatio... Read More about Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle.

Variation in Peritoneal Dialysis Time on Therapy by Country: Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study. (2022)
Journal Article

Background and objectives Quantifying contemporary peritoneal dialysis time on therapy is important for patients and providers. We describe time on peritoneal dialysis in the context of outcomes of hemodialysis transfer, death, and kidney transplanta... Read More about Variation in Peritoneal Dialysis Time on Therapy by Country: Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study..

International Icodextrin Use and Association with Peritoneal Membrane Function, Fluid Removal, Patient and Technique Survival (2022)
Journal Article

Key Points There are important national and center differences in the prescription of icodextrin, with the United States a clear outlier; across all countries, icodextrin was more likely to be used if membrane function tests indicated reduced ultrafi... Read More about International Icodextrin Use and Association with Peritoneal Membrane Function, Fluid Removal, Patient and Technique Survival.

Mortality Trends After Transfer From Peritoneal Dialysis to Hemodialysis (2022)
Journal Article

Introduction Transition to hemodialysis (HD) is a common outcome in peritoneal dialysis (PD), but the associated mortality risk is poorly understood. This study sought to identify rates of and risk factors for mortality after transitioning from PD t... Read More about Mortality Trends After Transfer From Peritoneal Dialysis to Hemodialysis.