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All Outputs (21)

A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children (2025)
Journal Article
Twohig, H., Franklin, L., Carroll, W., Corp, N., Jackson, E., Mallen, C., Ruan, B., Yapp, L., Van Der Windt, D., & Smith, J. (2025). A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children. Paediatric Respiratory Reviews, 1-37. https://doi.org/10.1016/j.prrv.2025.04.005

Background
Dry powder inhalers (DPIs) are a lower-carbon option than pressurised metered dose inhalers (pMDIs). However, DPIs require a forceful inhalation to achieve good lung deposition and there is uncertainty as to whether younger children can e... Read More about A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children.

How do patients determine when their inhaler is empty? Insights from an analysis of returned inhalers and a patient survey. (2024)
Journal Article
Murphy, A. C., Carroll, W., Gotsell, M., Potter, C., Quint, J. K., & Malone, R. (in press). How do patients determine when their inhaler is empty? Insights from an analysis of returned inhalers and a patient survey. BMJ Open Respiratory Research, 11(1), e002579. https://doi.org/10.1136/bmjresp-2024-002579

Inhalers are widely used for the management of asthma and chronic obstructive pulmonary disease. However, there is little knowledge about the extent to which an inhaler is used and when it is disposed of, despite the implications for an individual's... Read More about How do patients determine when their inhaler is empty? Insights from an analysis of returned inhalers and a patient survey..

Treating severe paediatric asthma with mepolizumab or omalizumab: a protocol for the TREAT randomised non-inferiority trial (2024)
Journal Article
Cornelius, V., Babalis, D., Carroll, W. D., Cunningham, S., Fleming, L., Gaillard, E., Gupta, A., Janani, L., Kennington, E., Murray, C., Nagakumar, P., Roberts, G., Seddon, P., Sinha, I., Streatfield, C., Weir, E., & Saglani, S. (2024). Treating severe paediatric asthma with mepolizumab or omalizumab: a protocol for the TREAT randomised non-inferiority trial. BMJ Open, 14(8), https://doi.org/10.1136/bmjopen-2024-090749

Introduction: A minority of school-aged children with asthma have persistent poor control and experience frequent asthma attacks despite maximal prescribed maintenance therapy. These children have higher morbidity and risk of death. The first add-on... Read More about Treating severe paediatric asthma with mepolizumab or omalizumab: a protocol for the TREAT randomised non-inferiority trial.

P46 How and when do patients dispose of old or unwanted inhalers? (2023)
Presentation / Conference
Murphy, A., Carroll, W., Gotsell, M., Potter, C., Quint, J., & Malone, R. (2023, November). P46 How and when do patients dispose of old or unwanted inhalers?. Poster presented at British Thoracic Society Winter Meeting 2023, QEII Centre, Broad Sanctuary, Westminster, London SW1P 3EE, England

Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis (2021)
Journal Article
Carroll, W., Green, J., & Gilchrist, F. J. (in press). Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. Cochrane Database of Systematic Reviews, 2021(12), https://doi.org/10.1002/14651858.cd012619.pub3

Background
Cystic fibrosis (CF) is the most common, life‐limiting, genetically inherited disease. It affects multiple organs, particularly the respiratory system. However, gastrointestinal problems such as constipation and distal intestinal obstruct... Read More about Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis.

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis (2021)
Journal Article
Gilchrist, F. J., Green, J., & Carroll, W. (2021). Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD012798.pub3

BACKGROUND: Cystic fibrosis is the most common life-limiting autosomal recessive genetic disorder in white populations. Distal intestinal obstruction syndrome (DIOS) is an important morbidity in cystic fibrosis. It is the result of the accumulation o... Read More about Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis.

Chapter 17: Respiratory Disorders (2021)
Book Chapter
Gilchrist, F., & Carroll, W. (2021). Chapter 17: Respiratory Disorders. In Illustrated Textbook of Paediatrics, 6th Edition. Elsevier

Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis (2019)
Presentation / Conference
Grose-Hodge, E., Carroll, W., Rainford, N., Gamble, C., & Gilchrist, F. (2019, September). Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis. Presented at ERS International Congress 2019, Madrid, Spain

Background: Protracted Bacterial Bronchitis (PBB) is a leading cause of chronic wet cough in children. Antibiotic response is a diagnostic criterion but there is little evidence to inform duration of treatment. Relapse is common and those who relapse... Read More about Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis.

Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres (2019)
Journal Article
Ditchfield, N., Carroll, W., & Gilchrist, F. (2019). Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2019.09.004

Highlights

IV aminoglycosides are frequently used to treat infective exacerbations in CF due to efficacy against PA.

The side effects of aminoglycosides include nephrotoxicity, ototoxicity and vestibulotoxicity.

More than one third of UK CF... Read More about Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres.

Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. (2018)
Journal Article
Green, J., Gilchrist, F., & Carroll, W. (2018). Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. Cochrane Database of Systematic Reviews, CD012619 - ?. https://doi.org/10.1002/14651858.CD012619.pub2

BACKGROUND: Cystic fibrosis (CF) is the most common, life-limiting, genetically inherited disease. It affects multiple organs, particularly the respiratory system. However, gastrointestinal problems such as constipation and distal intestinal obstruct... Read More about Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis..

Combined influence of gene-specific cord blood methylation and maternal smoking habit on birth weight (2013)
Journal Article
Haworth, K. E., Farrell, W. E., Emes, R. D., Ismail, K. M. K., Carroll, W. D., Borthwick, H.-A. D., Yates, A. M., Hubball, E., Rooney, A., Khanam, M., Aggarwal, N., Jones, P. W., & Fryer, A. A. (2013). Combined influence of gene-specific cord blood methylation and maternal smoking habit on birth weight. Epigenomics, 5(1), 37-49. https://doi.org/10.2217/EPI.12.72

Aim: Evidence suggests that folic acid intake affects birth weight and that these effects may be mediated via the fetal epigenome. Our previous array data indicate that methylation in human cord blood at gene-specific CpGs is associated with birth we... Read More about Combined influence of gene-specific cord blood methylation and maternal smoking habit on birth weight.

Antiepileptic drugs and the fetal epigenome (2012)
Journal Article
Emes, R. D., Clifford, H., Haworth, K. E., Farrell, W. E., Fryer, A. A., Carroll, W. D., Ismail, K. M. K., & KM, I. (2013). Antiepileptic drugs and the fetal epigenome. Epilepsia, 54(1), e16-e19. https://doi.org/10.1111/j.1528-1167.2012.03673.x

Antiepileptic drugs (AEDs) can lower maternal folate and increase maternal homocysteine levels, which are known to affect the methyl cycle and hence DNA methylation levels. The influence of in utero exposure to AEDs on fetal DNA methylation was inves... Read More about Antiepileptic drugs and the fetal epigenome.

Asthma severity and atopy: how clear is the relationship? (2006)
Journal Article
Carroll, W. D., Lenney, W., Child, F., Strange, R. C., Jones, P. W., Whyte, M. K., Primhak, R. A., & Fryer, A. A. (2006). Asthma severity and atopy: how clear is the relationship?. Archives of Disease in Childhood, 91(5), 405 - 409. https://doi.org/10.1136/adc.2005.088278

BACKGROUND: The relationship between asthma severity and atopy is complex. Many studies have failed to show significant relationships between clinical severity or lung function and markers of atopic sensitisation. AIM: To determine whether increasing... Read More about Asthma severity and atopy: how clear is the relationship?.

Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. (2005)
Journal Article
Carroll, W., Lenney, W., Jones, P., Strange, R., Child, F., Whyte, M., Primhak, R., & Fryer, A. (2005). Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. Clinical and Experimental Allergy, 35(9), 1155 - 1161. https://doi.org/10.1111/j.1365-2222.2005.02313.x

RATIONALE: Previous data have suggested that glutathione-S-transferase (GST) genotypes are important in determining the rate of lung function growth in childhood. This effect was most marked in Caucasian children with asthma. OBJECTIVES: We investiga... Read More about Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families..