681 USING NANOPORE SEQUENCING TO DIAGNOSE PROSTHETIC JOINT INFECTIONS
(2024)
Presentation / Conference
All Outputs (62)
Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study (2024)
Journal Article
This project investigates if third-generation genomic sequencing can be used to identify the species of bacteria causing prosthetic joint infections (PJIs) at the time of revision surgery. Samples of prosthetic fluid were taken during revision surger... Read More about Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study.
Poor adherence to national guidance in the management of patients with metastatic bone disease (2024)
Journal Article
Cite this article: Bone Joint J 2024;106-B(1):6–8.
PRELIMINARY FINDINGS ON THE USE OF GENOMIC SEQUENCING TO DIAGNOSE ORTHOPAEDIC INFECTIONS (2023)
Journal Article
AbstractObjectivesThe objective of this study is to investigate if genomic sequencing is a useful method to diagnose orthopaedic infections. Current methods used to identify the species of bacteria causing orthopaedic infections take considerable tim... Read More about PRELIMINARY FINDINGS ON THE USE OF GENOMIC SEQUENCING TO DIAGNOSE ORTHOPAEDIC INFECTIONS.
Aneurysmal bone cysts: A UK wide tumor center experience (2023)
Journal Article
Background and Objectives This multicenter retrospective series of consecutive extra-spinal aneurysmal bone cysts aims to identify risk factors for treatment failure. Methods Aneurysmal bone cysts treated within seven collaborating centers with... Read More about Aneurysmal bone cysts: A UK wide tumor center experience.
Machine learning models based on routinely sampled blood tests can predict the presence of malignancy amongst patients with suspected musculoskeletal malignancy (2023)
Journal Article
This study explores the possibility of using routinely taken blood tests in the diagnosis and triage of patients with suspected musculoskeletal malignancy. A retrospective study was performed on results of patients who had presented for assessment to... Read More about Machine learning models based on routinely sampled blood tests can predict the presence of malignancy amongst patients with suspected musculoskeletal malignancy.
The British Orthopaedic Oncology Management (BOOM) audit (2023)
Journal Article
AimsMost patients with advanced malignancy suffer bone metastases, which pose a significant challenge to orthopaedic services and burden to the health economy. This study aimed to assess adherence to the British Orthopaedic Oncology Society (BOOS)/Br... Read More about The British Orthopaedic Oncology Management (BOOM) audit.
Clinical outcome of open ankle fractures in patients above 70 years of age (2023)
Journal Article
Background: Open fractures of the ankle are complex injuries requiring multidisciplinary input and are associated with significant morbidity and mortality. However, data on the clinical outcomes of open ankle fracture management in patients older tha... Read More about Clinical outcome of open ankle fractures in patients above 70 years of age.
Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report (2023)
Journal Article
There is currently no "gold-standard" method to diagnose prosthetic joint infections (PJI), and the current practice of using microbiological cultures has many limitations. The identification of the bacterial species causing the infection is crucial... Read More about Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report.
A genetic model for central chondrosarcoma evolution correlates with patient outcome (2022)
Journal Article
BACKGROUND: Central conventional chondrosarcoma (CS) is the most common subtype of primary malignant bone tumour in adults. Treatment options are usually limited to surgery, and prognosis is challenging. These tumours are characterised by the presenc... Read More about A genetic model for central chondrosarcoma evolution correlates with patient outcome.
1Abstract1.1IntroductionSpinal Cord Injury (SCI) is a major cause of disability, with complications post-injury often leading to life-long health issues with need of extensive treatment. Neurological outcome post-SCI can be variable and difficult to... Read More about A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome.
Image Guided Needle Biopsies for Musculoskeletal Soft Tissue Lesions: A 9-Year Analysis of Non-Diagnostic Biopsies (2022)
Journal Article
Background: Non-diagnostic (ND) musculoskeletal biopsies of soft tissue lesions can increase patient anxiety and delay definitive diagnosis and treatment. It is thought the specific histotype of the lesion may influence accuracy of the biopsy. This s... Read More about Image Guided Needle Biopsies for Musculoskeletal Soft Tissue Lesions: A 9-Year Analysis of Non-Diagnostic Biopsies.
Mirels’ score for upper limb metastatic lesions: do we need a different cutoff for recommending prophylactic fixation? (2022)
Journal Article
The aim of this study was to investigate the reproducibility, reliability and accuracy of Mirels’s score in upper limb bony metastatic disease and validate its use in predicting pathological fractures. Methods 45 patients with upper limb bony metasta... Read More about Mirels’ score for upper limb metastatic lesions: do we need a different cutoff for recommending prophylactic fixation?.
A Rare Presentation of a Solitary Melanoma Bone Metastasis. (2022)
Journal Article
A 74-year-old woman presented with sudden onset pain and swelling in her right wrist. Plain radiographs showed a pathological fracture through a lytic lesion. The patient had a past medical history of melanoma on her right thigh, which had been excis... Read More about A Rare Presentation of a Solitary Melanoma Bone Metastasis..
Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic (2021)
Journal Article
There is considerable interest in data analytics because of its value in informing decisions in healthcare. Data variables can be derived from routinely collected records or from primary studies. The level of detail for individual variables in quanti... Read More about Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.
Circulating tumour DNA is a promising biomarker for risk stratification of central chondrosarcoma with IDH1/2 and GNAS mutations (2021)
Journal Article
Chondrosarcoma (CS) is a rare tumour type and the most common primary malignant bone cancer in adults. The prognosis, currently based on tumour grade, imaging and anatomical location, is not reliable and more objective biomarkers are required. We aim... Read More about Circulating tumour DNA is a promising biomarker for risk stratification of central chondrosarcoma with IDH1/2 and GNAS mutations.
Distal femoral replacement - Does length matter? Mid-term results for distal femoral replacements. (2021)
Journal Article
BACKGROUND: Review of mid-term results (five years) for tumour and revision arthroplasty surgery using the Stanmore METS® distal femoral replacement. METHODS: Data were collected retrospectively for 90 patients for procedures performed between 20... Read More about Distal femoral replacement - Does length matter? Mid-term results for distal femoral replacements..
Joint replacement surgery for elbow tumours: a systematic review of outcomes (2021)
Journal Article
Background Tumour resection followed by joint reconstruction is a surgical option in the appropriate patient. The evidence for such reconstructive surgery of the elbow joint is limited. The aim of this study is to review the literature to evaluate t... Read More about Joint replacement surgery for elbow tumours: a systematic review of outcomes.