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State-of-the-art in sub-phenotyping midbrain dopamine neurons (2024)
Journal Article
Basso, V., Dobrossy, M., Thompson, L., Kirik, D., Fuller, H., & Gates, M. (2024). State-of-the-art in sub-phenotyping midbrain dopamine neurons. Biology, 13(9),

Dopaminergic neurons in the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNpc) comprise around 75% of all dopaminergic neurons in the human brain. While both groups of dopaminergic neurons are in close proximity in the midbrai... Read More about State-of-the-art in sub-phenotyping midbrain dopamine neurons.

Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome (2024)
Journal Article
Tierney, L., Kuiper, J. H., Roberts, S., Snow, M., Williams, M., Harrington, M. B., …Wright, K. T. (in press). Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1002/ksa.12433

Purpose: To investigate patient demographic, injury and surgery/treatment‐associated factors that can influence the patient‐reported outcome (Lysholm score), following autologous chondrocyte implantation (ACI) in a large, ‘real‐world’, nonuniform, pr... Read More about Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome.

Nanoscale synchrotron x-ray analysis of intranuclear iron in melanised neurons of Parkinson’s substantia nigra (2024)
Journal Article
Brooks, J., Everett, J., Hill, E., Billimoria, K., Morris, C. M., Sadler, P. J., …Collingwood, J. F. (in press). Nanoscale synchrotron x-ray analysis of intranuclear iron in melanised neurons of Parkinson’s substantia nigra. Communications Biology, 7(1), Article 1024. https://doi.org/10.1038/s42003-024-06636-1

Neuromelanin-pigmented neurons of the substantia nigra are selectively lost during the progression of Parkinson’s disease. These neurons accumulate iron in the disease state, and iron-mediated neuron damage is implicated in cell death. Animal models... Read More about Nanoscale synchrotron x-ray analysis of intranuclear iron in melanised neurons of Parkinson’s substantia nigra.

Concurrent validity between self-reported International Physical Activity Questionnaire Short Form and Fibion accelerometer data among young adults in the UAE (2024)
Journal Article
Arumugam, A., Alsaafin, N., Shalash, R. J., Qadah, R. M., Al-Sharman, A., Moustafa, I. M., …Maffulli, N. (in press). Concurrent validity between self-reported International Physical Activity Questionnaire Short Form and Fibion accelerometer data among young adults in the UAE. European Journal of Medical Research, 29(1), Article 426. https://doi.org/10.1186/s40001-024-01975-5

Self-reported physical activity questionnaires (e.g., International Physical Activity Questionnaire, IPAQ) are a cost-effective, time-saving, and accessible method to assess sedentary behaviour and physical activity. There are conflicting findings re... Read More about Concurrent validity between self-reported International Physical Activity Questionnaire Short Form and Fibion accelerometer data among young adults in the UAE.

Metamizole in the Management of Musculoskeletal Disorders: Current Concept Review (2024)
Journal Article
Jeyaraman, N., Migliorini, F., Murugan, S., Ramasubramanian, S., Balaji, S., Maffulli, N., & Jeyaraman, M. (in press). Metamizole in the Management of Musculoskeletal Disorders: Current Concept Review. Journal of Clinical Medicine, 13(16), Article 4794. https://doi.org/10.3390/jcm13164794

Metamizole, or dipyrone, has been used for decades as a non-narcotic analgesic, providing pain relief from musculoskeletal disorders and antipyretic and antispasmolytic properties. Despite being in use since the 1920s, its mechanism of action still n... Read More about Metamizole in the Management of Musculoskeletal Disorders: Current Concept Review.

Testosterone undecanoate is associated with improved ageing male symptoms score in men with type 2 diabetes and adult-onset testosterone deficiency: re-analyzed results from a randomised controlled trial (2024)
Journal Article
Ramachandran, P., Zitzmann, M., König, C. S., Mulhern, J., Ramachandran, S., & Hackett, G. (in press). Testosterone undecanoate is associated with improved ageing male symptoms score in men with type 2 diabetes and adult-onset testosterone deficiency: re-analyzed results from a randomised controlled trial. Exploration of Endocrine and Metabolic Diseases, 2024(1), 177-190. https://doi.org/10.37349/eemd.2024.00015

Aim: To evaluate changes in quality of life via the ageing male symptom scale (AMSS) and somatic, psychological, and sexual sub-scales following testosterone undecanoate (TU) or placebo (P) treatment in men with type 2 diabetes mellitus (T2DM) and ad... Read More about Testosterone undecanoate is associated with improved ageing male symptoms score in men with type 2 diabetes and adult-onset testosterone deficiency: re-analyzed results from a randomised controlled trial.

Antithrombotic prophylaxis following total knee arthroplasty: a level I Bayesian network meta-analysis. (2024)
Journal Article
Migliorini, F., Maffulli, N., Velaj, E., Bell, A., Kämmer, D., Eschweiler, J., & Hofmann, U. K. (in press). Antithrombotic prophylaxis following total knee arthroplasty: a level I Bayesian network meta-analysis. European Journal of Orthopaedic Surgery and Traumatology, https://doi.org/10.1007/s00590-024-04071-w

Venous thromboembolism (VTE) is a major concern following total knee arthroplasty (TKA). The optimal pharmacological prophylaxis remains, however, controversial. The present investigation compared several non-vitamin K antagonist oral anticoagulants... Read More about Antithrombotic prophylaxis following total knee arthroplasty: a level I Bayesian network meta-analysis..

Brain Punch: K-1 Fights Affect Brain Wave Activity in Professional Kickboxers. (2024)
Journal Article
Rydzik, Ł., Kopańska, M., Wąsacz, W., Ouergui, I., Obmiński, Z., Pałka, T., …Szczygielski, J. (in press). Brain Punch: K-1 Fights Affect Brain Wave Activity in Professional Kickboxers. Sports Medicine, https://doi.org/10.1007/s40279-024-02082-5

Kickboxing is a popular striking combat sport, and K-1 is a type of kickboxing. Direct head blows can cause significant long-term injury and affect brain wave activity. We aim to compare the changes in brain wave activities of fighters during a K-1 k... Read More about Brain Punch: K-1 Fights Affect Brain Wave Activity in Professional Kickboxers..

Modelling take-off moment arms in an ornithocheiraean pterosaur (2024)
Journal Article
Griffin, B. W., Martin-Silverstone, E., Pêgas, R. V., Meilak, E. A., Costa, F. R., Palmer, C., & Rayfield, E. J. (in press). Modelling take-off moment arms in an ornithocheiraean pterosaur. PeerJ, 12, Article e17678. https://doi.org/10.7717/peerj.17678

Take-off is a vital part of powered flight which likely constrains the size of birds, yet extinct pterosaurs are known to have reached far larger sizes. Three different hypothesised take-off motions (bipedal burst launching, bipedal countermotion lau... Read More about Modelling take-off moment arms in an ornithocheiraean pterosaur.

Exploring non-viral methods for the delivery of CRISPR-Cas ribonucleoprotein to hematopoietic stem cells (2024)
Journal Article
Molaei, Z., Jabbarpour, Z., Omidkhoda, A., & Ahmadbeigi, N. (in press). Exploring non-viral methods for the delivery of CRISPR-Cas ribonucleoprotein to hematopoietic stem cells. Stem Cell Research and Therapy, 15(1), Article 233. https://doi.org/10.1186/s13287-024-03848-4

Gene manipulation of hematopoietic stem cells (HSCs) using the CRISPR/Cas system as a potent genome editing tool holds immense promise for addressing hematologic disorders. An essential hurdle in advancing this treatment lies in effectively deliverin... Read More about Exploring non-viral methods for the delivery of CRISPR-Cas ribonucleoprotein to hematopoietic stem cells.

PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review (2024)
Journal Article
Kirkby, M., Sabri, A. H. B., Holmes, A., Moss, G. P. J., & Scurr, D. (in press). PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review. Journal of Pharmacy and Pharmacology, 1-17. https://doi.org/10.1093/jpp/rgae080

Objectives Poly(amidoamine) dendrimers have been widely investigated as potential nanomaterials that can enhance the skin permeation of topically applied drugs. This article reviews the studies that have used dendrimers as penetration enhancers and e... Read More about PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review.

FIFA 11+ KIDS in the prevention of soccer injuries in children: a systematic review (2024)
Journal Article
Ramos, A. P., de Mesquita, R. S., Migliorini, F., Maffulli, N., & Okubo, R. (2024). FIFA 11+ KIDS in the prevention of soccer injuries in children: a systematic review. Journal of Orthopaedic Surgery and Research, 19(1), 1-10. https://doi.org/10.1186/s13018-024-04876-9

Background: The “FIFA 11+” is an injury prevention program conceived for soccer athletes aged over 14. The use of FIFA 11+ Kids in soccer was associated with a reduction of the overall risk of injuries in children by 48%, and of 74% for serious injur... Read More about FIFA 11+ KIDS in the prevention of soccer injuries in children: a systematic review.

Osteointegration of functionalised high-performance oxide ceramics: imaging from micro-computed tomography (2024)
Journal Article
Migliorini, F., Eschweiler, J., Betsch, M., Maffulli, N., Tingart, M., Hildebrand, F., …Schenker, H. (2024). Osteointegration of functionalised high-performance oxide ceramics: imaging from micro-computed tomography. Journal of Orthopaedic Surgery and Research, 19(1), 1-8. https://doi.org/10.1186/s13018-024-04918-2

Background
This study evaluated the osseointegration potential of functionalised high-performance oxide ceramics (HPOC) in isolation or coated with BMP-2 or RGD peptides in 36 New Zeeland female rabbits using micro-computed tomography (micro CT). Th... Read More about Osteointegration of functionalised high-performance oxide ceramics: imaging from micro-computed tomography.

Non‐surgical management of acute proximal hamstring avulsions can produce clinically acceptable results (2024)
Journal Article
Maffulli, N., Hassan, R., Poku, D., Chan, O., & Oliva, F. (in press). Non‐surgical management of acute proximal hamstring avulsions can produce clinically acceptable results. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1002/ksa.12368

AbstractPurposeTo evaluate the mid‐term clinical outcomes for the non‐surgical and surgical management of acute proximal hamstring avulsions.MethodsSixty physically active individuals were offered surgical or non‐surgical management for their proxima... Read More about Non‐surgical management of acute proximal hamstring avulsions can produce clinically acceptable results.

Spontaneous Resolution of Symptomatic Synovial Cysts of the Lumbar Spine: A Comprehensive Review with Two Illustrative Cases (2024)
Journal Article
Scrofani, R., De Simone, M., Migliorini, F., Amoroso, E., Maffulli, N., Narciso, N., & Iaconetta, G. (in press). Spontaneous Resolution of Symptomatic Synovial Cysts of the Lumbar Spine: A Comprehensive Review with Two Illustrative Cases. Medicina, 60(7), Article 1115. https://doi.org/10.3390/medicina60071115

Although lumbar synovial cysts (LSCs) are frequently described in the literature, they are a relatively uncommon cause of low back and radicular leg pain. Furthermore, their spontaneous resolution is an even rarer event. The standard treatment of the... Read More about Spontaneous Resolution of Symptomatic Synovial Cysts of the Lumbar Spine: A Comprehensive Review with Two Illustrative Cases.

Percutaneous transverse pinning for metacarpal fractures: a clinical trial. (2024)
Journal Article
Pintore, A., Astone, A., Vecchio, G., Asparago, G., Calabrò, G., Migliorini, F., & Maffulli, N. (in press). Percutaneous transverse pinning for metacarpal fractures: a clinical trial. Archives of Orthopaedic and Trauma Surgery, https://doi.org/10.1007/s00402-024-05422-2

Metacarpal fractures account for 25%-50% of all hand fractures and may negatively impact hand function and ability to work. Percutaneous transverse pinning of non-articular metacarpal fractures allows mobilisation immediately after the procedure. Bet... Read More about Percutaneous transverse pinning for metacarpal fractures: a clinical trial..

A bacteriocin-based coating strategy to prevent vancomycin-resistant Enterococcus faecium biofilm formation on materials of interest for indwelling medical devices. (2024)
Journal Article
Kranjec, C., Mathew, J. P., Ovchinnikov, K., Fadayomi, I., Yang, Y., Kjos, M., & Li, W.-W. (2024). A bacteriocin-based coating strategy to prevent vancomycin-resistant Enterococcus faecium biofilm formation on materials of interest for indwelling medical devices. Biofilm, 8, Article 100211. https://doi.org/10.1016/j.bioflm.2024.100211

The ever-increasing use of exogenous materials as indwelling medical devices in modern medicine offers to pathogens new ways to gain access to human body and begin, in some cases, life threatening infections. Biofouling of such materials with bacteri... Read More about A bacteriocin-based coating strategy to prevent vancomycin-resistant Enterococcus faecium biofilm formation on materials of interest for indwelling medical devices..

Are the metal identity and stoichiometry of metal complexes important for colchicine site binding and inhibition of tubulin polymerization? † (2024)
Journal Article
Besleaga, I., Raptová, R., Stoica, A.-C., Milunovic, M. N. M., Zalibera, M., Bai, R., …Arion, V. B. (in press). Are the metal identity and stoichiometry of metal complexes important for colchicine site binding and inhibition of tubulin polymerization? †. Dalton Transactions, https://doi.org/10.1039/d4dt01469c

Quite recently we discovered that copper(ii) complexes with isomeric morpholine-thiosemicarbazone hybrid ligands show good cytotoxicity in cancer cells and that the molecular target responsible for this activity might be tubulin. In order to obtain b... Read More about Are the metal identity and stoichiometry of metal complexes important for colchicine site binding and inhibition of tubulin polymerization? †.

IS SARM - Selective Androgen Receptor Modulator: A Chance for Therapeutic Approach in Muscle-Wasting Chronic Conditions? (2024)
Journal Article
Bartoli, A., Maffulli, N., Oliva, G., Ziello, S., & Oliva, F. (in press). IS SARM - Selective Androgen Receptor Modulator: A Chance for Therapeutic Approach in Muscle-Wasting Chronic Conditions?. M.L.T.J. Muscles, Ligaments and Tendons Journal, 14(02), 361. https://doi.org/10.32098/mltj.02.2024.17

Purpose of review. The purpose of this paper is to review the current concepts regard­ing a new-old pharmacological class, SARM (Selective Androgen Receptor Modula­tor). Especially how SARM can be beneficial in treatment of orthopedic disease.
Mater... Read More about IS SARM - Selective Androgen Receptor Modulator: A Chance for Therapeutic Approach in Muscle-Wasting Chronic Conditions?.