Amid a substantial rise in gabapentin and pregabalin (gabapentinoid) prescribing and increasing concerns with their potential for misuse and diversion, there are anecdotal reports of their use for osteoarthritis. The aim of my thesis was to understan... Read More about Gabapentinoid prescriptions in patients with osteoarthritis: an analysis of data from the Clinical Practice Research Datalink.
All Outputs (18694)
The association of parity with cardiovascular disease: systematic review and cohort study
Thesis
Background and Aims: A woman’s cardiovascular and metabolic systems undergo considerable adaptations during pregnancy, which can affect a woman’s physiology long term. This research aimed to investigate whether parity increases the risk of future car... Read More about The association of parity with cardiovascular disease: systematic review and cohort study.
Computer modelling of pure and doped stoichiometric and congruent lithium niobate
Thesis
This investigation has modelled lithium niobate in its congruent form, stoichiometric form and paraelectric phase to determine whether the preference of doping schemes changes, specifically when the concentration of a dopant is varied. Mott-Littleton... Read More about Computer modelling of pure and doped stoichiometric and congruent lithium niobate.
Delivering nanoengineered neural stem cells within neurosurgical grade biomaterials
Thesis
Achieving neural regeneration after spinal cord injury (SCI) represents a significant challenge. Neural stem cell (NSC) therapy offers replacement of damaged cells and delivery of pro-regenerative factors, but >95% of cells die when transplanted to s... Read More about Delivering nanoengineered neural stem cells within neurosurgical grade biomaterials.
The present thesis investigates the role of justice when informing health policies such as the reforms of health systems or those aimed at tackling health inequalities. I set the problem as a case study derived from the reforms of the Chilean health... Read More about An enquiry concerning justice in health, or what ethical account best informs health policies aimed at tackling health inequalities..
Against the New Atheism: A Defence of Salvation-Sensitive Exclusivism
Thesis
In the last decade, there have been several publications and articles by academics (especially Dawkins, Dennett, and Harris), attacking the rationale behind religious belief through the presupposition of scientism. According to these ‘New Atheists,'... Read More about Against the New Atheism: A Defence of Salvation-Sensitive Exclusivism.
How can the concept of parrhesia be used to challenge the politics of sovereign exceptionalism?
Thesis
This research paper is one that seeks to contribute to the resistance debate that focuses on ‘life’ as a governmental practice of ‘sovereign exceptionalism’. Sovereign exceptionalism is a term given to encompass a wide-ranging literature with its key... Read More about How can the concept of parrhesia be used to challenge the politics of sovereign exceptionalism?.
This thesis employs Chalmers’ (1996) hard problem of consciousness in an attempt to highlight the fundamental issues with the physicalist zeitgeist that has predominated much of contemporary philosophical thought, before championing an alternative me... Read More about Against the physicalist zeitgeist: evaluating the contemporary case for physicalism and the prospect of property dualism.
Evidence based hydrotherapy: a community of practice approach
Thesis
Health Care Professionals and patients report that hydrotherapy is valuable in managing inflammatory arthritis and musculoskeletal pain. However, clinical services are increasingly required to justify the clinical and cost effectiveness of hydrothera... Read More about Evidence based hydrotherapy: a community of practice approach.
Development of a clinical care pathway for anaemic patients
Thesis
Improving cancer survival in the UK is one of the leading items on the agenda of the government. Survival from gastrointestinal cancer is yet to come into line with Europe. In 2000 the department of health (DoH) introduced guidelines for referral of... Read More about Development of a clinical care pathway for anaemic patients.
Following the 2008 financial crash the UK Government, through the Local Enterprise Partnership model has been driving major economic regeneration in localised economies for high value job creation, uplifting skills and infrastructure investment. LEPs... Read More about Decentralised Energy Development: A study examining its potential to drive economic regeneration in the UK.
This thesis explores a selection of African based activist, literary and scholarly women’s writings to consider whether one can identify African feminism contributions to the development of international human rights. The purpose of the research is... Read More about An Exploration of the Contributions of African Feminism to the Development of International Human Rights.
Is my red yours? Understanding experience and perception in light of spectral inversion
Thesis
The problem of Scepticism has long haunted the Philosophy of Mind—a particularly noxious form of Scepticism is articulated by John Locke’s problem of Inversion. The problem of inversion acts to undermine two of the dominant theories of mind: Function... Read More about Is my red yours? Understanding experience and perception in light of spectral inversion.
Literacy, health literacy and the association with health behaviours
Thesis
Background Socioeconomic status is directly related to health in the UK. People from non-skilled households are twice as likely to smoke, drink excessively, have a poor diet and insufficient activity levels compared to those in professional househol... Read More about Literacy, health literacy and the association with health behaviours.
Health Literacy and Chronic Health Management among Older Adults
Thesis
Health literacy is an expanding area of health research which focuses on individuals’ ability to “access, understand, appraise and use information to make decisions about health.” (1) Research has shown the impact health literacy can have on patient... Read More about Health Literacy and Chronic Health Management among Older Adults.
The ethics of electroconvulsive therapy
Thesis
During the last forty years, there has been increasing interest in the concept of professional ethics, particularly in the area of medical ethics. Psychiatry as a medical speciality has been part of the process because it is deeply concerned with the... Read More about The ethics of electroconvulsive therapy.
An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells
Thesis
Type 1 diabetes is a challenging condition to manage effectively. Utilising the mesenchymal stem cell (MSC) secretome is an avenue being researched in regenerative medicine which could potentially ameliorate the condition. Previous studies have ident... Read More about An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells.
Interventions for the Management of Distal Intestinal Obstruction Syndrome in Cystic Fibrosis
Thesis
Distal intestinal obstruction syndrome (DIOS) is a major gastrointestinal complication in cystic fibrosis (CF). It arises when thick mucus and viscid faecal material combine in the bowel, commonly at the terminal ileum or caecum, leading to partial o... Read More about Interventions for the Management of Distal Intestinal Obstruction Syndrome in Cystic Fibrosis.
Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes
Thesis
Recent study suggested that the anti-platelet effect of nicergoline is caused by inhibiting agonist-evoked Ca2+ signalling by disrupting the normal localization of the dense tubular system in human platelets. This effect is brought about by the disru... Read More about Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes.